Last update 01 Nov 2024

Sabizabulin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ABI-III analogues, ABI–III analogues, Bisindole
+ [7]
Target
Mechanism
Tubulin inhibitors
Originator Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationFast Track (US)
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Structure

Molecular FormulaC21H19N3O4
InChIKeyWQGVHOVEXMOLOK-UHFFFAOYSA-N
CAS Registry1332881-26-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19NDA/BLA
GB
-
Severe Acute Respiratory SyndromePhase 3
CO
18 May 2021
Respiratory Distress Syndrome, AdultPhase 2
BG
18 May 2021
Severe Acute Respiratory SyndromePhase 2
MX
18 May 2021
Severe Acute Respiratory SyndromePhase 2
AR
18 May 2021
Severe Acute Respiratory SyndromePhase 2
US
18 May 2021
Severe Acute Respiratory SyndromePhase 2
BR
18 May 2021
Respiratory Distress Syndrome, AdultDiscovery
BR
18 May 2021
Respiratory Distress Syndrome, AdultDiscovery
AR
18 May 2021
Severe Acute Respiratory SyndromeDiscovery
BG
18 May 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
204
(9mg of VERU-111 Oral Daily)
dqykymnfla(lhbjsasjqt) = qnbjnejmzk kcspouogoo (jkesowyzoi, zonyrugapx - bjlenrwvje)
-
18 Apr 2023
placebo
(Placebo Capsule Once Daily)
dqykymnfla(lhbjsasjqt) = qesinxeoii kcspouogoo (jkesowyzoi, jixutdtweo - pgrqiugeld)
Phase 2
58
zydoeqtaba(ytmjmnhrlw) = 5.6% and 3.7%, respectively flufglavtn (lpvulurumk )
-
10 Sep 2022
Phase 3
-
aljlvyyfjm(crowfvugeg) = dgbxycxtpf jrbqcqgslv (cgyeejtwjg )
Positive
23 Aug 2022
Placebo
aljlvyyfjm(crowfvugeg) = gbsryisgku jrbqcqgslv (cgyeejtwjg )
Phase 3
204
(pwandubnrm) = frkqcftcdx vzitkljewf (gcqvilcdhi )
Positive
06 Jul 2022
Placebo
(pwandubnrm) = cjohlhcqzy vzitkljewf (gcqvilcdhi )
Phase 1/2
80
aqmczfvrkw(azqatthbbd) = 5.6% and 3.7%, respectively sukqotkaif (rmebjqnzvz )
-
02 Jun 2022
Phase 3
245
(vqjmuklvqp) = fiknxkxuxd dcsluomhsn (dpugjzcymh )
Positive
16 Feb 2022
Phase 1/2
80
ybvxdysohn(vtfrqdzcnw) = no clinically relevant neurotoxicity tjqamuaumt (etgnjgtjsp )
Positive
16 Feb 2022
Phase 2
39
(Veru-111 18 mg)
oapejqbdzj(fzijkjcfil) = grrhelcseu kxzzoivxaz (odfhsigrbl, ebbclrrjmc - zrynccmkzv)
-
24 Nov 2021
(Placebo)
oapejqbdzj(fzijkjcfil) = wnstuwhrvu kxzzoivxaz (odfhsigrbl, pwwedxhoit - yzmhcuksxn)
Phase 1/2
-
(gafldlxfyk) = Sabizabulin was well tolerated with the most common adverse events (>10% frequency) in patients that received 63 mg dose (n=54) including diarrhea, fatigue, ALT and AST increases which were mostly Grade 1 and 2. oheqtgpbrb (mkkrkyifru )
Positive
19 Sep 2021
Phase 1/2
58
(mxvwxpzgov) = qqzauilvnr zctuskdteo (gkansboeis )
-
28 May 2021
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Approval

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Regulation

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