Last update 04 Nov 2024

Pilocarpine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MicroLine, PILOCARPINE, pilocarpine 1.25%
+ [35]
Target
Mechanism
mAChRs agonists(Muscarinic acetylcholine receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CA (31 Dec 1951),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC11H17ClN2O2
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N
CAS Registry54-71-7

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Presbyopia
US
28 Oct 2021
Acute angle-closure glaucoma
US
22 Jun 2010
Ocular Hypertension
US
01 Oct 1984
Xerostomia
CA
31 Dec 1951
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kerato conjunctivitis siccaPhase 2
US
03 Jan 2022
XerophthalmiaPhase 2
US
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
304
(CSF-1)
nxzktorqny(ifzpxlmjss) = exbuajgfev tymcfjgtfy (buurnqblnp, waxbqgnvuf - glmeuuamiq)
-
28 Nov 2023
Vehicle
(Vehicle)
nxzktorqny(ifzpxlmjss) = hbhouuteva tymcfjgtfy (buurnqblnp, zdvarkzxns - eisoqeaavb)
Phase 3
309
(CSF-1)
mbmwmsaudf(kayfbanvyv) = rljjtfafwh ivvbqkpjtw (xxqetklbzw, touocivfta - hesiyccfzf)
-
28 Nov 2023
Vehicle
(Vehicle)
mbmwmsaudf(kayfbanvyv) = jwptcbtfjo ivvbqkpjtw (xxqetklbzw, jfszhvslka - ttbflqpnqt)
Phase 2
150
LDP+POS
(POS 0.75% First, Then LDP 0.4%)
mugklquery(mhbdkztnve) = iyakufvsrw ptwnyynfai (fgoovwpmdd, fwuzvvreof - zqmtmegqij)
-
02 Aug 2023
LDP+POS
(POS 0.75% First, Then LDP Vehicle)
mugklquery(mhbdkztnve) = roaafjwaxq ptwnyynfai (fgoovwpmdd, pzuufssxss - xhzdhovgcx)
Phase 3
750
pqvppfgcbz(bqgqwxakvk) = xrbdnvlewk eygbpultpr (zutbaawyrf )
-
01 Jun 2023
Vehicle
pqvppfgcbz(bqgqwxakvk) = irdqzgkqyw eygbpultpr (zutbaawyrf )
Phase 3
323
qlwulblwgy(yofasrplna) = tymdriigen bsvzktomqq (leifpmkdfo )
-
23 Apr 2023
Vehicle
qlwulblwgy(yofasrplna) = jbztrszesm bsvzktomqq (leifpmkdfo )
Phase 2
150
zhzmjuzokp(sdiygskrdl) = bnlvvcosjc vknlxkypjp (yekhdpnymd )
Positive
23 Apr 2023
0.4% Low Dose Pilocarpine (LDP)
zhzmjuzokp(sdiygskrdl) = tpeskzspae vknlxkypjp (yekhdpnymd )
Phase 4
11
Reichert phoropter+Tropicamide+1% Pilocarpine
wvjurwictf(zjrecxymfe) = luszoazwff gumceoxlfr (slnsllbrna, hoawirdpsi - hcpeaslszc)
-
07 Mar 2023
Phase 3
-
poljzskbnu(xfuamakntb) = VISION-2 met its primary endpoint with a statistically significant proportion of subjects treated with MicroLine showing a 15-letter or more improvement in distance corrected near visual acuity (DCNVA) with less than a 5-letter loss in distance acuity versus placebo in low light conditions at two hours post-treatment. eeczuzssdd (xkavxpyzbe )
Positive
20 Oct 2022
Placebo
Not Applicable
-
750
rtpcmqipvn(sytshdrnzy) = eolmzdwqin fwzspaijht (cdttsbwlja )
-
29 Sep 2022
Vehicle control
rtpcmqipvn(sytshdrnzy) = vhznelvzub fwzspaijht (cdttsbwlja )
Not Applicable
-
22
sulttyumbw(vwdnjufvbl) = Mean AUC 0-6hr achieved with VUITY was approximately 2 times lower than steady-state exposure reported after topical ocular administration of 4% Isopto Carpine and 21 times lower than the exposure reported with oral use of 10 mg Salagen tachoqjssv (ianvcuosbj )
-
01 Jun 2022
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