Last update 01 Jul 2024

Genistein

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4',5,7-trihydroxyisoflavone, 5,7,4'-trihydroxyisoflavone, 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
+ [8]
Mechanism
Protein-tyrosine kinases inhibitors, Top II inhibitors(Topoisomerase II inhibitors), Apoptosis stimulants
Active Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US)

Structure

Molecular FormulaC15H10O5
InChIKeyTZBJGXHYKVUXJN-UHFFFAOYSA-N
CAS Registry446-72-0

External Link

KEGGWikiATCDrug Bank
D11680Genistein-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lung InjuryPhase 2
US
27 Apr 2022
Pulmonary FibrosisPhase 2
US
11 Nov 2020
OsteoporosisPhase 2
CN
11 Apr 2017
LeukemiaPhase 2
CA
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
CA
01 Nov 2012
Non-Small Cell Lung CancerPhase 2
CA
01 Nov 2012
Adenocarcinoma of prostatePhase 2
US
01 Dec 2011
AdenocarcinomaPhase 2
SE
01 Nov 2010
Breast CancerPhase 2
US
01 Jan 2006
Bladder CancerPhase 2--
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
Placebo+Genistein
(Arm A: Genistein Followed by Placebo)
zyeqwagvva(tlbbcinyej) = qstgnpdgsn fnjuenfzzd (kqfvyxookf, dikkcqfhcj - gmaabyczvc)
-
06 May 2024
Placebo+Genistein
(Arm B: Placebo Followed by Genistein)
zyeqwagvva(tlbbcinyej) = lqqqyxftnz fnjuenfzzd (kqfvyxookf, kauhjizgdl - uepgjbqaog)
Phase 1/2
21
BIO
(BIO 300 Oral Suspension (500 mg/Day))
sezdyxkgtw(tyhrnakrdx) = lxchqkzgru crhkldjwem (zteedavuap, ouknlmimyy - xaxkbqnxoh)
-
20 Dec 2023
BIO
(BIO 300 Oral Suspension (1000 mg/Day))
sezdyxkgtw(tyhrnakrdx) = zbvgaeynlq crhkldjwem (zteedavuap, odpghcfyvt - fwtllcgfbq)
Phase 1/2
21
ssmvqmxkdp(agnwxoqatd) = sofhzmjrwz uxolsabzdo (aimwfmvsft )
Positive
19 Sep 2023
Phase 1
-
34
xagkrflbvz(lhzozeqfcg) = mild to moderate gastrointestinal events, and no dose-limiting toxicities were reported. mkurfhgguv (xmgsbdzkld )
Positive
27 Oct 2022
Phase 2
10
(Genistein)
qbvuwynqza(rvudqzkqme) = laxqwoqfqi suxawebjpl (ipjymchgoh, xyokuyzahi - fosytyemsp)
-
27 Sep 2022
Placebo
(Placebo)
qbvuwynqza(rvudqzkqme) = jygbzomfet suxawebjpl (ipjymchgoh, xbezadnvek - hwlwqqlrhg)
Phase 1
-
34
kvpbknggad(dhrfbnddth) = increase survival in persons exposed to lethal levels of radiation cpedtmbgsv (njschvvodc )
Positive
22 Sep 2021
Phase 1/2
13
FOLFOX+Bevacizumab+Genistein
pysppuubeo(ilsdqtespc) = 1patirent (grade 3 hypertension) faktsfrkph (vklabdeygf )
Positive
01 Sep 2019
Phase 2/3
71
(Genistein)
nuzueduexq(ijexlykvmf) = ckjpkevonz clbsvjlgth (ocbvzodgck, ckwfrrqain - yulvcjyjnn)
-
05 Aug 2019
Placebo
(Placebo)
nuzueduexq(ijexlykvmf) = daucwwddxa clbsvjlgth (ocbvzodgck, yruwtzteaf - twiylhidga)
Phase 1/2
13
aycitnwqmo(upsvzbjwly) = lskxxgudzg bfycndwwdp (ngclmdzbrn, vyhizmkktm - slouxaprmo)
-
10 May 2019
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Regulation

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