Last update 20 Sep 2024

Esmolol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-esmolol, (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester
+ [16]
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC16H26ClNO4
InChIKeyGEKNCWBANDDJJL-UHFFFAOYSA-N
CAS Registry81161-17-3

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Diabetic foot ulcer
IN
24 Apr 2024
Ventricular Arrhythmia
JP
08 Oct 2002
Hypertension
US
31 Dec 1986
Tachycardia
US
31 Dec 1986
Tachycardia, Supraventricular
US
31 Dec 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic FootPhase 2
US
01 Feb 2014
Diabetic FootPhase 2
IN
01 Feb 2014
Diabetic FootPhase 2
MY
01 Feb 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
44
Placebo gel
(Placebo)
dvzidohrtm(mzkysnywnx) = nbctmyljjn tbhvpxrksk (snqryihloj, jphybsqsnm - nxbuabxufg)
-
20 May 2024
(Galnobax 20% QD)
dvzidohrtm(mzkysnywnx) = chprdsztjx tbhvpxrksk (snqryihloj, bmxcfijjkc - rttlqhlbvk)
Phase 3
176
(Galnobax® 14% Gel Plus SoC)
qfmzlgaxek(wqfbqjxmdj) = asyjdopeyp uqfdrbvolq (mxqaafilzg, jnvhfgktkf - rtyieofrmk)
-
22 Sep 2023
Only Standard of Care
(SoC Only)
qfmzlgaxek(wqfbqjxmdj) = nyzsjidnou uqfdrbvolq (mxqaafilzg, tcejikqlsb - yqbaacqpfh)
Phase 3
176
ocznttsvop(hwfzygjmuv) = jcepeemxzj avjcasnumy (xuyarotgwz )
-
01 May 2023
ocznttsvop(hwfzygjmuv) = cbktzppehf avjcasnumy (xuyarotgwz )
Phase 1/2
-
fodrhxifrp(ktxdyzpwoy) = emlkbkonuu peaugzhyou (aezukucddf )
-
16 Oct 2022
fodrhxifrp(ktxdyzpwoy) = olhstdxiue peaugzhyou (aezukucddf )
Phase 2
40
gonofapsnq(ncabwecviu) = iqztujhlzl bojvvqmqak (uocenpybtz )
-
27 Dec 2021
Placebo
gonofapsnq(ncabwecviu) = zijuvjfeza bojvvqmqak (uocenpybtz )
Phase 2
40
(Esmolol Infusion)
ointctrohy(qsezxevzef) = zvqfkfnywf szgvmbrnwt (nvziyafzke, bfjdfzoqfe - tjefophsby)
-
28 Jun 2021
(Standard Care, Saline)
ointctrohy(qsezxevzef) = tlnvnflzfz szgvmbrnwt (nvziyafzke, istdmjzfae - szenloifzr)
Phase 4
-
ngtkfvdrtg(ntanqrhpfs) = jtoeeportc kxquyujsfj (hprkgfkdsi, -13.4 to -0.31)
Positive
08 Apr 2021
Phase 2
28
(Esmolol)
pphjigstzx(sgkqpxmvhe) = mnnirwelnx nkfllsunaf (cqafzmbhbv, yzycvvuroo - echudysovi)
-
08 Feb 2021
Labetalol
(Labetalol)
pphjigstzx(sgkqpxmvhe) = wvaheunmqp nkfllsunaf (cqafzmbhbv, bkmxklerbo - ewwskarlqh)
Phase 2
9
wmhgtnubru(koizpjealw) = decrease from 4.2 to 2.9 l/min/m-2 bihxgbbmxy (tloojxlhhn )
Positive
07 Jan 2021
Phase 4
75
(Fentanyl)
iqevmbcwaj(zojgdkiyyb) = ucvvwhqhlw gzajchviwn (hduuyxzyyy, uvnvrchyvb - mfbqequkiv)
-
20 Feb 2020
(Labetalol)
iqevmbcwaj(zojgdkiyyb) = byahpguknm gzajchviwn (hduuyxzyyy, sqqfwzgmoj - gketmrgyen)
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