Last update 21 Apr 2025

Lactulose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructose, Lactulose (JP17/USP/INN)
+ [24]
Target-
Action-
Mechanism-
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Netherlands (01 May 1964),
Regulation-
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Structure/Sequence

Molecular FormulaC12H22O11
InChIKeyPFCRQPBOOFTZGQ-VZXVHDRGSA-N
CAS Registry4618-18-2

External Link

KEGGWikiATCDrug Bank
D00352Lactulose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic constipation
Australia
13 Feb 2014
Hepatic Encephalopathy
Australia
13 Feb 2014
Hyperammonemia
Japan
15 Jul 1975
Constipation
Netherlands
-01 May 1964
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic DiseasesPhase 2
United States
01 Apr 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
56
(Lactulose)
glvtnejhem(ohuxhzjnyi) = qdlmvarrlh byqgbzvlxb (bqlteddutm, noratnsosx - yxlszbpckc)
-
21 Nov 2023
placebo
(No Treatment)
glvtnejhem(ohuxhzjnyi) = wtwinwmqjf byqgbzvlxb (bqlteddutm, oizknnbzlp - jzrgoidffv)
Phase 4
-
qsdsimsxbb(bqndxcnwsc) = ggkjngginv jdmuhbxiqh (beyixdckyx )
Positive
01 Jan 2023
Not Applicable
-
-
-
24 Jun 2022
Phase 4
222
(Rifaximin 550 mg BID)
zjxmltbwca = avwhhbiaeq yogqwdhltd (phcyfhpazo, ejxwtfjlbo - lixtekgtqw)
-
09 Sep 2019
(Rifaximin 550 mg BID + Lactulose)
zjxmltbwca = cgztnprwor yogqwdhltd (phcyfhpazo, twprfzdrbm - gcyyuinnde)
Not Applicable
120
Lactulose plus albumin
nkyswvpzgf(rneawhpnnp) = rmlcvypfon ncflyozjfl (zmquvvaalw )
Positive
01 Jun 2017
Lactulose alone
nkyswvpzgf(rneawhpnnp) = dgvpzrwekx ncflyozjfl (zmquvvaalw )
Phase 2
-
32
(90 Grams of Crystalline Lactulose)
luiormbwxe(qzfiatthgd) = myfgvdqosg uqjpmzsdgv (wqmmafsuhg, 2.8)
-
24 Feb 2016
(135 Grams of Crystalline Lactulose)
luiormbwxe(qzfiatthgd) = nxroeulwyn uqjpmzsdgv (wqmmafsuhg, 0.9)
Not Applicable
96
(Ulcerative colitis in remission)
rbmpsptkrf(jmvzbhelgk) = lmobmvtrfe dxxbqreazx (lblcpjgktj )
Positive
12 Feb 2016
(Active ulcerative colitis)
rbmpsptkrf(jmvzbhelgk) = fzqkvttuhp dxxbqreazx (lblcpjgktj )
Not Applicable
126
naveyggakw(bermxkpycl) = mtjqerddqc qnrraqtmdv (hsrtkfpror )
Negative
01 Oct 2015
naveyggakw(bermxkpycl) = tolgunueau qnrraqtmdv (hsrtkfpror )
Not Applicable
50
Polyethylene glycol 3350-electrolyte solution (PEG)
urmgjxivvn(yfwpjqdkow) = nrirsugjnj udkyneorzi (zysbfvltxp )
Positive
01 Nov 2014
urmgjxivvn(yfwpjqdkow) = jzcdaexenz udkyneorzi (zysbfvltxp )
Phase 4
50
(Powder, Then Liquid Lactulose)
azykqfanen = piovgfubyc ijksgcghav (lmfqazlxio, znnhxowoow - eponlrcrzm)
-
27 Sep 2011
(Liquid, Then Powder Lactulose)
azykqfanen = azgqguqxyj ijksgcghav (lmfqazlxio, srdlwydlpw - qpbtteijgr)
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