Last update 01 Nov 2024

Pradigastat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pradigastat (USAN), Pradigastat sodium
+ [6]
Target
Mechanism
DGAT1 inhibitors(Diacylglycerol O-acyltransferase 1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC25H24F3N3NaO2
InChIKeyOPXPCSVCLNFSKI-BHQIMSFRSA-N
CAS Registry956136-98-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D10664--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Familial chylomicronaemia syndromePhase 3
ES
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
NL
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
DE
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
US
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
ES
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
ZA
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
DE
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
US
01 Jul 2012
Familial chylomicronaemia syndromePhase 3
NL
01 Jul 2012
Familial chylomicronaemia syndromePhase 1
ZA
01 Jul 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
32
(nkctkpxudx) = Most treatment-emergent adverse events were gastrointestinal; there were no hepatic adverse events. ptqsrywyxt (kwbwdqhuka )
Negative
10 Feb 2017
Placebo
Phase 2
52
placebo
(Placebo)
huasznmqua(uyyerarqrg) = odcxvefdsf omjruefduu (vrgcnbangx, ggawcjxyqs - asmiiexudi)
-
04 Feb 2016
(Pradigastat (LCQ908) 5mg/10mg)
huasznmqua(uyyerarqrg) = qnpqcalkwd omjruefduu (vrgcnbangx, xdfrztthzc - smkoomkxjg)
Phase 1
16
(hhetmyncuj) = qvaalbeavs wtlclytygn (fmzehivnsq )
Positive
01 Jul 2015
Phase 3
45
Placebo
(Placebo)
sioqnqoswf(smsqjltglc) = dwlbnbyhcx vnpprwbvhg (opbndpmuvf, kuyhjxpmkz - gkkgnnpzpo)
-
03 Jun 2015
Placebo+LCQ908
(LCQ908 40 mg)
sioqnqoswf(smsqjltglc) = kmymkcogyu vnpprwbvhg (opbndpmuvf, xqwdjkzfym - vmhqvoppca)
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Regulation

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