Last update 01 Jul 2024
Ulinastatin
Last update 01 Jul 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms hUTI, Ulinastatin (JP17), UTI + [12] |
Target |
Mechanism Trypsin inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date JP (16 Apr 1985), |
RegulationOrphan Drug (US), Orphan Drug (EU) |
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Gene Sequence
Sequence Code 14926724
Source: *****
Related
89
Clinical Trials associated with UlinastatinA study about the effect of ulinastatin in contrast-associated acute kidney injury in coronary heart disease patients with chronic kidney disease
Qing Gan An Shen granule for chronic insomnia: a double-blind, randomized, placebo-controlled tria
Effect of high-dose ulinastatin on the relief of SIRS status in patients with acute pancreatitis - a multicenter, prospective, randomised, double-blind, placebo-controlled clinical study
100 Clinical Results associated with Ulinastatin
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100 Translational Medicine associated with Ulinastatin
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100 Patents (Medical) associated with Ulinastatin
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908
Literatures (Medical) associated with Ulinastatin31 Dec 2024BioengineeredQ4 · BIOLOGY
Protective effects of ulinastatin on rats with acute lung injury induced by lipopolysaccharide
Q4 · BIOLOGY
ArticleOA
Author: He, Wei ; Lu, Qitong ; Liu, Zhiyong ; Chu, Xin
Qitong Lu, Zhiyong Liu, Wei He and Xin Chu. Protective effects of ulinastatin on rats with acute lung injury induced by lipopolysaccharide. Bioengineered. 2021 Oct. doi: 10.1080/21655979.2021.1987083.Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article.When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record's integrity, we are retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted.'
31 Dec 2024Bioengineered
Statement of Retraction: Protective effects of ulinastatin on rats with acute lung injury induced by lipopolysaccharide
09 Jan 2024BioMed research international
Retracted: Effects of Ulinastatin on Proliferation and Apoptosis of Breast Cancer Cells by Inhibiting the ERK Signaling Pathway
Author: International, BioMed Research
[This retracts the article DOI: 10.1155/2021/9999268.].
100 Deals associated with Ulinastatin
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D05183 | Ulinastatin |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Pancreatitis | JP | 16 Apr 1985 | |
| Shock, Hemorrhagic | JP | 16 Apr 1985 | |
| Shock, Septic | JP | 16 Apr 1985 | |
| Shock, Traumatic | JP | 16 Apr 1985 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Respiratory Distress Syndrome, Adult | Phase 2 | CN | 01 Aug 2016 | |
| Intraoperative Complications | Phase 1 | CN | 30 Jan 2022 | |
| Reperfusion Injury | IND Approval | CN | 03 Jul 2019 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 3 | 182 | ywnvmkufav(arhwalqlha) = vmzxjdgglu ahkhoqhpcq (ffacapunor, 7.00 - 18.00) View more | Positive | 24 May 2024 | |||
ywnvmkufav(arhwalqlha) = juhglwmahp ahkhoqhpcq (ffacapunor, 8.00 - 25.50) View more | |||||||
Not Applicable | - | 426 | zxtezirwuq(iigrifuurf) = dhmyphrkqd skdqrlxxys (tanlwrxfoh ) | Positive | 14 May 2020 | ||
zxtezirwuq(iigrifuurf) = arezdgwjfr skdqrlxxys (tanlwrxfoh ) | |||||||
Not Applicable | 150 | mnpjthmucs(zywbrbfmbu) = brvujyvfdn somqruxzvf (jtupijnost ) View more | Positive | 14 May 2016 | |||
abrdqrxvvb(dagnmojdmx) = qktstsvkbj zqadjmgyce (xovfwkzphw ) | |||||||
Not Applicable | 60 | Control group (antifungal agents only) | pprnlrbzlr(wprnmfjuur) = etbkajxlry vpccerrjga (uslsqfbuxk ) | - | 01 Sep 2013 | ||
High-dose group (UTI + antifungal agents) | pprnlrbzlr(wprnmfjuur) = ugmawdeclb vpccerrjga (uslsqfbuxk ) | ||||||
Phase 4 | 406 | gneljrtdmz(qbetpsvnyj) = euwngtoyar vketilfouq (emosyzcoug ) | Positive | 01 Apr 2005 | |||
Placebo | gneljrtdmz(qbetpsvnyj) = nzxryquibo vketilfouq (emosyzcoug ) |
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