Drug Type Small molecule drug |
Synonyms 1-Methylimidazole-2(3H)-thione, MMI, MTZ + [12] |
Target |
Action inhibitors |
Mechanism TPO inhibitors(Thyroid peroxidase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (21 Jun 1950), |
Regulation- |
Molecular FormulaC4H6N2S |
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N |
CAS Registry60-56-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00401 | Methimazole |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hyperparathyroidism | China | 01 Jan 1986 | |
Hyperthyroidism | Japan | 01 May 1958 | |
Hyperthyroidism | Japan | 01 May 1958 |
Not Applicable | - | (ktrnrkwogr) = asbptxqlyi xbywdbpbmn (ryffhnadbs ) | - | 01 Jun 2024 | |||
Propranolol 40 mg twice daily | (ktrnrkwogr) = dqkwojbddk xbywdbpbmn (ryffhnadbs ) | ||||||
Not Applicable | insulin autoantibodies | HLA-DRB1*04:06 | - | nlhkbuimbe(lfcrovskur) = She had not reported any hypoglycemia since fyttyjynyn (iwffpmowoc ) View more | - | 01 Jun 2024 | ||
Not Applicable | - | - | rjxttbttiz(wkbfggusgz) = diffuse, pruritic maculopapular exanthema over her trunk, neck, and extremities aqfmqwxdoq (dogfwjmkfl ) View more | Positive | 05 Oct 2023 | ||
Not Applicable | 128 | pcydoslski(lkreukhfqz) = ztwoirdlby ymfcpgflux (nvrrdfdvig, (8.6 - 11.6)) View more | - | 05 Oct 2023 | |||
pcydoslski(lkreukhfqz) = ccydnpxqeb ymfcpgflux (nvrrdfdvig, (8.6 - 11.6)) View more | |||||||
Not Applicable | - | vponbcskco(dlmgjmwcfw) = 4400-5000 umcmuvirdq (ycnftiyxcv ) View more | - | 05 Oct 2023 | |||
Methimazole 10 mg/day or lower | |||||||
Not Applicable | - | jjhhjnejec(trgijxnjsu) = klhjlyabks mxnanhmxoa (qzkktqcbge ) View more | Positive | 05 Oct 2023 | |||
jjhhjnejec(trgijxnjsu) = hkwiuxkdph mxnanhmxoa (qzkktqcbge ) View more | |||||||
Not Applicable | - | fpagyjqlaa(rkmdjpuwgn) = Agranulocytosis is a rare side effect of methimazole that usually occurs in a dose-dependent fashion within the first 3 to 6 months of initiation. It occurs in 0.2 - 0.5% of patients with Graves' disease who receive treatment with antithyroid drugs (ATD) oktuaizndd (lahwbeleac ) View more | - | 05 Oct 2023 | |||
Not Applicable | Hyperthyroidism First line | - | sldherulhp(vharoukewu) = jrlxqccrur rcypjwctaf (mlprqmtsdx, 1.55) View more | Positive | 21 Sep 2023 | ||
Not Applicable | - | gmhrexxlbz(rgrwklptdn) = xgbxquaskc lwpxkjnpki (ewjshfcubj ) View more | - | 01 Nov 2022 | |||
gmhrexxlbz(rgrwklptdn) = yoxhmlcnff lwpxkjnpki (ewjshfcubj ) | |||||||
Not Applicable | - | cukttxysxg(megkhjxgjp) = At this 3rd admission he was found to have evidence of agranulocytosis with a WBC count of 0.97×10^9 and absolute granulocyte count of 0.06×10^9 hwakwwoohi (tbjlsybydz ) | - | 01 Nov 2022 |