This is a 4-week pilot, multicenter, randomized, double-blinded placebo controlled trial of hydroxocobalamin and butyrate in ulcerative colitis (UC) that will occur in two phases. The main objectives of this study are to determine the capacity of hydroxocobalamin and butyrate to reduce calprotectin in those with inflammatory disease in UC to determine the safety and preferential dose of hydroxocobalamin with butyrate in UC.

Start Date01 Jan 2024

Sponsor / Collaborator

The Brigham & Women's Hospital, Inc.

NCT05536596 / Not yet recruitingPhase 2/3IIT

Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy: a Randomized, Double-blind Trial

The bilateral sagittal split osteotomy (BSSO) of the mandible is one of the most used surgical techniques to achieve a harmonious jaw relation in the context of orthognathic surgery. Nevertheless, one of its main complications is neurosensory damage to the inferior alveolar nerve, which can cause severe impact in the quality of life on patients who suffer from it permanently. The purpose of this randomized clinical trial is to provide rigorous scientific evidence of the pharmacological effect of 1) Melatonin, 2) combination uridine triphosphate (UTP), cytidine monophosphate (CMP), and hydroxycobalamin (UTP/CMP/hydroxycobalamin) and 3) hydroxycobalamin regarding neurosensory disturbances incidence and persistence after BSSO.

Start Date30 Sep 2022

Sponsor / Collaborator

Universitat Internacional de Catalunya

[+1]

IRCT20211207053311N1 / RecruitingPhase 3IIT

Evaluation of response rate to hydroxycobalamin treatment in patients with methylmalonic acidemia

Start Date04 Feb 2022

Sponsor / Collaborator

Mashhad University of Medical Sciences

100 Clinical Results associated with Hydroxocobalamin

100 Translational Medicine associated with Hydroxocobalamin

100 Patents (Medical) associated with Hydroxocobalamin

3,670

Literatures (Medical) associated with Hydroxocobalamin

01 Feb 2025·Archivos Argentinos de Pediatria

Acute cyanide intoxication due to apricot seed ingestion

Article

Author: Güngör, Emre ; Orhan, Özhan ; Talay, Mehmet N

Introduction: Cyanide poisoning, whether it be accidental or intentional, remains a significant danger to adults and children, especially in societies where agriculture is a primary source of income. We examined the clinical follow-up, complications, and results of cyanide poisoning cases that occurred after eating the pits and seeds of plants containing cyanide glycosides, such as apricot kernels and almonds. Methods: Between 01/01/2017 and 01/08/2022, 14 children aged 1-18 years who were followed up with a prediagnosis of cyanide poisoning in our Paediatric Intensive Care Unit (PICU) were retrospectively analysed. Results: Eight of the patients followed with a preliminary diagnosis of cyanide poisoning were female and six were male. The most common admission month was July (42.8%) coinciding with the agricultural season. The most common symptoms at presentation were weakness and fatigue (n = 7). In the PICU, 4 patients presented lip cyanosis; 3, altered level of consciousness. Vomiting, seizure, headache, dizziness and palpitatons were less frequent. Four patients were treated with hydroxocobalamin (Cyanokit®) as an antidote due to acidosis in their blood gases. All patients treated for cyanide poisoning were discharged. Conclusions: Cyanide poisoning should be considered in paediatric patients with suspicious findings, sudden loss of consciousness, increased anion gap acidosis and lactic acidosis. The history of eating the seeds of plants such as apricot and almonds should be investigated.

01 Jan 2025·Food Chemistry

Impact of fermentation by Saccharomyces Cerevisiae on the macronutrient and in vitro digestion characteristics of Chinese noodles

Article

Author: Sun, Jingwei ; Liu, Shuhang ; Yao, Ke ; Qiu, Shoukuan ; Song, Xiaoyan

This study examined the impact of live bread yeast (Saccharomyces cerevisiae) on the nutritional characteristics of Asian dried noodles. Micronutrient analysis of fermented noodles revealed a 6.9% increase in the overall amino acid content, a 37.1% increase in the vitamin B content and a 63.0% decrease in the phytic acid level. Molecular weight analysis of starch and protein contents revealed moderate decrease in the fermented noodles. The in vitro digestion of fermented noodles showed a slightly faster initial acidification, four-fold decrease in the initial shear viscosity (from 8.85 to 1.94 Pa·s). The initial large food particle count (>2 mm diameter) was 19.5% lower in the fermented noodles. The fermented noodles contained slightly higher free sugar content (73.5 mg g^-1 noodle) during the gastric digestion phase. The overall nutrition and digestion results indicate nutritional improvement and digestion-easing attributes in the fermented noodles.

01 Dec 2024·Current Opinion in Critical Care

Developments in the epidemiology of calcium channel blocker poisoning and implications for management

Review

Author: Simpson, Michael D. ; Cole, Jon B.

Purpose of reviewThe aim of this study was to outline recent developments in calcium channel blocker (CCB) poisoning. The dihydropyridine CCB amlodipine is commonly prescribed in the United States, and amlodipine poisoning is increasing in frequency, presenting new challenges for clinicians because current paradigms of CCB poisoning management arose from literature on non-dihydropyridine agents.Recent findingsAmlodipine is now the most common CCB involved in poisoning. High-dose insulin is a potent inotrope and vasodilator; as such, it should be used cautiously, and typically in conjunction with vasopressors, as it theoretically may worsen vasodilation in amlodipine poisoning. High-dose insulin is best used when some degree of cardiogenic shock is suspected. Venoarterial extracorporeal membrane oxygenation utilization in CCB poisoning appears to be increasing, but high flow rates may be needed to combat amlodipine-induced vasoplegia. Intravenous lipid emulsion cannot be routinely recommended but may have a role in peri-arrest situations. Adjunct treatments such as angiotensin II, methylene blue, and hydroxocobalamin offer theoretical benefit but warrant further study.SummaryAmlodipine causes most cases of CCB poisoning and can induce both cardiogenic and distributive shock through multiple mechanisms. Clinicians should tailor treatment to suspected shock etiology, be aware of adjunct treatments for refractory shock, and consult an expert in poisoning.

News (Medical) associated with Hydroxocobalamin

06 Feb 2024

·www.prnewswire.com

Dermal Repair Complex from Beverly Hills MD Can Help Nourish Dry Skin This Winter

A Dietary Supplement That Supports Visibly Firmer and More Lifted-Looking Skin, A Reduced Appearance of Wrinkles, and Enhanced Radiance BEVERLY HILLS, Calif., Feb. 6, 2024 /PRNewswire/ -- As Winter temperatures begin to drop, many of us find that the cold weather can bring on a set of challenges, particularly for our skin. The harsh winter conditions often leave us grappling with dry skin, causing plump skin cells to shrivel and potentially leading to fine lines and wrinkles. Continue Reading Beverly Hills MD Dermal Repair Complex is a dietary supplement designed to revitalize the look of skin from the inside out. Formulated to address the key causes of dermal breakdown, this supplement aims to help visibly firm and lift the skin, reduce the appearance of wrinkles, enhance radiance, and contribute to a significantly younger and healthier overall appearance. In combating the effects of winter-induced dryness, skincare experts Dr. John Layke and Dr. Payman Danielpour emphasize the importance of constant moisturizing and the potential benefits of dietary supplements. One such supplement is the Beverly Hills MD Dermal Repair Complex. Beverly Hills MD Dermal Repair Complex is a dietary supplement designed to revitalize the look of skin from the inside out. Formulated to address the key causes of dermal breakdown, this supplement aims to help visibly firm and lift the skin, reduce the appearance of wrinkles, enhance radiance, and contribute to a significantly younger and healthier overall appearance. As we bid farewell to winter, it's time to consider incorporating such skincare solutions to help rejuvenate and nourish the skin for the upcoming seasons.†* What is Beverly Hills MD Dermal Repair Complex? Beverly Hills MD Dermal Repair Complex is a dietary supplement crafted with an advanced blend of scientifically-backed nutrients. This formula is designed to aid your body in reducing visible signs of aging by combating the impact of skin-aging hormones, reduced body moisture, and collagen loss. The ingredients in Beverly Hills MD Dermal Repair Complex, including hydrolyzed collagen, hyaluronic acid, MSM, and vitamins A and B, collaborate to help diminish the appearance of wrinkles, crow's feet, pucker lines, forehead creases, and fine lines.†* Over time, users can experience visibly firmer and more lifted-looking skin, particularly in areas prone to the appearance of sagging like the jowls, neck, jawline, cheeks, and chin. Beyond skin nourishment, Beverly Hills MD Dermal Repair Complex can also provide many users with bonus benefits, including thicker-looking hair and fuller-looking lips — enhancing a youthful appearance.* What are the Key Ingredients in Beverly Hills MD Dermal Repair Complex?† Vitamin A: A potent antioxidant that acts as a protective shield against external factors like pollution and stress. It helps address visible signs of aging, including pucker lines, fine lines, crow's feet, and forehead creases.* Vitamin B: As an essential antioxidant, vitamin B supports the healthy turnover of cells, supporting visibly firmer and more lifted-looking skin.* Hyaluronic Acid: Functioning as a moisture-attracting molecule, hyaluronic acid helps visibly smooth wrinkles from the inside out, contributing to a more youthful complexion.* Saw Palmetto: Enriched with antioxidants and fatty acids, Saw Palmetto is a potent extract that helps the body fight the adverse effects of the skin-sagging hormone DHT, leading to noticeable improvements.* MSM (Methylsulfonylmethane): This organic compound works to strengthen the appearance of the skin, promoting a firmer and more radiant look.* Hydrolyzed Collagen: This easily absorbable protein is rich in essential amino acids, working to support the skin's youthful elasticity and achieve a plump, "bouncy" appearance.* The Suggested Use of Beverly Hills MD Dermal Repair Complex For optimal results, take 2 capsules of Dermal Repair Complex dietary supplement daily with 8 fl. oz. of water and a meal. Where to purchase Beverly Hills MD Dermal Repair Complex? Beverly Hills MD Dermal Repair Complex can be purchased on the Beverly Hills MD website for the purchase price of $58.00 with a 90-day money-back guarantee. About Dr. Layke and Dr. Danielpour Dr. John Layke and Dr. Payman Danielpour are renowned plastic surgeons and co-founders of the Beverly Hills Plastic Surgery Group. Both doctors trained at the prestigious Long Island Plastic Surgical Group before offering world-class procedures at their Beverly Hills clinic. In 2014, their passion for science inspired them to develop advanced ingredient formulations to help users achieve results in the comfort of their homes, and the Beverly Hills MD skincare line was born. Dr. John Layke and Payman Danielpour also launched the Forever Young Podcast and Youtube channel where they discuss beauty trends and anti-aging remedies. For more, follow them on Instagram @plastixdocs and TikTok. About Beverly Hills MD Beverly Hills MD was created by co-founders Dr. John Layke and Dr. Payman Danielpour of the innovative Beverly Hills Plastic Surgery Group. Now, with their cutting-edge skincare line, Beverly Hills MD, they're able to reach beyond the walls of their office and offer at-home "look younger" results to those looking for the very best non-surgical, anti-aging solutions available. Each product works to visibly correct the most stubborn skincare concerns. Their bestsellers include Deep Regenerating Stem Cell Moisturizer, Deep Wrinkle Filler, and Beverly Hills MD Rejuv-GH Timeless Beauty Concentrate. For the latest news, follow Beverly Hills MD on Instagram @officialbhmd and YouTube. *All individuals are unique. Your results can and will vary. Media Contact: Shari Mesulam [email protected] SOURCE Beverly Hills MD

01 Dec 2023

·www.sciencedaily.com

How pre- and postnatal B-12 vitamins improve breast milk vitamin B-12 levels, which supports infant brain development

According to a new study B-12 vitamins increase the presence of the micronutrient in mothers' breast milk, which is especially helpful in countries where it can be difficult to eat what is needed for the body to produce B-12 naturally. Babies and children need vitamins, including vitamin B-12, to help their brains and bodies develop and grow. Babies get B-12 from their mothers and can have low levels of B-12 if their mothers had low vitamin levels during pregnancy and breastfeeding. The vitamin B-12 levels of infants strongly depend on maternal levels. Adequacy of vitamin B-12 in breast milk is particularly important for infants during the first six months of life when breastfeeding is highly recommended. Even after the first six months of life, breast milk may continue to be a critical source of vitamin B-12 for infants. Pregnant and lactating women are at exceptionally high risk for vitamin B-12 deficiency due to the increased nutritional demands as they provide the micronutrient for themselves and their babies. Many people receive the necessary B-12 the body needs from animal-source foods. However, in countries with low intake of animal-source diets, mother's and infant's deficiency in vitamin B-12 is a serious public health challenge. In resource-limited settings where maternal undernutrition is pervasive, researchers sought to understand the optimal timing and dosage of B-12 supplements during pregnancy and lactation. A new study led by Mason Assistant Professor in the College of Public Health Dongqing Wang found that pregnant women who took high doses of oral vitamin B-12 supplements prior to delivery experienced short-term benefits on the levels of B-12 in their breast milk. However, women who took high doses of vitamin B-12 supplements during lactation experienced these benefits for a longer period of time. "Understanding the impacts of prenatal and postnatal vitamin B-12 supplements on the level of B-12 in breast milk is crucial to design effective nutritional interventions to protect mothers and infants from vitamin B-12 deficiencies," said Wang, who was the principal investigator. "Our findings underscore the importance of prenatal vitamins for short-term benefits in breast milk and postnatal vitamins for more sustained impacts on B-12 adequacy in breast milk; both prenatal and postnatal supplements support healthy growth and development in the baby." The study also found that the effect of the prenatal vitamin B-12 supplement diminished when used together with the postnatal supplement. Likewise, the effect of the postnatal vitamin B-12 supplement diminished when used together with the prenatal supplement. "It appears that there was a certain plateau in the effect when prenatal and postnatal supplements were used together," said Wang. "The plateau could mean that either prenatal or postnatal vitamins could correct maternal vitamin B-12 deficiency, but the plateau does not preclude the need for combined prenatal and postnatal supplements through pregnancy and breastfeeding to sustain maternal B-12 levels in populations with high levels of dietary inadequacy." The research was primarily funded by an Early Career Award from the Thrasher Research Fund.

Clinical Result

100 Deals associated with Hydroxocobalamin

External Link

KEGG	Wiki	ATC	Drug Bank
D01027	Hydroxocobalamin	V03AB33 B03BA03	DB00200

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Cyanide poisoning	US	BTG International, Inc.	15 Dec 2006
Anemia, Megaloblastic	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	01 Jan 1996
Anemia, Megaloblastic	CN	Anyang Jiuzhou Pharmaceutical Co. Ltd.	01 Jan 1996
Anemia, Pernicious	CN	Anyang Jiuzhou Pharmaceutical Co. Ltd.	01 Jan 1996
Anemia, Pernicious	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	01 Jan 1996
Neuralgia	CN	Anyang Jiuzhou Pharmaceutical Co. Ltd.	01 Jan 1996
Neuralgia	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	01 Jan 1996
Vitamin B 12 Deficiency	CN	Anyang Jiuzhou Pharmaceutical Co. Ltd.	01 Jan 1996
Vitamin B 12 Deficiency	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	01 Jan 1996
Poisoning	US	Actavis	16 Aug 1978

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Methylmalonic Acidemia	Preclinical	US	National Institutes of Health	09 Oct 2024

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04054999 (CTgov)	Phase 4	Vasoplegia \| Liver transplant rejection	19	Hydroxocobalamin (Cyanokit)	iashnnuhcj(xdkjqxcrxy) = omgmhbczpi fvmpvvmjnz (gljffxbrax, ixmzowvtkm - rqrynjmlus) View more	-	24 Jun 2024
				Methylene Blue (Methylene Blue)	iashnnuhcj(xdkjqxcrxy) = uofeodmfrm fvmpvvmjnz (gljffxbrax, altkqrrmva - zmgvjatqix) View more
ATS2023	Not Applicable	-	-	Hydroxycobalamin	(zhpaxotxmo) = wkcnkhwbfn nqcuhpysgd (cgufszajub ) View more	-	21 May 2023
				Vasopressors (norepinephrine, vasopressin, epinephrine)	(zhpaxotxmo) = ewwekoxsld nqcuhpysgd (cgufszajub ) View more
NCT03735316 (CTgov)	Phase 2	Vasoplegia \| Hypotension	8	Cardiopulmonary Bypass+Hydroxocobalamin (B12a)	fqusetlzoz(slgfanbuml) = phybklyozr hxsdnbmygw (nrchnsowvp, ixckmatrgr - fhsovepkzk) View more	-	10 May 2023
				Cardiopulmonary Bypass (Placebo)	fqusetlzoz(slgfanbuml) = wnkbcfbjxt hxsdnbmygw (nrchnsowvp, fihuuaqspq - utrtsyrbya) View more
SSIEM2022	Not Applicable	Transcobalamin II Deficiency vitamin B12 \| folic acid \| homocysteine ... View more	-	Parenteral hydroxocobalamin	jyktquizbn(kkvdayxtnk) = aljndexdrf egagjshdsz (pjtmqoaoqa ) View more	-	30 Aug 2022
ATS2021	Not Applicable	Vasoplegia	-	Hydroxocobalamin	(lfigkblhaj) = lghiqfztsq hhfqrfiifp (qwqubvmarh )	-	03 May 2021
START Program (ASH2007)	Not Applicable	Blast Phase Chronic Granulocytic Leukemia	157	Dasatinib 70 mg BID	mobgylqhpl(ujvjpfwphm) = Cytopenias were noted for the majority of patients, and were manageable; grade 3-4 febrile neutropenia was recorded in 8% of patients vaevhdhoqp (qragwiydaz ) View more	-	16 Nov 2007
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