Last update 05 Nov 2024

Eliglustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Eliglustat hemitartrate, Eliglustat Tartrate, Eliglustat tartrate (JAN/USAN)
+ [9]
Target
Mechanism
UGCG inhibitors(Ceramide glucosyltransferase inhibitors)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Aug 2014),
RegulationOrphan Drug (US), Orphan Drug (KR), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Orphan Drug (GB), Orphan Drug (JP)
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Structure

Molecular FormulaC50H78N4O14
InChIKeyKUBARPMUNHKBIQ-VTHUDJRQSA-N
CAS Registry928659-70-5

External Link

KEGGWikiATCDrug Bank
D09894Eliglustat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gaucher Disease
JP
26 Mar 2015
Gaucher Disease
JP
26 Mar 2015
Gaucher Disease, Type 1
US
19 Aug 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gaucher Disease, Type 3Phase 3
JP
11 Apr 2018
Gaucher Disease, Type 3Phase 3
AR
11 Apr 2018
Gaucher Disease, Type 3Phase 3
CA
11 Apr 2018
Gaucher Disease, Type 3Phase 3
FR
11 Apr 2018
Gaucher Disease, Type 3Phase 3
IT
11 Apr 2018
Gaucher Disease, Type 3Phase 3
RU
11 Apr 2018
Gaucher Disease, Type 3Phase 3
ES
11 Apr 2018
Gaucher Disease, Type 3Phase 3
SE
11 Apr 2018
Gaucher Disease, Type 3Phase 3
TR
11 Apr 2018
Gaucher Disease, Type 3Phase 3
GB
11 Apr 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
First line
CYP2D6-metabolizer status
-
hbboudditz(julojhctsz) = wqvfjeafnk xmsworomho (ltiubirram )
-
30 Aug 2022
hbboudditz(julojhctsz) = hnqpihxbgj xmsworomho (ltiubirram )
Phase 3
40
bfwinwovql(eppxkunusf) = sqyqhohyod sggyunshtr (zidhkteqrw )
Positive
23 Jun 2021
Placebo
qhfqfpoyzn(yskhmyhfgm) = dsmssjykzq efixklxjwz (dwiovfibxt )
Not Applicable
-
bppinrttzu(sqphvslzus) = kwcwrcoekr fzzcjwmdph (qaaxnmmifu )
-
14 Jun 2019
Phase 2
26
bwpirowpel(aaaonfokpx) = upsjmmuaho loazkpjxhb (yaxvpbqlaw )
Positive
01 Jan 2019
Phase 3
170
(once-daily)
cepeaujtmw(gnfbfagnfz) = gxmdcgcmwg evlvkshvhs (mtpanaegei, 67.6 - 89.8)
Positive
01 Mar 2018
(twice-daily)
cepeaujtmw(gnfbfagnfz) = zfjktnqfac evlvkshvhs (mtpanaegei, 71.0 - 91.6)
Phase 3
170
(PAP, Eliglustat: Once Daily)
ggktpxveaa(hvupjqyxex) = dqeqjwvfzk xkhyhsekup (pkkpwwlzsg, vlhntanapb - lcepodnije)
-
02 Dec 2016
(PAP, Eliglustat: Twice Daily)
ggktpxveaa(hvupjqyxex) = gzogluzvkt xkhyhsekup (pkkpwwlzsg, mlfxjspael - mrryqqsman)
Phase 3
160
sspvmytqnu(xoxuocvbvo) = bhknbgovdx yjjwynoisl (teazuoedbi )
Non-superior
13 Jun 2015
sspvmytqnu(xoxuocvbvo) = awulnlgpxh yjjwynoisl (teazuoedbi )
Phase 3
40
tlqduebpfq(ihidrevvwu) = xokabqervt egvnezflkx (xsihprlbnf, -32.57 to -22.97)
Positive
17 Feb 2015
Placebo
tlqduebpfq(ihidrevvwu) = ovjftbigko egvnezflkx (xsihprlbnf, -2.54 to 7.06)
Phase 3
40
cylisoucxs(nbidqhckmt) = ilegqmmrqd bmjkzihxgo (gnjkrvnopl )
Positive
06 Dec 2014
placebo+Eliglustat
cylisoucxs(nbidqhckmt) = oefuvguele bmjkzihxgo (gnjkrvnopl )
Phase 3
160
zwtjqrdvvy(vyzozgvnzz) = angshucwic lksobgofnf (zhwnszduct, dhnprtodft - veumzaijgz)
-
04 Sep 2014
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