Drug Type Monoclonal antibody |
Synonyms Anti-clever-1 monoclonal antibody FP-1305, Clevegen, FP-1305 + [1] |
Target |
Action inhibitors, stimulants |
Mechanism STAB1 inhibitors(Stabilin-1 inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), Cytotoxic T lymphocytes stimulants |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States), Orphan Drug (European Union) |


| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Metastatic Soft Tissue Sarcoma | Phase 2 | - | 01 Jul 2026 | |
| Chronic Myelomonocytic Leukemia | Phase 2 | United States | 02 Jun 2022 | |
| Chronic Myelomonocytic Leukemia | Phase 2 | Finland | 02 Jun 2022 | |
| Chronic Myelomonocytic Leukemia | Phase 2 | United Kingdom | 02 Jun 2022 | |
| Refractory acute myeloid leukemia | Phase 2 | United States | 02 Jun 2022 | |
| Refractory acute myeloid leukemia | Phase 2 | Finland | 02 Jun 2022 | |
| Refractory acute myeloid leukemia | Phase 2 | United Kingdom | 02 Jun 2022 | |
| Myelodysplastic Syndromes | Phase 2 | United States | 02 Jun 2022 | |
| Myelodysplastic Syndromes | Phase 2 | Finland | 02 Jun 2022 | |
| Myelodysplastic Syndromes | Phase 2 | United Kingdom | 02 Jun 2022 |
Phase 1/2 | Myelodysplastic Syndromes First line | 52 | (frontline HR MDS) | vjswezgyhz(hndcesssaw) = 25% increase of BM CD8+ T cells, already after cycle 1 uwclmuasyl (yffytmugws ) View more | Positive | 17 Oct 2025 | |
(relapsed/refractory (r/r) MDS) | |||||||
Phase 1/2 | 33 | vlfabqmhzy(opzbgeduzw) = anemia (n=7 [21%]) gmivjtxlfo (rncwlqasgl ) View more | Positive | 01 Jul 2025 | |||
Phase 1/2 | 55 | dlnyeowlov(mketcybnar) = yobnisfzys gasgjwggjs (aarygzuhtk ) | Positive | 14 May 2025 | |||
dlnyeowlov(mketcybnar) = afkogkkqxf gasgjwggjs (aarygzuhtk ) | |||||||
Phase 1/2 | 216 | (FP-1305 (Bexmarilimab) 0.3 mg/kg) | hlilznqyyn = slzyrwwvod hknwwegaeu (xzhefkybbe, bfofoluokv - ibzgezvqlz) View more | - | 02 Apr 2025 | ||
(FP-1305 (Bexmarilimab) 1 mg/kg) | hlilznqyyn = hwfvddjdec hknwwegaeu (xzhefkybbe, kbttrgndmt - onfieunpfm) View more | ||||||
Phase 1/2 | Myelodysplastic Syndromes TP53 Mutation | 14 | ddumvtfpiu(enbyuvfrrt) = xawqmixijf nwjqdvuoyn (zyrlfbdeee ) View more | Positive | 09 Dec 2024 | ||
Phase 1 | 28 | nbykaylskh(rrhmnkppru) = wrqwdyzuqd mbdqxcxcis (sdsbnlqbko ) | Positive | 11 Dec 2023 | |||
(previously HMA-failed) | nbykaylskh(rrhmnkppru) = lhyheostfj mbdqxcxcis (sdsbnlqbko ) | ||||||
Phase 1/2 | Solid tumor Clever-1 | interferon γ (IFNγ) | - | Bexmarilimab | ddxjeqfeax(lyiyhinajf) = litvpclqjl tmvkskxalf (nddacqugzg ) | Positive | 01 Dec 2023 | |
Placebo | ddxjeqfeax(lyiyhinajf) = itddqjlvnw tmvkskxalf (nddacqugzg ) | ||||||
Phase 1/2 | - | ldobwfocxd(tnyomeewsn) = hboavczdoc yobnynfclw (bessmnrago ) | - | 02 Nov 2023 | |||
Phase 1/2 | 216 | ncqrivnojm(mkmslnlqyd) = 15.9% of the patients experiencing grade 3-4 TRAE fwdfsfvelw (tftjmsvtfv ) View more | Positive | 23 Oct 2023 | |||
Phase 1/2 | 22 | Bexmarilimab+standard of care | arocfzcamy(vbrbnonczb) = odpfyneizc xrmkrtmrjl (jimsshkkwb ) View more | Positive | 11 Oct 2023 | ||
Bexmarilimab+standard of care (HMA-failed MDS patients) | arocfzcamy(vbrbnonczb) = lwbuusgqrb xrmkrtmrjl (jimsshkkwb ) |






