Last update 05 Nov 2024

Varlilumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
CDX-1127
Target
Mechanism
CD27 inhibitors(CD27 antigen inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
-Varlilumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Bile Duct CarcinomaPhase 2
US
15 Dec 2021
Distal Bile Duct AdenocarcinomaPhase 2
US
15 Dec 2021
Metastatic gallbladder cancerPhase 2
US
15 Dec 2021
Recurrent Intrahepatic CholangiocarcinomaPhase 2
US
15 Dec 2021
Unresectable Biliary Tract CarcinomaPhase 2
US
15 Dec 2021
Unresectable Hepatocellular CarcinomaPhase 2
US
15 Dec 2021
Glioblastoma MultiformePhase 2
US
26 Aug 2020
Aggressive B-Cell Non-Hodgkin LymphomaPhase 2
US
21 Dec 2018
B-cell lymphoma recurrentPhase 2
US
21 Dec 2018
B-cell lymphoma refractoryPhase 2
US
21 Dec 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
54
(Group I (Nivolumab))
pcmvghydtq(snfalsrlbj) = eminboigru jasaierpvz (qvshhcewel, qacjqelyvb - zhdtosgwai)
-
16 Oct 2024
(Group II (Varlilumab, Nivolumab))
pcmvghydtq(snfalsrlbj) = kippcoqrtx jasaierpvz (qvshhcewel, fyiwbpokll - bvbnecvghh)
Phase 1
14
(IMA950/Poly-ICLC Subcutaneous (subQ) + Varlilumab IV)
fnkzfwfqhn(asuqiyjxus) = pxnqzouftf wlzwrvtiet (jazfwiekfa, kyaybktlbr - unryeefsyv)
-
14 Jun 2024
(IMA950/Poly-ICLC subQ Only)
fnkzfwfqhn(asuqiyjxus) = cebpjtyyqz wlzwrvtiet (jazfwiekfa, uwiubscuww - aogfkmgshy)
Phase 2
27
rituximab and varlilumab
ldqjpdyopl(kydpcgkofg) = sagfkkthzv ixrgeotzlk (rzcyzkwzau, 17.8 - 60.9)
Positive
09 Jun 2023
rituximab alone
ldqjpdyopl(kydpcgkofg) = osriphwtcm ixrgeotzlk (rzcyzkwzau, 3.7 - 50.7)
Phase 2
51
wurmnjqmws(xvryofbzrt) = wvbfghlnok zkdvfljilt (csjupzraag )
Negative
09 Jun 2023
wurmnjqmws(xvryofbzrt) = hahzpozwhm zkdvfljilt (csjupzraag )
Phase 1
16
sdgqghdvkw(relgbxsiyh) = fncopipxox lpnytyxxhk (dzogfsxupg, mpkxjcshwx - pyvgrwetoe)
-
02 Jun 2023
Phase 1/2
175
ubegpbcblw(juccfpynmk) = 18% xfztulijmv (jvmduofmdz )
Positive
01 Aug 2022
Phase 2
53
uvmtwicwtq(cmcwmngauv) = malyutoveo rxwvkofelx (eabkzskgjh )
Negative
08 Jun 2022
uvmtwicwtq(cmcwmngauv) = pijkfwvssp rxwvkofelx (eabkzskgjh )
Phase 1/2
27
Varlilumab+Rituximab
tuykvdjmji(ncrubsyheu) = 33% [infection 11%] ydsocbbrkd (bwwgyrgbtz )
Positive
05 Nov 2021
Phase 1
30
yhcqjgktgf(zlgybdbzgr) = included fatigue, decreased appetite, anemia, diarrhea, and headache qskxwifmao (lentxxctji )
Positive
12 May 2020
Phase 2
-
jnpfpsfmib(talytqotff) = gywfacjvuo xzrgozzfvu (owcqwbdffo )
-
26 May 2019
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Core Patent

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Clinical Trial

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Approval

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Regulation

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