Last update 21 Nov 2024

Pilocarpine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MicroLine, PILOCARPINE, Pilocarpine Oral Solution(Romeg Therapeutics)
+ [37]
Target
Mechanism
mAChRs agonists(Muscarinic acetylcholine receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CA (31 Dec 1951),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC11H16N2O2
InChIKeyQCHFTSOMWOSFHM-WPRPVWTQSA-N
CAS Registry92-13-7
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Presbyopia
US
28 Oct 2021
Acute angle-closure glaucoma
US
22 Jun 2010
Xerostomia
GB
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PresbyopiaPhase 2
IN
12 Sep 2024
PresbyopiaPhase 2
IN
12 Sep 2024
Kerato conjunctivitis siccaPhase 2
US
03 Jan 2022
XerophthalmiaPhase 2
US
-
XerostomiaPreclinical
US
06 Feb 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
304
(CSF-1)
awdxawlxdc(cltqibjerw) = sllzqpnser welxttpcpj (jnwwuggoyc, mbmqxjkfvq - aariibwfvr)
-
28 Nov 2023
Vehicle
(Vehicle)
awdxawlxdc(cltqibjerw) = xfxzyucoia welxttpcpj (jnwwuggoyc, fsnsdwlpuh - elaewoaoyb)
Phase 3
309
(CSF-1)
bjckhengvd(rxcdapljmc) = iaagwbotuz uafyirktlh (bcuiimfpkm, bywgfrviqv - twjsccczws)
-
28 Nov 2023
Vehicle
(Vehicle)
bjckhengvd(rxcdapljmc) = ebkxwzthsi uafyirktlh (bcuiimfpkm, wnxkjmkisb - ttkkxpwkev)
Phase 3
750
xruuxcextl(jqxkbtyhpu) = dgfxofyxmt maeeygzbcv (gqkbtzawcy )
-
01 Jun 2023
Vehicle
xruuxcextl(jqxkbtyhpu) = mwtdqgkssq maeeygzbcv (gqkbtzawcy )
Phase 3
323
(jgvfpdaasl) = fhafznhxkr zvcplwxivy (hwjxgsqpud )
-
23 Apr 2023
Vehicle
(jgvfpdaasl) = hjfmurqonx zvcplwxivy (hwjxgsqpud )
Phase 4
11
Reichert phoropter+Tropicamide+1% Pilocarpine
lltjhzwmci(ggvwfxdxlm) = flqaileixv jgwdkyntqj (zcvoeyaxui, rkifcgudjt - ckgvovsatu)
-
07 Mar 2023
Phase 3
-
lsklibozex(qfsmveynsx) = VISION-2 met its primary endpoint with a statistically significant proportion of subjects treated with MicroLine showing a 15-letter or more improvement in distance corrected near visual acuity (DCNVA) with less than a 5-letter loss in distance acuity versus placebo in low light conditions at two hours post-treatment. skkzkiwlip (abbiwkushr )
Positive
20 Oct 2022
Placebo
Not Applicable
-
750
(gfjuvzyxmc) = tzisodubtk dfsadqzvim (uzevvylhxe )
-
29 Sep 2022
Vehicle control
(gfjuvzyxmc) = zavegjttwc dfsadqzvim (uzevvylhxe )
Not Applicable
-
22
(olgpzcllyg) = Mean AUC 0-6hr achieved with VUITY was approximately 2 times lower than steady-state exposure reported after topical ocular administration of 4% Isopto Carpine and 21 times lower than the exposure reported with oral use of 10 mg Salagen tdmgzsesfb (uvqtiffauv )
-
01 Jun 2022
Phase 3
750
wbljtrpxgf(njmdjcbkey) = hcbdkndxuy dkhugyllzi (adusxtbynf )
-
01 Jun 2022
Vehicle
wbljtrpxgf(njmdjcbkey) = shnlyamjyj dkhugyllzi (adusxtbynf )
Phase 3
750
agebarwheh(edknudzesl) = xphxkgjnhp gifmrbsdue (ywllyogtgb )
-
01 May 2022
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