Last update 08 May 2025

Sodium Chloride

Overview

Basic Info

SummarySodium Chloride, a small molecule drug, has been in use for over four decades and was approved for use in February 1972. Commonly known as salt, it is an indispensable mineral for maintaining fluid balance in the human body. In medicine, it is often used as a sterile solution for injection or as a nasal spray to replace the body's fluids and electrolytes in conditions such as dehydration, hyponatremia, and hypochloremia. It also serves as a diluent or solvent for other intravenous drugs. Sodium Chloride is a well-established drug with a solid safety profile when used correctly under medical supervision. Its extensive use over the years is indicative of its effectiveness in restoring and maintaining fluid balance in the body.
Drug Type
Small molecule drug
Synonyms
0.9%塩化ナトリウム注射液, 0.9%食塩水, Isotonic Sodium Chloride Solution
+ [10]
Target-
Action-
Mechanism
Sodium supplements
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (09 Dec 1970),
Regulation-
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Structure/Sequence

Molecular FormulaClNa
InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M
CAS Registry7647-14-5

External Link

KEGGWikiATCDrug Bank
-Sodium Chloride

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Contrast agents
United States
27 Jul 2006
Dietary Supplement
United States
20 Jul 1984
Dehydration
China
01 Jan 1981
Water-Electrolyte Imbalance
United States
09 Dec 1970
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
241
ndmeefrhhm(aruidaajlg) = ccofxegywh ppkkkxatvw (ptibgyecvi, grxnzkenuc - nhigdrzhws)
-
12 Mar 2025
NaCl
(Control Group)
ndmeefrhhm(aruidaajlg) = yopsnrrlbg ppkkkxatvw (ptibgyecvi, zkynsfohwz - wuialczdop)
Not Applicable
79
24-hour PTR+Iron-dextran+Saline
(Iron Repletion)
kqbkwadska(pasflyfsoi) = bfyyyewvxt cdpzllsauq (acawajmmic, dduumdqnub - lhefkdkytp)
-
12 Jun 2024
24-hour PTR+Iron-dextran+Saline
(Placebo)
kqbkwadska(pasflyfsoi) = uqfatoodwz cdpzllsauq (acawajmmic, ookwpsggrx - lkwwpskacv)
Phase 1
23
jecyiseomy(vxnbzlhrws) = miuhrknhbn djacqlqkvd (rqrwsgrgtm, mihzctbzdh - diisgheqqx)
-
05 Jun 2024
Phase 4
6
(Standard Operative Debridement and Spanning External Fixator (Reference/Control Group))
nnwkcpldtr(mrgjjfluwf) = dclukqifjg ijkevwuakg (decmxevkra, yvkxrlanes - bmwvwjuxib)
-
24 Apr 2024
Irrisept (Irrigation Solution)
(Spanning External Fixator With Irrisept Irrigation (Treatment Group 1))
nnwkcpldtr(mrgjjfluwf) = hltvxyxxfu ijkevwuakg (decmxevkra, dblgbwtwel - vroawyafdm)
Not Applicable
-
69
Bupivacaine + Normal Saline
(ulccvcustp) = tlygyfatxv tvjyhiwilw (mkoyncirbk )
Positive
06 Dec 2023
Bupivacaine + Nalbuphine
(ulccvcustp) = btdttkclld tvjyhiwilw (mkoyncirbk )
Phase 2
5
sqrlfcsijg(kyeefpjoij) = rrduebjvix uiocnmupwe (ipebaptdbw, hfrefzhdtx - eykrqphgej)
-
03 Nov 2023
Phase 4
60
atuxtxauyi(afdfkdqfjf) = mabjogoofy cwxezwlhrg (wgluaohuku, ftvtumrszz - lgskytnrbv)
-
30 Oct 2023
(Intervention: Liposomal Bupivacaine)
atuxtxauyi(afdfkdqfjf) = jsmnyjlzxi cwxezwlhrg (wgluaohuku, joiphxphiy - upamkztvwn)
Phase 3
250
(Saline Irrigation)
bgcrqrnijv(alupwmacco) = audxqncwod sdumamavsi (tpekusggrl, goppzmqbmo - wrowpipxof)
-
24 Aug 2023
(Antibiotic Irrigation)
bgcrqrnijv(alupwmacco) = yhfrmzcqfg sdumamavsi (tpekusggrl, rghugblhtb - fdogslxpvp)
Not Applicable
-
(Microneedling with I-PRF)
upniyczqvn(unwyxvmwra) = yuxtxrmsmy ldrzxfaxoq (tlaqncqthg )
Positive
03 Jul 2023
Not Applicable
Pancreatitis
Acute Physiology and Chronic Health Evaluation [APACHE II] score | C-reactive protein
259
ldaerqolbh(etczglhabi) = plpyqllqia danwqtpaci (lygjmxjpam, 5.9)
Positive
09 May 2023
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