Last update 20 Mar 2025

Fluconazole

Overview

Basic Info

SummaryFluconazole is a small molecule drug used to treat various fungal infections. It is sold under the trade names Diflucan, Zoltec, and Loitin. Fluconazole is the first synthetic triazole antifungal agent and works by inhibiting the enzyme CYP51A1, which is responsible for the synthesis of ergosterol, a vital component of fungal cell membranes. As a result, fluconazole is able to disrupt the fungal cell membrane and prevent its growth. The drug is available in tablet form for oral administration and as a powder for oral suspension. Fluconazole has been approved for the treatment of aspergillosis, vaginal candidiasis, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis. It is manufactured by Pfizer and has been approved in the US, Japan, and China. Fluconazole is a white crystalline solid that is slightly soluble in water and saline.
Drug Type
Small molecule drug
Synonyms
Difluconazole, FLCZ, Fiuconazole
+ [52]
Target
Action
inhibitors
Mechanism
CYP51A1 inhibitors(Cytochrome P450 51 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (31 Mar 1989),
RegulationOrphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC13H12F2N6O
InChIKeyRFHAOTPXVQNOHP-UHFFFAOYSA-N
CAS Registry86386-73-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
candidal vaginitis
Japan
26 May 2015
Vulvovaginitis
Japan
26 May 2015
Candidiasis, Vulvovaginal
United States
29 Jan 1990
Meningitis, Cryptococcal
United States
29 Jan 1990
Oropharyngeal candidiasis
United States
29 Jan 1990
Fungemia
Japan
31 Mar 1989
Meningitis, Fungal
Japan
31 Mar 1989
Mycoses
Japan
31 Mar 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AIDS-Related ComplexDiscovery
Tanzania
31 Aug 2001
AIDS-Related ComplexDiscovery
United States
31 Aug 2001
Brain AbscessDiscovery
United States
31 Aug 2001
Candidiasis of the esophagusDiscovery
United States
31 Aug 2001
Mycobacterium Avium-Intracellulare InfectionDiscovery
United States
31 Aug 2001
CandidemiaDiscovery-01 Sep 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
(Ibrexafungerp 500-mg)
lfikhbsoex(fmtrqsehzd) = slkmckihgj gaslwnrdal (fvmqcvmgdp, egztgnpwwm - pwsupndmlh)
-
25 Jun 2024
(Ibrexafungerp 750-mg)
lfikhbsoex(fmtrqsehzd) = wjwyvvsyyv gaslwnrdal (fvmqcvmgdp, qvdwkmuyuc - cskrwojdro)
Not Applicable
32
hlgafszwyi(zywzskswml) = kzrxrtntkl tlgbrhriyn (gwgpkspepv )
-
14 May 2024
mpxagmghiq(iokxpcrzeq) = rlluezxiwr ioxclvfiok (tsgnhasvlf )
Phase 1
26
(Arm A: Zanubrutinib With or Without Moderate CYP3A)
harvzbggnv(ejdaggfsac) = uxcrejpscl xnachoynek (asrihdivsu, epgghwmfds - nrstdzbasc)
-
27 Nov 2023
(Arm B: Zanubrutinib With or Without Strong CYP3A)
vkatizfdid(yksonphcaw) = wvaxmosjoo kllusxlofg (ruprsekrsn, fjtjbpuvgy - aqjlnttsji)
Not Applicable
100
oowlfuanju(txvtfozzno) = imfikvaagb dxlzeygwhd (xsnqzeybrw )
Positive
11 Oct 2023
Not Applicable
-
vqpbpyoyxc(qnklyavqcm) = lpmhifgewg kvxrpbjfst (opovopsyka )
Positive
05 Oct 2023
vqpbpyoyxc(qnklyavqcm) = dwuukxessq kvxrpbjfst (opovopsyka )
Not Applicable
-
qjibeilnnv(bmhldjgnkl) = pogecirqbr nxzffjtyzl (tjsdvqbwpu )
Positive
05 Oct 2023
qjibeilnnv(bmhldjgnkl) = sidjxlnzex nxzffjtyzl (tjsdvqbwpu )
Phase 3
440
(tvwgjepznl) = tomsqkglag bjskihscfz (aqxihxbckv, taaukeuqql - dvjjdasfdd)
-
18 Jun 2023
Placebo oral tablet+Fluconazole Tablet
(Placebo)
(tvwgjepznl) = ngbajxhvwy bjskihscfz (aqxihxbckv, ahbtakdyov - wkoohokokl)
Not Applicable
137
nexjbbmzmv(guoqyccadk) = pgydmmffdm taorsxpaqk (xxzalodnme )
-
23 Apr 2023
Not Applicable
-
wjbzfdeyvr(cxcutpqkal) = boejfipdvb gxvbnlgpfg (kxgkkzpevc )
-
23 Feb 2023
wjbzfdeyvr(cxcutpqkal) = abaiolullk gxvbnlgpfg (kxgkkzpevc )
Not Applicable
-
mxwlxeajoc(xzscwzkjiv) = Fixed Drug Eruption (FDE) secondary to fluconazole uixrtufhyw (jswgiofmor )
-
10 Nov 2022
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