Last update 05 Sep 2025

Leucovorin Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Calcium Folinate, Calcium folinate (JP17), Calcium Folinate and Sodium Chloride
+ [42]
Target-
Action-
Mechanism-
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (20 Jun 1952),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H23CaN7O7
InChIKeyBZPWXVJDMRBCMD-ZEDZUCNESA-N
CAS Registry1492-18-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Megaloblastic
Brazil
22 Jun 1999
Colorectal Cancer
Brazil
22 Jun 1999
Methotrexate poisoning
Brazil
22 Jun 1999
Drug intoxication
Japan
11 Jan 1963
Anemia
United States
20 Jun 1952
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Stage III Colon CancerPhase 3
Austria
01 Jan 2001
Stage III Colon CancerPhase 3
Belgium
01 Jan 2001
Stage III Colon CancerPhase 3
Egypt
01 Jan 2001
Stage III Colon CancerPhase 3
France
01 Jan 2001
Stage III Colon CancerPhase 3
Germany
01 Jan 2001
Stage III Colon CancerPhase 3
Italy
01 Jan 2001
Stage III Colon CancerPhase 3
Portugal
01 Jan 2001
Stage III Colon CancerPhase 3
Spain
01 Jan 2001
Stage III Colon CancerPhase 3
Switzerland
01 Jan 2001
Stage III Colon CancerPhase 3
United Kingdom
01 Jan 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
25
mqrpulxwln(yvuqlajxne) = xyagybryiv dcilgzvxxh (ozkrcaatjt, peukcauigp - bdetvndrsi)
-
23 Jul 2025
Phase 2
6
nigpmlmlwv = xojwclyihd zcdqhzivdc (cbhbseilyz, spskeancos - dbwygjuohm)
-
08 Jun 2025
nigpmlmlwv = enpmnrrtan zcdqhzivdc (cbhbseilyz, rgfqqdtewm - oqfplsigbv)
Phase 3
Stomach Cancer
Neoadjuvant
69
FLOT (5-fluorouracil, leucovorin, oxaliplatin and docetaxel)
mcmatgxgqv(pcfcdwidja) = weisrmoent jgounkihqa (lbixiydqne, 31.9 - 65.6)
Positive
01 Jun 2025
mcmatgxgqv(pcfcdwidja) = znjssynkao jgounkihqa (lbixiydqne, 8.9 - 39.8)
Phase 3
Metastatic Colorectal Carcinoma
First line | Maintenance
RAS - | BRAFV600E
-
FOLFIRI plus cetuximab
aaqyukmwxw(fqdifmdgba) = afgwxpbbji jvnbrhvwdz (gpiisgqfwz )
Positive
20 Apr 2025
aaqyukmwxw(fqdifmdgba) = lkthgbdkos jvnbrhvwdz (gpiisgqfwz )
Phase 2
28
tdviflidel = zurjciabrq pcjumydglc (zlmdhurxrd, ifzxrndbfx - dpdfpdufan)
-
18 Apr 2025
Phase 2
38
walouwjtap = kyjzwqsysl iucaqfxdsp (xkrbhjneqi, hbmrxfoxyw - anuiwgvwrf)
-
25 Feb 2025
Not Applicable
150
Nanoliposomal irinotecan and fluorouracil with folinic acid (NFF)
xalmnhxatm(lurisbykic) = djjmtrzndh ywyfjlkhoa (agphtclfcu, 6.6 - 9.2)
Positive
23 Jan 2025
Not Applicable
150
Nanoliposomal irinotecan and fluorouracil with folinic acid (NFF)
zcpgsanmxc(hnqklqoxcz) = osxfsirlyv mnpeydsthe (zmgettyffa )
Positive
23 Jan 2025
Phase 2
176
Arm A: Gemcitabine + Nab-Paclitaxel
fzrfxisfua(wvjrajbxxu) = gydzkkzdva fhpgjdkigj (nwpxfuftoz )
Positive
23 Jan 2025
Arm B: 5-Fluorouracil + Leucovorin + Liposomal Irinotecan
fzrfxisfua(wvjrajbxxu) = wbwgyevopc fhpgjdkigj (nwpxfuftoz )
Phase 1
14
avcumnkqpj(trfnjimtoi) = one pt at DL1 with transient G3 AST/ALT elevation and transient G2 colitis (resolved with steroids and infliximab), one pt at DL1 with G2 hypothyroidism and one patient at DL2 with G2 hyperthyroidism mfqfxrzbga (fdxvfjklov )
Positive
23 Jan 2025
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