Last update 31 May 2025

Simmitecan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LP, Simmitecan hydrochloride
Target
Action
inhibitors
Mechanism
TOP1 inhibitors(DNA topoisomerase I inhibitors)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC34H39ClN4O6
InChIKeyUWNITDCAZZJJFF-GXUZKUJRSA-N
CAS Registry1247847-78-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neuroendocrine TumorsPhase 3
China
-
Colorectal CancerPhase 2
China
26 Feb 2019
Colorectal CancerPhase 2
China
26 Feb 2019
Metastatic Colorectal CarcinomaPhase 1
China
01 Oct 2016
Rectal CancerPhase 1
China
01 Oct 2016
Advanced Malignant Solid NeoplasmPhase 1
China
01 Dec 2012
Advanced Malignant Solid NeoplasmPhase 1
China
01 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
41
qywgdscdlg(vogwhxayye) = similar, i.e. anemia and febrile neutropenia (11.1% each) in LP, diarrhea (10%) in LP+5-FU/LV, febrile neutropenia (5.6%) in LP+T. hmqhtmkzoa (lijenupsdy )
Positive
29 May 2020
5-fluorouracil+leucovorin+simmitecan
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Clinical Trial

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Approval

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Regulation

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