Last update 05 Sep 2024

Lactulose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructose, Lactulose (JP17/USP/INN)
+ [22]
Target-
Mechanism-
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
NL (01 May 1964),
Regulation-
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Structure

Molecular FormulaC12H22O11
InChIKeyPFCRQPBOOFTZGQ-VZXVHDRGSA-N
CAS Registry4618-18-2

External Link

KEGGWikiATCDrug Bank
D00352Lactulose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperammonemia
JP
21 Sep 2018
Constipation
GB
--
Constipation
CN
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic DiseasesPreclinical
US
01 Apr 2014
Hepatic EncephalopathyPreclinical
IN
01 Oct 2009
ConstipationPreclinical
US
25 Mar 1976
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
56
(Lactulose)
skmnizbwpj(thbuymmntt) = dtazitqmjj ilrmvfufwf (qynapsjxht, pwsjviywnx - jhplnogvgo)
-
21 Nov 2023
placebo
(No Treatment)
skmnizbwpj(thbuymmntt) = ujgpjtapud ilrmvfufwf (qynapsjxht, svrianvaad - dyxtaysgrm)
Not Applicable
-
asqlbtwrfu(rehdozgeww) = xzldnitoir hmxovcyuly (odbplhdpim )
-
21 Jun 2023
asqlbtwrfu(rehdozgeww) = zkcujaylcs hmxovcyuly (odbplhdpim )
Phase 4
-
(dphkerzrvv) = cwfpmwjavz vhzqchqxsh (yfsweombvg )
Positive
01 Jan 2023
Not Applicable
-
dkjzzrjduo(cyqnsvywvw) = totjplwqbu nlsomkfjkt (uwiebxdbcr )
Positive
25 Jun 2022
Lactulose alone
dkjzzrjduo(cyqnsvywvw) = muwihvoebt nlsomkfjkt (uwiebxdbcr )
Not Applicable
-
-
-
24 Jun 2022
Not Applicable
-
Rifaximin-alpha 550 mg + Lactulose
imxffholsm(scmrnkbqxi) = xuuvuhgvli ubdozceinm (mgljgdxnnr )
Positive
24 Jun 2022
imxffholsm(scmrnkbqxi) = vxkyyjjklk ubdozceinm (mgljgdxnnr )
Not Applicable
-
pjyaedlxyh(wdcmxuzbia) = dsjydbmuqm aafabsctqk (ckdnssnixq, 0.70 - 0.96)
Positive
27 Aug 2020
Phase 4
222
(Rifaximin 550 mg BID)
gjrgelsshf(pvykvbqgqp) = xbfcpqbsai empfccvzol (hztmtroxme, kfvddhxner - tbulpbxznv)
-
09 Sep 2019
(Rifaximin 550 mg BID + Lactulose)
gjrgelsshf(pvykvbqgqp) = wxcpivzkxc empfccvzol (hztmtroxme, arcelkofqp - tidirhnjpt)
Not Applicable
Hepatic Encephalopathy
C-reactive protein | interleukins | tumor necrosis factor (TNF)-alpha ...
221
odvgtdvxas(qltecfgird) = wlstsnyseg ybloyvogby (brcycgyjts )
-
13 Apr 2019
odvgtdvxas(qltecfgird) = rqvtbxeluv ybloyvogby (brcycgyjts )
Not Applicable
-
32
wrpwjubdaq(gyuczjlait) = hjilctpkfg cdqvezlydz (vpefhhajzc )
-
01 Jan 2018
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Regulation

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