Golodirsen

New CEO Michael Severino , MD, brings extensive biopharma leadership and a proven track record of advancing innovation, building franchises, and delivering growth Net product revenues for the second quarter 2026 totaled $328.7 million , consisting of $230.6 million of PMO net product revenue and $98.1 million of ELEVIDYS net product revenue Achieved GAAP and non-GAAP operating income of $13.3 million and $86.5 million for the second quarter 2026, respectively CAMBRIDGE, Mass. --(BUSINESS WIRE)--Aug. 5, 2026-- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today reported financial results for the second quarter of 2026. “As I begin my tenure as CEO, I am excited by the strength of Sarepta's foundation, the impact our therapies are having for patients, and the significant opportunities ahead,” said Michael Severino , MD, chief executive officer, Sarepta Therapeutics . “Our second quarter results, including $328.7 million in total net product revenue and both GAAP and non-GAAP operating profitability, reflect the strength and resilience of our business. With important data readouts expected in DM1 and FSHD, continued progress across our broader pipeline, and a talented team dedicated to transforming the lives of patients with rare diseases, we have significant opportunities ahead and remain committed to delivering sustainable long-term value. Our priorities are clear: execute our commercial strategy, advance our promising siRNA pipeline, and continue allocating capital with discipline. With a strong balance sheet, an innovative pipeline, and an experienced leadership team, I believe Sarepta is well positioned to deliver on its long-term potential.” Corporate Highlights: Leadership transition positions Sarepta for continued execution and next phase of growth: Appointed Michael Severino , MD, as Chief Executive Officer and member of the Board of Directors, effective July 28, 2026 . Dr. Severino brings more than 25 years of biopharmaceutical leadership experience, including senior executive roles at AbbVie, Amgen and Merck, and a proven track record of advancing innovation, building leading franchises and executing across the full development and commercialization continuum. Doug Ingram retired from Sarepta and will serve in an advisory capacity through the end of 2026 to support a seamless leadership transition. Key 2H 2026 milestones update: Readouts from our MAD cohorts of our ongoing phase 1/2 studies in DM1 and FSHD remain on track for 2H 2026. For ELEVIDYS, full enrollment of ENDEAVOR Cohort 8 expected by year-end 2026 and 12-week data from the full cohort in Q1 2027. Huntington’s disease program advances: Dosing underway in INSIGHTT, the first-in-human Phase 1 study of SRP-1005, Sarepta’s investigational siRNA candidate for Huntington’s disease. Regulatory progress for PMO therapies: FDA has accepted for review Sarepta’s supplemental New Drug Applications (sNDAs) seeking conversion of AMONDYS 45 and VYONDYS 53 from accelerated to traditional approval. The applications are supported by data from the ESSENCE confirmatory study, substantial published real-world evidence, and the favorable, consistent safety profiles of both exon-skipping therapies. Narrowed FY 2026 Guidance: With six months remaining for the year and consistent with prior expectations toward the lower end of the $1.2-$1.4 billion range, Company narrowed its 2026 total net product revenue guidance to $1.2-$1.3 billion while also narrowing combined non-GAAP R&D and SG&A expense guidance from $800.0-$900.0 million to $800.0-$850.0 million . Strong financial position supports advancement of our pipeline and funding of medium-term liabilities: Delivered another quarter of operating profitability and ended with approximately $945.0 million of cash, cash equivalents, restricted cash and investments, an increase of approximately $197.0 million in the quarter. Company is well-positioned to advance DM1 and FSHD programs with commercial cash flows while maintaining disciplined capital allocation. Conference Call The event will be webcast live under the investor relations section of Sarepta's website at https://investorrelations.sarepta.com/events-presentations and following the event a replay will be archived there for one year. This event can be accessed using this link. Q2 2026 Financial Highlights1 For the Three Months Ended June 30 , 2026 2025 QTD Change (in millions, except for per share amounts) $ % Total revenues $ 401.3 $ 611.1 $ (209.8 ) (34 )% Operating income: GAAP $ 13.3 $ 115.6 $ (102.3 ) (89 )% Non-GAAP $ 86.5 $ 162.8 $ (76.3 ) (47 )% Net (loss) income: GAAP $ (4.9 ) $ 196.9 $ (201.8 ) * Non-GAAP $ 78.6 $ 215.2 $ (136.6 ) (63 )% Diluted (loss) earnings per share GAAP $ (0.05 ) $ 1.89 $ (1.94 ) * Non-GAAP $ 0.64 $ 2.02 $ (1.38 ) (68 )% For the Six Months Ended June 30 , 2026 2025 YTD Change (in millions, except for per share amounts) $ % Total revenues $ 1,132.1 $ 1,355.9 $ (223.8 ) (17 )% Operating income (loss): GAAP $ 371.7 $ (184.8 ) $ 556.5 * Non-GAAP $ 484.2 $ (86.8 ) $ 571.0 * Net income (loss): GAAP $ 326.1 $ (250.6 ) $ 576.7 * Non-GAAP $ 464.0 $ (117.3 ) $ 581.3 * Diluted earnings (loss) per share GAAP $ 2.99 $ (2.57 ) $ 5.56 * Non-GAAP $ 3.79 $ (1.20 ) $ 4.99 * 1For an explanation of our use of non-GAAP financial measures, please refer to the “Use of Non-GAAP Financial Measures” section later in this press release, and for a reconciliation of each non-GAAP financial measure from the most comparable GAAP measures, see the table at the end of this press release. *Not meaningful As of June 30, 2026 As of December 31, 2025 (in millions) Cash, cash equivalents, restricted cash and investments $ 945.0 $ 953.8 Revenues Total revenues were $401.3 million for the three months ended June 30, 2026 , as compared to $611.1 million for the same period of 2025, a decrease of $209.8 million . This primarily reflects a lower volume of ELEVIDYS sales due to our updated label that only includes the ambulatory patient population for treatment, as well as a decrease of $63.5 million in collaboration revenues related to a milestone payment received from F. Hoffmann-La Roche Ltd. (“Roche”) for the regulatory approval of ELEVIDYS in Japan (the “Japan Approval Milestone”) during the three months ended June 30, 2025 , with no similar activity for the same period of 2026. The decrease is partially offset by an increase of $27.4 million in contract manufacturing revenues associated with increased commercial ELEVIDYS supply delivered to Roche as well as the recognition of $10.0 million in license revenue related to the grant of intellectual property rights under a certain license agreement executed during the three months ended June 30, 2026 , with no similar activity for the same period of 2025. Total revenues were $1,132.1 million for the six months ended June 30, 2026 , as compared to $1,355.9 million for the same period of 2025, a decrease of $223.8 million . This primarily reflects a lower volume of ELEVIDYS sales due to our updated label that only includes the ambulatory patient population for treatment. The decrease is partially offset by an increase of $189.5 million in collaboration revenues related to the $365.0 million of collaboration revenue recognized related to Roche's declined option for certain program rights and the milestone recognized under the Roche collaboration agreement for the first commercial dosing of ELEVIDYS in Japan during the six months ended June 30, 2026 , as compared to $175.5 million of collaboration revenue in 2025 related to Roche’s expiration of an option to acquire a certain program and the Japan Approval Milestone. Furthermore, contract manufacturing revenues increased $41.1 million associated with increased commercial ELEVIDYS supply delivered to Roche as well as the recognition of $10.0 million in license revenue related to the grant of intellectual property rights under a certain license agreement executed during the six months ended June 30, 2026 , with no similar activity for the same period of 2025. Cost of sales (excluding amortization of in-licensed rights) Cost of sales (excluding amortization of in-license rights) were $149.4 million for the three months ended June 30, 2026 , as compared to $152.6 million for the same period of 2025, a decrease of $3.2 million . Cost of sales (excluding amortization of in-license rights) were $258.2 million for the six months ended June 30, 2026 , as compared to $290.1 million for the same period of 2025, a decrease of $31.9 million . The decreases in both periods primarily reflect a lower volume of ELEVIDYS sales and corresponding royalty payments, partially offset by an increase in cost of sales related to products sold to Roche, primarily related to increased volume of ELEVIDYS shipments as well as an increase in the write-offs of certain batches of products not meeting quality specifications under the Roche collaboration agreement. Operating expenses and others Research and development expenses were $91.3 million for the three months ended June 30, 2026 , as compared to $204.4 million for the same period of 2025, a decrease of $113.1 million . The decrease primarily reflects a decrease in manufacturing and clinical expenses primarily due to our decision to reprioritize our pipeline and developmental priorities announced in July 2025 , as well as a decrease in compensation, other personnel, and stock-based compensation expenses, all as a result of our restructuring plan announced in July 2025 (the "Restructuring"). For the three months ended June 30, 2026 , non-GAAP research and development expenses were $76.7 million , as compared to $181.7 million for the same period of 2025, a decrease of $105.0 million . Research and development expenses were $245.2 million for the six months ended June 30, 2026 , as compared to $977.8 million for the same period of 2025, a decrease of approximately $732.6 million . The decrease primarily reflects the recognition of up-front and collaboration license fees of $583.6 million associated with the licensing, collaboration and stock purchase agreement with Arrowhead Pharmaceutical, Inc. (“Arrowhead”) executed during the six months ended June 30, 2025 , with no similar activity for the six months ended June 30, 2026 . In addition, there was a decrease in manufacturing and clinical expenses primarily due to our decision to reprioritize our pipeline and developmental priorities announced in July 2025 , as well as a decrease in compensation, other personnel, and stock-based compensation expenses, all as a result of the Restructuring. This decrease was partially offset by the $50.0 million annual collaboration license fee incurred and paid to Arrowhead during the six months ended June 30, 2026 . For the six months ended June 30, 2026 , non-GAAP research and development expenses were $214.2 million , as compared to $930.9 million for the same period of 2025, a decrease of $716.7 million . Selling, general and administrative expenses were $107.6 million for the three months ended June 30, 2026 , as compared to $137.9 million for the same period of 2025, a decrease of $30.3 million . Selling, general and administrative expenses were $216.6 million for the six months ended June 30, 2026 , as compared to $271.5 million for the same period of 2025, a decrease of $54.9 million . The decreases in both periods primarily reflect a decrease in compensation, other personnel, and stock-based compensation expenses, all as a result of the Restructuring, as well as a decrease in professional services used related to ELEVIDYS commercialization efforts. For the three months ended June 30, 2026 , non-GAAP selling, general and administrative expenses were $88.0 million , as compared to $113.4 million for the same period of 2025, a decrease of $25.4 million . For the six months ended June 30, 2026 , non-GAAP selling, general and administrative expenses were $174.1 million , as compared to $220.5 million for the same period of 2025, a decrease of $46.4 million . Litigation contingency charge was $39.0 million for the three and six months ended June 30, 2026 , with no similar activity for the same periods of 2025. We recorded a litigation contingency charge of $39.0 million related to the potential resolution of certain patent litigations. Following the parties' agreement in principle and based on management's assessment of the available information, we determined that a loss was probable and estimable as of June 30, 2026 , and recognized our best estimate of the liability. The potential settlement remains outstanding subject to further negotiation and execution of definitive documentation as of the issuance of this release. Other (expense) income, net for the three months ended June 30, 2026 and 2025 was approximately $(15.0) million and $38.1 million , respectively. Other expense, net for the six months ended June 30, 2026 and 2025 was approximately $30.3 million and $45.1 million , respectively. The change primarily reflects a decrease in our strategic investments as a result of the sale of our investment in Arrowhead in August 2025 , partially offset by an increase in interest expense due to our 2030 Notes carrying a higher interest rate than our 2027 Notes during the three and six months ended June 30, 2026 . Income tax expense for the three and six months ended June 30, 2026 , was approximately $3.1 million and $15.4 million , respectively. Income tax (benefit) expense for the three and six months ended June 30, 2025 , was $(43.3) million and $20.7 million , respectively. Income tax expense for all periods presented primarily relates to state income taxes as a result of taxable profits in certain states requiring the capitalization of research and development costs and states which have suspended or limited the utilization of net operating loss carryforwards. Use of Non-GAAP Financial Measures In addition to the GAAP financial measures set forth in this press release, we have included the following non-GAAP measurements: The following components are used to adjust our GAAP financial measures into the previously defined non-GAAP measurements: We use these non-GAAP measures as key performance measures for the purpose of evaluating operational performance and cash requirements internally. We also believe these non-GAAP measures increase comparability of period-to-period results and are useful to investors as they provide a similar basis for evaluating our performance as is applied by management. These non-GAAP measures are not intended to be considered in isolation or to replace the presentation of our financial results in accordance with GAAP. Use of the terms non-GAAP research and development expenses, non-GAAP selling, general and administrative expenses, non-GAAP operating income (loss), non-GAAP net income (loss), and non-GAAP diluted earnings (loss) per share may differ from similar measures reported by other companies, which may limit comparability, and are not based on any comprehensive set of accounting rules or principles. All relevant non-GAAP measures are reconciled from their respective GAAP measures in the attached table “Reconciliation of GAAP Financial Measures to Non-GAAP Financial Measures.” About EXONDYS 51 EXONDYS 51 uses Sarepta’s proprietary phosphorodiamidate morpholino oligomer (PMO) chemistry and exon-skipping technology to bind to exon 51 of dystrophin pre-mRNA, resulting in exclusion, or “skipping”, of this exon during mRNA processing in patients with genetic mutations that are amenable to exon 51 skipping. Exon skipping is intended to allow for production of an internally truncated dystrophin protein. EXONDYS 51 is indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 51 skipping. This indication is approved under accelerated approval based on an increase in dystrophin in skeletal muscle observed in some patients treated with EXONDYS 51. Continued approval for this indication may be contingent upon verification of a clinical benefit in confirmatory trials. EXONDYS 51 has met the full statutory standards for safety and effectiveness and as such is not considered investigational or experimental. Important Safety Information About EXONDYS 51 Hypersensitivity reactions, including bronchospasm, chest pain, cough, tachycardia, and urticaria have occurred in patients who were treated with EXONDYS 51. If a hypersensitivity reaction occurs, institute appropriate medical treatment and consider slowing the infusion or interrupting the EXONDYS 51 therapy. Adverse reactions in DMD patients (N=8) treated with EXONDYS 51 30 mg or 50 mg/kg/week by intravenous (IV) infusion with an incidence of at least 25% more than placebo (N=4) (Study 1, 24 weeks) were (EXONDYS 51, placebo): balance disorder (38%, 0%), vomiting (38%, 0%) and contact dermatitis (25%, 0%). The most common adverse reactions were balance disorder and vomiting. Because of the small numbers of patients, these represent crude frequencies that may not reflect the frequencies observed in practice. The 50 mg/kg once weekly dosing regimen of EXONDYS 51 is not recommended. The most common adverse reactions from observational clinical studies (N=163) seen in greater than 10% of patients were headache, cough, rash, and vomiting. Other adverse events may occur. To report SUSPECTED ADVERSE REACTIONS, contact Sarepta Therapeutics, Inc. at 1-888-SAREPTA (1-888-727-3782) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. For further information, please see the full U.S . Prescribing Information for EXONDYS 51 (eteplirsen). About VYONDYS 53 VYONDYS 53 (golodirsen) uses Sarepta’s proprietary phosphorodiamidate morpholino oligomer (PMO) chemistry and exon-skipping technology to bind to exon 53 of dystrophin pre-mRNA, resulting in exclusion, or “skipping,” of this exon during mRNA processing in patients with genetic mutations that are amenable to exon 53 skipping. Exon skipping is intended to allow for production of an internally truncated dystrophin protein. VYONDYS 53 is indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 53 skipping. This indication is approved under accelerated approval based on an increase in dystrophin production in skeletal muscle observed in patients treated with VYONDYS 53. Continued approval for this indication may be contingent upon verification of a clinical benefit in confirmatory trials. VYONDYS 53 has met the full statutory standards for safety and effectiveness and as such is not considered investigational or experimental. Important Safety Information for VYONDYS 53 CONTRAINDICATIONS: VYONDYS 53 is contraindicated in patients with a serious hypersensitivity reaction to golodirsen or to any of the inactive ingredients in VYONDYS 53. Anaphylaxis has occurred in patients receiving VYONDYS 53. WARNINGS AND PRECAUTIONS Hypersensitivity Reactions: Hypersensitivity reactions, including anaphylaxis, rash, pyrexia, pruritus, urticaria, dermatitis, and skin exfoliation have occurred in VYONDYS 53-treated patients, some requiring treatment. If a hypersensitivity reaction occurs, institute appropriate medical treatment and consider slowing the infusion, interrupting, or discontinuing the VYONDYS 53 therapy and monitor until the condition resolves. VYONDYS 53 is contraindicated in patients with a history of a serious hypersensitivity reaction to golodirsen or to any of the inactive ingredients in VYONDYS 53. Kidney Toxicity: Kidney toxicity was observed in animals who received golodirsen. Although kidney toxicity was not observed in the clinical studies with VYONDYS 53, the clinical experience with VYONDYS 53 is limited, and kidney toxicity, including potentially fatal glomerulonephritis, has been observed after administration of some antisense oligonucleotides. Kidney function should be monitored in patients taking VYONDYS 53. Because of the effect of reduced skeletal muscle mass on creatinine measurements, creatinine may not be a reliable measure of kidney function in DMD patients. Serum cystatin C, urine dipstick, and urine protein-to-creatinine ratio should be measured before starting VYONDYS 53. Consider also measuring glomerular filtration rate using an exogenous filtration marker before starting VYONDYS 53. During treatment, monitor urine dipstick every month, and serum cystatin C and urine protein-to-creatinine ratio every three months. Only urine expected to be free of excreted VYONDYS 53 should be used for monitoring of urine protein. Urine obtained on the day of VYONDYS 53 infusion prior to the infusion, or urine obtained at least 48 hours after the most recent infusion, may be used. Alternatively, use a laboratory test that does not use the reagent pyrogallol red, as this reagent has the potential to cross react with any VYONDYS 53 that is excreted in the urine and thus lead to a false positive result for urine protein. If a persistent increase in serum cystatin C or proteinuria is detected, refer to a pediatric nephrologist for further evaluation. ADVERSE REACTIONS: Adverse reactions observed in at least 20% of treated patients and greater than placebo were (VYONDYS 53, placebo): headache (41%, 10%), pyrexia (41%, 14%), fall (29%, 19%), abdominal pain (27%, 10%), nasopharyngitis (27%, 14%), cough (27%, 19%), vomiting (27%, 19%), and nausea (20%, 10%). Other adverse reactions that occurred at a frequency greater than 5% of VYONDYS 53-treated patients and at a greater frequency than placebo were: administration site pain, back pain, pain, diarrhea, dizziness, ligament sprain, contusion, influenza, oropharyngeal pain, rhinitis, skin abrasion, ear infection, seasonal allergy, tachycardia, catheter site related reaction, constipation, and fracture. Other adverse events may occur. To report SUSPECTED ADVERSE REACTIONS, contact Sarepta Therapeutics, Inc. at 1-888-SAREPTA (1-888-727-3782) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. For further information, please see the full U.S . Prescribing Information for VYONDYS 53 (golodirsen). About AMONDYS 45 AMONDYS 45 (casimersen) uses Sarepta’s proprietary phosphorodiamidate morpholino oligomer (PMO) chemistry and exon-skipping technology to bind to exon 45 of dystrophin pre-mRNA, resulting in exclusion, or “skipping,” of this exon during mRNA processing in patients with genetic mutations that are amenable to exon 45 skipping. Exon skipping is intended to allow for production of an internally truncated dystrophin protein. AMONDYS 45 is indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping. This indication is approved under accelerated approval based on an increase in dystrophin production in skeletal muscle observed in patients treated with AMONDYS 45. Continued approval for this indication may be contingent upon verification of a clinical benefit in confirmatory trials. AMONDYS 45 has met the full statutory standards for safety and effectiveness and as such is not considered investigational or experimental. Important Safety Information for AMONDYS 45 CONTRAINDICATION: AMONDYS 45 is contraindicated in patients with a known serious hypersensitivity to casimersen or any of the inactive ingredients in AMONDYS 45. Instances of hypersensitivity including angioedema and anaphylaxis have occurred. WARNINGS AND PRECAUTIONS Hypersensitivity: Hypersensitivity reactions, including angioedema and anaphylaxis, have occurred in patients who were treated with AMONDYS 45. If a hypersensitivity reaction occurs, institute appropriate medical treatment, and consider slowing the infusion, interrupting, or discontinuing the AMONDYS 45 infusion and monitor until the condition resolves. AMONDYS 45 is contraindicated in patients with known serious hypersensitivity to casimersen or to any of the inactive ingredients in AMONDYS 45. Kidney Toxicity: Kidney toxicity was observed in animals who received casimersen. Although kidney toxicity was not observed in the clinical studies with AMONDYS 45, kidney toxicity, including potentially fatal glomerulonephritis, has been observed after administration of some antisense oligonucleotides. Kidney function should be monitored in patients taking AMONDYS 45. Because of the effect of reduced skeletal muscle mass on creatinine measurements, creatinine may not be a reliable measure of kidney function in DMD patients. Serum cystatin C, urine dipstick, and urine protein-to-creatinine ratio should be measured before starting AMONDYS 45. Consider also measuring glomerular filtration rate using an exogenous filtration marker before starting AMONDYS 45. During treatment, monitor urine dipstick every month, and serum cystatin C and urine protein to-creatinine ratio (UPCR) every three months. Only urine expected to be free of excreted AMONDYS 45 should be used for monitoring of urine protein. Urine obtained on the day of AMONDYS 45 infusion prior to the infusion, or urine obtained at least 48 hours after the most recent infusion, may be used. Alternatively, use a laboratory test that does not use the reagent pyrogallol red, as this reagent has the potential to cross react with any AMONDYS 45 that is excreted in the urine and thus lead to a false positive result for urine protein. If a persistent increase in serum cystatin C or proteinuria is detected, refer to a pediatric nephrologist for further evaluation. Adverse Reactions: Adverse reactions occurring in at least 20% of patients treated with AMONDYS 45 and at least 5% more frequently than in the placebo group were (AMONDYS 45, placebo): upper respiratory infections (65%, 55%), cough (33%, 26%), pyrexia (33%, 23%), headache (32%, 19%), arthralgia (21%, 10%), and oropharyngeal pain (21%, 7%). Other adverse reactions that occurred in at least 10% of patients treated with AMONDYS 45 and at least 5% more frequently than in the placebo group were: ear pain, nausea, ear infection, post-traumatic pain, and dizziness and light-headedness. Other adverse events may occur. To report SUSPECTED ADVERSE REACTIONS, contact Sarepta Therapeutics, Inc. at 1-888-SAREPTA (1-888-727-3782) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. For further information, please see the full U.S . Prescribing Information for AMONDYS 45 (casimersen). About ELEVIDYS (delandistrogene moxeparvovec-rokl) ELEVIDYS (delandistrogene moxeparvovec-rokl) is a single-dose, adeno-associated virus (AAV)-based gene transfer therapy for intravenous infusion designed to address the underlying genetic cause of Duchenne muscular dystrophy – mutations or changes in the DMD gene that result in the lack of dystrophin protein – through the delivery of a transgene that codes for the targeted production of ELEVIDYS micro-dystrophin in skeletal muscle. ELEVIDYS is indicated for the treatment of ambulatory patients 4 years of age and older with Duchenne muscular dystrophy (DMD) who have a confirmed mutation in the DMD gene. Limitations of Use ELEVIDYS is not recommended in patients with: Preexisting liver impairment (defined as gamma-glutamyl transferase [GGT] > 2 x upper limit of normal or total bilirubin > the upper limit of normal not due to Gilbert’s syndrome) or active hepatic viral infection due to the high risk of acute serious liver injury and acute liver failure. Recent vaccination (within 4 weeks of treatment) due to immunogenicity and potential safety concerns. Active or recent (within 4 weeks) infections due to safety concerns. IMPORTANT SAFETY INFORMATION BOXED WARNING: Acute Serious Liver Injury and Acute Liver Failure Acute serious liver injury, including life-threatening and fatal acute liver failure, has occurred. Patients with preexisting liver impairment may be at higher risk. Prior to infusion, assess liver function by clinical examination and laboratory testing. Administer systemic corticosteroids before and after ELEVIDYS infusion. Continue to monitor liver function weekly for the first 3 months after infusion and continue until results are unremarkable. Instruct patients to maintain proximity to an appropriate healthcare facility, as determined by the healthcare provider, for at least 2 months following ELEVIDYS infusion. Obtain prompt consultation with a specialist (e.g., gastroenterologist or hepatologist) if acute serious liver injury or impending acute liver failure is suspected. CONTRAINDICATION: ELEVIDYS is contraindicated in patients with any deletion in exon 8 and/or exon 9, including a deletion of any portion or the entirety of these exons, in the DMD gene. WARNINGS AND PRECAUTIONS: Acute Serious Liver Injury and Acute Liver Failure See Boxed Warning. Acute serious liver injury marked by elevations of liver enzymes (e.g., GGT, ALT) and total bilirubin and acute liver failure has occurred with ELEVIDYS. Onset of the liver injury typically begins within 8 weeks of ELEVIDYS administration. In non-ambulatory patients treated with ELEVIDYS, acute liver failure with fatal outcome has occurred in the clinical and post-marketing settings. Life-threatening mesenteric vein thrombosis, complicated by bowel ischemia and necrosis, and portal hypertension have been reported following acute liver injury associated with ELEVIDYS in a non-ambulatory patient. Patients with preexisting liver impairment, chronic hepatic condition, or acute liver disease (e.g., acute hepatic viral infection) may be at higher risk of acute serious liver injury or acute liver failure. Postpone ELEVIDYS administration in patients with acute liver disease until resolved or controlled. Systemic corticosteroid treatment is recommended for patients before and after ELEVIDYS infusion. Adjust corticosteroid regimen when indicated. Serious Infections Increased susceptibility to serious infections may occur due to concomitant administration of corticosteroid regimen and additional immunosuppressants, and ELEVIDYS. Serious respiratory infections, including with fatal outcomes, have occurred in patients taking immunosuppressant corticosteroids required for ELEVIDYS administration. Monitor patients for signs and symptoms of infection before and after ELEVIDYS administration and treat appropriately. Administer immunizations according to best clinical practices and immunization guidelines prior to initiation of the corticosteroid regimen required before ELEVIDYS infusion. Avoid administration of ELEVIDYS to patients with active infections. Myocarditis Acute, serious, life-threatening myocarditis and troponin-I elevations have been observed within 24 hours to more than 1 year following ELEVIDYS infusion. If a patient experiences myocarditis, those with pre-existing left ventricle ejection fraction (LVEF) impairment may be at higher risk of adverse outcomes. Monitor troponin-I before ELEVIDYS infusion and weekly for the first month following infusion and continue monitoring if clinically indicated, until results return to near baseline levels or stabilize. More frequent monitoring may be warranted in the presence of cardiac symptoms, such as chest pain or shortness of breath. Advise patients to contact a physician immediately if they experience cardiac symptoms. Infusion-related Reactions Infusion-related reactions, including hypersensitivity reactions and anaphylaxis, have occurred during or up to several hours following ELEVIDYS administration. Closely monitor patients during and for at least 3 hours after the end of infusion. If symptoms of infusion-related reactions occur, slow or stop the infusion and give appropriate treatment. Once symptoms resolve, the infusion may be restarted at a lower rate. ELEVIDYS should be administered in a setting where treatment for infusion-related reactions is immediately available. Discontinue infusion for anaphylaxis. Immune-mediated Myositis Immune-mediated myositis, including serious and life-threatening events, has occurred approximately 1 month following ELEVIDYS infusion. Signs and symptoms include severe muscle weakness, including dysphagia, dyspnea, dysphonia, and hypophonia. Severe to life-threatening immune-mediated myositis has been reported in patients with deletions including portions of exons 1-17 and/or exons 59-71 of the DMD gene. Regardless of genetic mutation, advise patients to contact a physician immediately if they experience any unexplained increased muscle pain, tenderness, or weakness, including dysphagia, dyspnea, dysphonia, or hypophonia, as these may be symptoms of myositis. Consider additional immunomodulatory treatment based on patient’s clinical presentation and medical history if these symptoms occur. Preexisting Immunity against AAVrh74 In AAV-vector based gene therapies, preexisting anti-AAV antibodies may impede transgene expression at desired therapeutic levels. Following treatment with ELEVIDYS, all patients developed anti-AAVrh74 antibodies. Perform baseline testing for the presence of anti-AAVrh74 total binding antibodies prior to ELEVIDYS administration. ELEVIDYS administration is not recommended in patients with elevated anti-AAVrh74 total binding antibody titers ≥1:400. ADVERSE REACTIONS The most common adverse reactions (incidence ≥5%) reported in clinical studies were vomiting, nausea, liver injury, pyrexia, thrombocytopenia, and troponin-I increased. Report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Sarepta Therapeutics at 1-888-SAREPTA (1-888-727-3782). Please see the full Prescribing Information for ELEVIDYS, including Boxed Warning and Medication Guide. About Sarepta Therapeutics Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. For more information, please visit www.sarepta.com or follow us on LinkedIn, X, Instagram and Facebook. Forward-Looking Statements In order to provide Sarepta’s investors with an understanding of its current results and future prospects, this press release contains statements that are forward-looking. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as “believes,” “anticipates,” “plans,” “expects,” “will,” “may,” “intends,” “prepares,” “looks,” “potential,” “possible” and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements relating to our future operations, financial performance, projections and guidance, business plans, market opportunities and potential growth, priorities and research and development programs and technologies; the potential benefits of our technologies and scientific approaches, including our siRNA programs; the timing of our ongoing and planned clinical trials; and our expected plans and milestones, including upcoming data readouts for DM1 and FSHD in the second half of 2026 and for ELEVIDYS, full enrollment of ENDEAVOR Cohort 8 by the end of 2026 and 12-week data from the full cohort in the first quarter of 2027. These forward-looking statements involve risks and uncertainties, many of which are beyond Sarepta’s control. Actual results could materially differ from those stated or implied by these forward-looking statements as a result of such risks and uncertainties. Known risk factors include the following: different methodologies, assumptions and applications we use to assess particular safety or efficacy parameters may yield different statistical results, and even if we believe the data collected from clinical trials are positive, the results of future research may not be consistent with past positive results, or may fail to meet regulatory approval requirements for the safety and efficacy of our products; success in preclinical and clinical trials, especially if based on a small patient sample, does not ensure that later clinical trials will be successful; we may not be able to reach alignment with the FDA regarding traditional approval for casimersen and golodirsen, including due to any limitations on the FDA’s reliance of real-world evidence; our products or product candidates may be perceived as insufficiently effective, unsafe or may result in unforeseen adverse events; we may observe adverse reactions in our clinical trials or in patients who receive our approved products; our products may not be widely adopted by patients, payors or healthcare providers, which would adversely impact our business; our products or product candidates may cause undesirable side effects that result in significant negative consequences following any marketing approval; we may not be able to comply with all FDA post-approval commitments and requirements with respect to our products in a timely manner or at all; certain programs may never advance in the clinic or may be discontinued for a number of reasons, including regulators imposing a clinical hold and us suspending or terminating clinical research or trials; if the actual number of patients suffering from the diseases we aim to treat is smaller than estimated, our revenue and ability to achieve profitability may be adversely affected; we may not be able to execute on our business plans, including meeting our expected or planned regulatory milestones and timelines, research and clinical development plans, and bringing our product candidates to market, for various reasons, some of which may be outside of our control, including possible limitations of company financial and other resources, manufacturing limitations that may not be anticipated or resolved for in a timely manner, and regulatory, court or agency decisions, such as decisions by the United States Patent and Trademark Office with respect to patents that cover our product candidates; and those risks identified under the heading “Risk Factors” in our most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) as well as other SEC filings made by the Company which you are encouraged to review. Internet Posting of Information We routinely post information that may be important to investors in the 'For Investors' section of our website at www.sarepta.com. We encourage investors and potential investors to consult our website regularly for important information about us. Sarepta Therapeutics, Inc. Condensed Consolidated Statements of (Loss) Income (unaudited, in thousands, except per share amounts) For the Three Months Ended June 30 , For the Six Months Ended June 30 , 2026 2025 2026 2025 Revenues: Products, net $ 328,689 $ 513,123 $ 659,204 $ 1,124,646 Collaboration and other 72,562 97,968 472,850 231,301 Total revenues 401,251 611,091 1,132,054 1,355,947 Cost and expenses: Cost of sales (excluding amortization of in-licensed rights) 149,385 152,558 258,153 290,122 Research and development 91,258 204,392 245,218 977,840 Selling, general and administrative 107,600 137,897 216,551 271,526 Litigation contingency charge 39,000 — 39,000 — Amortization of in-licensed rights 717 667 1,408 1,268 Total cost and expenses 387,960 495,514 760,330 1,540,756 Operating income (loss) 13,291 115,577 371,724 (184,809 ) Other (loss) income, net: Other (expense) income, net (15,040 ) 38,061 (30,299 ) (45,071 ) (Loss) income before income tax expense (1,749 ) 153,638 341,425 (229,880 ) Income tax expense (benefit) 3,141 (43,254 ) 15,356 20,736 Net (loss) income $ (4,890 ) $ 196,892 $ 326,069 $ (250,616 ) (Loss) earnings per share: Basic $ (0.05 ) $ 2.01 $ 3.10 $ (2.57 ) Diluted $ (0.05 ) $ 1.89 $ 2.99 $ (2.57 ) Weighted average number of shares of common stock used in computing (loss) earnings per share: Basic 105,431 98,005 105,211 97,685 Diluted 105,431 106,623 122,260 97,685 Sarepta Therapeutics, Inc. Reconciliation of GAAP Financial Measures to Non-GAAP Financial Measures (unaudited, in thousands, except per share amounts) For the Three Months Ended June 30 , For the Six Months Ended June 30 , 2026 2025 2026 2025 GAAP net (loss) income $ (4,890 ) $ 196,892 $ 326,069 $ (250,616 ) Interest expense (income), net 13,341 (1,921 ) 26,293 (9,846 ) Depreciation and amortization expense 9,692 10,173 19,595 19,550 Stock-based compensation expense 24,472 37,025 53,871 78,453 Loss (gain) on strategic investments 448 (36,721 ) 2,160 54,007 Impairment of strategic investment 1,000 — 1,000 — Litigation contingency charge 39,000 — 39,000 — Income tax effect of adjustments (4,477 ) 9,728 (4,023 ) (8,870 ) Non-GAAP net income (loss) $ 78,586 $ 215,176 $ 463,965 $ (117,322 ) GAAP (loss) earnings per share - diluted: $ (0.05 ) $ 1.89 $ 2.99 $ (2.57 ) Add: impact of GAAP to Non-GAAP adjustments 0.69 0.13 0.80 1.37 Non-GAAP earnings (loss) per share - diluted1 $ 0.64 $ 2.02 $ 3.79 $ (1.20 ) Weighted average number of shares of common stock used in computing diluted earnings (loss) per share: GAAP 105,431 106,623 122,260 97,685 Non-GAAP 122,648 106,623 122,284 97,685 1GAAP and non-GAAP earnings per share is calculated using diluted shares whereas GAAP and non-GAAP net loss per share is calculated using basic shares as all other instruments are anti-dilutive. Sarepta Therapeutics, Inc. Reconciliation of GAAP Financial Measures to Non-GAAP Financial Measures (unaudited, in thousands, except per share amounts) For the Three Months Ended June 30 , For the Six Months Ended June 30 , 2026 2025 2026 2025 GAAP research and development expenses $ 91,258 $ 204,392 $ 245,218 $ 977,840 Stock-based compensation expense (8,509 ) (15,277 ) (18,786 ) (32,594 ) Depreciation and amortization expense (6,023 ) (7,397 ) (12,229 ) (14,374 ) Non-GAAP research and development expenses $ 76,726 $ 181,718 $ 214,203 $ 930,872 For the Three Months Ended June 30 , For the Six Months Ended June 30 , 2026 2025 2026 2025 GAAP selling, general and administrative expenses $ 107,600 $ 137,897 $ 216,551 $ 271,526 Stock-based compensation expense (15,963 ) (21,748 ) (35,085 ) (45,859 ) Depreciation expense (3,669 ) (2,776 ) (7,366 ) (5,176 ) Non-GAAP selling, general and administrative expenses $ 87,968 $ 113,373 $ 174,100 $ 220,491 For the Three Months Ended June 30 , For the Six Months Ended June 30 , 2026 2025 2026 2025 GAAP operating income (loss) $ 13,291 $ 115,577 $ 371,724 $ (184,809 ) Stock-based compensation expense 24,472 37,025 53,871 78,453 Depreciation and amortization expense 9,691 10,173 19,594 19,550 Litigation contingency charge 39,000 — 39,000 — Non-GAAP operating income (loss) $ 86,454 $ 162,775 $ 484,189 $ (86,806 ) For the Three Months Ended June 30 , For the Six Months Ended June 30 , 2026 2025 2026 2025 Total effective tax rate, GAAP (179.6 )% (28.2 )% 4.5 % (9.0 )% Less: impact of GAAP to Non-GAAP adjustments 188.4 (4.4 ) (0.5 ) (25.0 ) Total effective tax rate, Non-GAAP 8.8 % (32.6 )% 4.0 % (34.0 )% Sarepta Therapeutics, Inc. Condensed Consolidated Balance Sheets (unaudited, in thousands, except share and per share amounts) As of June 30, 2026 As of December 31, 2025 Assets Current assets: Cash and cash equivalents $ 571,148 $ 801,282 Short-term investments 217,341 138,368 Accounts receivable, net 376,824 398,233 Inventory 904,273 914,744 Manufacturing-related deposits and prepaids 48,454 113,455 Other current assets 105,784 171,856 Total current assets 2,223,824 2,537,938 Property and equipment, net 325,991 345,125 Right of use assets 120,847 125,495 Non-current inventory 226,333 184,543 Non-current investments 145,372 1,048 Other non-current assets 146,145 155,554 Total assets $ 3,188,512 $ 3,349,703 Liabilities and Stockholders’ Equity Current liabilities: Accounts payable $ 50,982 $ 280,841 Accrued expenses 325,232 359,659 Deferred revenue, current portion 110,132 443,397 Other current liabilities 16,562 11,393 Total current liabilities 502,908 1,095,290 Long-term debt 847,623 828,974 Lease liabilities, net of current portion 198,226 199,378 Deferred revenue, net of current portion 110,132 83,910 Other non-current liabilities 1,825 1,529 Total liabilities 1,660,714 2,209,081 Stockholders’ equity: Preferred stock, $0.0001 par value, 3,333,333 shares authorized; none issued and outstanding — — Common stock, $0.0001 par value, 198,000,000 shares authorized; 106,279,142 and 105,623,500 issued and outstanding, respectively, at June 30, 2026 and 105,615,096 and 104,964,220 issued and outstanding, respectively, at December 31, 2025 11 11 Treasury stock, at cost, 655,642 and 650,876 shares at June 30, 2026 and December 31, 2025 , respectively (25,263 ) (25,263 ) Additional paid-in capital 6,104,530 6,042,586 Accumulated other comprehensive (loss) income, net of tax (565 ) 272 Accumulated deficit (4,550,915 ) (4,876,984 ) Total stockholders’ equity 1,527,798 1,140,622 Total liabilities and stockholders’ equity $ 3,188,512 $ 3,349,703 View source version on businesswire.com: https://www.businesswire.com/news/home/20260805692741/en/ Investor Contacts: Ian Estepan , 617-274-4052, iestepan@sarepta.com Ryan Wong , 617-800-4112, rwong@sarepta.com Tam Thornton , 617-803-3825, tthornton@sarepta.com Media Contacts: Tracy Sorrentino , 617-301-8566, tsorrentino@sarepta.com Kara Hoeger , 617-710-3898, khoeger@sarepta.com Source: Sarepta Therapeutics, Inc.

Sarepta Therapeutics announced Monday that it has found a successor to long-time CEO Doug Ingram, who is retiring at the end of the year. The rare disease company tapped Michael Severino as its next chief executive, effective July 28. To ease the leadership transition, Ingram — who has helmed the biotech since 2017 — will serve in an advisory role until the end of 2026. Under Ingram's leadership, Sarepta secured FDA approval for the first-ever Duchenne muscular dystrophy (DMD) gene therapy, Elevidys (delandistrogene moxeparvovec-rokl). While early momentum for the treatment prompted Ingram to call it the most successful gene therapy launch in history, Elevidys was rocked by a safety controversy last year that temporarily halted shipments and sent sales plummeting (see – Spotlight On: Sarepta's DMD dilemma).The company's older exon-skipping therapies, Vyondys 53 (golodirsen) for patients with DMD amenable to exon 53 skipping in 2019, and Amondys 45 (casimersen) for those amenable to exon 45 skipping in 2021, also stumbled last year when they failed a confirmatory trial.Despite the miss, Sarepta is looking to convert their accelerated approvals into full FDA approvals. Applications for both therapies are under review with the US regulator, with a decision expected by Feb. 28, 2027. Alongside its flagship programmes, Sarepta is also advancing a pair of siRNA therapies in-licensed from Arrowhead Pharmaceuticals: SRP-1001 (ARO-DUX4) in facioscapulohumeral muscular dystrophy type 1 and SRP-1003 (ARO-DM1) in myotonic dystrophy type 1."I was very encouraged by the long-term data supporting our approved products, and the pre-clinical and clinical data from the siRNA pipeline programmes and the potential for best-in-class treatments," Severino said in a statement Monday. Before joining Sarepta, Severino served as CEO of Tessera Therapeutics, as well as a CEO-partner at Flagship Pioneering, which founded the biotech in 2018. Tessera's lead in vivo gene editing therapy, TSRA-196, is in a Phase I study for alpha-1 antitrypsin deficiency. It collected $230 million in a 2021 series B, followed by a $300-million-plus C round in 2022. Prior to Tessera, Severino held an eight-year tenure at AbbVie, most recently serving as vice chairman and president, where he oversaw R&D and the corporate strategy office. He helped the biopharma achieve a rapid pipeline expansion, making "significant contributions" to over a dozen of AbbVie's approved therapies like Rinvoq (upadacitinib) and Skyrizi (risankizumab).Previously, Severino spent close to 12 years at Amgen, where he held several roles including senior vice president of global development and chief medical officer. He was responsible for shepherding the pharma's clinical work in oncology, inflammation, neuroscience, cardiovascular and metabolic disorders."Over a distinguished 25-year career in biopharmaceuticals, Mike has demonstrated a combination of scientific depth, development expertise, and proven execution that consistently delivers results," said M. Kathleen Behrens, chair of Sarepta’s board. "His industry experience, strategic vision and commitment to patients, coupled with having built industry-leading franchises across multiple therapeutic areas, give us great confidence as he works to build on Sarepta’s strengths and steer the company as it continues to advance promising science on behalf of patients."