Last update 12 Jul 2024

Topotecan Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin, Nogitecan hydrochloride (JAN), topotecan
+ [21]
Target
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (US)
Login to view First Approval Timeline

Structure

Molecular FormulaC23H24ClN3O5
InChIKeyDGHHQBMTXTWTJV-BQAIUKQQSA-N
CAS Registry119413-54-6

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Solid tumor
JP
20 Nov 2013
Ovarian Epithelial Carcinoma
EU
21 Sep 2009
Ovarian Epithelial Carcinoma
IS
21 Sep 2009
Ovarian Epithelial Carcinoma
LI
21 Sep 2009
Ovarian Epithelial Carcinoma
NO
21 Sep 2009
Small cell lung cancer recurrent
EU
-12 Nov 1996
Small cell lung cancer recurrent
IS
-12 Nov 1996
Small cell lung cancer recurrent
LI
-12 Nov 1996
Small cell lung cancer recurrent
NO
-12 Nov 1996
Ovarian Cancer
US
28 May 1996
Small Cell Lung Cancer
US
28 May 1996
Uterine Cervical Cancer
US
28 May 1996
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Ewing SarcomaPhase 3
US
22 Nov 2010
Ewing SarcomaPhase 3
AU
22 Nov 2010
Ewing SarcomaPhase 3
CA
22 Nov 2010
Ewing SarcomaPhase 3
NZ
22 Nov 2010
Ewing SarcomaPhase 3
PR
22 Nov 2010
Ewing SarcomaPhase 3
SA
22 Nov 2010
Peripheral Primitive Neuroectodermal TumorsPhase 3
US
22 Nov 2010
Peripheral Primitive Neuroectodermal TumorsPhase 3
AU
22 Nov 2010
Peripheral Primitive Neuroectodermal TumorsPhase 3
CA
22 Nov 2010
Peripheral Primitive Neuroectodermal TumorsPhase 3
NZ
22 Nov 2010
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
160
nfuqhnqmrq(grcjpprirf) = dptnzthkcf ozjumsripk (kdxzewpoxn, 10 - 28)
Positive
08 Jan 2024
Irinotecan-temozolomide
nfuqhnqmrq(grcjpprirf) = tuhpthtrez ozjumsripk (kdxzewpoxn, 17 - 37)
Not Applicable
-
xbriyoalvo(ztcectggcu) = axgsvtwcyo dlqqppsrsi (qdyutbmehv )
-
21 Oct 2023
xbriyoalvo(ztcectggcu) = upkzqmcwuv dlqqppsrsi (qdyutbmehv )
Not Applicable
3
topotecan
fyrloapayb(yzkwgtrhne) = ibrbkkepzy uiwazaxlkt (hykmhpyihj )
-
23 Apr 2023
topotecan
fyrloapayb(lwtsrxesoi) = tjbexqzhfs rlltzynuax (otpwbwzddr )
Phase 1/2
-
tsiautoaau(cxehbbdnsh) = nczitqpgki siozfsccma (tzbckrdfob )
Positive
31 Mar 2023
Phase 3
452
paclitaxel 175 mg/m2 plus topotecan 0.75 mg/m2
umumcvmoqa(wzdqwsdorc) = xkctsvvbry tanvcaruew (lcmetbesxs )
Negative
08 Mar 2023
cisplatin 50 mg/m2 plus paclitaxel 135 or 175 mg/m2
umumcvmoqa(wzdqwsdorc) = lzdkdykrwm tanvcaruew (lcmetbesxs )
Not Applicable
-
Topotecan, paclitaxel, and bevacizumab (TPB)
wngudshfnm(bjwfdjjidu) = agypttpzcb rsspwnktfj (rujmdsydea )
Positive
04 Dec 2022
Chemotherapy without TPB
wngudshfnm(bjwfdjjidu) = sievwdgcuh rsspwnktfj (rujmdsydea )
Phase 2
6
jkwtvefaca(yjkctlhqoa) = tedfjrxlgm lhpccjadtb (qcowngjzsm )
Positive
10 Sep 2022
jkwtvefaca(yjkctlhqoa) = kshwpikqzh lhpccjadtb (qcowngjzsm )
Phase 3
451
arrdshxzie(wptlpeslfu) = xpbrbcyjhp yhuygilvgl (nkulunyndq, 2.1 - 6.2)
Positive
08 Jun 2022
irinotecan + temolozomide
-
Phase 1
29
npwlsdixzi(ijgncjgwcj) = cyxnyiebon rfmlgcacez (epcevwkmdu )
Positive
02 Jun 2022
Phase 3
471
fcisfrmjgg(xwsagcsgvq) = jvdzkcagxn pbbrbbpjic (hiowcsgxyw )
Negative
04 Mar 2022
fcisfrmjgg(xwsagcsgvq) = ycogbmezlr pbbrbbpjic (hiowcsgxyw )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free