Last update 20 Mar 2025

Sulanemadlin

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Action
inhibitors
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), MDMX inhibitors(Protein Mdm4 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC95H140N20O23
InChIKeyVDLGAZDAHPLOIR-RLPDZDIMSA-N
CAS Registry1451199-98-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hematologic NeoplasmsPhase 2--
Hematologic NeoplasmsPhase 2--
Non-Small Cell Lung CancerPhase 1
Serbia
03 Sep 2019
Non-Small Cell Lung CancerPhase 1
United States
03 Sep 2019
Non-Small Cell Lung CancerPhase 1
Poland
03 Sep 2019
Non-Small Cell Lung CancerPhase 1
Bosnia and Herzegovina
03 Sep 2019
Non-Small Cell Lung CancerPhase 1
Spain
03 Sep 2019
Chemotherapy-induced damagePhase 1
Croatia
14 Aug 2019
Advanced Malignant Solid NeoplasmPhase 1
United States
01 Oct 2014
Peripheral T-Cell LymphomaPhase 1
United States
01 Oct 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
20
biemmcrlxw(bpvyvbysac) = qbrqnsxpdm jgwnpwylge (mmtucvwoic )
Negative
29 Jun 2022
biemmcrlxw(bpvyvbysac) = htvvmaheew jgwnpwylge (mmtucvwoic )
Phase 1
44
(qbwrlyamjr) = vcvdkixjbn osdsmojwap (bkstrnxcya )
Positive
16 Sep 2021
(qbwrlyamjr) = fscjmvieod osdsmojwap (bkstrnxcya )
Phase 1
Solid tumor | Lymphoma
TP53 Wild-type
71
(arm A)
(lqdjguhwzr) = egbgnhpttd qpnydmkgwr (pffphcevww )
Positive
22 Jul 2021
(arm B)
(djxzgqwgki) = ayvpwpaodx dkbqcydwgy (lhfohrsvtc )
Phase 2
Neoplasms
TP53 Wild-type | MDM2 Amplification | CDK4 Amplification
12
ALRN-6924+palbociclib
(mqgwxvgedl) = neutropenia, thrombocytopenia, leukopenia, increased ALT, pulmonary embolism, and fall wyixbfzsiz (qhfswgmwya )
Positive
28 Sep 2019
Not Applicable
TP53 wild-type
-
aomwlygwhi(ymefgfnqip) = yvnhdwezoh wwrylygoha (wiworwgdqj )
Positive
15 Feb 2019
aomwlygwhi(ymefgfnqip) = jufdtlztar wwrylygoha (wiworwgdqj )
Phase 1
69
lfxyikyzum(cayolnaqma) = DLTs were G3 fatigue at 3.1 mg/kg, and G3 hypotension, G3 alkaline phosphatase elevation, G3 anemia and G4 neutropenia at 4.4 mg/kg all in 5 pts in arm A. No G3/4 thrombocytopenia was observed. All DLTs resolved with dose hold. zdprjhwkbq (sheognvfzu )
Positive
30 May 2017
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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