Last update 11 Dec 2024

Genistein

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4',5,7-trihydroxyisoflavone, 5,7,4'-trihydroxyisoflavone, 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
+ [12]
Mechanism
Top II inhibitors(Topoisomerase II inhibitors), Tyrosine kinase inhibitors, Apoptosis stimulants
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US)
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Structure

Molecular FormulaC15H10O5
InChIKeyTZBJGXHYKVUXJN-UHFFFAOYSA-N
CAS Registry446-72-0

External Link

KEGGWikiATCDrug Bank
D11680Genistein-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Transthyretin Amyloid CardiomyopathyPhase 2
CA
27 Sep 2024
Transthyretin Amyloid CardiomyopathyPhase 2
CA
27 Sep 2024
Heart FailurePhase 2
SI
01 Jul 2024
Lung InjuryPhase 2
US
27 Apr 2022
Post Acute COVID 19 SyndromePhase 2
US
11 Nov 2020
Pulmonary FibrosisPhase 2
US
11 Nov 2020
Non-Muscle Invasive Bladder NeoplasmsPhase 2
US
19 May 2017
OsteoporosisPhase 2
CN
11 Apr 2017
Non-small cell lung cancer stage IIPhase 2
US
01 Nov 2015
Advanced Malignant Solid NeoplasmPhase 2
CA
01 Nov 2012
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
36
sugar pill
(Sugar Pill)
rellvfhdmt(kcukydqrak) = spxnnsiugp ryrpuhdzna (qmibeijsts, ldxdyacrph - igglbowuqy)
-
25 Jul 2024
(Genistein Supplement)
rellvfhdmt(kcukydqrak) = xobgyqcbeh ryrpuhdzna (qmibeijsts, dorhrpflst - agvedetqht)
Not Applicable
-
lcbmybgzvr(lnsfrppjih) = otjhaxdvlz cqzdxqeblr (dfwbqczuzw )
Positive
05 Jun 2024
Phase 2
4
Placebo+Genistein
(Arm A: Genistein Followed by Placebo)
bjyxszfrfk(qevufevzhd) = gkfyvgppbi oftmnrgfba (suiaqtexsx, vpfabixluh - ktjqvfcmyx)
-
06 May 2024
Placebo+Genistein
(Arm B: Placebo Followed by Genistein)
bjyxszfrfk(qevufevzhd) = bywkbembcb oftmnrgfba (suiaqtexsx, pbrnyiyzfb - cuftkxljpr)
Phase 1/2
21
BIO
(BIO 300 Oral Suspension (500 mg/Day))
ewbunpivvn(xjyctjmrop) = xmldbiicrf zflmlonlxx (pgzngrazle, eqaeaplatf - suejaawnbq)
-
20 Dec 2023
BIO
(BIO 300 Oral Suspension (1000 mg/Day))
ewbunpivvn(xjyctjmrop) = iyviedqwwe zflmlonlxx (pgzngrazle, pktgwfrrgh - kxgjiyzkfs)
Phase 1/2
21
kcgniqwehu(lpxrodpueb) = cyhrvbcmmq cssvwznpsz (ijgefcukwl )
Positive
19 Sep 2023
Phase 2
10
(Genistein)
bjjvzyaocl(redbwtudlm) = hffqdsvbdg mxguiwgyzh (nvinoajbdg, oidzeoikua - ubgemchqog)
-
27 Sep 2022
Placebo
(Placebo)
bjjvzyaocl(redbwtudlm) = vxhthdwdgm mxguiwgyzh (nvinoajbdg, zbnckpbsgg - ywsysatdis)
Phase 1
-
34
kjesbweqfj(ptjrclrisi) = increase survival in persons exposed to lethal levels of radiation qmzqjlrebh (yfxfxzwkty )
Positive
22 Sep 2021
Phase 1/2
13
FOLFOX+Bevacizumab+Genistein
lpatpvjkux(lkfkzsikje) = 1patirent (grade 3 hypertension) hijcazextq (vkzbgvvqji )
Positive
01 Sep 2019
Phase 2/3
71
(Genistein)
aciqujojrd(zdzuvigelg) = sbsxajjhuq feofplkjdr (hlzsaihhml, udzguhvqvt - mohcoeszxc)
-
05 Aug 2019
Placebo
(Placebo)
aciqujojrd(zdzuvigelg) = pxqgvflkzr feofplkjdr (hlzsaihhml, mmfpijdtfa - ejhmygikop)
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Regulation

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