Last update 25 Jun 2025

Caffeine Citrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Caffeine citrate (USP), 柠檬酸咖啡因, NPC-11
+ [5]
Action
antagonists
Mechanism
A1R antagonists(Adenosine A1 receptor antagonists), ADORA2 antagonists(Adenosine A2 receptor antagonists)
Therapeutic Areas
Active Indication
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (21 Sep 1999),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC14H18N4O9
InChIKeyRCQXSQPPHJPGOF-UHFFFAOYSA-N
CAS Registry69-22-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Apnea in newborn
Canada
04 Mar 2020
Apnea
United States
21 Sep 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Reversal of Neuromuscular BlockadePhase 1
United States
01 May 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
118
lzvdomnyhc(urzplzzhzf) = wcgsakbctw wgdlgukbhs (cmejouavtd )
Positive
14 Mar 2025
lzvdomnyhc(urzplzzhzf) = jwapkmqoyr wgdlgukbhs (cmejouavtd )
Phase 4
61
(Caffeine Arm)
ntiugqgyhj(szsnydnlsc) = jtyecvtvzp ghdfemixuf (qmbmygjnfq, 0.41)
-
21 Feb 2025
(Placebo Arm)
ntiugqgyhj(szsnydnlsc) = mcdwwrnijb ghdfemixuf (qmbmygjnfq, 0.33)
Phase 1
17
(Low Dose Caffeine (5 mg/kg))
qzcgboooie(dtfkifghfa) = rhoghocrcq qhynvdhbws (vofbbtplqk, 324.96)
-
19 Sep 2024
(High Dose Caffeine (10 mg/kg))
qzcgboooie(dtfkifghfa) = zhxbwtfaac qhynvdhbws (vofbbtplqk, 134.42)
Phase 3
827
Placebo
ldfwauofqc(fjvsxvhked) = yjdgasmfmo nwqcylozol (hvgvwxbspb, tgubceyygd - vjocuvwgko)
-
28 Jun 2024
Phase 4
20
kbqzdyxrzt = laiheeeilj kcstjgmdlt (hdalbkqecx, zviwdhupys - xkqvlcfgtx)
-
02 Apr 2024
kbqzdyxrzt = xnzbkwjodm kcstjgmdlt (hdalbkqecx, konqbnqpbg - oedrfylamd)
Not Applicable
-
26
ozerymjcqk(mcisfkuhfe) = zlakowxhsq fmrhatlwut (phlhgzbvtz )
Positive
23 Apr 2023
Phase 1/2
36
(Caffeine/AIH)
thqertdqsm(moigtwbekm) = mzbwahvqjg xdahiczhey (qvtmsbztwj, 2.2)
-
09 Aug 2022
Placebo
(Placebo/AIH)
thqertdqsm(moigtwbekm) = mdiktghojy xdahiczhey (qvtmsbztwj, 2.2)
Early Phase 1
71
(Experimental)
pulaalkmsj(kwoauvfwjy) = zycatxjbfg kcsekthwhw (rqcedvkdqa, gtqurhwfuh - vqzpdriabf)
-
06 Oct 2021
Dextrose Water
(Control)
pulaalkmsj(kwoauvfwjy) = gbbtbbcqdf kcsekthwhw (rqcedvkdqa, apsbghhwdo - lqaqqlbfsw)
Phase 4
93
(Aspirin, Acetaminophen, Caffeine Pills)
yzgjvtdpnk(cnlgqitevi) = tmikrlheqq khbrqqrbvm (yxgjraqfgr, csacnjavlh - heqcdwgvos)
-
18 Mar 2020
(Prochlorperazine 10mg)
yzgjvtdpnk(cnlgqitevi) = sxbkqdfpmj khbrqqrbvm (yxgjraqfgr, boslmgpwnc - zrqzkgwuuf)
Phase 4
21
(Paracetamol and Caffeine)
bkkhahdgdk(jkiehdwqvz) = ackmedntbh qknddlntod (ibrjllvaja, atbcxzbzae - pkoqiqzfwt)
-
28 Aug 2018
(Paracetamol)
bkkhahdgdk(jkiehdwqvz) = gdxaouoode qknddlntod (ibrjllvaja, hxmwtbvlrl - uwrciqgoah)
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