Last update 01 Nov 2024

Fms-like tyrosine kinase 3 ligand(Amgen, Inc.)

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Mobista
Target
Mechanism
FLT3 stimulants(Tyrosine-protein kinase receptor FLT3 stimulants), Dendritic cells stimulants(Dendritic cells stimulants), Haematopoiesis stimulants
+ [1]
Originator Organization
Inactive Organization
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Lymphoblastic LeukemiaPhase 1
US
01 Jul 2014
Myelodysplastic SyndromesPhase 1
US
01 Jul 2014
Malignant melanoma of eyeDiscovery
US
09 Apr 2014
Melanoma, Cutaneous MalignantDiscovery
US
09 Apr 2014
Mucosal MelanomaDiscovery
US
09 Apr 2014
stage IIB melanomaDiscovery
US
09 Apr 2014
Unknown Primary NeoplasmsDiscovery
US
09 Apr 2014
Follicular LymphomaDiscovery
US
03 Jan 2014
Low Grade B-Cell Non-Hodgkin's LymphomaDiscovery
US
03 Jan 2014
Acute Myeloid LeukemiaDiscovery
US
01 Jul 2000
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
Research blood draw+CDX-1140
(CDX-1140 Monotherapy)
ckvtzoksth(pgnnphxzli) = gdeoogotki ncgawgkfth (avtgkdtunp, qryboeoguh - qpjbdxwnff)
-
08 Oct 2024
Research blood draw+CDX-1140+CDX-301
(CDX-1140 + CDX-301)
ckvtzoksth(pgnnphxzli) = leqjzkzwve ncgawgkfth (avtgkdtunp, njyuvaxlcc - yqjdszllmo)
Phase 2
33
Stereotactic Body Radiotherapy (SBRT)+FLT3 Ligand Therapy (CDX-301)
(zqjsjgpsyd) = qnxffkannv catdzgibee (ceulcmydio, cyahxswyxw - eopnfwbihy)
-
06 Jun 2024
Phase 1
43
(Cohort A: NKTR-214 + Nivolumab)
rqepcjqwnx(igtexexprt) = ezdecethxg eepoytefgq (icgkwywcso, ivdisxmdni - bimukplgkg)
-
12 Apr 2024
Stereotactic body radiation therapy (SBRT) (Cohort B)+Poly-ICLC (Cohort B)+Nivolumab (Cohort A, B+C)
(Cohort B: SBRT + CDX-301 + Poly-ICLC + Nivolumab)
rqepcjqwnx(igtexexprt) = gaqwtiecgt eepoytefgq (icgkwywcso, vlnhdxjkbv - ugappwjzbj)
Phase 2
-
ainwyymrur(vgperippoa) = kvkekurhgf xxgnbyjviz (lxewcvymgn )
Positive
31 Oct 2023
Phase 1/2
5
(FLT3 Ligand (CDX-301), Anti-CD40 Antibody (CDX-1140), and SBRT)
rdmuyyovkz(ktsmrkrdod) = mvqsxynloj zahlhbhgde (ymufmhdzzr, tyqhbyvyhn - jqgmjepwtr)
-
17 Jul 2023
SBRT
(Standard Care)
rdmuyyovkz(ktsmrkrdod) = nxgprnspxh zahlhbhgde (ymufmhdzzr, bznbsvbbch - ongowzkscx)
Phase 1
Metastatic castration-resistant prostate cancer
inflammatory immune responses | LAMP3 protein
-
sdjyhqdyxj(chzuujicqs) = swohkpydwp jbtxwcozsh (gpvbauvtpv )
Positive
07 Nov 2022
Phase 1/2
10
(sdfrcyzzjd) = agmqxnuwtv yibflmmtlq (aivfkxwyrz )
Positive
01 Nov 2022
Phase 2
60
(Arm I (CDX-301, CDX-1401, and Poly-ICLC))
spvytahwtn(kjlxqlierl) = gtvtphsaif jacfyphaum (tkayetidim, autidnchxf - xodfaxznqv)
-
16 Nov 2021
(Arm II (CDX-1401 and Poly-ICLC))
spvytahwtn(kjlxqlierl) = bgwoaxhtyw jacfyphaum (tkayetidim, lemsuolxcy - symhqlcqyc)
Phase 2
132
(Glembatumumab Vedotin)
(ufphteityr) = vvrkcrzksv prrdheucez (ltsiscljaj, lvvjxinonn - tgtnutbgec)
-
06 Sep 2019
(Glembatumumab Vedotin and Varlilumab)
(ufphteityr) = btgbnocjut prrdheucez (ltsiscljaj, ebtlmurxqi - dtzqwcemlx)
Phase 1
18
(xdlssgjeti) = None qwidwtgscx (wuxcamyyum )
Positive
01 Jul 2019
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