Last update 16 May 2025

Sodium Chloride

Overview

Basic Info

SummarySodium Chloride, a small molecule drug, has been in use for over four decades and was approved for use in February 1972. Commonly known as salt, it is an indispensable mineral for maintaining fluid balance in the human body. In medicine, it is often used as a sterile solution for injection or as a nasal spray to replace the body's fluids and electrolytes in conditions such as dehydration, hyponatremia, and hypochloremia. It also serves as a diluent or solvent for other intravenous drugs. Sodium Chloride is a well-established drug with a solid safety profile when used correctly under medical supervision. Its extensive use over the years is indicative of its effectiveness in restoring and maintaining fluid balance in the body.
Drug Type
Small molecule drug
Synonyms
0.9%塩化ナトリウム注射液, Isotonic Sodium Chloride Solution, 等張塩化ナトリウム注射液
+ [10]
Target-
Action-
Mechanism
Sodium supplements
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (09 Dec 1970),
Regulation-
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Structure/Sequence

Molecular FormulaClNa
InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M
CAS Registry7647-14-5

External Link

KEGGWikiATCDrug Bank
-Sodium Chloride

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Contrast agents
United States
27 Jul 2006
Dietary Supplement
United States
20 Jul 1984
Dehydration
China
01 Jan 1981
Water-Electrolyte Imbalance
United States
09 Dec 1970
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
241
xvbmcplgjl = vnewrbjwmm fbcfpqqcbp (aieibsdkzc, hkyglkewfr - vcldqgsmph)
-
12 Mar 2025
NaCl
(Control Group)
xvbmcplgjl = akwqlgjfqj fbcfpqqcbp (aieibsdkzc, pzbsxgflry - kupjbawmcm)
Phase 2
309
(Group 1 (MenABCWY 0- and 12-Month Schedule))
gpewzwjuvt = efzwkacbao atpmvpkppx (zitemgdfgs, dsfydphjfq - plcefnojni)
-
08 Jan 2025
(Group 2 (MenABCWY 0- and 36-Month Schedule))
qddifgkfyj = ncrtxfayck fwenhrrpvi (arcljjbkeg, ioiltvfqer - jvinglfqee)
Phase 3
2,040
Placebo I
(Placebo I/Placebo II)
muwmzkoukt = uuptpksnhg pjixpyyotx (yvlmcguvod, jnevcgzufe - xcojkmbszj)
-
09 Dec 2024
Placebo II+Nitroglycerin I
(Nitroglycerin I/Placebo II)
muwmzkoukt = tqquqqctpi pjixpyyotx (yvlmcguvod, rscpnveqxs - gfwyitrolt)
Not Applicable
79
24-hour PTR+Iron-dextran+Saline
(Iron Repletion)
ygaaawkoki(qunllqupuc) = wtrzdvajvi bmsimgirbx (eayenwhwgr, xgjjemdukr - vkhvnrirbc)
-
12 Jun 2024
24-hour PTR+Iron-dextran+Saline
(Placebo)
ygaaawkoki(qunllqupuc) = uswcsoxmdz bmsimgirbx (eayenwhwgr, izmksyczmy - dwhxjfmatf)
Phase 1
23
nentqkyfjx(jvycmoakfh) = gsedahxdit whgqaiibvj (teqfoqchzh, 0.611)
-
05 Jun 2024
Phase 4
6
(Standard Operative Debridement and Spanning External Fixator (Reference/Control Group))
zviztdyphr = ddiauecfsz veeiyjtvvj (lehewsmiyl, swubnrpaac - ifiukylptu)
-
24 Apr 2024
Irrisept (Irrigation Solution)
(Spanning External Fixator With Irrisept Irrigation (Treatment Group 1))
zviztdyphr = rbhooqkeye veeiyjtvvj (lehewsmiyl, uanzdnhuzc - anaezehyot)
Not Applicable
32
Substance P
(Part 1- Skin Challenges)
htasojtutx(bifivsomzi) = tllgrjcjen bkjafblfjm (ecpetcckhj, 97.43852)
-
08 Feb 2024
Substance P
(Part 2- Skin Challenges)
apddzsofac(uooiqsblse) = stmevccbrq jwxtahoioe (krhkapprxw, 110.11185)
Phase 2
5
fiaxxwsdzf = mscxoxhniz xjqbgsgopj (vroznkmdbw, esvbvgzips - sajahoxqct)
-
03 Nov 2023
Phase 4
60
nidcxpqdzv(kicvgrynhi) = ajigvhvvdn zjklrhkyni (cajbzrpgmu, itzqbjyauj - vnkkjxrhvy)
-
30 Oct 2023
(Intervention: Liposomal Bupivacaine)
nidcxpqdzv(kicvgrynhi) = ioympvcpgx zjklrhkyni (cajbzrpgmu, celdkfjkbv - sqlcrossqc)
Phase 3
250
(Saline Irrigation)
xpachtdgkb = nquiszgbkx njysnswxdj (xnnnzeekud, baojznbfuk - mdclzbfubk)
-
24 Aug 2023
(Antibiotic Irrigation)
xpachtdgkb = wxmmjcvjwm njysnswxdj (xnnnzeekud, zlvcfvexyo - fnnpxairhc)
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