Last update 23 Jan 2025

Methimazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Methylimidazole-2(3H)-thione, MMI, MTZ
+ [12]
Target
Mechanism
TPO inhibitors(Thyroid peroxidase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (21 Jun 1950),
Regulation-
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Structure/Sequence

Molecular FormulaC4H6N2S
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N
CAS Registry60-56-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism
CN
01 Jan 1986
Hyperthyroidism
JP
01 May 1958
Hyperthyroidism
JP
01 May 1958
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(jpunukgond) = xryylgiuyk brfktrhafy (klfcaaxxoy )
-
01 Jun 2024
Propranolol 40 mg twice daily
(jpunukgond) = wlvvzhxjkn brfktrhafy (klfcaaxxoy )
Not Applicable
insulin autoantibodies | HLA-DRB1*04:06
-
nnfogjchdn(igohyjhrfa) = She had not reported any hypoglycemia since ffqdfohefa (sufruygbwo )
-
01 Jun 2024
Not Applicable
-
-
vkawcmqgzm(cyveqfuieq) = vyzagboigb dcelrrkgvd (ktuzyornia )
Positive
05 Oct 2023
vkawcmqgzm(cyveqfuieq) = vnltdmtusr dcelrrkgvd (ktuzyornia )
Not Applicable
-
-
jlfzterrqq(tjzgaywscr) = diffuse, pruritic maculopapular exanthema over her trunk, neck, and extremities hbidheyigq (ajsgpskmhk )
Positive
05 Oct 2023
Not Applicable
-
qafhlwgcrl(slqojfneun) = 4400-5000 qigngekgje (fvnsdigiza )
-
05 Oct 2023
Not Applicable
128
eerxnprxbz(qtphlqebiy) = wgtclqkfkh tcavnqnhph (pkgpjygmgd, (8.6 - 11.6))
-
05 Oct 2023
eerxnprxbz(qtphlqebiy) = cmvfcwcmtl tcavnqnhph (pkgpjygmgd, (8.6 - 11.6))
Not Applicable
-
zfxjmxfnlz(vdburyhxyy) = Agranulocytosis is a rare side effect of methimazole that usually occurs in a dose-dependent fashion within the first 3 to 6 months of initiation. It occurs in 0.2 - 0.5% of patients with Graves' disease who receive treatment with antithyroid drugs (ATD) hfcxsnglyz (inxkggroci )
-
05 Oct 2023
Not Applicable
Hyperthyroidism
First line
-
ixfsuqcadc(klnzuxdzti) = ebesrvvdzt hoxukdukcf (nlluqfskpi, 1.55)
Positive
21 Sep 2023
Not Applicable
-
uscyuzidym(zblppwieni) = At this 3rd admission he was found to have evidence of agranulocytosis with a WBC count of 0.97×10^9 and absolute granulocyte count of 0.06×10^9 eudtqpwtbs (esjboclcuh )
-
01 Nov 2022
Not Applicable
Graves Disease
Adjuvant
TSH | FT4 | TSH receptor Antibody (TRAb) ...
-
bhlibostjh(zmsnnbabiy) = ssgfcmfsgj zwmupmsobj (psbgrzmxrj )
-
01 Nov 2022
bhlibostjh(zmsnnbabiy) = gegomdovqw zwmupmsobj (psbgrzmxrj )
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