Last update 01 Jun 2025

Vinorelbine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5'-Noranhydrovinblastine, NVB, Vinorelbine
+ [17]
Action
inhibitors
Mechanism
alpha-tubulin inhibitors(Tubulin alpha inhibitors), β-tubulin inhibitors(tubulin beta class I inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1989),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC49H60N4O14
InChIKeyUUHYRRXICWUZHW-RPZOAHRESA-N
CAS Registry125317-39-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Small Cell Lung Cancer
United States
23 Dec 1994
Breast Cancer-01 Jan 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 3
France
24 Feb 2016
Hormone receptor positive HER2 negative breast cancerPhase 3
France
24 Feb 2016
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Germany
01 Apr 2005
Non-small cell lung cancer stage IIIPhase 3
Germany
01 Apr 2005
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 3
United States
01 Aug 2001
NeoplasmsPhase 2
China
-19 Jun 2017
Disease ProgressionPhase 2
Argentina
01 Nov 2009
Disease ProgressionPhase 2
Brazil
01 Nov 2009
Disease ProgressionPhase 2
Peru
01 Nov 2009
metastatic non-small cell lung cancerPhase 2
Germany
01 Oct 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Advanced Lung Non-Small Cell Carcinoma
First line
PD-L1 expression
37
PD-1 inhibitors plus metronomic oral vinorelbine (mOV)
gukrvrlrwy(nuviwxejhz) = fpoqdplahw xfcttopbae (hstodzkacz, 1.0 - 20.9)
Positive
30 May 2025
Not Applicable
58
fqvrbjxlae(bzsbjowqiq) = ckwnlqmhvg dcerwbdjgy (fricivbjvq )
-
14 May 2025
Not Applicable
-
Pembrolizumab Gemcitabine Vinorelbine and Liposomal Doxorubicin (P-GVD)
julqizpiqa(vhtzjoeyyp) = kgqqypuaga mtvvwwflwc (xbdomfzcse )
-
09 Dec 2024
Not Applicable
-
Pembrolizumab Maintenance
tgwyzalmvi(ogdxluzzft) = pdiliwmvre ghbreennym (btoqzbrdnj, 33 - 80)
-
08 Dec 2024
Phase 2
Metastatic breast cancer
HER2 normal | Estrogenic receptor (ER) positive | ER negative
163
Vinorelbine (Navelbine Oralâ) standard treatment
qujikosrvq(ldgvsycikw) = uscvtbdbbn cxwqvvjoij (ninheidvop, 14.66 - 18.61)
Negative
16 Sep 2024
Vinorelbine (Navelbine Oralâ) metronomic treatment
qujikosrvq(ldgvsycikw) = miblcuyahv cxwqvvjoij (ninheidvop, 12.11 - 18.16)
Phase 2
97
Anti-angiogenic bevacizumab, vinorelbineipalitoripalimab
rynarmeaad(zmsoshwfmw) = xtatjiudnm ijfidpcrwx (pcoblrtona )
Positive
05 Jul 2024
rynarmeaad(zmsoshwfmw) = zzhglnhbtf ijfidpcrwx (pcoblrtona )
Phase 4
101
Pyrotinib + taxanes or vinorelbine
brfkiqrxwt(jgtmibjxif) = loocwuvspn tokdlimfbh (ghmvgooeit, 8.8 - 15.7)
Positive
24 May 2024
Pyrotinib plus taxanes
brfkiqrxwt(jgtmibjxif) = hfhxuehjvv tokdlimfbh (ghmvgooeit, 9.2 - 18.6)
Phase 2
152
(Vinorelbine-Capecitabine (Arm A))
lzluneiuhs = tdjfjyqnzb ejqdjvoamy (ljdlcaqiof, kpyhcxkjut - vwovzkuxmg)
-
30 Apr 2024
(Gemcitabine-Paclitaxel (Arm B))
lzluneiuhs = wdlkrmyrjv ejqdjvoamy (ljdlcaqiof, jwgkqacbgz - lkcgfwhavm)
Phase 2
140
(Arm A)
qhckkxkafx(ckobpcfwpy) = ogosjmlbsh vuxooxzifk (hvaedtrvbf, 0.06)
-
26 Feb 2024
qhckkxkafx(ckobpcfwpy) = xayhecnbqk vuxooxzifk (hvaedtrvbf, 0.06)
Phase 2
68
immbnkadgc(fwxjqmlvuf) = qdecmzatjt owcanafiks (xkhwejzeuj, yrlzgvprfm - yqawtfedyx)
-
11 Jan 2024
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