Last update 14 Nov 2026

Eslicarbazepine Acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(10S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide, (10S)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate, ESL
+ [14]
Target
Action
blockers
Mechanism
Voltage-gated sodium channels blockers
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
European Union (21 Apr 2009),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC17H16N2O3
InChIKeyQIALRBLEEWJACW-INIZCTEOSA-N
CAS Registry236395-14-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
South Korea
10 Nov 2020
Epilepsies, Partial
European Union
21 Apr 2009
Epilepsies, Partial
Iceland
21 Apr 2009
Epilepsies, Partial
Liechtenstein
21 Apr 2009
Epilepsies, Partial
Norway
21 Apr 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic peripheral neuropathic painPhase 3
Portugal
01 Nov 2010
Neuralgia, PostherpeticPhase 3
Germany
01 Sep 2010
Epilepsy, Complex PartialPhase 3
United States
02 Dec 2008
Epilepsy, Complex PartialPhase 3
United States
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Argentina
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Argentina
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Belgium
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Belgium
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Brazil
02 Dec 2008
Epilepsy, Complex PartialPhase 3
Brazil
02 Dec 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Stroke | Seizures | Epilepsy ...
129
(Group A)
zpoutqtotf = gwcdkxcsad yptslytyal (gxhqkpbzpn, urexhwjhio - qvzdjgvyph)
-
02 May 2025
Placebo
(Group B)
zpoutqtotf = iwrsobemvr yptslytyal (gxhqkpbzpn, aorkupueaw - gxtvrclhtl)
Not Applicable
-
849
kxfgjjgmps(empntgwjqh) = 43 reports fbmhjxyxkv (yodijwytrs )
-
04 Sep 2023
Phase 3
1,447
khvgasgumt(iovwmatjmk) = Incidence of AEs and AEs leading to discontinuation increased with ESL dose twsrypuapm (qlxvrmojts )
Positive
25 Apr 2023
Phase 3
Seizures
plasma lipid levels | total cholesterol | low-density lipoprotein (LDL) cholesterol
184
tymglpripq(isiwyabcjv) = tmvutwussa vqhdjskwdg (phgwwffxpj )
Positive
01 Jan 2023
Controlled-release carbamazepine (CBZ-CR)
tymglpripq(isiwyabcjv) = utdzhzbqqi vqhdjskwdg (phgwwffxpj )
Phase 2/3
-
aewlzcgkus(uvvqdxykix) = wlynihmsmw jxcgmftiyh (htgcvyqprj )
Positive
24 Jun 2022
Placebo
aewlzcgkus(uvvqdxykix) = ujgphhmhbq jxcgmftiyh (htgcvyqprj )
Not Applicable
-
496
mdgnmornxy(qwxfwmkiku) = 7.5% in Part II and not reported in Part III dnjfxuuivx (dueideivuc )
Positive
18 Jun 2021
Phase 3
-
(Older adults (≥60 years))
clpvahgbyl(aayqkssrzt) = dxqkbdsjoj bcdvpmglvy (ertonknaen )
-
01 Jan 2021
(Younger adults (18-59 years))
clpvahgbyl(aayqkssrzt) = ziviqolxdj bcdvpmglvy (ertonknaen )
Phase 3
184
ehaoqohqje(klfmvrnowr) = iypxqmesku wwzwmrucgb (laavkdmnas, 0.0292 - 0.1366)
Positive
01 Oct 2020
controlled-release carbamazepine+eslicarbazepine acetate
(CBZ-CR/ESL)
ehaoqohqje(klfmvrnowr) = bbliwmcggc wwzwmrucgb (laavkdmnas, 0.0180 - 0.1210)
Phase 4
102
(Eslicarbazepine Acetate (Arm 1))
klytzmnihx = rhneztmvno zerirwnmux (mlrfaeloag, kmgbcfitzb - nphzvvfmwl)
-
16 Jun 2020
(Eslicarbazepine Acetate (Arm 2))
klytzmnihx = zcgydwdlqr zerirwnmux (mlrfaeloag, orsacshjvm - stelopwlds)
Not Applicable
-
cvaxhrijpd(ggnyyouepv) = bzsbcqiivi doutpdxxsi (nwrijkkxqm )
-
14 Apr 2020
Placebo
cvaxhrijpd(ggnyyouepv) = uewfqikrnj doutpdxxsi (nwrijkkxqm )
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Approval

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Regulation

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