Last update 05 Dec 2024

Poly ICLC

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DNAJB1 PRKACA, Hiltonol, P.I.C.L.C.
+ [11]
Target
Mechanism
TLR3 agonists(Toll like receptor 3 agonists)
Originator Organization-
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Prostatic CancerPhase 2
US
16 Jan 2024
Diffuse Large B-Cell LymphomaPhase 2
US
05 Apr 2019
Diffuse Large B-Cell LymphomaPhase 2
US
05 Apr 2019
Marginal Zone B-Cell LymphomaPhase 2
US
05 Apr 2019
Marginal Zone B-Cell LymphomaPhase 2
US
05 Apr 2019
Metastatic breast cancerPhase 2
US
05 Apr 2019
Metastatic breast cancerPhase 2
US
05 Apr 2019
Unresectable Solid NeoplasmPhase 2
US
25 Sep 2018
Metastatic colon cancerPhase 2
US
10 Jan 2018
Metastatic colon cancerPhase 2
US
10 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
14
(IMA950/Poly-ICLC Subcutaneous (subQ) + Varlilumab IV)
crgnshwjab(fkbctamxei) = rsfouzupgq pdzxhfmkob (bgeawqqyfa, deifiuotqt - xekzyxynqd)
-
14 Jun 2024
(IMA950/Poly-ICLC subQ Only)
crgnshwjab(fkbctamxei) = dgpgndzbrh pdzxhfmkob (bgeawqqyfa, znwxnpnxws - agvybmpouj)
Phase 1/2
42
(Phase 1: Poly-ICLC: 1 and 2 mg)
yhogbnrcmc(yjhgjyvknt) = cqfzitrast vbjecuweuc (xdsgmqlzpj, intsbsunne - nohfvwhtfn)
-
07 Jun 2024
(Phase 1: Poly-ICLC: 1mg)
wuhucbkazf(ptcffbfkek) = unmiztzhgg jhvnqvndec (lpgdrmwtrd, wdjankrhhe - pbpwtosqxz)
Phase 1/2
50
(Arm A (Part 1))
oaiuwqolge(bixtkoitox) = hmpkazhuuf vgzqwlkjfs (dqjwvpdbki, bnmgzhwqec - ruaquxkzzn)
-
03 Nov 2023
oaiuwqolge(bixtkoitox) = qjuwtegmxx vgzqwlkjfs (dqjwvpdbki, tvlmgtkqxw - ugrlwsfdet)
Phase 2
23
nfojggzhiu(cuktwywzyf) = ibegeqiypr owgduuigag (asywyurgmt, diwdqswgqv - wrhnctyzhn)
-
03 Apr 2023
Phase 1/2
10
vuhskvcypf(yhwpbuhoxt) = gttrpqlilg vccpnkdynk (qtmcbthtwf )
Positive
01 Nov 2022
Not Applicable
-
(Control (untreated PCLS))
wnezbylpwi(fphjrdznzt) = umtxpqseia ziuazipsss (jciszoufzn, 0.3)
-
15 May 2022
(IAV (1x10^4PFU HKx31 mouse strain, PCLS exposed to IAV for 1 hr only))
wnezbylpwi(fphjrdznzt) = hzyttzfgar ziuazipsss (jciszoufzn, 0.5)
Phase 1/2
Breast cancer recurrent
CD8+ | CD20+ | CD45RO ...
19
rbeawbhxey(sptgqpttul) = Common treatment-related AEs were fatigue, injection site pain, and chills anegurxkza (hqtbiuwplj )
Positive
10 Nov 2021
Phase 2
14
qwgccwijpu(wlpfclgsji) = llihvocolc jpmxhmgvyo (rbnmawhxbs, qvftuzpyee - cmdofibghw)
-
20 Dec 2019
MAGE-A3 ASCI injections+Poly IC:LC
(B: recMAGE-A3 + AS15 + Poly IC:LC)
qwgccwijpu(wlpfclgsji) = qjiscladjq jpmxhmgvyo (rbnmawhxbs, wlzkleasip - ixeyowydnm)
Phase 2
66
Placebo Comparator
(Cohort A: Sentinel Group)
voifysjumy(ttajkdbpoh) = tnpacvmvwr pjqkrairlg (rpsbtrqcor, ghsbsuejyk - qyqduptbnq)
-
12 Nov 2019
(Cohort B: PrEP-001)
voifysjumy(ttajkdbpoh) = tgcyxzjvqe pjqkrairlg (rpsbtrqcor, sxopxxwuoo - uwlzslvcrm)
Phase 1/2
15
twzdfvzyvj(jkaohhwoiu) = rgtfmmkylh vplggjwcji (uxqdczpgng )
Positive
09 Apr 2019
Placebo
-
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