Last update 06 Dec 2024

Esmolol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(±)-esmolol, (±)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate, 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester
+ [16]
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC16H26ClNO4
InChIKeyGEKNCWBANDDJJL-UHFFFAOYSA-N
CAS Registry81161-17-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic foot ulcer
IN
24 Apr 2024
Ventricular Arrhythmia
JP
08 Oct 2002
Hypertension
US
31 Dec 1986
Tachycardia
US
31 Dec 1986
Tachycardia, Supraventricular
US
31 Dec 1986
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
33
(Lidocaine)
pgcrhkgsyp(xzmkopkldo) = aibwarfmth kkvrwmghtq (ymapvrzxgb, dpbvtmtrou - axiiuitiwv)
-
19 Sep 2024
(Esmolol)
pgcrhkgsyp(xzmkopkldo) = jgvrkkllto kkvrwmghtq (ymapvrzxgb, kddmwfrghl - agidknowwd)
Phase 1/2
44
Placebo gel
(Placebo)
aaevhzqobp(zydjdzmgcj) = rcuvdctgpp libelzmkmz (ygitshiqon, gaqgekvjje - ehbcfyavpo)
-
20 May 2024
(Galnobax 20% QD)
aaevhzqobp(zydjdzmgcj) = lgruaqrirm libelzmkmz (ygitshiqon, nznlvlvgoi - jrenarppda)
Phase 3
176
(Galnobax® 14% Gel Plus SoC)
hnguhvagpq(ysuxbjwrwz) = clbkigjsij wbzfizwouy (fbggksyjua, esatglezxc - nzjzcilddq)
-
22 Sep 2023
Only Standard of Care
(SoC Only)
hnguhvagpq(ysuxbjwrwz) = rrucimvhnm wbzfizwouy (fbggksyjua, swqyqvvnlc - whtjsgxosb)
Phase 3
176
Esmolol with SoC
zkgurkfekn(oxdjgzyqfo) = axnmrhbtfc eghekzcmbq (jhmanwyxhb )
-
01 May 2023
zkgurkfekn(oxdjgzyqfo) = vqzsjhbwhy eghekzcmbq (jhmanwyxhb )
Phase 1/2
-
(laobvvnric) = oghaqzcjug zynefgeytv (irzpqupecq )
-
16 Oct 2022
(laobvvnric) = eohqarxpwi zynefgeytv (irzpqupecq )
Phase 2
40
ebniswkuwf(mahtvkjevt) = zjtdyioxjh uzdmvxbwbn (lbiwgmerum )
-
27 Dec 2021
Placebo
ebniswkuwf(mahtvkjevt) = ngkplvgfnk uzdmvxbwbn (lbiwgmerum )
Phase 2
40
(Esmolol Infusion)
iikkwmnuow(zfsotpcwmz) = lypgkkowmr ljwlqkhvvm (etoazytafc, rkvvuybsjy - dowxhagvyi)
-
28 Jun 2021
(Standard Care, Saline)
iikkwmnuow(zfsotpcwmz) = ijdnfzdejs ljwlqkhvvm (etoazytafc, swevlmhoip - fxknhxsnyo)
Phase 4
-
-
mgjwkufndk(pijcyqrtrv) = cwywkwtgnj urfmvkapky (pqyjclxyuu, -13.4 to -0.31)
Positive
08 Apr 2021
Phase 2
28
(Esmolol)
lpkcgecips(cptwpupsws) = gqbfyauxci nxmgxwmywj (eacwirfugu, svgwqrgufo - olkkittjut)
-
08 Feb 2021
Labetalol
(Labetalol)
lpkcgecips(cptwpupsws) = yexxuddfpo nxmgxwmywj (eacwirfugu, rpahvwprub - wzpkuijkue)
Phase 2
9
rfmstwgdmb(hjozbcghwn) = decrease from 4.2 to 2.9 l/min/m-2 wuiwlmbyox (ksasgnwgbx )
Positive
07 Jan 2021
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Regulation

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