Caffeine Citrate

WEDNESDAY, Nov. 12, 2025 -- For adults with persistent atrial fibrillation (AF) or atrial flutter with a history of AF, planned for electrical cardioversion, consumption of one cup of caffeinated coffee per day is associated with less recurrence, according to a study published online Nov. 7 in the Journal of the American Medical Association to coincide with the American Heart Association Scientific Sessions 2025, held from Nov. 7 to 10 in New Orleans. Christopher X. Wong, M.B.B.S., M.P.H., Ph.D., from the University of California San Francisco, and colleagues examined the effect of caffeinated coffee consumption versus abstinence from coffee and caffeine on recurrent AF. Two hundred current or previous coffee-drinking adults with persistent AF or atrial flutter with a history of AF, planned for electrical cardioversion, were enrolled and randomly assigned to regular caffeinated coffee consumption or caffeine abstinence for six months (100 to each group). The researchers found that coffee intake was seven and zero cups per week in the consumption and abstinence groups, respectively, during follow-up. In the primary analysis, AF or atrial flutter recurrence occurred less often in the coffee consumption group versus the coffee abstinence group (47 versus 64 percent; hazard ratio, 0.61). Coffee consumption yielded a comparable benefit with AF recurrence only. No significant difference in adverse events was seen between the groups. "It is reasonable for health care professionals to let their AF patients consider experimenting with naturally caffeinated substances that they may enjoy, such as caffeinated tea and coffee," senior author Gregory M. Marcus, M.D., also from the University of California San Francisco, said in a statement. Several authors disclosed ties to the biopharmaceutical industry. Abstract/Full Text More Information

New research finds that daily coffee drinking may cut AFib risk by nearly 40%, defying decades of medical caution. Scientists discovered that caffeine’s effects on activity, blood pressure, and inflammation could all contribute to a healthier heart rhythm. The DECAF clinical trial’s findings suggest coffee could be not only safe but beneficial for people with A-Fib. New research suggests that drinking coffee may actually help protect against atrial fibrillation (AFib), a common heart rhythm disorder that causes the heart to beat too quickly and irregularly, sometimes leading to stroke or heart failure. For years, doctors have advised people with AFib and other heart issues to stay away from caffeine, fearing it could worsen symptoms. But a new study from UC San Francisco and the University of Adelaide has found the opposite: participants who drank one cup of caffeinated coffee a day had a 39% lower risk of developing AFib. Why Coffee May Help the Heart "Coffee increases physical activity which is known to reduce atrial fibrillation," explained Gregory M. Marcus, MD, MAS, an electrophysiologist at UCSF Health and the senior author of the study, published November 9 in JAMA. Marcus added that "caffeine is also a diuretic, which could potentially reduce blood pressure and in turn lessen AFib risk. Several other ingredients in coffee also have anti-inflammatory properties that could have positive effects." Rates of AFib have been climbing in recent years, largely due to aging populations and increasing obesity. More than 10 million adults in the United States have been diagnosed, and experts estimate that as many as one in three people may experience the condition at some point in their lives. Testing Coffee's Effect on Heart Rhythm To explore whether coffee helps or harms, researchers designed the DECAF study (Does Eliminating Coffee Avoid Fibrillation?), the first randomized clinical trial to test the relationship between caffeinated coffee and AFib. The project was funded by the National Institutes of Health. The trial involved 200 patients who were regular coffee drinkers and had persistent AFib or a related condition known as atrial flutter, along with a history of AFib. All were scheduled to undergo electrical cardioversion, a procedure that uses a controlled electrical shock to restore normal heart rhythm. Participants were randomly assigned to either drink at least one cup of caffeinated coffee or an espresso shot each day, or to completely avoid coffee and other caffeinated beverages for six months. Coffee Drinkers Had Lower Risk At the end of the study, the group that drank coffee experienced a 39% lower risk of recurring AFib episodes. In addition to coffee's potential anti-inflammatory effects, the researchers proposed that those who drank coffee may have naturally replaced less healthy drinks, such as sugary sodas, with coffee instead. "The results were astounding," said first author Christopher X. Wong, PhD, of UCSF, the University of Adelaide, and the Royal Adelaide Hospital. "Doctors have always recommended that patients with problematic AFib minimize their coffee intake, but this trial suggests that coffee is not only safe but likely to be protective." Authors from UCSF include Gabrielle Montenegro; Hannah H. Oo; Isabella J. Pena; Janet J. Tang, PhD; Grace Wall; Thomas A. Dewland, MD; Joshua D. Moss, MD; Edward P. Gerstenfeld, MD; Zian H. Tseng, MD; Henry H. Hsia, MD; Randall J. Lee, MD, PhD; Jeffrey E. Olgin, MD; Vasanth Vedantham, MD; Melvin M. Scheinman, MD; and Catherine Lee, PhD. Marcus is supported by R01 HL158825-01, R01 HL167975-01, R01 DA058069-01, and R01 HL159069-01A1 grants from the National Heart, Lung and Blood Institute, as well as R01 AA022222 from the National Institute on Alcohol Abuse and Alcoholism.