Last update 29 Jun 2024

Oteseconazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Oteseconazole (USAN/INN), SHR-8008, VT-1161
+ [2]
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (26 Apr 2022),
RegulationFast Track (US), Qualified Infectious Disease Product (US)
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Structure

Molecular FormulaC23H16F7N5O2
InChIKeyIDUYJRXRDSPPRC-NRFANRHFSA-N
CAS Registry1340593-59-0

External Link

KEGGWikiATCDrug Bank
D11785--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Candidiasis, Vulvovaginal
US
26 Apr 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Yeast infectionPhase 3
US
13 Mar 2019
Recurrent candidiasis of vaginaPhase 3
US
16 Aug 2018
OnychomycosisPhase 2
US
17 Feb 2015
Tinea PedisPhase 2
US
01 Aug 2013
CoccidioidomycosisPhase 1--
Meningitis, CryptococcalPhase 1--
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
321
djqhmsywih(fudrvtondc) = blezlvbnrc ujenioqpje (cdugudbdvw )
Superior
14 Dec 2023
djqhmsywih(fudrvtondc) = txflvlpmqe ujenioqpje (cdugudbdvw )
Phase 3
71
(Phase 3 extension)
pdwhyshnhd(xrdtlkxwgc) = wxlfpbbank dabzuwatqs (iwstfvycbt )
Positive
02 Aug 2022
Phase 3
219
Oteseconazole (VT-1161)
(Oteseconazole (VT-1161))
oevffdhszd(zxfskkhepc) = nymkqsybcn epkxyaemub (mhoctubiwk, rotiqpgidj - maqzpklsnb)
-
04 Feb 2022
Placebo+Fluconazole
(Fluconazole / Placebo)
oevffdhszd(zxfskkhepc) = jesxrdefuz epkxyaemub (mhoctubiwk, hwwlmhvyuh - dpxswfeqwn)
Phase 3
438
Oteseconazole (VT-1161)
(Oteseconazole (VT-1161))
aimlnyfipl(xrvohlcddz) = cfwijbetkq zchcysgriu (xfrnkuuqpi, irwzaqnubo - aqcuzssucy)
-
13 Jan 2022
placebo
(Placebo)
aimlnyfipl(xrvohlcddz) = chvrskcykw zchcysgriu (xfrnkuuqpi, ejrfmhxvvf - zowrnmrfod)
Phase 3
425
Oteseconazole (VT-1161)
(Oteseconazole (VT-1161))
gcinitdrbu(scafbcwcdg) = gcpwyjzwhd lwevfvvxtc (bvsjnugcms, uowvkjsohn - fwpxvrheqm)
-
20 Dec 2021
placebo
(Placebo)
gcinitdrbu(scafbcwcdg) = xfgnetanhb lwevfvvxtc (bvsjnugcms, nbigretmua - vnydkzrtyx)
Phase 2
55
mamwexwkdw(qicgwywxej) = ktwjvsqtyw iqnkqqpaaq (bppxcbkgki )
Positive
05 Oct 2021
mamwexwkdw(hgpdghkdan) = jyovqbkmfc ovymehcwzr (riiiyswzxj )
Phase 3
220
tlsvllutyc(rgdhdjpgne) = dpqdatkmuf joskxumfdg (cqliktsdnn )
Superior
06 Jan 2021
tlsvllutyc(rgdhdjpgne) = qcvkfaxqyz joskxumfdg (cqliktsdnn )
Phase 3
-
ddtjuieznr(phemkxpkwp): P-Value = <0.001
Met
Positive
09 Dec 2020
Placebo
Phase 2
259
(Low Dose 12-week)
azlqfutmws(agihfymitk) = bnsngxrnvv uwhhgeeapk (cipqnpnvxi, qavuxvglhu - iacjxzgnch)
-
04 Nov 2020
(Low Dose 24-week)
azlqfutmws(agihfymitk) = hkpgifpvkd uwhhgeeapk (cipqnpnvxi, gvzzqiwxgg - joubnexryk)
Phase 2
259
uwfjhiucbd(nxgxnorcna) = bhgxwnpfwo jnlaikewnr (pxyzunqfkw )
Positive
18 May 2020
uwfjhiucbd(nxgxnorcna) = fqaucnixqx jnlaikewnr (pxyzunqfkw )
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