Delving into the Latest Updates on Technetium Tc-99M Sulfur Colloid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Diagnostic radiopharmaceuticals

Synonyms

Technetium Tc-99M Sulfur Colloid Kit, 锝[99mTc]硫化胶体, An-Sulfur Colloid

+ [3]

Target-

Mechanism

PET imaging(Positron-emission tomography enhancers)

Therapeutic Areas

NeoplasmsDigestive System DisordersMouth and Tooth Diseases+ [3]

Active Indication

MelanomaBreast CancerDiagnostic agents+ [1]

Inactive Indication-

Originator Organization

GE Healthcare, Inc.

Active Organization

HTA Co., Ltd.

Sun Pharmaceutical Industries, Inc.

Inactive Organization

Mallinckrodt, Inc.(Old)GE Healthcare, Inc.

Drug Highest PhaseApproved

First Approval Date

US (24 Sep 1974),

Diagnostic agents

Regulation-

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Structure

Molecular FormulaS8Tc

InChIKeyFJTPHHNWVXNMEK-IEOVAKBOSA-N

CAS Registry-

主要目的：评价锝[99mTc]硫化胶体注射液在乳腺癌患者中进行前哨淋巴结示踪的有效性；次要目的：评价锝[99mTc]硫化胶体注射液在乳腺癌患者中进行前哨淋巴结示踪的安全性；探索性目的：探索锝[99mTc]硫化胶体注射液注射前预处理时间对检出率的影响；探索手持伽马计数器对前哨淋巴结闪烁记数阳性阈值的合理性。

[Translation]

Primary purpose: To evaluate the effectiveness of technetium [99mTc] sulfide colloid injection in sentinel lymph node tracing in breast cancer patients; Secondary purpose: To evaluate the safety of technetium [99mTc] sulfide colloid injection in sentinel lymph node tracing in breast cancer patients; Exploratory purpose: To explore the effect of pretreatment time before technetium [99mTc] sulfide colloid injection on the detection rate; To explore the rationality of the positive threshold of sentinel lymph node scintigraphy by handheld gamma counter.

Start Date02 Jan 2024

Sponsor / Collaborator

HTA Co., Ltd.

NCT02881554 / Active, not recruitingNot ApplicableIIT

Functional Liver Imaging With Sulfur Colloid SPECT/CT in Primary and Metastatic Liver Cancer Patients Receiving Liver-Directed Treatment: A Pilot Study

This pilot trial studies how well single photon emission computed tomography (SPECT)/computed tomography (CT) with technetium Tc-99m sulfur colloid works in measuring liver function in patients with liver cancer that has or has not spread to other place in the body who are undergoing radiation therapy or surgery. Diagnostic procedures, such as sulfur colloid SPECT/CT scans, may measure normal liver tissue before, during and after treatment and help doctors plan better treatment for liver cancer patients.

Start Date21 Dec 2016

Sponsor / Collaborator

University of Washington

NCT02336737 / CompletedNot Applicable

A Pivotal, Prospective, Open-Label, Multicenter Paired Comparison Study Of SentiMag/SiennaXP And The Standard Of Care In Patients With Breast Cancer Who Are Undergoing Lymph Node Mapping As Part Of A Sentinel Node Biopsy Procedure

The purpose of this pivotal study is to provide prospective evidence that the SentiMag®/SiennaXP® is safe and non-inferior to the current standard of care for lymph node localization in patients with breast cancer as part of a sentinel lymph node biopsy (SLNB) procedure and to summarize measures of product safety and performance.

Start Date01 Jan 2015

Sponsor / Collaborator

Endomagnetics Ltd.

[+1]

100 Clinical Results associated with Technetium Tc-99M Sulfur Colloid

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100 Translational Medicine associated with Technetium Tc-99M Sulfur Colloid

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100 Patents (Medical) associated with Technetium Tc-99M Sulfur Colloid

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87

Literatures (Medical) associated with Technetium Tc-99M Sulfur Colloid

01 Mar 2023·World Journal of Nuclear Medicine

Tagging Efficiency of 99mTc-SC Radiolabeled Alternative Gastric Emptying Meals: A Quantitative Study

Article

Author: Singh, Dhananjay Kumar ; Deswal, Satyawati ; Pathak, Anurag ; Pal, Deepak Kumar

Abstract Objective The aim of this study was to know the tagging efficiencies of technetium-99m labeled sulfur colloid (99mTc-SC) with different meals. Materials and Methods Egg white sandwiches are the gold standard for gastric-emptying scan (GES); thus, an egg white omelet labeled with 99mTc-SC is taken as a standard meal. For evaluation, we included four meals, bread and butter, instant oatmeal, idli, and chapatti, and all meals were prepared by labeling them with 99mTc-SC. After preparation, food articles were chopped with the help of a metal fork and mixed in simulated gastric fluid. Four samples were taken simultaneously from each food article and analyzed for 1 to 4hours after agitation within the centrifuge. The samples were filtered and separated from the sediments and supernatants. We analyzed the activity in each sample before and after filtration. Results The mean values of labeling efficiency in per cent of various meals were obtained. There was no significant difference in labeling stability for egg whites, chapatti, and idli meals labeled with 99mTc-SC from 1 to 4hours as their p-value (p>0.05) was insignificant. Conclusion Radiolabeled chapatti and idli with 99mTc-SC show higher labeling stability, while oatmeal and bread and butter samples show relatively low stability. Thus, for GES, chapatti and idli labeled with 99mTc-SC can be used as alternatives to eggs for vegetarian people or for those allergic to eggs.

01 Jul 2022·Indian Journal of Nuclear Medicine

Sentinel Node Mapping in Early Breast Cancer

Article

Author: Srivastava, Anurag ; Pandey, Ravindra Mohan ; Mathur, Sandeep ; Mishra, Piyush Ranjan ; Dhar, Anita ; Prem, Amar ; Kataria, Kamal ; Khadka, Sarada ; Seenu, Vuthaluru ; Hari, Smriti ; Suresh, Jayesh ; Kumar, Rakesh ; Bal, Chandershekhar

Purpose:Evaluation of fluorescein along with blue dye as an affordable tracer for sentinel node biopsy in comparison with technetium + methylene blue. A randomized trial was conducted with the following objectives: (1) to demonstrate that the identification of sentinel lymph node by fluorescein + methylene blue is not inferior to the identification by Tc-99 m sulfur colloid + methylene blue and (2) to evaluate the cost-effectiveness of sentinel node biopsy by above two tracers.Subjects and Methods:One-thirty patients above age 18 years presenting with early breast cancer T1, T2, N0 breast carcinoma were randomized to undergo sentinel node biopsy by either fluorescein + methylene blue or Tc-99 m sulfur colloid + methylene blue.Results:The sentinel lymph nodes were identified in 89% in Fluorescein + methylene blue group and 90.9% with Tc-99 m sulfur colloid + methylene blue group. The trial demonstrated noninferiority of fluorescein + methylene blue as compared to isotope + methylene blue with effect size = 1; 95% confidence interval- 9.54 to + 11.54. The fluorescein + methylene blue was more cost-effective than isotope guided sentinel node biopsy.Conclusion:Fluorescein-guided sentinel node biopsy is noninferior and more cost-effective than isotope-guided sentinel node biopsy.

01 Mar 2022·Journal of Surgical OncologyQ3 · MEDICINE

How much time is enough? Sentinel lymph node mapping time depends on the radiotracer agent

Q3 · MEDICINE

Article

Author: Berger, Adam ; Beasley, Georgia M. ; Tyler, Douglas S. ; Leddy, Margaret ; Silvestri, Caitlin ; Stroobant, Emily ; Farrow, Norma E. ; Eckhoff, Austin ; Intenzo, Charles

AbstractBackgroundIn 2014, technetium‐99m tilmanocept (TcTM) replaced technetium‐99m sulfur colloid (TcSC) as the standard lymphoscintigraphy (LS) mapping agent in melanoma patients undergoing sentinel lymph node biopsy (SLNB). The aim of this study was to examine differences in mapping time, intra‐operative identification of sentinel lymph node (SLN), and false negative rate (FNR) between patients who underwent SLNB with TcTM compared to TcSC.MethodsPatients who underwent SLNB between 2010 and 2018 were retrospectively identified. Patient demographic, tumor, and imaging data was stratified by receipt of TcSC (n = 258) or TcTM (n = 133). Student's t test and χ2 test were used to compare characteristics and outcomes.ResultsBoth cohorts were similar in demographic, primary tumor characteristics, and total number of SLN identified (TcTM 3.56 vs. TcSC 3.28, p = 0.244). TcTM was associated with significantly shorter LS mapping times (51.8 vs. 195.1 min, p < 0.01). There was no significant difference in the number of patients with positive SLN (TcTM 11.3 vs. TcSC 17.4%, p = 0.109) and the FNR was similar between both groups (TcTM 25% vs. TcSC 22%).ConclusionTcTM was associated with significantly shorter LS mapping time while identifying similar numbers of SLN. Our results support further study to ensure similar FNR and oncologic outcomes between agents.

100 Deals associated with Technetium Tc-99M Sulfur Colloid

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	V09DB05	DB09397

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Melanoma	US	Sun Pharmaceutical Industries, Inc.	13 Aug 2012
Breast Cancer	US	Sun Pharmaceutical Industries, Inc.	17 Apr 1978
Diagnostic agents	US	Sun Pharmaceutical Industries, Inc.	17 Apr 1978
Gastroesophageal Reflux	US	Sun Pharmaceutical Industries, Inc.	17 Apr 1978

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Breast Cancer	Phase 3	CN	HTA Co., Ltd.	28 Dec 2023

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SNMMI2021	Not Applicable	-	-	99m Tc-filtered sulfur colloid (99mTc-filtered sulfur colloid)	(pguklpyfer) = The pH of the samples did not change over the time period evaluated phexizvezt (bidiiqyrhe )	Positive	18 May 2021
SNMMI2021	Not Applicable	-	-	Lidocaine HCl 1%		Positive	18 May 2021
NCT02336737 (SentiMagIC, CTgov)	Not Applicable	Breast Cancer	160	SiennaXP+Technetium Tc99m Sulfur Colloid+Isosulfan blue dye	qkywiygzzk(ohvqcjbpue) = savvhrkhig zucxbgapsj (pcazbnkpoy, zesbvvxhpb - jrbjoeeouv) View more	-	03 Nov 2020