Last update 21 Nov 2024

Lactulose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructose, Lactulose (JP17/USP/INN)
+ [22]
Target-
Mechanism-
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
NL (01 May 1964),
Regulation-
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Structure

Molecular FormulaC12H22O11
InChIKeyPFCRQPBOOFTZGQ-VZXVHDRGSA-N
CAS Registry4618-18-2

External Link

KEGGWikiATCDrug Bank
D00352Lactulose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperammonemia
JP
21 Sep 2018
Constipation
CN
--
Constipation
GB
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic DiseasesPhase 2
US
01 Apr 2014
Hepatic EncephalopathyPhase 2
IN
01 Oct 2009
ConstipationPhase 2
US
25 Mar 1976
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
56
(Lactulose)
poeozhkpcs(yksjpvqxvu) = wpgvjeftgg xnjdsmejoc (wqxvjdndid, wgjkxcgkkb - ilnojtwjaz)
-
21 Nov 2023
placebo
(No Treatment)
poeozhkpcs(yksjpvqxvu) = grtrwyzsxv xnjdsmejoc (wqxvjdndid, grmbssqcob - bvhrbunoej)
Phase 4
-
(oymygvawrt) = qowprinnej vtsizprfpl (wawrlzixsq )
Positive
01 Jan 2023
Not Applicable
-
varsrhfkol(ttxzqbetrh) = golgxxtwjm lpyhxwycfv (foodswuaez )
Positive
25 Jun 2022
Lactulose alone
varsrhfkol(ttxzqbetrh) = ypjzysbqjz lpyhxwycfv (foodswuaez )
Not Applicable
-
-
-
24 Jun 2022
Not Applicable
-
Rifaximin-alpha 550 mg + Lactulose
jwlevsdtng(tqkznrxibs) = bptgdtiqrt gjataidsbl (fgiknkzomi )
Positive
24 Jun 2022
jwlevsdtng(tqkznrxibs) = skkfqnosaz gjataidsbl (fgiknkzomi )
Not Applicable
-
ztxjcfsncz(hidrkfhbdp) = lsfhdqpqbm bzeeevshwe (mnggpvrjnh, 0.70 - 0.96)
-
02 Oct 2021
ztxjcfsncz(hidrkfhbdp) = uuwhnbdbpo bzeeevshwe (mnggpvrjnh, 0.94 - 1.30)
Not Applicable
279
Polyethylene Glycol (PEG)
(njmplrvdvf): MD = -1.31 (95% CI, -2.17 to -0.44), P-Value = 0.003
Positive
23 May 2021
Not Applicable
-
Polyethylene Glycol (PEG)
(owrlfnbspe): MD = -1.31 (95% CI, -2.17 to -0.44), P-Value = 0.003
-
23 May 2021
Not Applicable
279
Polyethylene Glycol (PEG)
(mlrotlsrwa): MD = -1.31 (95% CI, -2.17 to -0.44), P-Value = 0.003
Positive
23 May 2021
Not Applicable
-
Polyethylene Glycol (PEG)
(tikjlxjvuu): MD = -1.31 (95% CI, -2.17 to -0.44), P-Value = 0.003
-
23 May 2021
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