CARTIMMUNE: A Single-Center Study of Patients With Autoimmune Diseases Receiving an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T-Cell (KYV 101)

The purpose of this study is to assess the safety, tolerability, and clinical activity of KYV 101 (a fully-human anti-CD19 CAR T-cell therapy) in adult subjects with B cell-driven autoimmune diseases. The trial anticipates enrolling participants to reach a maximum of 24 participants who will receive 1 dose of KYV-101 and will be followed for 2 years.

Start Date01 Jun 2024

Sponsor / Collaborator

University of Pennsylvania

[+1]

NCT06400303 / Not yet recruitingPhase 1/2

A Phase 1/2, Open-Label, Multicentre Study of KYV 101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis (KYSA-5)

A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects with Systemic Sclerosis

Start Date01 May 2024

Sponsor / Collaborator

Kyverna Therapeutics, Inc.Startup

NCT06138132 / RecruitingPhase 1IIT

A Phase 1, Open-Label, Single Center Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis

A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy in Subjects with Non-relapsing and Progressive Forms of Multiple Sclerosis

Start Date10 Apr 2024

Sponsor / Collaborator

Stanford University

[+1]

100 Clinical Results associated with KYV-101

100 Translational Medicine associated with KYV-101

100 Patents (Medical) associated with KYV-101

Literatures (Medical) associated with KYV-101

01 Mar 2024·Transplantation and Cellular Therapy

Fully Human Anti-CD19 CAR T Cells Derived from Systemic Lupus Erythematosus Patients Exhibit Cytotoxicity with Reduced Inflammatory Cytokine Production

Article

Author: Schett, Georg ; Cheng, Joseph K ; Minopoulou, Ioanna ; Aigner, Michael ; Taubmann, Jule ; Kaplan, Charles D ; Park, Soo ; Lutzny-Geier, Gloria ; Dingfelder, Janin ; Van Blarcom, Tom ; Mackensen, Andreas

KYV-101 is an autologous anti-CD19 chimeric antigen receptor (CAR)-T cell therapy under investigation for patients with B-cell driven autoimmune diseases. Hu19-CD828Z is a fully human anti-CD19 CAR designed and demonstrated to have a favorable clinical safety profile. Since anti-CD19 CAR T cells target and kill B cells in both circulation and tissues, the treatment with Hu19-CD828Z CAR T cells offers great potential in depleting autoreactive B cells. Demonstrate that Hu19-CD828Z CAR T cells manufactured from cryopreserved leukaphereses from patients with systemic lupus erythematosus (SLE) exhibit CAR-mediated and CD19-dependent cytokine release, proliferation and cytotoxicity when co-cultured with autologous primary B cells. T cells were enriched from cryopreserved leukaphereses from SLE patients or healthy donors (HD). CAR T cells were generated by transducing these cells with a lentiviral vector encoding Hu19-CD828Z. CAR-mediated and CD19-dependent activity was monitored in vitro in a set of cytotoxicity, cytokine release, and proliferation studies, in response to autologous primary CD19⁺ B cells, a CD19⁺ cell line (NALM-6), or a CD19^- cell line (U937). Hu19-CD828Z CAR T cells produced from SLE patients or HD induced greater proliferation and dose-dependent cytotoxicity against both autologous primary B cells and the CD19⁺ NALM-6 cells than nontransduced control T cells or co-cultures with a CD19^- cell line. Interestingly, there was lower inflammatory cytokine production from SLE patient-derived CAR T cells compared to HD donor-derived CAR T cells with either CD19⁺ cells or primary B cells. Hu19-CD828Z CAR T cells generated from SLE patient lymphocytes demonstrate CAR-mediated and CD19-dependent activity against autologous primary B cells with reduced inflammatory cytokine production supporting KYV-101 as a novel potential therapy for the depletion of pathogenic B cells in SLE patients.

01 Mar 2024·Med

CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis

Article

Author: Heesen, Christoph ; Badbaran, Anita ; Gagelmann, Nico ; Seibel, Johan ; Fehse, Boris ; Kuhle, Jens ; Friese, Manuel A ; Reinhardt, Stefanie ; Borie, Dominic ; Rathje, Kristin ; Berger, Susanna Carolina ; Richter, Johanna ; Pfeffer, Lena Kristina ; Ayuk, Francis ; Kröger, Nicolaus ; Fischbach, Felix

BACKGROUNDProgressive multiple sclerosis (MS) is characterized by compartmentalized smoldering neuroinflammation caused by the proliferation of immune cells residing in the central nervous system (CNS), including B cells. Although inflammatory activity can be prevented by immunomodulatory therapies during early disease, such therapies typically fail to halt disease progression. CD19 chimeric antigen receptor (CAR)-T cell therapies have revolutionized the field of hematologic malignancies. Although generally considered efficacious, serious adverse events associated with CAR-T cell therapies such as immune effector cell-associated neurotoxicity syndrome (ICANS) have been observed. Successful use of CD19 CAR-T cells in rheumatic diseases like systemic lupus erythematosus and neuroimmunological diseases like myasthenia gravis have recently been observed, suggesting possible application in other autoimmune diseases.METHODSHere, we report the first individual treatment with a fully human CD19 CAR-T cell therapy (KYV-101) in two patients with progressive MS.FINDINGSCD19 CAR-T cell administration resulted in acceptable safety profiles for both patients. No ICANS was observed despite detection of CD19 CAR-T cells in the cerebrospinal fluid. In case 1, intrathecal antibody production in the cerebrospinal fluid decreased notably after CAR-T cell infusion and was sustained through day 64.CONCLUSIONSCD19 CAR-T cell administration in progressive MS resulted in an acceptable safety profile. CAR-T cell presence and expansion were observed in the cerebrospinal fluid without clinical signs of neurotoxicity, which, along with intrathecal antibody reduction, indicates expansion-dependent effects of CAR-T cells on CD19⁺ target cells in the CNS. Larger clinical studies assessing CD19 CAR-T cells in MS are warranted.FUNDINGBoth individual treatments as well the generated data were not based on external funding.

News (Medical) associated with KYV-101

11 Apr 2024

·www.prnewswire.com

Kyverna Therapeutics to attend the 2024 American Academy of Neurology (AAN) Annual Meeting in Denver, CO, With Data on KYV-101 in the Treatment of Patients with Neurological Autoimmune Diseases

Poster #14-006 describes the first successful treatment of concomitant myasthenia gravis and Lambert-Eaton myasthenic syndrome with autologous CD19-targeted CAR-T cells Kyverna to host a conference call on April 16 to review recent named-patient experience in patients suffering from multiple sclerosis and myasthenia gravis EMERYVILLE, Calif., April 11, 2024 /PRNewswire/ -- Kyverna Therapeutics, Inc. (Nasdaq: KYTX), a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases, announced today its attendance at the 2024 annual meeting of the American Academy of Neurology to be held in Denver, Colorado, starting on April 13. Of particular interest: On April 15, Jeremias Motte, M.D., a senior physician and neurologist at the University Hospital in Bochum, Germany, will present a case study of a successful treatment of patients suffering from concomitant myasthenia gravis and Lambert-Eaton syndrome1 On April 16, Kyverna will host a conference call discussing recent experience with KYV-101 in patients suffering from neurological autoimmune diseases. Call-in details will be published in advance on the company's website (ir.kyvernatx.com) On April 16, Marinos Dalakas, M.D., FAAN, a professor at the Thomas Jefferson University Hospitals and a neurology specialist, will discuss advances in the therapeutic algorithm for autoimmune neuromuscular disorders "We welcome the publication of these reports from named-patient case studies that contribute to building confidence in the desired safety and efficacy profile for innovating CAR T-cell therapies," said Jeffrey Dunn, M.D., the Lily Sarafan director of Neuroimmunology and clinical professor and chief of Neuroimmunology within the Department of Neurology and Neurological Sciences at Stanford University in Palo Alto, California. "We look forward to attending AAN and engaging with the scientific community in seeking to develop paradigm-shifting treatment options for patients living with autoimmune diseases," said Peter Maag, Ph.D., chief executive officer of Kyverna. Chimeric antigen receptor (CAR) T-cell therapy involves modifying a patient's T cells to recognize and remove B cells in the patient's body. CD19 CAR T-cell therapy specifically targets CD19, a protein expressed on the surface of B cells, which are involved in various types of autoimmune diseases. About Multiple Sclerosis (MS) Multiple sclerosis is a chronic neurodegenerative autoimmune disease affecting over 2.8 million individuals worldwide2. It affects more frequently women, people of Northern European descent, and is also associated with certain environmental and genetic factors. Patients with MS can experience a range of symptoms including blurred vision, slurred speech, tremors, numbness, extreme fatigue, problems with memory and concentration, and, in severe cases, the inability to walk or stand. Current disease-modifying treatments for MS aim to reduce the frequency of disease relapses and delay progression of disability, but the disease remains a chronic condition that will progressively worsen for most patients. About Myasthenia Gravis (MG) Myasthenia gravis is an autoimmune disorder associated with muscle weakness in tissues throughout the body, potentially manifesting in partial paralysis of eye movements, problems in chewing and swallowing, respiratory problems, speech difficulties and weakness in skeletal muscles. MG patients develop antibodies that lead to an immunological attack on critical signaling proteins at the junction between nerve and muscle cells, thereby inhibiting the ability of nerves to communicate properly with muscles. The symptoms of the disease can be transient and in the early stages of the disease can remit spontaneously. However, as the disease progresses, symptom-free periods become less frequent and disease exacerbations can last for months. Disease symptoms reach their maximum levels within two to three years in approximately 80% of patients. Up to 20% of MG patients experience respiratory crisis at least once in their lives.3 About KYV-101 KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate for use in B cell-driven autoimmune diseases. The CAR in KYV-101 was designed by the National Institutes of Health (NIH) to improve tolerability and tested in a 20-patient Phase 1 trial in oncology. Results were published by the NIH in Nature Medicine4. KYV-101 is currently being evaluated in sponsored, open-label, Phase 1/2 trials of KYV-101 in patients with lupus nephritis, an autoimmune disease in which more than half of patients do not achieve a complete response to current therapies and are at risk of developing kidney failure. Additionally, FDA's IND clearance has been obtained for Phase 2 trials of KYV-101 for multiple sclerosis and myasthenia gravis, and a Phase 1/2 trial for systemic sclerosis. We believe that the differentiated properties of KYV-101 are critical for the potential success of CAR T cells as autoimmune disease therapies. KYV-101 is also being evaluated in investigator-initiated trials for multiple indications in multiple geographies. About Kyverna Therapeutics Kyverna Therapeutics, Inc. (NASDAQ: KYTX) is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases. Our lead CAR T-cell therapy candidate, KYV-101 is advancing through clinical development with sponsored clinical trials across two broad areas of autoimmune disease: rheumatology and neurology, including Phase 2 trials for multiple sclerosis and myasthenia gravis, a Phase 1/2 trial for systemic sclerosis, and two ongoing multi-center, open-label Phase 1/2 trials in the United States and Germany for patients with lupus nephritis. Kyverna's pipeline includes next-generation CAR T-cell therapies in both autologous and allogeneic formats with properties intended to be well suited for use in B cell-driven autoimmune diseases. Forward-Looking Statements Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements." The words, without limitation, "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these or similar identifying words. Forward-looking statements in this press release include, without limitation, those related to: the potential impact of named-patient case studies; Kyverna's goals to develop certain paradigm-shifting treatment options; Kyverna's beliefs about the differentiated properties of KYV-101; and Kyverna's clinical trials. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties related to market conditions, and other factors discussed in the "Risk Factors" section of Kyverna's most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q that Kyverna has filed or may subsequently file with the U.S. Securities and Exchange Commission. Any forward-looking statements contained in this press release are based on the current expectations of Kyverna's management team and speak only as of the date hereof, and Kyverna specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. For more information, please visit . Kyverna Media Contact: Consort Partners for Kyverna [email protected] # # # SOURCE Kyverna Therapeutics

Cell TherapyPhase 1INDImmunotherapy

04 Apr 2024

·www.biospace.com

Companies Detail Potential Fallout as Pressure on WuXi AppTec Builds

Pictured: Collage of a dragon, congress, and money/Taylor Tieden for BioSpace WuXi AppTec, a key partner for many U.S.-based biopharma companies, has recently been caught up in controversy pertaining to the proposed BIOSECURE Act. Now, companies including Merck, Iovance Biotherapeutics and Kyverna Therapeutics, have detailed interactions with the SEC about potential impacts on their future programs. Introduced in January 2024 by Rep. Mike Gallagher (R-WI), the BIOSECURE Act aims to guarantee that taxpayer money isn’t used to help fund “foreign adversary biotech companies” posing threats to U.S. national security. It also prohibits federal contracting with “certain biotechnology providers” tied to foreign adversaries. The biotech companies of concern listed in the proposed legislation are WuXi AppTec, BGI, MGI and Complete Genomics. If signed into law, the legislation would prevent biopharma companies that contract with “companies of concern” from also having contracts with the U.S. government, according to the law firm Foley Hoag. On March 14, news emerged that WuXi had separated from the trade organization BIO after U.S. intelligence officials told senators that the company had shared a U.S. client’s intellectual property with the Chinese government without consent. In an SEC document filed Feb. 28, cell therapy biotech Iovance noted that it has contracted a WuXi subsidiary to manufacture its cell therapy products commercially, but also stated that the “current geopolitical tensions” with China may “impact our ability to expand manufacturing capacity” with the company’s facilities. Jen Saunders, senior director of investor relations and corporate communications at Iovance, told BioSpace in an email that the biotech does not anticipate any “significant impact” from the BIOSECURE Act—or a different version of it—on its ability to manufacture and meet the demand for its recently approved cell therapy Amtagvi. “Our manufacturing facility, the Iovance Cell Therapy Center, is built to support several thousand patients annually,” Saunders said, adding that the company is comfortable with its internal capabilities to address anticipated near-term demand and is currently working to expand its existing facility to more than double capacity. In February 2024, Rep. Gallagher and Rep. Raja Krishnamoorthi (D-IL) penned a letter to Commerce Secretary Gina Raimondo, Treasury Secretary Janet Yellen and Defense Secretary Lloyd Austin, asking them to investigate WuXi and have the company placed on control lists. These lists include the DoD’s Chinese Military Companies List (1260H list), the Department of Commerce’s Bureau of Industry and Security Entity List and the Department of Treasury’s Non-SDN Chinese Military-Industrial Complex Companies List. Iovance noted in the document that if WuXi is added to any of these lists, it could “materially impact” its manufacturing service agreement with the company. In its own SEC filing last week, Kyverna explained that it has partnered with a WuXi subsidiary to manufacture its CAR T cell candidate KYV-101 while developing its manufacturing methods. As with Iovance, the addition of WuXi to one or more of the aforementioned lists could “materially impact” Kyverna’s use of the subsidiary, according to the filing. In a statement emailed to BioSpace, a Kyverna spokesperson said it is aware of the “ongoing concerns related to the BIOSECURE Act” and is “closely monitoring the developments.” And it isn’t just smaller biotechs that could end up caught in the crosshairs of this proposed legislation. Merck detailed in an SEC document filed Feb. 26 that its business in China has been growing over the past few years, and said the country’s importance to its vaccine and pharma business has increased. Merck also has “significant” research and production operations in China and does work with WuXi. “If geopolitical tensions were to increase and disrupt the Company’s operations in China, such disruption could result in a material adverse effect on the Company’s product development, sales, business, cash flow, results of operations, financial condition and prospects,” according to the document. BioSpace reached out to Merck for further comment but has not heard back. Elsewhere, Jacob Van Naarden, president of Eli Lilly’s Loxo Oncology division, told BioSpace in a previous interview that the company is not facing direct pressure to divest from China but is “trying to be cautious” about the situation. Tyler Patchen is a staff writer at BioSpace. You can reach him at tyler.patchen@biospace.com. Follow him on LinkedIn.

Cell Therapy

29 Mar 2024

·www.prnewswire.com

First-in-Disease Use of Kyverna Therapeutics' KYV-101 in Patients With Progressive Multiple Sclerosis Published in Med

Two patients were treated with KYV-101, a fully human anti-CD19 CAR T-cell product candidate, in Germany as part of a named patient program after failure to respond to conventional therapies The treatment resulted in an acceptable safety profile, with no observed clinical signs of early neurotoxicity, warranting larger clinical studies in subjects with multiple sclerosis EMERYVILLE, Calif., March 29, 2024 /PRNewswire/ -- Kyverna Therapeutics, Inc. (Kyverna), a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases, announces today the publication in Med1, of a report describing the first use of KYV-101, a fully human anti-CD19 chimeric antigen receptor (CAR) T-cell product candidate, in two patients suffering from progressive multiple sclerosis (MS) as part of a named patient program for critically ill patients after both patients failed to respond to conventional therapies. "We are very pleased about offering this potentially paradigm-shifting treatment opportunity to patients that have exhausted other medical recourses," said Christoph Heesen, M.D., professor for clinical and rehabilitative MS research at the University Medical Center Hamburg-Eppendorf in Hamburg, Germany, and senior co-author. "Emerging findings indicating that this approach may affect disease biology in the central nervous system are promising, as preventing disease progression remains one of the most difficult challenges in MS therapy." "Exploring the safety profile of CAR T administration in this population and hopefully establishing that it compares favorably to hematopoietic stem cell transplant may bring the cell therapy approach to a larger number of patients in need," said Nicolaus Kröger, M.D., professor of Medicine and medical director, Department of Stem Cell Transplantation at the University Medical Center Hamburg-Eppendorf in Hamburg, Germany, and senior co-author. "If safe administration can be replicated in other patients and efficacy be formally established in clinical trials, this may bring a relevant therapeutic option to patients with MS." "We are committed to transforming the standard of treatment for patients living with multiple sclerosis," said Peter Maag, Ph.D., chief executive officer of Kyverna. "The pioneering work done with KYV-101 by medical teams in Hamburg and in our trials in the U.S. helps build the data backbone needed to further advance our knowledge and hopefully accelerate development of CAR T-cell therapies in autoimmune diseases." CAR T-cell therapy involves modifying a patient's T cells to recognize and remove B cells in the patient's body. CD19 CAR T-cell therapy specifically targets CD19, a protein expressed on the surface of B cells, which are involved in various types of autoimmune diseases. About Multiple sclerosis (MS) Multiple sclerosis is a chronic neurodegenerative autoimmune disease affecting over 2.8 million individuals worldwide2. It affects more frequently women, people of Northern European descent, and is also associated with certain environmental and genetic factors. Patients with MS can experience a range of symptoms including blurred vision, slurred speech, tremors, numbness, extreme fatigue, problems with memory and concentration, and, in severe cases, the inability to walk or stand. Current disease-modifying treatments for MS aim to reduce the frequency of disease relapses and delay progression of disability, but the disease remains a chronic condition that will progressively worsen for most patients. About KYV-101 KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate for use in B cell-driven autoimmune diseases. The CAR in KYV-101 was designed by the National Institutes of Health (NIH) to improve tolerability and tested in a 20-patient Phase 1 trial in oncology. Results were published by the NIH in Nature Medicine3. KYV-101 is currently being evaluated in sponsored, open-label, Phase 1/2 trials of KYV-101 in patients with lupus nephritis, an autoimmune disease in which more than half of patients do not achieve a complete response to current therapies and are at risk of developing kidney failure. Additionally, FDA's IND clearance has been obtained for Phase 2 trials of KYV-101 for multiple sclerosis and myasthenia gravis, and a Phase 1/2 trial for systemic sclerosis. We believe that the differentiated properties of KYV-101 are critical for the potential success of CAR T cells as autoimmune disease therapies. KYV-101 is also being evaluated in investigator-initiated trials for multiple indications in multiple geographies. About Kyverna Therapeutics Kyverna Therapeutics (NASDAQ: KYTX) is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases. Our lead CAR T-cell therapy candidate, KYV-101 is advancing through clinical development with sponsored clinical trials across two broad areas of autoimmune disease: rheumatology and neurology, including Phase 2 trials for multiple sclerosis and myasthenia gravis, a Phase 1/2 trial for systemic sclerosis, and two ongoing multi-center, open-label Phase 1/2 trials in the United States and Germany for patients with lupus nephritis. Kyverna's pipeline includes next-generation chimeric antigen receptor (CAR) T-cell therapies in both autologous and allogeneic formats with properties intended to be well suited for use in B cell-driven autoimmune diseases. Forward-Looking Statements Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements." The words, without limitation, "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these or similar identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties related to market conditions, and other factors discussed in the "Risk Factors" section of the final prospectus. Any forward-looking statements contained in this press release are based on the current expectations of Kyverna's management team and speak only as of the date hereof, and Kyverna specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. For more information, please visit . Kyverna Media Contact: Consort Partners for Kyverna [email protected] 1. Fischbach et al., Med (2024), 2. Walton C, et al., Mult Scler. 2020; 26:1816-1821. 3. Brudno et al., Nature Medicine 2020; 26:270-280. SOURCE Kyverna Therapeutics

Cell TherapyPhase 2Phase 1ImmunotherapyIND

100 Deals associated with KYV-101

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Scleroderma, Diffuse	Phase 2	-	Kyverna Therapeutics, Inc.Startup	01 May 2024
Multiple Sclerosis, Chronic Progressive	Phase 2	-	Kyverna Therapeutics, Inc.Startup	01 Apr 2024
Multiple Sclerosis, Primary Progressive	Phase 2	-	Kyverna Therapeutics, Inc.Startup	01 Apr 2024
Multiple Sclerosis, Secondary Progressive	Phase 2	-	Kyverna Therapeutics, Inc.Startup	01 Apr 2024
Myasthenia Gravis	Phase 2	-	Kyverna Therapeutics, Inc.Startup	01 Mar 2024
Lupus Nephritis	Phase 2	DE	Kyverna Therapeutics, Inc.Startup	01 Dec 2022
Scleroderma, Systemic	Phase 2	US	Kyverna Therapeutics, Inc.Startup	-
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	Phase 1	-	Kyverna Therapeutics, Inc.Startup	01 Jun 2024
Idiopathic Inflammatory Myopathies	Phase 1	-	Kyverna Therapeutics, Inc.Startup	01 Jun 2024
Dermatomyositis	Phase 1	US	Stanford University	01 Apr 2024

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


PRNewswire Manual	Not Applicable	Myasthenia Gravis	1	KYV-101	(iowtzxjrrn) = ppcdxkzcge flsyvdwfkn (wtgdygnquo ) View more	Positive	15 Nov 2023

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