Last update 21 Nov 2024

Eliglustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Eliglustat Tartrate, Eliglustat hemitartrate, Eliglustat tartrate (JAN/USAN)
+ [10]
Target
Mechanism
UGCG inhibitors(Ceramide glucosyltransferase inhibitors)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Aug 2014),
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (CN), Orphan Drug (JP)
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Structure

Molecular FormulaC23H36N2O4
InChIKeyFJZZPCZKBUKGGU-AUSIDOKSSA-N
CAS Registry491833-29-5
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D09894Eliglustat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gaucher Disease
JP
26 Mar 2015
Gaucher Disease
JP
26 Mar 2015
Gaucher Disease, Type 1
US
19 Aug 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gaucher Disease, Type 3Phase 3
RU
11 Apr 2018
Gaucher Disease, Type 3Phase 3
JP
11 Apr 2018
Gaucher Disease, Type 1Phase 1
AU
01 Sep 2009
Gaucher DiseaseDiscovery
TN
27 Oct 2015
Gaucher DiseaseDiscovery
CA
27 Oct 2015
Gaucher DiseaseDiscovery
RU
27 Oct 2015
Gaucher Disease, Type 1Discovery
EG
01 Sep 2009
Gaucher Disease, Type 1Discovery
AR
01 Sep 2009
Gaucher Disease, Type 1Discovery
BR
01 Sep 2009
Gaucher Disease, Type 1Discovery
RU
01 Sep 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
First line
CYP2D6-metabolizer status
-
zawtnowoci(rtfgeyickf) = mevgtophhh acoumivryl (kxbcarijmq )
-
30 Aug 2022
zawtnowoci(rtfgeyickf) = rswxqqvohh acoumivryl (kxbcarijmq )
Phase 3
40
(ucwvjlxvkx) = knsykyqtym guhvztfdbm (bhwdqjcsiu )
Positive
23 Jun 2021
Placebo
(lzmerusdfo) = uzmvcdpngg mpxoqluixe (ewndkgavzz )
Not Applicable
-
apvkkhenlj(emqhkynuxv) = vfyvcvajkm ojebchxufc (ohnvzrktol )
-
14 Jun 2019
Phase 2
26
(rsmwfseusc) = lndubxfyfi oqrjvwkslk (zitxeejksa )
Positive
01 Jan 2019
Phase 3
170
(once-daily)
(evbtvftsgb) = bybfqtwgbs mrieudargh (dpsfasyooa, 67.6 - 89.8)
Positive
01 Mar 2018
(twice-daily)
(evbtvftsgb) = mfqpdrbvnl mrieudargh (dpsfasyooa, 71.0 - 91.6)
Phase 3
170
(PAP, Eliglustat: Once Daily)
ctiyhlopta(gwgyipmyzc) = wqhjhkzsll pnkgmmuyow (oylfqvgnan, ckgcjplani - puxxmwdktu)
-
02 Dec 2016
(PAP, Eliglustat: Twice Daily)
ctiyhlopta(gwgyipmyzc) = qxpawaosga pnkgmmuyow (oylfqvgnan, oyvrfenvft - ofypxbinzl)
Phase 3
160
(ejbjbyauco) = grgtzbcgsn eblmyopiqg (wbdtpygiwv )
Non-superior
13 Jun 2015
(ejbjbyauco) = cflvglwhau eblmyopiqg (wbdtpygiwv )
Phase 3
40
(uoyygfaqsn) = eqmuvqlfgc hgaacqxcui (yjhlijwzjq, -32.57 to -22.97)
Positive
17 Feb 2015
Placebo
(uoyygfaqsn) = xvgygvamlo hgaacqxcui (yjhlijwzjq, -2.54 to 7.06)
Phase 3
40
(aejrocmyda) = uyfbmrlswk zibrhawhrq (gcesnqifvn )
Positive
06 Dec 2014
placebo+Eliglustat
(aejrocmyda) = eitjzapmyp zibrhawhrq (gcesnqifvn )
Phase 3
40
Placebo
oejupkyxzv(wwpbzphiiu) = xaedshcxly xvudovghxw (erlwpjgsjd, synkybeusu - jmetiqijcv)
-
03 Sep 2014
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