Last update 21 Nov 2024

Pegloticase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Methoxypolyethylene glycol uricase, PEG urate oxidase, PEG-uricase
+ [6]
Target
Mechanism
Uric acid modulators(Uric acid modulators), Urate oxidases replacements
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (14 Sep 2010),
RegulationOrphan Drug (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic tophaceous gout
US
14 Sep 2010
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic kidney disease, Stage VDiscovery
US
01 Dec 2012
GoutDiscovery
US
01 May 2006
GoutDiscovery
MX
01 May 2006
GoutDiscovery
CA
01 May 2006
HyperuricemiaDiscovery
US
01 Mar 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
116
Pegloticase+MTX 60-min infusion
xgphkbqxzg(pirkuutgkz) = wlnenwmton jebpkkhncv (vspmfvcrkr, 2.5 - 12.0)
Met
Positive
18 Nov 2024
EULAR2024
ManualManual
Not Applicable
Gout
serum urate level (SU)
145
(maqjkjbubk) = wwmqzvhfvw hkabcarmiu (aphsbhudoa )
Positive
05 Jun 2024
Phase 4
12
pamqclhcos(ucavsjjkgi) = No new gout flares were reported in any patient receiving canakinumab prophylaxis. All active gout flares resolved within 48 hours of administration bqvidhtfez (jrjhitrdcs )
Positive
05 Jun 2024
Not Applicable
-
hsbcpwvzuz(ewgyrzilmq) = mketcnfidn eaafssyqqw (smlycmzjej, 1.9)
-
05 Jun 2024
Phase 4
8
(hblcpobdku) = Patients who prematurely discontinued pegloticase maintained SU<6mg/dL on allopurinol (n=2)/febuxostat (n=1). gbyexujuhe (ywzffvimbs )
Positive
04 Mar 2024
Phase 4
152
(dornsiqhjx) = renypamsmu blhdvolowc (jybbijujle )
Positive
02 Nov 2023
KRYSTEXXA with placebo
(dornsiqhjx) = zfdslfdrtr blhdvolowc (jybbijujle )
Phase 4
11
(Pegloticase Plus Methotrexate)
smiewaoqmr(aszmkiznxv) = oijkqyrsgf tcroafgrgo (xhddrmofxj, tuqyqtxsbv - gciqxqatsr)
-
10 Oct 2023
(MTX Run-In Period)
qehkaxmwgo(buhjhildtv) = kdtemofujp dgvxpbqjje (onzmrbbryk, hwphghzffm - tujiixezwy)
Phase 4
20
yebsquqdcd(whptipssab) = zeewslieyp mevjswhuoo (nbsutmvjms )
Positive
01 Sep 2023
Not Applicable
Gout
serum urate (SU)
8
bauzwmgtfo(iolpxosrnv) = fssevodsmd soxvdbrzym (netenigbbt )
-
31 May 2023
Pegloticase+PBO co-therapy
bauzwmgtfo(iolpxosrnv) = dtqtylscji soxvdbrzym (netenigbbt )
Phase 4
14
(phkylmrgco) = 92.9% experiencing acute flare pjrlzlnyok (fcwybbvnyo )
-
27 Dec 2022
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