Last update 09 Dec 2024

Methimazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Methylimidazole-2(3H)-thione, Methimazole (USP), MMI
+ [12]
Target
Mechanism
TPO inhibitors(Thyroid peroxidase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (21 Jun 1950),
Regulation-
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Structure

Molecular FormulaC4H6N2S
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N
CAS Registry60-56-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism
CN
01 Jan 1986
Hyperthyroidism
US
21 Jun 1950
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Hyperthyroidism
First line
-
jkjdcfjcnm(auxgkthdwd) = ccgsjsqxhv zkajltykgu (yzxepkhenk, 1.55)
Positive
21 Sep 2023
Not Applicable
-
-
esrjturvgd(zetbqffegs) = qdwbcfodlk ybdvbudmxb (fkxdhftwhq )
-
22 Sep 2021
Not Applicable
-
-
qbuhvorqce(hdcvkevotu) = subsequent multiorgan failure after initiation of methimazole okphrwhopc (lxdolgthwp )
-
03 May 2021
Not Applicable
-
173
Control (no PTU)
oyugprxbds(tkrbiogfyf) = splzemoafb rdrlepjeso (kgcpwwbwth )
Negative
23 May 2018
PTU pretreatment
oyugprxbds(tkrbiogfyf) = ltnqqhbklv rdrlepjeso (kgcpwwbwth )
Not Applicable
Graves Disease
Th17 lymphocytes
60
exfrssrwrc(ulchwlephp) = bxuesfaagk tjoirfhrrz (kutloanbzp )
-
01 Oct 2015
Not Applicable
300
MMI alone
hhjojevlpw(uzxsbpqlgc) = wegltsywqj cqboozghdz (akvemmpgmk )
-
01 May 2004
(AIR alone)
hhjojevlpw(uzxsbpqlgc) = ekbsyfgxoe cqboozghdz (akvemmpgmk )
Not Applicable
ANCA antibodies | proteinase 3 | myeloperoxidase (MPO) ...
33
(Graves' hyperthyroidism patients)
urthardhiy(ktgcazoqzi) = djsehdctbu kfphdfhrda (ioogjsbvgz )
-
12 Jun 2002
(ANCA positive patients)
urthardhiy(ktgcazoqzi) = hjpnwjeosd kfphdfhrda (ioogjsbvgz )
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Regulation

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