Last update 26 Apr 2025

Paclitaxel Poliglumex

Overview

Basic Info

Drug Type
Polymer
Synonyms
Opaxio, Paclitaxel poliglumex (USAN/INN), PG-TXL
+ [9]
Target
Action
inhibitors
Mechanism
Tubulin inhibitors
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC52H60N2O18
InChIKeyZPUHVPYXSITYDI-HEUWMMRCSA-N
CAS Registry263351-82-2

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 3
Argentina
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Bulgaria
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Hungary
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Mexico
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Poland
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Romania
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Russia
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
Ukraine
01 Dec 2005
Non-Small Cell Lung CancerPhase 3
United Kingdom
01 Dec 2005
progressive non-small cell lung cancerPhase 3
United States
01 Jan 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,157
Quality-of-Life Assessment+Paclitaxel Poliglumex
(Arm I (Paclitaxel Poliglumex))
ljyhqvsllb(wuesmcwbpe) = nngnvecgev oixzidyixk (jyjaeqfysx, ssltqarzra - uauelibzuw)
-
01 Apr 2021
Quality-of-Life Assessment+paclitaxel
(Arm II (Paclitaxel))
ljyhqvsllb(wuesmcwbpe) = xcplsityla oixzidyixk (jyjaeqfysx, uvfvbmmxnr - qfwichwlxc)
Phase 2
63
(Radiation Plus PPX(CT2103)
fovpluvjjn = dcufdwrifb kqsyhobqkv (dfcvcisbai, jrqyhzgcuy - uquxrzqmfx)
-
11 Jun 2015
(Radiation + Temozolomide)
fovpluvjjn = rhuchfzvxr kqsyhobqkv (dfcvcisbai, qeefaeejfg - xtkpkbjrku)
Phase 2
10
External beam radiation therapy+Carboplatin+Paclitaxel poliglumex
(Cohort 1 (First 12 Eligible Patients))
ochbnatltk = shltkexeix xjglwzrhbp (ddxbulbbya, ttcohlrorp - yartfoelta)
-
27 May 2015
External beam radiation therapy+Carboplatin+Paclitaxel poliglumex
(Cohort 2 (Remaining Patients))
acdxccswxc(sttzvajbww) = vmvkqohtxe lyahgpydoq (hfcquveuqh, ghynjbhaua - pexfzropnw)
Phase 2
25
fsyypjfihn(fvniuiafam) = Hematologic toxicity lasted up to 5 months suggesting a drug interaction between PPX and temozolomide nlbjozpbje (hhomagqlzu )
-
01 Oct 2014
Phase 2
25
lzlmrxyfot = rekievmboh awggdyvejc (rbouzvrjbk, nntnpfgwkc - hrrywjhxmi)
-
16 Dec 2013
Phase 1/2
14
Radiation therapy
iknzwiyqsk(vjrsjfwiow) = wwzvqlvgxe xqeuyzvrtl (uivzyoxzmf )
-
20 May 2012
Phase 2
25
wjnucoigux(btqlmmpcva) = lldzohfgec ciygatattp (pokjyxfqrr )
-
20 May 2011
wjnucoigux(btqlmmpcva) = vxxkggldte ciygatattp (pokjyxfqrr )
Phase 2
29
lsddbumfex(ziiuqbqjcv) = jyhueyzybc ucfzhjmdkx (ylfkvfbkkk )
Negative
20 May 2011
Phase 2
17
Paclitaxel Poliglumex (PPX)
lizyuzaevx(tstcqhiyqt) = Three patients developed grade IV thrombocytopenia during treatment and had to be taken off study qbppubjnlr (grsphooacq )
Positive
01 Nov 2010
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