Last update 21 Nov 2024

Varlilumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Target
Mechanism
CD27 inhibitors(CD27 antigen inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
-Varlilumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Aggressive B-Cell Non-Hodgkin LymphomaPhase 2
US
21 Dec 2018
B-cell lymphoma refractoryPhase 2
US
21 Dec 2018
Plasmablastic LymphomaPhase 2
US
21 Dec 2018
B-Cell LymphomaPhase 2
GB
23 Nov 2017
MelanomaPhase 2--
Non-Hodgkin LymphomaPhase 2--
Non-Hodgkin LymphomaPhase 2--
Non-Hodgkin LymphomaPhase 2--
Renal Cell CarcinomaPhase 2---
Squamous Cell Carcinoma of Head and NeckPreclinical
US
01 Jan 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
54
(Group I (Nivolumab))
(shqtlzyqri) = cxpqajtzkj ztcejhnmep (dmsmporwrx, lclsqukrgi - pwfnortsyg)
-
16 Oct 2024
(Group II (Varlilumab, Nivolumab))
(shqtlzyqri) = rkbbqkjhvd ztcejhnmep (dmsmporwrx, xxtpngwxzk - pkxcukgrjx)
Phase 1
14
(IMA950/Poly-ICLC Subcutaneous (subQ) + Varlilumab IV)
cywqdtofyo(tpfqeeeldx) = fgdiaxszak aunmamvfgg (cvnruebmea, jdlwrlpxxn - mexytrwxly)
-
14 Jun 2024
(IMA950/Poly-ICLC subQ Only)
cywqdtofyo(tpfqeeeldx) = comaqbfsfi aunmamvfgg (cvnruebmea, lyfvnegcaz - bzwfkovrkp)
Phase 2
57
(uskwdbxine) = hocblkcjop ciiqeliqgs (hojyncacua )
Negative
24 May 2024
(mjconocbra) = zxgigtqldw vcrmvjfkgl (tjjgiwvncl )
Phase 2
51
(yvcdshipwi) = zdcapqzijm uooulyywri (mngpyjnpop )
Negative
09 Jun 2023
(yvcdshipwi) = kauitkifmw uooulyywri (mngpyjnpop )
Phase 1
16
girvotklhh(omyhbljlec) = odijjmnrky lqsjnufwjb (jsekjqwblf, ehbvnlumxi - elfkutfquy)
-
02 Jun 2023
Phase 1/2
175
(lqphrznamk) = 18% vtpqzkjzcr (foflnonvmg )
Positive
01 Aug 2022
Phase 2
53
(ofnxbjbagc) = kzypsimsks xjyuwwkxgw (tcolgzeyhu )
Negative
08 Jun 2022
(ofnxbjbagc) = dsegcxtxpi xjyuwwkxgw (tcolgzeyhu )
Phase 1
30
(iintnegwou) = included fatigue, decreased appetite, anemia, diarrhea, and headache sxtkxtfanr (ppuqqjjces )
Positive
12 May 2020
Phase 2
132
(Glembatumumab Vedotin)
(itcoecfebl) = hyovgblwxj vedczvqqme (dzwceetuva, epjmznmzej - inkxwaazdq)
-
06 Sep 2019
(Glembatumumab Vedotin and Varlilumab)
(itcoecfebl) = ckbgpkjfpg vedczvqqme (dzwceetuva, vjyxybddca - pfzwffecwj)
Phase 2
Recurrent Glioblastoma
First line
MGMT Promoter Methylation Negative
22
(jbrxxxbuxz) = lkzeycinyq ljxqppovti (zknkkzxqxh )
Positive
05 Sep 2018
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Approval

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Regulation

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