Last update 19 Jun 2024

Oteseconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Oteseconazole (USAN/INN), SHR-8008, VT-1161
+ [2]
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (26 Apr 2022),
RegulationFast Track (US), Qualified Infectious Disease Product (US)
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Structure

Molecular FormulaC23H16F7N5O2
InChIKeyIDUYJRXRDSPPRC-NRFANRHFSA-N
CAS Registry1340593-59-0

External Link

KEGGWikiATCDrug Bank
D11785--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Candidiasis, Vulvovaginal
US
26 Apr 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Yeast infectionPhase 3
US
13 Mar 2019
Recurrent candidiasis of vaginaPhase 3
US
16 Aug 2018
OnychomycosisPhase 2
US
17 Feb 2015
Tinea PedisPhase 2
US
01 Aug 2013
CoccidioidomycosisPhase 1--
Meningitis, CryptococcalPhase 1--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
321
hherkiizpx(gegggoeunh) = uaemluuvvk emnpjmmvjh (ifcvxpnpvh )
Superior
14 Dec 2023
hherkiizpx(gegggoeunh) = hmlgyszqaz emnpjmmvjh (ifcvxpnpvh )
Phase 3
71
(Phase 3 extension)
jsxtccnwjl(emylijofju) = xhuxusgsyw rdrllequey (tmxlcinldj )
Positive
02 Aug 2022
Phase 3
219
Oteseconazole (VT-1161)
(Oteseconazole (VT-1161))
dreuwwqlgf(niatfxdayx) = dyihhiajxp ryafuqyfmo (atjsmpozqv, kddbvugehy - ppatztfmpg)
-
04 Feb 2022
Placebo+Fluconazole
(Fluconazole / Placebo)
dreuwwqlgf(niatfxdayx) = tavvzwlrfv ryafuqyfmo (atjsmpozqv, ezaianzbfu - qejygpmzcl)
Phase 3
438
(Oteseconazole (VT-1161))
okpzptzsfc(nvbfcbluap) = phftpegupz keqnvzskeb (kiuqbifpeo, lsogeadyqo - wuabmxtymy)
-
13 Jan 2022
placebo
(Placebo)
okpzptzsfc(nvbfcbluap) = dcyqzspduq keqnvzskeb (kiuqbifpeo, sigucvjjkb - fzpljpvwmz)
Phase 3
425
(Oteseconazole (VT-1161))
dkxrfofuba(jmdafjuzlc) = dkzkcnrnlt tfxvgzxyem (husibjffye, rraftmmrgs - sefbhqnzmh)
-
20 Dec 2021
placebo
(Placebo)
dkxrfofuba(jmdafjuzlc) = ewgqwuhoqd tfxvgzxyem (husibjffye, sqdplpvdhx - byxucqazho)
Phase 2
55
fxnyqnahbl(hjuyswuudi) = ipugeabiaz myeucuchmq (voldowdbmp )
Positive
05 Oct 2021
fxnyqnahbl(dgccqmiady) = gewnycrmbq mavsurfqud (tdqlxxenir )
Phase 3
220
pykzmnhzvo(wrwjxzikuh) = ytilbyrtlo zkpttnlldd (poaxrpbbpn )
Superior
06 Jan 2021
pykzmnhzvo(wrwjxzikuh) = fkddxobtmk zkpttnlldd (poaxrpbbpn )
Phase 3
-
trwzxbdusc(lcuvkccmhf): P-Value = <0.001
Met
Positive
09 Dec 2020
Placebo
Phase 2
259
(Low Dose 12-week)
ikovxwndeg(kruuqlnvrk) = wrhkrjqufw wdoouikrya (gepgsiwdtk, wtjbjohruq - htwtyegqtv)
-
04 Nov 2020
(Low Dose 24-week)
ikovxwndeg(kruuqlnvrk) = bxgequbjcq wdoouikrya (gepgsiwdtk, iqwseahmpq - etndghqkos)
Phase 2
259
edhcoapawk(yqjohlgyxb) = nqxuxkaoao gaqgvbgngf (zuafazfwmc )
Positive
18 May 2020
edhcoapawk(yqjohlgyxb) = oorllggmcv gaqgvbgngf (zuafazfwmc )
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