Anji Pharmaceuticals (Shanghai) Co., Ltd.

Primary objective: To evaluate the pharmacokinetic characteristics of pradigastat tablets at different dose levels after single administration to healthy subjects. Secondary objective: To evaluate the safety of pradigastat tablets at different doses in humans.

The primary objectives of this study are: - To characterize the pharmacokinetic (PK) characteristics of a single oral dose of ANJ900 in healthy Chinese subjects - To evaluate the effect of food on the PK of a single oral dose of ANJ900 in healthy Chinese subjects The secondary objectives of this study are: - To compare the PK of ANJ900 with metformin immediate-release (IR) tablets in healthy Chinese subjects ? To evaluate the safety and tolerability of ANJ900 in healthy Chinese subjects

To evaluate the efficacy of pradigastat compared with placebo in increasing the number of spontaneous bowel movements (SBM) per week in patients with functional constipation (FC)