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Last update 08 Apr 2025
huCART19-IL18(University of Pennsylvania)
Last update 08 Apr 2025
Overview
Basic Info
Drug Type Autologous CAR-T |
Synonyms- |
Target |
Action inhibitors, agonists |
Mechanism CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors), IL18R1 agonists(Interleukin 18 receptor agonists) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Related
2
Clinical Trials associated with huCART19-IL18(University of Pennsylvania)NCT04684563
Phase I Trial of huCART19-IL18 Cells in Patients With Relapsed or Refractory CD19+ Cancers
NCT03620058
Phase 1 Study of Autologous Anti-CD22 Chimeric Antigen Receptor Redirected T Cells (CART22-65s) Alone and When Co-administered With Humanized Anti-CD19 Chimeric Antigen Receptor Redirected T Cells (huCART19) In Patients With Chemotherapy Resistant Or Refractory Acute Lymphoblastic Leukemia
100 Clinical Results associated with huCART19-IL18(University of Pennsylvania)
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100 Translational Medicine associated with huCART19-IL18(University of Pennsylvania)
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100 Patents (Medical) associated with huCART19-IL18(University of Pennsylvania)
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100 Deals associated with huCART19-IL18(University of Pennsylvania)
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| ALK positive large B-cell lymphoma | Phase 1 | United States | 06 May 2021 | |
| CD19 Expressing Malignancies | Phase 1 | United States | 06 May 2021 | |
| CD19-positive B-cell acute lymphoblastic leukemia | Phase 1 | United States | 06 May 2021 | |
| Cutaneous T-Cell Lymphoma | Phase 1 | United States | 06 May 2021 | |
| Diffuse Large B-Cell Lymphoma | Phase 1 | United States | 06 May 2021 | |
| Follicular Lymphoma | Phase 1 | United States | 06 May 2021 | |
| High grade B-cell lymphoma | Phase 1 | United States | 06 May 2021 | |
| Mantle-Cell Lymphoma | Phase 1 | United States | 06 May 2021 | |
| Mediastinal large B-cell lymphoma | Phase 1 | United States | 06 May 2021 | |
| Pre B-cell acute lymphoblastic leukemia | Phase 1 | United States | 06 May 2021 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | 21 | dfzuwnsacy(ayvengqvdm) = ftsxrqszzc kyfputhrfb (yujpblouqp ) View more | Positive | 14 May 2024 | |||
Not Applicable | Lymphoma CD19+ | 16 | jjlnbwbagb(xqclirpcnm) = udalvqmuwp ymxcaqlmfx (rvpmovfhov, 53 - 97) View more | Positive | 09 Jun 2023 | ||
Phase 1 | 9 | tzcrvzdrlm(wjlcpuesax) = Other non-hematologic G3 or higher adverse events at least possibly related to huCART19-IL18 included infections in 2 (25%), hypotension in 2 (25%), and AST elevation in 1 (12.5%) in the setting of CRS. glcmqmwnmq (lvpwlwfsdo ) | Positive | 15 Nov 2022 |
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