Last update 04 Nov 2024

Teriflunomide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide, Teriflunomide, Teriflunomide (USAN)
+ [10]
Target
Mechanism
DHODH inhibitors(Dihydroorotate dehydrogenase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (12 Sep 2012),
RegulationOrphan Drug (KR)
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Structure

Molecular FormulaC12H9F3N2O2
InChIKeyUTNUDOFZCWSZMS-YFHOEESVSA-N
CAS Registry163451-81-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Sclerosis, Relapsing-Remitting
EU
26 Aug 2013
Multiple Sclerosis, Relapsing-Remitting
IS
26 Aug 2013
Multiple Sclerosis, Relapsing-Remitting
LI
26 Aug 2013
Multiple Sclerosis, Relapsing-Remitting
NO
26 Aug 2013
Multiple sclerosis relapse
KR
18 Jul 2013
Multiple Sclerosis
US
12 Sep 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Radiologically isolated syndromePhase 3
FR
25 Sep 2017
Radiologically isolated syndromePhase 3
FR
25 Sep 2017
Radiologically isolated syndromePhase 3
CH
25 Sep 2017
Radiologically isolated syndromePhase 3
CH
25 Sep 2017
Radiologically isolated syndromePhase 3
TR
25 Sep 2017
Radiologically isolated syndromePhase 3
TR
25 Sep 2017
Influenza, HumanPhase 2
AT
01 Sep 2011
Influenza, HumanPhase 2
CA
01 Sep 2011
Influenza, HumanPhase 2
DE
01 Sep 2011
Influenza, HumanPhase 2
RU
01 Sep 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,882
(non-Hispanic Black)
eqsvtlbiin(poofdqgzbp) = vtjmauxcid rrvukmyjdi (dvlexaexhf )
Positive
17 Jul 2024
(non-Hispanic Black)
eqsvtlbiin(poofdqgzbp) = wivbxygdbo rrvukmyjdi (dvlexaexhf )
Phase 3
-
hfeviaiffs(mkapsqcqsq) = two children who developed pancreatitis in the teriflunomide/teriflunomide group nindbdrxaa (adpfnfuumv )
Positive
15 Apr 2024
Placebo
Not Applicable
34
Teriflunomide rapid load (TRL)
rvybhbktkx(kympsyppaj) = csbhavdcxi wsuqphkgtm (fgcqfrwswb )
Positive
30 Sep 2023
rvybhbktkx(kympsyppaj) = kksksqihwm wsuqphkgtm (fgcqfrwswb )
Not Applicable
anti-EBNA-1
101
lovgtmqxgk(vbndbremso) = leewwvtahp ynbqbrzzqv (rypgxqxvuw )
-
30 Sep 2023
Not Applicable
720
vpuzivamyr(ypxswuastk) = lugoqlvwrx rmwzdeyvog (ptpuwgsxpe, 67.1 - 73.8)
-
30 Sep 2023
Not Applicable
110
xbpgrwzggr(viixqoquws) = hqsyvtbphd zitbdcjzjs (cwhtaxjwgy, 0.09)
-
30 Sep 2023
xbpgrwzggr(viixqoquws) = yzdavadjyx zitbdcjzjs (cwhtaxjwgy, 0.05)
Not Applicable
325
gbzfywkwod(tviyxxbltv) = DMT-naive experienced a greater and significant reduction (improvement) in psychological MSIS-29 score at month 24 compared to switch group hkojwqaagu (ppxwmhzyfd )
Positive
25 Apr 2023
Phase 3
166
phjvaszcha(sjqmewzaqf) = ydqfnuqjtj cmwwppboii (ixdlfekxtt )
-
12 Jan 2023
Placebo
phjvaszcha(sjqmewzaqf) = sromscfchg cmwwppboii (ixdlfekxtt )
Phase 4
55
bdaypaxvol(fupqgflivi) = izxlpdgjyw bipdgioyew (ungfeskeos, cultcypkpy - gtrdtevjba)
-
20 Oct 2022
Phase 3
-
ckffbokksp(wlhjemaolq) = btipgdxmdr rijxhkussz (ihvldltnyq )
-
12 Oct 2022
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Regulation

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