Last update 21 Nov 2024

Esmolol Hydrochloride

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(±)-esmolol, (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester

+ [16]

Target

β1-adrenergic receptor

Mechanism

β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)

Therapeutic Areas

Nervous System DiseasesCardiovascular DiseasesEndocrinology and Metabolic Disease+ [1]

Active Indication

Diabetic foot ulcerTachycardiaVentricular Arrhythmia+ [2]

Inactive Indication-

Originator Organization

Baxter International, Inc.

Active Organization

Baxter Healthcare Corp.

Maruishi Pharmaceutical Co., Ltd.HQ Specialty Pharma Corp.

+ [1]

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

US (31 Dec 1986),

HypertensionTachycardia, Supraventricular

Regulation-

Structure

Molecular FormulaC16H26ClNO4

InChIKeyGEKNCWBANDDJJL-UHFFFAOYSA-N

CAS Registry81161-17-3

View All Structures (2)

177

Clinical Trials associated with Esmolol Hydrochloride

CTRI/2024/11/076120 / Not yet recruitingNot ApplicableIIT

Comparitive study of esmolol and labetalol in attenuation of pressor response to laryngoscopy and endotracheal intubation in patients posted under general anaesthesia:a randomised double blind study. - NIL

Start Date10 Nov 2024

Sponsor / Collaborator-

NCT06635707 / Not yet recruitingNot ApplicableIIT

The Study on the Efficacy and Safety of Using Urapidil Alone or in Combination With Esmolol for the Treatment of Acute Hypertensive Intracerebral Hemorrhage: A Prospective, Open-label, Observational, Multicenter Research

The objective of this study is to investigate the efficacy and safety of urapidil monotherapy versus the combination of esmolol in treating participants with acute hypertensive intracerebral hemorrhage through a prospective, open-label, observational, multicenter clinical trial, aiming to provide guidance for clinicians in formulating rational treatment plans.

Start Date01 Nov 2024

Sponsor / Collaborator

Qianfoshan Hospital of Shandong Province

NCT06620991 / Not yet recruitingNot ApplicableIIT

Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery

The aim of this study is to evaluate the efficacy of intra-operative phentolamine vs intraoperative esmolol for hypotensive anesthesia in functional endoscopic sinus surgery.

Start Date10 Oct 2024

Sponsor / Collaborator

Ain Shams University

100 Clinical Results associated with Esmolol Hydrochloride

100 Translational Medicine associated with Esmolol Hydrochloride

100 Patents (Medical) associated with Esmolol Hydrochloride

1,617

Literatures (Medical) associated with Esmolol Hydrochloride

15 Oct 2024·Analytical Chemistry

Ultrasensitive SERS Detection of Five β-Blockers Achieved Using Chemometrics with a Two-Dimensional Substrate Formed by Large-Sized Ag@SiO₂ Nanoparticles

Article

Author: Wu, Yiping ; Wang, Tianrun ; Guo, Xiaoyu ; Jiang, Yuning ; Cheng, Tao ; Yang, Haifeng ; Xie, Ziyue ; Liu, Xinling ; Wen, Ying

We report on a surface-enhanced Raman scattering (SERS) platform for the detection of five beta-blockers (β-blockers): atenolol, esmolol, labetalol, sotalol, and propranolol. Key to this platform was a two-dimensional substrate formed by self-assembling large Ag@SiO₂ nanoparticles (Ag@SiO₂ NPs) on a silicon wafer. The close arrangement of these large nanoparticles on the surface generated a strong and uniform electromagnetic field, which enhanced SERS signal intensity for the detection of small amounts of the target molecules. The intensities of characteristic peaks of the five β-blocker drugs increased linearly with the increase of their concentrations in the range of 10^-5 to 10^-8 mol/L. The detection limits were 10^-10 mol/L for propranolol, 10^-9 mol/L for atenolol, labetalol, and sotalol, and 10^-8 mol/L for esmolol. Determination of these five β-blocker drugs added to human urine samples, using a portable Raman spectroscopy instrument, showed quantitative recovery (93-101%). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) of SERS spectral data improved the differentiation among these five β-blockers. This study highlights the potential of the developed SERS platform for rapid, on-site detection of illicit drugs and for antidoping screening.

01 Sep 2024·Cardiology in Review

Landiolol: An Ultra-Short-Acting β-Blocker.

Review

Author: Danilov, Alexandrina ; Frishman, William H. ; Kanwal, Amreen ; Kanwal, Arjun ; Rao, Shiavax J.

Landiolol is an ultra-short-acting, highly cardio-selective, β-blocker, that is currently approved for clinical use in Japan and the European Union, for the treatment of tachyarrhythmias. Landiolol is highly cardio-selective with high β1 selectivity and receptor affinity, resulting in a more potent chronotropic effect and less potent hypotensive effect compared with other β-blockers such as esmolol and propranolol. Based on the recent randomized controlled trials, low-dose landiolol may have a beneficial role in the prevention and management of postoperative atrial fibrillation following noncardiac and cardiac surgeries, including on-pump and off-pump coronary artery bypass grafting and valve surgery. Additionally, landiolol may have potential utility for myocardial salvage and prevention of postpercutaneous coronary intervention myocardial infarction. Furthermore, the use of landiolol may also have a therapeutic effect for rate control of sepsis-related tachyarrhythmias. Positive results of recent randomized controlled trials should continue to inspire clinicians to conduct further, larger studies, to find new potential clinical applications for this novel drug.

12 Aug 2024·Cureus

Management Strategies for Hypertensive Crisis: A Systematic Review

Review

Author: Jurays, Najwa S ; Alqahtani, Mohammed A ; Althabet, Abdullah A ; Alghamdi, Sara F ; Khan, Naveed N ; Abdalla, Esra M ; Alghamdi, Afyaa M ; Althabet, Abdullah A ; Alassiri, Abdullah M ; Alassiri, Abdullah M ; Zurayyir, Elaf J ; Abdalla, Esra M ; Alzahrani, Hatoon A

A hypertensive crisis is defined as a sudden and significant rise in blood pressure. The blood pressure reading is 180/120 mmHg or higher. A hypertensive crisis is a medical emergency. It can lead to a heart attack, stroke, or other life-threatening medical problems. Investigating the management of the hypertensive crisis was the goal of this study. English-language articles were collected from 2010 to 2024 demonstrating the management of the hypertensive crisis. Overall, there were 15 articles. Surveys and analyses of national databases were the most widely used methods (n=15). The scientific studies documented (1) all investigative studies or reports that included a hypertensive crisis diagnosis, (2) data integrity and reproducibility, and (3) management studies. Other studies show that acute severe hypertension in the hospital is associated with high rates of mortality and morbidity, particularly with new or worsening end-organ damage. The problem is linked to poor medical adherence, but alarmingly low follow-up rates are likely to contribute to a high recurrence rate. The treatment of acute severe hypertension varies according to the hospital unit (medical ward or intensive care unit), medication, and blood pressure targets or thresholds. Because of a lack of evidence-based guidance, arbitrary blood pressure control targets are used, or blood pressure targets are crudely extrapolated from guidelines intended primarily for outpatient management. Patients with acute aortic dissection need to be administered intravenous esmolol within 5 to 10 minutes in order to lower their blood pressure right away. The goal is to maintain a systolic reading of less than 120 mm Hg. Vasodilators such as nitroglycerin or nitroprusside may be administered if the blood pressure persists following beta blocking. Intravenous administration of clevidipine, nicardipine, or phentolamine is required; the initial dose is 5 mg, with subsequent doses given every 10 minutes as necessary to achieve the desired reduction in blood pressure.

News (Medical) associated with Esmolol Hydrochloride

04 Jan 2024

·www.biospace.com

Amneal Launched Record Number of 39 New Retail and Injectable Products in 2023, Including 13 in Q4 2023

More new product innovations in 2023, as compared to 26 in 2022 13 new products launched in the fourth quarter of 2023 BRIDGEWATER, N.J.--(BUSINESS WIRE)-- Amneal Pharmaceuticals, Inc. (Nasdaq: AMRX) (“Amneal”) today announces that it has launched 39 new retail and injectable medicines in 2023, as compared to 26 new launches in 2022. In the fourth quarter of 2023, Amneal launched 13 new products, including 5 injectables. New injectable products added include potassium phosphate vials, tranexamic acid and esmolol intravenous bags. These launches provide a strong foundation for higher injectable revenues going forward. In addition, Amneal launched several key new retail products in the fourth quarter, including spironolactone suspension with 180-day exclusivity, valsartan and hydrochlorothiazide tablets, and icosapent capsules. “We are pleased to have brought an impressive number of new products to market in 2023,” said Dr. Srinivas Kone, Senior Vice President, Generics R&D. “Our R&D portfolio prioritizes complex and high-value products that provide better access to affordable medicines for providers and patients.” About Amneal Amneal Pharmaceuticals, Inc. (Nasdaq: AMRX), headquartered in Bridgewater, NJ, is a fully integrated global pharmaceuticals company. We make healthy possible through the development, manufacturing, and distribution of a diverse portfolio of over 270 pharmaceutical products, primarily within the United States. In its Generics segment, the Company is expanding across a broad range of complex product categories and therapeutic areas, including injectables and biosimilars. In its Specialty segment, Amneal has a growing portfolio of branded pharmaceuticals focused primarily on central nervous system and endocrine disorders, with a pipeline focused on unmet needs. Through its AvKARE segment, the Company is a distributor of pharmaceuticals and other products for the U.S. federal government, retail, and institutional markets. For more information, please visit . Cautionary Statement on Forward-Looking Statements Certain statements contained herein, regarding matters that are not historical facts, may be forward-looking statements (as defined in the U.S. Private Securities Litigation Reform Act of 1995). Such forward-looking statements include statements regarding management’s intentions, plans, beliefs, expectations, financial results, or forecasts for the future, including among other things: discussions of future operations, including international expansion; expected or estimated operating results and financial performance; the Company’s growth prospects and opportunities as well as its strategy for growth; product development and launches; the successful commercialization and market acceptance of new products, and other non-historical statements. Words such as “plans,” “expects,” “will,” “anticipates,” “estimates,” and similar words, or the negatives thereof, are intended to identify estimates and forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. These forward-looking statements are based on current expectations of future events, including with respect to future market conditions, company performance and financial results, operational investments, business prospects, new strategies and growth initiatives, the competitive environment, and other events. If the underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of the Company. Such risks and uncertainties include, but are not limited to: our ability to successfully develop, license, acquire and commercialize new products on a timely basis; the competition we face in the pharmaceutical industry from brand and generic drug product companies, and the impact of that competition on our ability to set prices; our ability to obtain exclusive marketing rights for our products; our ability to manage our growth through acquisitions and otherwise; our revenues are derived from the sales of a limited number of products, a substantial portion of which are through a limited number of customers; the continuing trend of consolidation of certain customer groups; our dependence on third-party suppliers and distributors for raw materials for our products and certain finished goods; our ability to complete the proposed holding company reorganization on the anticipated timeline or at all and to realize the expected benefits of such reorganization; our substantial amount of indebtedness and our ability to generate sufficient cash to service our indebtedness in the future, and the impact of interest rate fluctuations on such indebtedness; our ability to secure satisfactory terms when negotiating a refinancing or other new indebtedness; our dependence on third-party agreements for a portion of our product offerings; legal, regulatory and legislative efforts by our brand competitors to deter competition from our generic alternatives; risks related to federal regulation of arrangements between manufacturers of branded and generic products; our reliance on certain licenses to proprietary technologies from time to time; the significant amount of resources we expend on research and development; the risk of product liability and other claims against us by consumers and other third parties; risks related to changes in the regulatory environment, including U.S. federal and state laws related to healthcare fraud abuse and health information privacy and security and changes in such laws; changes to Food and Drug Administration product approval requirements; the impact of healthcare reform and changes in coverage and reimbursement levels by governmental authorities and other third-party payers; our potential expansion into additional international markets subjecting us to increased regulatory, economic, social and political uncertainties, including recent events affecting the financial services industry; our ability to identify, make and integrate acquisitions or investments in complementary businesses and products on advantageous terms; the impact of global economic, political or other catastrophic events; our ability to attract, hire and retain highly skilled personnel; our obligations under a tax receivable agreement may be significant; and the high concentration of ownership of our Class A Common Stock and the fact that we are controlled by the Amneal Group. The forward-looking statements contained herein are also subject generally to other risks and uncertainties that are described from time to time in the Company’s filings with the Securities and Exchange Commission, including under Item 1A, “Risk Factors” in the Company’s most recent Annual Report on Form 10-K and in its subsequent reports on Forms 10-Q and 8-K. Investors are cautioned not to place undue reliance on any such forward-looking statements, which speak only as of the date they are made. Forward-looking statements included herein speak only as of the date hereof and we undertake no obligation to revise or update such statements to reflect the occurrence of events or circumstances after the date hereof. View source version on businesswire.com: Contacts Investors: Anthony DiMeo Head of Investor Relations anthony.dimeo@amneal.com Source: Amneal Pharmaceuticals, Inc. View this news release online at:

20 Dec 2022

·www.biospace.com

Amneal Announces 26 Generic New Product Launches in 2022 and First Injection Large Volume Bag Approval

- 8 new product launches in Q4 closes out another successful year of innovation - First approval of a large volume bag product signals further expansion of injectables business BRIDGEWATER, N.J.--(BUSINESS WIRE)-- Amneal Pharmaceuticals, Inc. (NYSE: AMRX) (“Amneal” or the “Company”) today announced that the Company has successfully launched 26 new generic products in 2022. In the fourth quarter of 2022, the Company launched 8 new generic products, including clindamycin phosphate gel 1%, ipratropium bromide nasal sprays, and prednisolone sodium phosphate oral solution. “2022 was another successful year of innovation for Amneal. Across the portfolio we continue to innovate, further expand our portfolio of essential medicines, and drive incremental impact and benefit for health care professions and their patients. Looking to 2023, we expect more than 30 new product launches,” said Chirag Patel and Chintu Patel, Amneal Co-Chief Executive Officers. In addition, Amneal also announced it received Abbreviated New Drug Application approval from the U.S. Food and Drug Administration (“FDA”) for its first large volume bag, esmolol hydrochloride in sodium chloride injection. Harsher Singh, SVP for Amneal Biosciences, stated, “We are seeing continued momentum in expanding our injectables business. We are excited about this first ready to use bag approval utilizing one of our new manufacturing sites and look forward to more over the coming months.” Esmolol hydrochloride in sodium chloride injection is indicated for tachycardia. For full prescribing information, see package insert located here. According to IQVIA®, U.S. annual sales for this product for the 12 months ended October 2022 were $57 million. About Amneal Amneal Pharmaceuticals, Inc. (NYSE: AMRX), headquartered in Bridgewater, NJ, is a fully integrated essential medicines company. We make healthy possible through the development, manufacturing, and distribution of generic and specialty pharmaceuticals, primarily within the United States. The Company has a diverse portfolio of over 250 products in its Generics segment and is expanding across a broad range of complex products and therapeutic areas, including injectables and biosimilars. In its Specialty segment, Amneal has a growing portfolio of branded pharmaceutical products focused primarily on central nervous system and endocrine disorders, with a pipeline focused on unmet needs. Through its AvKARE segment, the Company is a distributor of pharmaceuticals and other products for the U.S. federal government, retail, and institutional markets. For more, please visit . Cautionary Statement on Forward-Looking Statements Certain statements contained herein, regarding matters that are not historical facts, may be forward-looking statements (as defined in the U.S. Private Securities Litigation Reform Act of 1995). Such forward-looking statements include statements regarding management’s intentions, plans, beliefs, expectations or forecasts for the future, including among other things: discussions of future operations; expected or estimated operating results and financial performance, the Company’s growth prospects and opportunities as well as its strategy for growth; product development and launches; the successful commercialization and market acceptance of new products, and expenditures. Words such as “plans,” “expects,” “will,” “anticipates,” “estimates,” and similar words are intended to identify estimates and forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. These forward-looking statements are based on current expectations of future events. If the underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of the Company. Such risks and uncertainties include, but are not limited to: our ability to successfully develop, license, acquire and commercialize new products on a timely basis; the competition we face in the pharmaceutical industry, in general, specifically from brand and generic drug product companies, and the impact of that competition on our ability to set prices; our ability to obtain exclusive marketing rights for our products; our substantial amount of indebtedness and our ability to generate sufficient cash to service our indebtedness in the future, and the impact of interest rate fluctuations on such indebtedness; our ability to manage our growth through acquisitions and otherwise; our dependence on the sales of a limited number of products for a substantial portion of our total revenues; the continuing trend of consolidation of certain customer groups; our dependence on third-party suppliers and distributors for raw materials for our products and certain finished goods and any associated supply chain disruptions; existing and future legal proceedings, the outcome of which are uncertain and may divert management resources and require us to incur substantial defense or settlement payments and costs; legal, regulatory and legislative efforts by our brand competitors to deter competition from our generic alternatives; the impact of severe weather; the impact of the ongoing COVID-19 pandemic, and the emergence of variant strains; risks related to federal regulation of arrangements between manufacturers of branded and generic products; our reliance on certain licenses to proprietary technologies from time to time; the significant amount of resources we expend on research and development; the risk of product liability and other claims against us by consumers and other third parties; risks related to changes in the regulatory environment, including U.S. federal and state laws related to healthcare fraud abuse and health information privacy and security and changes in such laws; changes to FDA product approval requirements; the impact of healthcare reform and changes in coverage and reimbursement levels by governmental authorities and other third-party payers; our dependence on third-party agreements for a portion of our product offerings; the impact of global economic conditions, including any economic effects stemming from adverse geopolitical events, an economic downturn, inflation and rising interest rates; our ability to identify, make and integrate acquisitions or investments in complementary businesses and products on advantageous terms; our obligations under a tax receivable agreement may be significant; and the high concentration of ownership of our Class A Common Stock and the fact that we are controlled by the Amneal Group. The forward-looking statements contained herein are also subject generally to other risks and uncertainties that are described from time to time in the Company’s filings with the Securities and Exchange Commission, including under Item 1A, “Risk Factors” in the Company’s most recent Annual Report on Form 10-K and in its subsequent reports on Forms 10-Q and 8-K. Investors are cautioned not to place undue reliance on any such forward-looking statements, which speak only as of the date they are made. Forward-looking statements included herein speak only as of the date hereof and we undertake no obligation to revise or update such statements to reflect the occurrence of events or circumstances after the date hereof.

Drug Approval

100 Deals associated with Esmolol Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D00644	Esmolol Hydrochloride	C07AB09	DB00187

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Diabetic foot ulcer	IN	NovaLead Pharma Pvt Ltd.	24 Apr 2024
Tachycardia	US	HQ Specialty Pharma Corp.	07 Apr 2016
Ventricular Arrhythmia	JP	Maruishi Pharmaceutical Co., Ltd.	08 Oct 2002
Hypertension	US	Baxter Healthcare Corp.	31 Dec 1986
Tachycardia, Supraventricular	US	Baxter Healthcare Corp.	31 Dec 1986

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Diabetic foot ulcer	Phase 2	US	NovaLead Pharma Pvt Ltd.	20 Feb 2014

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04356352 (CTgov)	Phase 2/3	Pain \| Injection Site Reaction	33	Lidocaine (Lidocaine)	hxyehifnvd(gsgeqtlpao) = aeylxnpheu dsrqyeigli (htrnuzbted, bzanswpzac - sxksxmjctp) View more	-	19 Sep 2024
				Esmolol (Esmolol)	hxyehifnvd(gsgeqtlpao) = pzgoolaxww dsrqyeigli (htrnuzbted, jeaqpomoew - yzaggmqlmo) View more
NCT01113515 (CTgov)	Phase 1/2	Diabetic foot ulcer	44	Placebo gel (Placebo)	cjxwzblbky(ggydssmkyk) = gemlirmdav numabzmncf (vsonjoopbf, rukjxhqrqn - fjtxbdguzd) View more	-	20 May 2024
				Esmolol hydrochloride (Galnobax 20% QD)	cjxwzblbky(ggydssmkyk) = ncioccireh numabzmncf (vsonjoopbf, ipctrmdhqc - vuvvpknllq) View more
NCT03998436 \| CTRI/2018/11/016295 (CTgov)	Phase 3	Diabetic foot ulcer	176	Esmolol Hydrochloride (Galnobax® 14% Gel Plus SoC)	occcvrzcfr(yojnmauwdk) = ptgeshwxtq teufnfaweb (yxiojxemqp, fswxlqujyo - soyuwhsght) View more	-	22 Sep 2023
				Only Standard of Care (SoC Only)	occcvrzcfr(yojnmauwdk) = nqhcfmkrgj teufnfaweb (yxiojxemqp, cqbfigqauc - ohhfccstii) View more
Pubmed	Phase 1/2	Diabetic foot ulcer	-	Galnobax 14%	(optfhvmtdg) = hqekzxigyp pbupqcpgqq (anpuhmbgdt ) View more	-	16 Oct 2022
				Galnobax 20%	(optfhvmtdg) = qcfvaroqug pbupqcpgqq (anpuhmbgdt ) View more
NCT02369900 (Pubmed)	Phase 2	Shock, Septic	40	Esmolol	(vetflinfoa) = jtwgloygil ylwmizsmhv (nsuvvlptjg )	-	27 Dec 2021
				Placebo	(vetflinfoa) = srklweckaq ylwmizsmhv (nsuvvlptjg )
ERS2021	Not Applicable	Heart Failure	-	Landiolol	(fqcktxnzjm) = yvnbotyxxs umoduxtahg (cffdvdyizn )	Positive	05 Sep 2021
				Esmolol	(fqcktxnzjm) = jkncznvtcx umoduxtahg (cffdvdyizn )
NCT02369900 (CTgov)	Phase 2	Shock, Septic \| Hypotension \| Tachycardia	40	Esmolol (Esmolol Infusion)	spogmjmxkn(zkzxislwue) = qocadkcfyd qcaqantbqp (yzutqgsudv, sodrhsijbn - gyecswasjz) View more	-	28 Jun 2021
				saline (Standard Care, Saline)	spogmjmxkn(zkzxislwue) = ahhnybudjj qcaqantbqp (yzutqgsudv, zawhmbeyja - eqmutiexjf) View more
NCT02466542 (Pubmed \| Eur J Anaesthesiol)	Phase 4	Pain	-	Esmolol infusion	(gzspbchtfj) = ofswqildut onwjdnskef (fpwieqoiyh, -13.4 to -0.31)	Positive	08 Apr 2021
NCT03661346 (CTgov)	Phase 2	Hemorrhage \| Chronic sinusitis	28	Esmolol (Esmolol)	kmtduxlpre(mpotveiorc) = plrmfxgmqo iulupwiovj (yuwpxqhrnr, diyuinqnnq - knytjpgayn) View more	-	08 Feb 2021
				Labetalol (Labetalol)	kmtduxlpre(mpotveiorc) = tkeicyrlyb iulupwiovj (yuwpxqhrnr, ubyrwhuhxq - wedfcmuvqw) View more
NCT02068287 (ESMOSEPSIS, Pubmed \| Crit Care) Manual	Phase 2	Shock, Septic	9	Esmolol	cmdogpebbx(brgakmkxpo) = decrease from 4.2 to 2.9 l/min/m-2 tztdiczvyp (rvrqmxqxvl ) View more	Positive	07 Jan 2021

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