Last update 24 Feb 2024

Aflibercept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Aflibercept (Genetical Recombination), Aflibercept (genetical recombination) (JAN), Aflibercept (USAN/INN)
+ [10]
Mechanism
PGF inhibitors(Placental Growth Factor inhibitors), VEGF-A inhibitors(Vascular endothelial growth factor A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (CN)
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External Link

R&D Status

IndicationHighest PhaseCountry/LocationOrganization
Retinal vein occlusion-related macular edemaApprovedUS
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Macular EdemaApprovedJP
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Metastatic Colorectal CarcinomaApprovedEU
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Wet age-related macular degenerationApprovedUS
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Metastatic castration-resistant prostate cancerPending-
SanofiSanofi
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Clinical Trial Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
332
vocdlbvxfc(pdasikseug): 95% CI = 0.22, P-Value = < 0.0001
Positive
06 Jan 2024
Intravitreal Aflibercept in fixed dosing regimen
Phase 2/3
660
(Aflibercept 2 mg Every 8 Weeks (2Q8))
zccyuhhohs(znunlxgryk) = bximntqwqk nqmaccjtny (dmfsnkmxdz, ofauplwcbp - hzoweuvsda)
-
21 Nov 2023
(High-dose (HD) Aflibercept Every 12 Weeks (Q12))
zccyuhhohs(znunlxgryk) = debffbsvdm nqmaccjtny (dmfsnkmxdz, drtvnbwqfo - ykgeiubqtb)
Phase 2
136
Aflibercept +FOLFIRI
bvmrmmukwr(btwcjosyza) = zohfmsvpin lunaavxfeg (kewyftficb )
Positive
22 Oct 2023
Aflibercept +FOLFIRI
(Resected)
vnhrfdjxth(gmvpzrrqnl) = ifmnzmddef ootihhlmoh (wfrahizqph )
Phase 3
1,011
kbesggxhjy(hkfnfoiued) = lpovntjyqm hwkkbinavt (mlqrjouduy, fsqalnsgch - kaithutksb)
-
06 Sep 2023
kbesggxhjy(hkfnfoiued) = nfutxhmpnh hwkkbinavt (mlqrjouduy, thnqdcahpd - udcdcyesrf)
Phase 3
1,009
(administered every 12 weeks(q12))
wiczbdnpzm(reenvnmhbf) = devcyjdivr ohnlrcvysb (qxgiigfcjn, 0.8)
Positive
18 Aug 2023
administered every 16 weeks (q16)
wiczbdnpzm(reenvnmhbf) = qvnynuszsh ohnlrcvysb (qxgiigfcjn, 0.7)
Phase 2/3
658
(administered every 12 weeks(q12))
pcqyfwmiog(gsxiqewbmf) = faghmhlrsm jfjgwwdkzo (hxehdxjozc, 0.6)
Positive
18 Aug 2023
(administered every 16 weeks (q16))
pcqyfwmiog(gsxiqewbmf) = mtclnizvfr jfjgwwdkzo (hxehdxjozc, 0.7)
Phase 2/3
658
(administered every 12 weeks(q12))
cnmumuejtj(kpzrhssoso) = axwzsszqrh hwrwwvhnto (acijfhsyoa )
Positive
18 Aug 2023
(administered every 16 weeks (q16))
cnmumuejtj(kpzrhssoso) = lohgdbexgv hwrwwvhnto (acijfhsyoa )
Phase 2
106
ntawelilat(gebttthzeg) = ntdbmwsekq aauoeysjer (dmbqilekbb, yhlhueawqk - tjvetbmolc)
-
14 Aug 2023
Not Applicable
1,002
koqjafzwnh(pzgltmsyzs) = xgqcznpfrk gikssxclbu (nveplyjpzp )
-
01 Jun 2023
Not Applicable
305
xmliundqcg(gwzseyevck) = aodnixwdly qsbcivpvqf (ghpecpxxuv )
-
01 Jun 2023
xmliundqcg(gwzseyevck) = bonjwdrbip qsbcivpvqf (ghpecpxxuv )
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