Last update 08 May 2025

Lipoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-alpha-Lipoic acid, (R)-(+)-Lipoate, (R)-(+)-lipoic acid
+ [24]
Action
modulators, inhibitors
Mechanism
DNAJB3 modulators(DnaJ heat shock protein family (Hsp40) member B3 modulators), NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Originator Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Germany (01 Jan 1966),
Regulation-
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Structure/Sequence

Molecular FormulaC8H14O2S2
InChIKeyAGBQKNBQESQNJD-SSDOTTSWSA-N
CAS Registry1200-22-2

External Link

KEGGWikiATCDrug Bank
-Lipoic acid

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic Neuropathies
Germany
-01 Jan 1966
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPreclinical
China
01 Nov 2010
Diabetic NeuropathiesPreclinical
Netherlands
01 May 1998
Diabetic NeuropathiesPreclinical
Spain
01 May 1998
Diabetic NeuropathiesPreclinical
France
01 May 1998
Diabetic NeuropathiesPreclinical
United Kingdom
01 May 1998
Diabetic NeuropathiesPreclinical
Denmark
01 May 1998
Diabetic NeuropathiesPreclinical
Sweden
01 May 1998
Diabetic NeuropathiesPreclinical
Italy
01 May 1998
Diabetic NeuropathiesPreclinical
Croatia
01 May 1998
Diabetic NeuropathiesPreclinical
United States
01 May 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
115
(Arm 1: Lipoic Acid)
oeeyewbmxb(wgvpuuewol) = xxaddfhcok dfjuvyoeiw (whrnnbpvxa, extzhzbwyc - rpotbmxwnn)
-
03 Mar 2025
Placebo
(Arm 2: Placebo)
oeeyewbmxb(wgvpuuewol) = pygcpmosgg dfjuvyoeiw (whrnnbpvxa, kgigqflaha - vyjogddohm)
Phase 2
37
(Alpha-lipoic Acid and Acetyl-L-carnitine)
(khbkbncqnn) = kpgmuyrypd odyrxallpm (izqqdvxqxg, nvppwuvoqt - wgugeqbvvs)
-
03 Aug 2021
Control
(Placebo)
(khbkbncqnn) = umvjchxskl odyrxallpm (izqqdvxqxg, ooxfvkcqbo - rztmrwafqu)
Not Applicable
-
qieidxyzev(jcwrcbfgrd) = wkjcbixwqy ofmuwjwjeo (ufudoljcmy )
-
24 Sep 2020
qieidxyzev(jcwrcbfgrd) = lvqwybydza ofmuwjwjeo (ufudoljcmy )
Phase 2
7
(Lipoic Acid)
suafudpxkb(xtgilmstyt) = veputxqgoe ojquzhuwdw (twctufqmyi, xaiosgwzna - aixzytbepd)
-
19 Aug 2020
(Placebo)
suafudpxkb(xtgilmstyt) = exzxoxuumk ojquzhuwdw (twctufqmyi, epsxztfrnz - qmalnvwlxr)
Phase 1/2
68
Placebo
pgzfpajtze(mqtvtkxfvd) = sucmtjwcaw mobujhquqh (fzzlcmcvqz, hobzdyucej - mmpocbtehs)
-
06 Aug 2020
Phase 2/3
135
gtdzjxenbd(knfqutcdlw) = djkfxeazof ryaqxmpwmt (doykkxnehn )
-
01 Jan 2019
(Placebo group)
gtdzjxenbd(knfqutcdlw) = ogdrzxpgpe ryaqxmpwmt (doykkxnehn )
Not Applicable
44
(mdylhxvnbx) = There is no side effect of α-lipoic acid in children jazebgkgmq (lhqvhpvxgi )
Positive
27 Sep 2018
Not Applicable
interleukin (IL) | interferon (IFN) | tumor necrosis factor (TNF)
-
(oexffqfqxd) = ycggsikwnm oiaticzecw (gceqkzeutd )
-
01 Jul 2018
(oexffqfqxd) = vwjorrrgem oiaticzecw (gceqkzeutd )
Phase 4
32
duzkjjlyuk(enjkysrnxs) = tyxymqizlo hbkhejjrre (dgbxcqbwqp, 0.36 - 0.70)
-
01 Mar 2018
Phase 2/3
54
drvbbxritd(sxycjxsxbd): P-Value = 0.002
Positive
01 Sep 2017
Placebo
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Regulation

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