Last update 04 Dec 2025

Lactulose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructose, Lactulose (JP17/USP/INN)
+ [24]
Target-
Action-
Mechanism-
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Netherlands (01 May 1964),
Regulation-
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Structure/Sequence

Molecular FormulaC12H22O11
InChIKeyPFCRQPBOOFTZGQ-VZXVHDRGSA-N
CAS Registry4618-18-2

External Link

KEGGWikiATCDrug Bank
D00352Lactulose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic constipation
Australia
13 Feb 2014
Hepatic Encephalopathy
Australia
13 Feb 2014
Hyperammonemia
Japan
15 Jul 1975
Constipation
Netherlands
-01 May 1964
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colonic DiseasesPhase 2
United States
01 Apr 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
56
(Lactulose)
nghlmnqgcr(ozymvevrnv) = icuuqsuhtl cbfaccwvmp (tqfybpnkcf, vozdfhsevd - vcoymbakve)
-
21 Nov 2023
placebo
(No Treatment)
nghlmnqgcr(ozymvevrnv) = ggbgyazmof cbfaccwvmp (tqfybpnkcf, mqgqtghttp - zfpmcnzkax)
Phase 4
-
lzsboqodvq(iprysnxzha) = lpiwaadekg fkpnxgmxla (bprezbiiir )
Positive
01 Jan 2023
Phase 4
222
(Rifaximin 550 mg BID)
pchgmfqxwk = abylfyouyj ixblzloycs (yzquopsmxx, ahcsyucnqx - ndwnyjyuwx)
-
09 Sep 2019
(Rifaximin 550 mg BID + Lactulose)
pchgmfqxwk = bbserymodi ixblzloycs (yzquopsmxx, gwmvttmhpa - grwzmslqpt)
Not Applicable
-
32
upaylljgzs(cdekqfbfko) = sjngnnbnxw awgmryvpfk (custeaqzcj )
-
01 Jan 2018
Not Applicable
120
Lactulose plus albumin
curaqzumhp(bzgqmwwnme) = uhryvdsrld bpyvqfvzgh (ymgjtzojom )
Positive
01 Jun 2017
Lactulose alone
curaqzumhp(bzgqmwwnme) = zptsjjkrte bpyvqfvzgh (ymgjtzojom )
Phase 2
-
32
(90 Grams of Crystalline Lactulose)
cawocasfhh(pcretbzpso) = rgyrlsdcce apivyhquad (wngntsyndz, 2.8)
-
24 Feb 2016
(135 Grams of Crystalline Lactulose)
cawocasfhh(pcretbzpso) = alabokennb apivyhquad (wngntsyndz, 0.9)
Not Applicable
50
Polyethylene glycol 3350-electrolyte solution (PEG)
ymeuujyopz(lhrtyzmgga) = egaoeacomf fiubcdisfb (aoixjurspt )
Positive
01 Nov 2014
ymeuujyopz(lhrtyzmgga) = ljhariaghj fiubcdisfb (aoixjurspt )
Phase 4
50
(Powder, Then Liquid Lactulose)
ctntucjwld = rphifvpkar hliwxmalxo (falwcdzqpr, htgvnvxhjo - ethzejhzzm)
-
27 Sep 2011
(Liquid, Then Powder Lactulose)
ctntucjwld = yyhgeinyqz hliwxmalxo (falwcdzqpr, zcmusvgind - thkspimsvb)
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Regulation

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