A Multi-Center, Double-Blind, Randomized, Vehicle-Controlled, Parallel-Group Study Comparing AM001 Cream to Vehicle in the Treatment of Plaque Psoriasis

To compare the safety and efficacy profile of AM001 Cream and its vehicle in the treatment of plaque psoriasis.

Start Date01 Aug 2013

Sponsor / Collaborator

Amderma

100 Clinical Results associated with AM-001

100 Translational Medicine associated with AM-001

100 Patents (Medical) associated with AM-001

126

Literatures (Medical) associated with AM-001

19 Sep 2024·bioRxiv : the preprint server for biology

Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation.

Article

Author: Lemay, Sarah E ; Hadri, Lahouaria ; Bonnet, Sebastien ; Orchando, Jordi ; Perez Rodriguez, Leticia ; Lozano-Ojalvo, Daniel ; Lezoualc'h, Frank ; Sauvaget, Mélanie ; Provencher, Steeve ; Jagana, Vineeta ; Cortijo, Julio ; Turnbull, Irene C ; Jankowski, Katherine ; Bisserier, Malik ; Zhang, Shihong ; Formoso, Karina ; Milara, Javier ; Breuils-Bonnet, Sandra

BackgroundIdiopathic Pulmonary fibrosis (IPF) is characterized by progressive scarring and fibrosis within the lungs. There is currently no cure for IPF; therefore, there is an urgent need to identify novel therapeutic targets that can prevent the progression of IPF. Compelling evidence indicates that the second messenger, cyclic adenosine monophosphate (cAMP), inhibits lung fibroblast proliferation and differentiation through the classical PKA pathway. However, the contribution of the e xchange p rotein directly a ctivated by c AMP 1 (Epac1) to IPF pathophysiological processes is yet to be investigated.ObjectiveTo determine the role of the cAMP-binding protein Epac1 in the progression of IPF.MethodsWe used lung samples from IPF patients or healthy controls, mouse lung samples, or lung fibroblast isolated from a preclinical mouse model of PF induced by bleomycin intratracheal injection. The effect of bleomycin (BLM) treatment was determined in Epac1 knock-out mice or wild-type littermates. Epac1 expression was modulated in vitro by using lentiviral vectors or adenoviruses. The therapeutic potential of the Epac1-selective pharmacological inhibitor, AM-001, was tested in vivo and in vitro, using a bleomycin mouse model of PF and an ex vivo precision-cut lung slices (PCLs) model of human lung fibrosis.ResultsEpac1 expression was increased in the lung tissue of IPF patients, in IPF-diseased fibroblasts and in BLM-challenged mice. Furthermore, Epac1 genetic or pharmacological inhibition with AM-001 decreased normal and IPF fibroblast proliferation and the expression of profibrotic markers, αSMA, TGF-β/SMAD2/3, and interleukin-6 (IL-6)/STAT3 signaling pathways. Consistently, blocking Epac1 protected against BLM-induced lung injury and fibrosis, suggesting a therapeutic effect of Epac1 inhibition on PF pathogenesis and progression. Global gene expression profiling revealed a decrease in the key components of the profibrotic gene signature and neddylation pathway in Epac1-deficient lung fibroblasts and IPF human-derived PLCs. Mechanistically, the protective effect of Epac1 inhibition against PF development involves the inhibition of FoxO3a neddylation and its subsequent degradation by NEDD8, and in part, by limiting the proliferative capacity of lung-infiltrating monocytes.ConclusionsWe demonstrated that Epac1 is an important regulator of the pathological state of fibroblasts in PF and that small molecules targeting Epac1 can serve as novel therapeutic drugs against PF.

17 Sep 2024·Langmuir

Increased Ordering of Potassium Stearate/Stearic Acid/Glyceryl Stearate Confined between Swollen Cross-Linked Poly(acrylic acid)

Article

Author: Shi, Shanling ; Liu, Chung-Hao ; Song, Qing ; Shih, Kuo-Chih ; Burford, Mark ; Chang, Shing-Yun ; Nieh, Mu-Ping ; Ma, Anson W. K. ; Chen, Liang Bin ; Moaddel, Teanoosh

In this paper, we investigate the phase behavior of a surfactant mixture comprising glyceryl stearate, potassium stearate, and stearic acid, in the presence of Carbopol, a commonly used thickener in personal care products. At low Carbopol concentrations (<0.03%), the surfactant mixture interacted with Carbopol electrostatically, increasing the degree of Carbopol swelling and, consequently, the overall viscosity. However, such an effect diminished as the Carbopol concentration was further increased. At a Carbopol concentration of 0.2%, two types of liquid crystalline surfactant structures, namely, multilamellar vesicles and lamellae, were observed between the swollen Carbopol domains. Although similar types of surfactant structures were present in a much more concentrated surfactant solution having a similar viscosity but without Carbopol, the lamellae in the presence of Carbopol were more ordered and with a larger d spacing. The increased ordering was probably induced by the interactions between the surfactants and Carbopol as the surfactants were confined between the swollen Carbopol domains.

03 Mar 2024·Ultrastructural Pathology

Protective effects of Urtica dioica on the cerebral cortex damage induced by Potassium bromate in adult male albino rats

Article

Author: Mahmoud, Abeer A. ; Hassen, Ebtehal Z. ; Zayed Mohamed, Maha

Potassium bromate is used in cheese production, beer making and is also used in pharmaceutical and cosmetic. It is a proven carcinogen as it is a strong oxidizing agent that generates free radicals during xenobiotic metabolism. Urtica dioica (Ud) (from the plants' family of Urticaceae) is a plant that has long been used as a medicinal plant in many parts of the world. It has been shown to have anti-inflammatory, antioxidant and immunosuppressive properties. So, this study aimed to clarify the effect of Potassium bromate on the histological structure of cerebral cortex of adult male albino rats, evaluate the possible protective role of Urtica dioica. Thirty adult healthy male albino rats were divided into three groups; group I (Control group), group II (KBrO3 treated group). Group III (KBrO3 and Urtica dioica treated group).At the end of the experiment, rats in all groups were anesthetized and specimens were processed for light and electron microscope. Morphometric and statistical analyses were also performed. Nerve cells of the treated group showed irregular contours, dark nuclei, irregular nuclear envelopes, dilated RER cisternae, and mitochondria with ruptured cristae. Vacuolated neuropil was also observed. Immunohistochemically, stained sections for GFAP showed strong positive reaction in the processes of astrocytes. Recovery group showed revealed nearly the same as the histological picture as the control group. In conclusion, potassium bromate induces degenerative effects on neurons of cerebral cortex and urtica dioica provide an important neuroprotective effects against these damaging impacts through their antioxidant properties.

100 Deals associated with AM-001

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Actinic Keratosis	Phase 2	US	AmDerma Pharmaceuticals LLC	06 Jun 2017
Plaque psoriasis	Phase 2	US	-	-
Psoriasis	Phase 2	-	Everett Laboratories Inc	-

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