Last update 07 Nov 2024

CDX-1140

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms-
Target
Mechanism
CD40 agonists(Tumor necrosis factor receptor superfamily member 5 agonists)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerPhase 2
US
13 Aug 2021
Bile Duct NeoplasmsPhase 1
US
01 Dec 2017
Breast CancerPhase 1
US
01 Dec 2017
Colorectal CancerPhase 1
US
01 Dec 2017
Diffuse Large B-Cell LymphomaPhase 1
US
01 Dec 2017
Esophageal CarcinomaPhase 1
US
01 Dec 2017
Fallopian Tube CarcinomaPhase 1
US
01 Dec 2017
Follicular LymphomaPhase 1
US
01 Dec 2017
Liver CancerPhase 1
US
01 Dec 2017
Lymphoid LeukemiaPhase 1
US
01 Dec 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
Research blood draw+CDX-1140
(CDX-1140 Monotherapy)
tjttinrszz(jboptbaxmt) = xrkuxmbvyl yikjpetsvo (mbfiakznpd, margnvwlpa - ptapzsayfe)
-
08 Oct 2024
Research blood draw+CDX-1140+CDX-301
(CDX-1140 + CDX-301)
tjttinrszz(jboptbaxmt) = svralzbcwc yikjpetsvo (mbfiakznpd, otayrupnlj - oaectxsyfe)
Phase 1
25
(dose-escalation cohorts)
trliayrzqb(rwmlddvfeu) = The most frequent TRAE at the CDX-1140 1.5 mg/kg dose level (n=21) were arthralgia (62%), fatigue (62%), nausea (48%), diarrhea (48%), vomiting (43%), myalgia (43%), fever (38%), chills (38%), AST increase (38%), bilirubin increase (24%), ALT increase (19%), and cytokine release syndrome (CRS) (19%). ttoqeuixox (rtctnaqwna )
Positive
01 Nov 2022
(Expansion cohorts)
Phase 1
18
qmudqgfhmg(siwjyzzrqt) = None aqyimrwowj (gxghcyezkq )
Positive
01 Jul 2019
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Regulation

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