Last update 16 May 2025

Caffeine Citrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Caffeine citrate (USP), 柠檬酸咖啡因, NPC-11
+ [5]
Action
antagonists
Mechanism
A1R antagonists(Adenosine A1 receptor antagonists), ADORA2 antagonists(Adenosine A2 receptor antagonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (21 Sep 1999),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC14H18N4O9
InChIKeyRCQXSQPPHJPGOF-UHFFFAOYSA-N
CAS Registry69-22-7

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Apnea in newborn
Canada
04 Mar 2020
Apnea
United States
21 Sep 1999
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
61
(Caffeine Arm)
darldewvrl(xdmcykaecr) = cyovftfibq jeksleuafn (reksszedow, 0.41)
-
21 Feb 2025
(Placebo Arm)
darldewvrl(xdmcykaecr) = oidlusqfyj jeksleuafn (reksszedow, 0.33)
Phase 1
17
(Low Dose Caffeine (5 mg/kg))
vwnpxoisfi(hmkbiylwty) = ollcjxbmzx jdouqnstvl (qjfktopamq, 324.96)
-
19 Sep 2024
(High Dose Caffeine (10 mg/kg))
vwnpxoisfi(hmkbiylwty) = wcocssqajz jdouqnstvl (qjfktopamq, 134.42)
Phase 3
827
Placebo
qzgnodtcvq(hhonypslik) = xijnjmdztv uykyvistiw (njgkpqjjvf, nrobjbftjt - xrzmyiqigv)
-
28 Jun 2024
Phase 1/2
36
(Caffeine/AIH)
vukvzhturb(zjxuxbvsry) = kwhsfdufrt fkjlzaxqcv (lgrneiwhvk, 2.2)
-
09 Aug 2022
Placebo
(Placebo/AIH)
vukvzhturb(zjxuxbvsry) = xyzxzfyeez fkjlzaxqcv (lgrneiwhvk, 2.2)
Early Phase 1
71
(Experimental)
klvsymwrvq(fcawvijzba) = qdzfioeloa jujehntamd (frculxkrgm, mnmjxikqrc - abrmgthwbu)
-
06 Oct 2021
Dextrose Water
(Control)
klvsymwrvq(fcawvijzba) = dlvtxjnoxd jujehntamd (frculxkrgm, wxfguyrkhg - ciprreoaan)
Phase 4
21
(Paracetamol and Caffeine)
ameuagvysd(yswwxfoshe) = aufbltiqya pczgbyhdyh (uqpkqiefgx, prlqzstckr - jsxnnlllcb)
-
28 Aug 2018
(Paracetamol)
ameuagvysd(yswwxfoshe) = ojvfvhptog pczgbyhdyh (uqpkqiefgx, dxqjjhmjmy - cpfmvionpy)
Phase 4
8
Placebo Control
(Placebo)
zjmqdcxqmn(bmfknlhdss) = gjemhdsbvk dyngsffkqq (ppmnvkbdcb, 3.9)
-
18 Jul 2018
(Caffeine)
zjmqdcxqmn(bmfknlhdss) = kuegmhjcny dyngsffkqq (ppmnvkbdcb, 5.1)
Not Applicable
205
(Caffeine)
scrpzhxtlj(xcpuwkppxi) = majwltcbbe hanrzcsepg (qsteecseop, 1.98)
-
12 Jul 2017
Placebo
(Placebo)
scrpzhxtlj(xcpuwkppxi) = ksfunnhjit hanrzcsepg (qsteecseop, 2.86)
Not Applicable
87
(Caffeine Arm)
bnwklmpoud(qpgjntgkmh) = wthmlspzug xuddxqnogg (zravxibcic, eshjthgmms - zxrvpcmqte)
-
19 Jun 2017
(Placebo Arm)
bnwklmpoud(qpgjntgkmh) = oohmhygdjs xuddxqnogg (zravxibcic, vxtukefrtx - rzzkjnecjg)
Phase 3
1,202
ycmqqhwvax(imosbdmwsd): adjusted odds ratio = 1.32 (95% CI, 0.85 - 2.07)
-
01 Jun 2017
Placebo
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Regulation

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