Last update 20 Mar 2025

Methimazole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Methylimidazole-2(3H)-thione, MMI, MTZ
+ [12]
Target
Action
inhibitors
Mechanism
TPO inhibitors(Thyroid peroxidase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 Jun 1950),
Regulation-
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Structure/Sequence

Molecular FormulaC4H6N2S
InChIKeyPMRYVIKBURPHAH-UHFFFAOYSA-N
CAS Registry60-56-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperparathyroidism
China
01 Jan 1986
Hyperthyroidism
Japan
01 May 1958
Hyperthyroidism
Japan
01 May 1958
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(ktrnrkwogr) = asbptxqlyi xbywdbpbmn (ryffhnadbs )
-
01 Jun 2024
Propranolol 40 mg twice daily
(ktrnrkwogr) = dqkwojbddk xbywdbpbmn (ryffhnadbs )
Not Applicable
insulin autoantibodies | HLA-DRB1*04:06
-
nlhkbuimbe(lfcrovskur) = She had not reported any hypoglycemia since fyttyjynyn (iwffpmowoc )
-
01 Jun 2024
Not Applicable
-
-
rjxttbttiz(wkbfggusgz) = diffuse, pruritic maculopapular exanthema over her trunk, neck, and extremities aqfmqwxdoq (dogfwjmkfl )
Positive
05 Oct 2023
Not Applicable
128
pcydoslski(lkreukhfqz) = ztwoirdlby ymfcpgflux (nvrrdfdvig, (8.6 - 11.6))
-
05 Oct 2023
pcydoslski(lkreukhfqz) = ccydnpxqeb ymfcpgflux (nvrrdfdvig, (8.6 - 11.6))
Not Applicable
-
vponbcskco(dlmgjmwcfw) = 4400-5000 umcmuvirdq (ycnftiyxcv )
-
05 Oct 2023
Not Applicable
-
jjhhjnejec(trgijxnjsu) = klhjlyabks mxnanhmxoa (qzkktqcbge )
Positive
05 Oct 2023
jjhhjnejec(trgijxnjsu) = hkwiuxkdph mxnanhmxoa (qzkktqcbge )
Not Applicable
-
fpagyjqlaa(rkmdjpuwgn) = Agranulocytosis is a rare side effect of methimazole that usually occurs in a dose-dependent fashion within the first 3 to 6 months of initiation. It occurs in 0.2 - 0.5% of patients with Graves' disease who receive treatment with antithyroid drugs (ATD) oktuaizndd (lahwbeleac )
-
05 Oct 2023
Not Applicable
Hyperthyroidism
First line
-
sldherulhp(vharoukewu) = jrlxqccrur rcypjwctaf (mlprqmtsdx, 1.55)
Positive
21 Sep 2023
Not Applicable
Graves Disease
Adjuvant
TSH | FT4 | TSH receptor Antibody (TRAb) ...
-
gmhrexxlbz(rgrwklptdn) = xgbxquaskc lwpxkjnpki (ewjshfcubj )
-
01 Nov 2022
gmhrexxlbz(rgrwklptdn) = yoxhmlcnff lwpxkjnpki (ewjshfcubj )
Not Applicable
-
cukttxysxg(megkhjxgjp) = At this 3rd admission he was found to have evidence of agranulocytosis with a WBC count of 0.97×10^9 and absolute granulocyte count of 0.06×10^9 hwakwwoohi (tbjlsybydz )
-
01 Nov 2022
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