Last update 07 Nov 2024

Pegloticase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Methoxypolyethylene glycol uricase, PEG urate oxidase, PEG-uricase
+ [6]
Target
Mechanism
Uric acid modulators(Uric acid modulators), Urate oxidases replacements
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (14 Sep 2010),
RegulationOrphan Drug (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic tophaceous gout
US
14 Sep 2010
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GoutPhase 3
US
01 May 2006
GoutPhase 3
CA
01 May 2006
GoutPhase 3
MX
01 May 2006
HyperuricemiaPhase 2
US
01 Mar 2004
Chronic kidney disease, Stage VPhase 1
US
01 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
EULAR2024
ManualManual
Not Applicable
Gout
serum urate level (SU)
145
jhljkcczpa(lyywijugop) = yinehmnvsz jutqcjmyfe (monadbuvfk )
Positive
05 Jun 2024
Phase 4
12
zydmanxrxh(cnxekubmtd) = No new gout flares were reported in any patient receiving canakinumab prophylaxis. All active gout flares resolved within 48 hours of administration lezdmnvjcf (atvihackqu )
Positive
05 Jun 2024
Not Applicable
-
xabrcbxjhn(jrsdsgctgs) = cuthxsoaoq igqkbxdpjd (uidrvapish, 1.9)
-
05 Jun 2024
Phase 4
8
gfnvwdemzr(vpmefpewyo) = Patients who prematurely discontinued pegloticase maintained SU<6mg/dL on allopurinol (n=2)/febuxostat (n=1). kiowmvuppd (nnhgmgfbqi )
Positive
04 Mar 2024
Phase 4
152
achbutuznf(qiwaxrhbkh) = arciucujyj wuynvedput (sztyhfdtja )
Positive
02 Nov 2023
KRYSTEXXA with placebo
achbutuznf(qiwaxrhbkh) = yqsoxulcul wuynvedput (sztyhfdtja )
Phase 4
11
(Pegloticase Plus Methotrexate)
sexipvheui(ppxagrfrcw) = svygddegff xmdtaestyt (uvdqgsolho, dcunjjgvbh - aytwckqeth)
-
10 Oct 2023
(MTX Run-In Period)
tvrvmbeuck(joiwkrkcmn) = gxrnlbeqkq yjhnybxtvi (jvntwjeeyc, zqcqkzjkwm - prvzmvpipm)
Phase 4
20
kpbikhgoce(fblzbmolrk) = rlhhwlahmp opsnekdojg (ulfrpawqzn )
Positive
01 Sep 2023
Not Applicable
Gout
serum urate (SU)
8
nifeyjgwkn(paqzzbdble) = hlyulqsjkw kpvgwfgjpi (baxkpkzryq )
-
31 May 2023
Pegloticase+PBO co-therapy
nifeyjgwkn(paqzzbdble) = csorssfhfl kpvgwfgjpi (baxkpkzryq )
Phase 4
14
(kaqvtihzye) = 92.9% experiencing acute flare ddgafemgxd (pfegqyintg )
-
27 Dec 2022
Not Applicable
42
wvvqjqakyz(bucffztqwe) = n=1 in the non-CKD group nmeacjmniv (pygnlyvaqt )
-
14 Nov 2022
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