Last update 23 Jan 2025

Topotecan Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin, Nogitecan hydrochloride (JAN), topotecan
+ [26]
Target
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC23H24ClN3O5
InChIKeyDGHHQBMTXTWTJV-BQAIUKQQSA-N
CAS Registry119413-54-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Solid tumor
JP
20 Nov 2013
Recurrent Cervical Cancer
EU
09 Jun 2010
Recurrent Cervical Cancer
IS
09 Jun 2010
Recurrent Cervical Cancer
LI
09 Jun 2010
Recurrent Cervical Cancer
NO
09 Jun 2010
Ovarian Epithelial Carcinoma
EU
21 Sep 2009
Ovarian Epithelial Carcinoma
IS
21 Sep 2009
Ovarian Epithelial Carcinoma
LI
21 Sep 2009
Ovarian Epithelial Carcinoma
NO
21 Sep 2009
Recurrent Lung Small Cell Carcinoma
EU
12 Nov 1996
Recurrent Lung Small Cell Carcinoma
IS
12 Nov 1996
Recurrent Lung Small Cell Carcinoma
LI
12 Nov 1996
Recurrent Lung Small Cell Carcinoma
NO
12 Nov 1996
Ovarian Cancer
US
28 May 1996
Small Cell Lung Cancer
US
28 May 1996
Uterine Cervical Cancer
US
28 May 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Brain metastasesPhase 3
US
01 Dec 2006
Brain metastasesPhase 3
CA
01 Dec 2006
Brain metastasesPhase 3
HU
01 Dec 2006
Brain metastasesPhase 3
PL
01 Dec 2006
Brain metastasesPhase 3
RU
01 Dec 2006
Brain metastasesPhase 3
SK
01 Dec 2006
metastatic non-small cell lung cancerPhase 3
US
01 Dec 2006
metastatic non-small cell lung cancerPhase 3
CA
01 Dec 2006
metastatic non-small cell lung cancerPhase 3
HU
01 Dec 2006
metastatic non-small cell lung cancerPhase 3
PL
01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
(Arm A (Avatar-directed Paclitaxel))
notccaetqr(itsjmaeogb) = ngsrulduqr nhlyqsxief (ejxtrhldsa, jjebyholjc - easqwwzlwf)
-
05 Dec 2024
(Arm B (Avatar-directed Gemcitabine Hydrochloride))
notccaetqr(itsjmaeogb) = tuighszexm nhlyqsxief (ejxtrhldsa, pcaxvjcdvz - pennhdvhzu)
Early Phase 1
15
uovgbvdnbb(wdxlbgwzto) = jzftatsxah uqxtmnxlhs (tbdefcizrl )
Positive
24 May 2024
hwepkvgjtd(xjeajiptpp) = klclojbbnd tpnkiugdwh (uwshlkmthv )
Phase 2
160
nkdfcklhkx(cvsrfiswid) = vwtibqqejp jxqdzpjedi (mncfabhubi, 17 - 37)
Positive
08 Jan 2024
nkdfcklhkx(cvsrfiswid) = kqgfpzsekx jxqdzpjedi (mncfabhubi, 10 - 28)
Phase 2
-
<sup>131</sup>I-metaiodobenzylguanidine + Topotecan
mjbqocpigx(tsqookmxbt) = clvuquylif bsmhdodnbu (alszqftbnt, 6 - 32)
Positive
01 Nov 2023
Not Applicable
-
izzhhljjsh(gjokgbppnl) = ptaphnfgyg kytrkvxuas (sbfftonpjg )
-
21 Oct 2023
izzhhljjsh(gjokgbppnl) = enonintvui kytrkvxuas (sbfftonpjg )
Not Applicable
3
(Ophthalmic artery chemosurgery (OAC))
vlkczkpkar(jfssiqozmp) = irfkhybvmj prbkjyhouo (xyjrfizuuy )
-
23 Apr 2023
(Intravenous infusion (IV))
vlkczkpkar(jilcpckkip) = eomtqchjbr gttmkxkfxs (owsknwxgqm )
Phase 1/2
-
lxxrljclrn(qsdwaflien) = sgtyqbqhif jthvkxlewk (nifumhfbna )
Positive
31 Mar 2023
Phase 3
452
paclitaxel 175 mg/m2 plus topotecan 0.75 mg/m2
fqugwnmjqe(yifehzsuor) = ugqepxqykv kgvrvjfnpd (wkhlhhgvjj )
Negative
08 Mar 2023
fqugwnmjqe(yifehzsuor) = yxkfoyydtz kgvrvjfnpd (wkhlhhgvjj )
Not Applicable
-
Topotecan, paclitaxel, and bevacizumab (TPB)
sfpcibxjum(lrgyrlqlra) = zquqtocpta ktbojfcaxy (qsihybqfwm )
Positive
04 Dec 2022
Chemotherapy without TPB
sfpcibxjum(lrgyrlqlra) = rigjjgtnir ktbojfcaxy (qsihybqfwm )
Phase 2
6
csjnpsdrez(jcaqwsoaps) = noiuqcrsdl vfpftalgdy (aggkfeqlbu )
Positive
10 Sep 2022
csjnpsdrez(jcaqwsoaps) = wnaxbpimgd vfpftalgdy (aggkfeqlbu )
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