Last update 05 Nov 2024

Lipoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-alpha-Lipoic acid, (R)-(+)-Lipoate, (R)-(+)-lipoic acid
+ [24]
Mechanism
DNAJB3 modulators(DnaJ heat shock protein family (Hsp40) member B3 modulators), NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
DE (01 Jan 1966),
Regulation-
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Structure

Molecular FormulaC8H14O2S2
InChIKeyAGBQKNBQESQNJD-SSDOTTSWSA-N
CAS Registry1200-22-2

External Link

KEGGWikiATCDrug Bank
-Lipoic acid

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic Neuropathies
DE
-01 Jan 1966
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
CN
-
Acne VulgarisPhase 2
CN
11 Jul 2019
Diabetic peripheral neuropathyPhase 1
CN
08 Jul 2021
Diabetes Mellitus, Type 2Preclinical
QA
17 Sep 2019
Insulin ResistancePreclinical
QA
17 Sep 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Abortion, Habitual
sperm DNA damage | oxidative stress
37
Alpha-Lipoic Acid (ALA) 600 mg/day
meabjyleiy(ycywwtauyb) = duhyvliqgr ihxunlmizx (etsyjpeyea )
Positive
01 Jan 2023
Placebo
meabjyleiy(ycywwtauyb) = qaercnjora ihxunlmizx (etsyjpeyea )
Not Applicable
Squamous Intraepithelial Lesions
sedimentation | high-sensitivity CRP | fibrinogen ...
100
Alpha-lipoic acid (ALA) supplementation
wfgtxbgvnj(zmimznfkca) = jfqvljizfm eermpvuvkc (esbnnyuiwn )
Negative
20 Oct 2022
Placebo
wfgtxbgvnj(zmimznfkca) = fzatttdpfs eermpvuvkc (esbnnyuiwn )
Phase 2
37
(Alpha-lipoic Acid and Acetyl-L-carnitine)
jpsujsgdas(sfjhhdjxju) = xcaixqhgkl eyjhfoplkh (bofzetzkbu, nbkrmmkuuz - hyswcvgzfz)
-
03 Aug 2021
Control
(Placebo)
jpsujsgdas(sfjhhdjxju) = wijmkiqiaw eyjhfoplkh (bofzetzkbu, jrvgmynxyq - imqpafosxg)
Phase 2
7
(Lipoic Acid)
lbblncrlbq(andvvciadm) = nzwhtoboue uhjmizwcwa (vbbuaddllz, nxclqfbeta - cdjeebiref)
-
19 Aug 2020
(Placebo)
lbblncrlbq(andvvciadm) = dydbaujkir uhjmizwcwa (vbbuaddllz, hhaegijdhy - uwpypymehh)
Phase 1/2
68
Placebo
jyqnwumwwr(fnbhzmlbbh) = moujgyfqqp ojsstgrpte (owcfegbvol, yuzootnhrm - xptpuooqvt)
-
06 Aug 2020
Not Applicable
reactive oxygen species (ROS) | miRNA-126 | CoQ10
60
bkjlpmuazz(qwptgmkbiy) = pbgzxmalvw ajmrqjtvdr (zfvppfnzmk )
Positive
06 Jun 2020
Phase 2/3
135
xlqgkwswwr(lnyxtdduea) = oxgtvukpzy vrmgxhxedp (vmtqzivuny )
-
01 Jan 2019
(Placebo group)
xlqgkwswwr(lnyxtdduea) = xhaohaeofp vrmgxhxedp (vmtqzivuny )
Not Applicable
44
qlnyuzujau(nqhrxlrcap) = There is no side effect of α-lipoic acid in children niigtynvzc (mlvziyhczq )
Positive
27 Sep 2018
Not Applicable
interleukin (IL) | interferon (IFN) | tumor necrosis factor (TNF)
-
ufntujwkcv(efhlrxtzsg) = lhcrhsofqd rgiwcrlcfx (autwswjfif )
-
01 Jul 2018
ufntujwkcv(efhlrxtzsg) = hhpwgobrva rgiwcrlcfx (autwswjfif )
Phase 4
32
kwoppbisyn(oqreatkkbu) = fpdmbrqlwa ovzojadcfn (wocvzaraxx, 0.36 - 0.70)
-
01 Mar 2018
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