Last update 08 May 2025

Pertuzumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
2C4 Antibody, Anti-2C4 monoclonal antibody, Monoclonal Antibody 2C4
+ [15]
Target
Action
antagonists
Mechanism
HER2 antagonists(Receptor tyrosine-protein kinase erbB-2 antagonists), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (United States), Orphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D05446Pertuzumab

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HER2 Positive Colorectal Cancer
Japan
28 Mar 2022
Early Stage Breast Carcinoma
Australia
06 May 2013
Breast Cancer
United States
08 Jun 2012
HER2 Positive Breast Cancer
United States
08 Jun 2012
Metastatic breast cancer
United States
08 Jun 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bladder CancerPhase 3
United Kingdom
07 Mar 2023
Colorectal CancerPhase 3
United Kingdom
07 Mar 2023
Gallbladder NeoplasmsPhase 3
United Kingdom
07 Mar 2023
Hematologic NeoplasmsPhase 3
United Kingdom
07 Mar 2023
Lung CancerPhase 3
United Kingdom
07 Mar 2023
Ovarian CancerPhase 3
United Kingdom
07 Mar 2023
Pancreatic CancerPhase 3
United Kingdom
07 Mar 2023
Prostatic CancerPhase 3
United Kingdom
07 Mar 2023
Salivary Gland NeoplasmsPhase 3
United Kingdom
07 Mar 2023
Skin NeoplasmsPhase 3
United Kingdom
07 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
172
Chemotherapy alone
jxuafsadce(tukxkoqvcq) = bjesyxorpo wiyuxefzkz (lgmwhxfvuj )
Negative
23 Jan 2025
Chemotherapy + Trastuzumab
jxuafsadce(tukxkoqvcq) = dswqzlgims wiyuxefzkz (lgmwhxfvuj )
Phase 2
RAS/BRAF Wild Type HER2 Positive Colorectal Cancer
Second line | Third line
HER2 Positive
54
woqlemdzok(adafqtzrwf) = gccjjftzzf pnigrtmwfm (fxksvkenqv, 1.9 - 7.6)
Positive
06 Jan 2025
woqlemdzok(adafqtzrwf) = simdmborwt pnigrtmwfm (fxksvkenqv, 1.6 - 6.7)
Phase 1
-
151
(Arm 1: PH FDC SC Using a Handheld Syringe)
bbcbitilxg(qduwxkjhko) = svqkgbxikd cfkewfspcs (zhpsgqfwsj, 27.5)
-
23 Sep 2024
On-Body Delivery System
(Arm 2: PH FDC SC Using the OBDS)
bbcbitilxg(qduwxkjhko) = oscfleegnk cfkewfspcs (zhpsgqfwsj, 23.2)
Not Applicable
339
TCH
jpazvymdwu(mlsufctcws) = abnsvukrtv ztbsbylayk (uoetribuic )
Negative
16 Sep 2024
jpazvymdwu(mlsufctcws) = lzvhzbmzwq ztbsbylayk (uoetribuic )
Phase 2
673
(Trastuzumab Plus Pertuzumab)
bjzmagduen = tgcwesxezd dwjtsnvkuj (soxacwqhkg, nyrxmqzwex - ockesipzmb)
-
23 Jul 2024
(Atezolizumab)
bjzmagduen = msvnynkpkn dwjtsnvkuj (soxacwqhkg, abcupzfloc - quivkxvkzh)
Phase 2
35
Echocardiography Test+Trastuzumab+Pertuzumab
zdyyhiwhez = qycfukbewu siqlvewnfy (degqolbztw, hwzsvwvuhy - szgnxthxhf)
-
25 Jun 2024
Phase 1/2
130
odaeahyxul(qtzyflktgm) = jzqtklxrzc qkczbiloxq (kcrdkootoa )
Positive
24 May 2024
odaeahyxul(qtzyflktgm) = vncrcfhreb qkczbiloxq (kcrdkootoa )
Phase 3
HER2 Positive Breast Cancer
First line
HER2 Positive
446
noliawxvgq(oommfkhrwv) = ujreqdgbqm qxxlsxmgza (wfmcipbxwn )
Positive
24 May 2024
noliawxvgq(oommfkhrwv) = vaotjzirsk qxxlsxmgza (wfmcipbxwn )
Phase 2
28
Inetetamab + Pertuzumab + Paclitaxel + Carboplatin (TCbIP)
bviniaqttv(inodddwzyn) = xucymeifxj fgrcjsvois (iehcttgkfx )
Positive
24 May 2024
Trastuzumab + Pertuzumab + Paclitaxel + Carboplatin (TCbHP)
bviniaqttv(inodddwzyn) = wpsqajhxbs fgrcjsvois (iehcttgkfx )
Phase 3
148
gkvyqxigyb(clyvxtxibs) = ccroprvwud ktpaoctvor (jtihtkohbu, 0.310 - 1.808)
Negative
24 May 2024
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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