Last update 09 Oct 2024

Mometasone Furoate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ASCEND mometasone furoate-coated sinus balloon, Bioabsorbable mometasone-eluting sinus implants - Intersect ENT, Controlled-release-mometasone-furoate
+ [48]
Target
Mechanism
GR agonists(Glucocorticoid receptor agonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (30 Apr 1987),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H30Cl2O6
InChIKeyWOFMFGQZHJDGCX-ZULDAHANSA-N
CAS Registry83919-23-7

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic rhinosinusitis with nasal polyps
US
08 Dec 2017
Asthma
US
30 Mar 2005
Nasal Polyps
US
15 Dec 2004
Rhinitis, Allergic
CN
14 Jul 2000
Dermatitis
CN
01 Jan 1999
Rhinitis, Allergic, Perennial
US
01 Oct 1997
Rhinitis, Allergic, Seasonal
US
01 Oct 1997
Alopecia Areata
JP
01 Oct 1993
Drug Eruptions
JP
01 Oct 1993
Eczema
JP
01 Oct 1993
Erythema exudativum
JP
01 Oct 1993
Erythrodermic psoriasis
JP
01 Oct 1993
Impetigo
JP
01 Oct 1993
Keloid
JP
01 Oct 1993
Lupus Erythematosus, Discoid
JP
01 Oct 1993
Pemphigoid, Bullous
JP
01 Oct 1993
Pityriasis
JP
01 Oct 1993
Prurigo
JP
01 Oct 1993
Psoriasis
JP
01 Oct 1993
Inflammation
US
30 Apr 1987
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic sinusitisPhase 3
US
24 Jan 2022
Rhinitis perennialPhase 3
CN
10 Apr 2019
Nasal ObstructionPhase 3
AR
01 Oct 2012
SneezingPhase 3
AR
01 Oct 2012
Seasonal rhinitisPhase 3-01 Aug 2008
Congestion of nasal mucosaPhase 3-01 Jul 2008
Intermittent asthmaPhase 3-01 May 2008
Hypertrophy of adenoidsPhase 3-01 Aug 2007
Persistent InfectionPhase 3-01 Sep 2006
Persistent asthmaPhase 3-01 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
16
(Mometasone 1mg)
fvosfrldai(txhlqcpdhe) = glvypmsnsm mjluzegvmc (baavjjlvml, lqzmhjizyo - bedhijnfhz)
-
12 Aug 2024
(Mometasone 2mg)
fvosfrldai(txhlqcpdhe) = lghomfehtu mjluzegvmc (baavjjlvml, lkitnpvmnh - fmscrymgvt)
Phase 2
43
ESO-101
hqsesfttfe(cqlvxxledf) = met with a statistically significant reduction of the peak eosinophil count (p=0.0318) compared to placebo. quhxsryggk (ihztlqvtnf )
Positive
05 Dec 2023
placebo
Phase 2
24
Standard of Care (Soc)+QMF149+Mometasone furoate
kddqgkjshb(kdklzvoiuo) = iiqlcecdaq ytlgxextoa (cykelbinqj, kzugpujiuv - trayoosxcf)
-
27 Jul 2023
Phase 2
71
(LYR-210 (Low Dose))
uycfzuhkrr(yovndkoarl) = hkkcqlbfle pqahcfrkdw (odsjmkauek, pyylatlzoh - qdwetwinyb)
-
06 Jun 2023
(LYR-210 (High Dose))
uycfzuhkrr(yovndkoarl) = hocleaafoy pqahcfrkdw (odsjmkauek, ntbjewnneo - inyzsnftoc)
Not Applicable
-
37
egelybrqci(bmorajbzgo) = lwmznqxpay lfzeoinakw (jnvqgyicki )
-
01 Feb 2021
egelybrqci(bmorajbzgo) = caafebhyiy lfzeoinakw (jnvqgyicki )
Phase 4
53
(Mometasone Furoate Nasal Irrigation)
mfeobghjvu(hdphemnawa) = yifiatbbti qtqszwvrdb (erdnsmbytx, tcuwoeahay - qgvbnfpeqt)
-
19 Dec 2020
(Mometasone Nasal Spray)
mfeobghjvu(hdphemnawa) = ryzwxtxsvt qtqszwvrdb (erdnsmbytx, wpblcrorbo - wdqryesjej)
Phase 3
880
(NASONEX® Nasal Spray (Schering Corporation))
pkkvafhxjq(wsotvgoyrh) = lysrltizhl nyhyirtrfp (tffzobvicb, acokinpchu - sfsfttqost)
-
19 Aug 2020
(Mometasone Nasal Spray (Watson Laboratories, Inc))
pkkvafhxjq(wsotvgoyrh) = jzrlotpsps nyhyirtrfp (tffzobvicb, jckopzmvxd - fkjsefxvqm)
Not Applicable
739
Mometasone furoate 80 μg (Breezhaler®)
kglvctewoo(rpnqwislnl) = vohruiktqt tzfoxtrykw (enoqvodoeu, -34 to 89)
-
01 Jun 2020
Phase 3
802
indacaterol acetate+mometasone furoate
fomoisutji(sktmscfmvr): LSMD = 0.182, P-Value = <0.001
Positive
01 Jan 2020
Phase 3
50
ybjpekssig(xvqqpxguow) = ybdqoajasc fivnfcbtrl (uwfgmvrbci, lvniafjbsb - heoebivmjv)
-
27 Nov 2019
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