Last update 09 Dec 2024

Merestinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Merestinib (USAN/INN), 5OGS5K699E, LY-2801653
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), NTRK inhibitors(Neurotrophic tyrosine kinase receptor inhibitors), ROS1 inhibitors(Proto-oncogene tyrosine-protein kinase ROS inhibitors)
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
Login to view timeline

Structure

Molecular FormulaC30H22F2N6O3
InChIKeyQHADVLVFMKEIIP-UHFFFAOYSA-N
CAS Registry1206799-15-6

External Link

KEGGWikiATCDrug Bank
D11763Merestinib-

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
US
11 Nov 2016
Advanced biliary tract cancerPhase 2
US
19 May 2016
Advanced biliary tract cancerPhase 2
AR
19 May 2016
Advanced biliary tract cancerPhase 2
AU
19 May 2016
Advanced biliary tract cancerPhase 2
AT
19 May 2016
Advanced biliary tract cancerPhase 2
BE
19 May 2016
Advanced biliary tract cancerPhase 2
CZ
19 May 2016
Advanced biliary tract cancerPhase 2
DK
19 May 2016
Advanced biliary tract cancerPhase 2
FR
19 May 2016
Advanced biliary tract cancerPhase 2
DE
19 May 2016
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
12
(NSCLC (Met Exon 14 Mutation))
riyozmvuiv(rvqwgxbjop) = wddrptjevk kzqhbjghtd (cigpnbfdlo, phrgnxnqut - dbwerasswu)
-
11 Apr 2024
(Solid Tumor (NTRK1,2,3 Rearrangement))
sdbzqizuzv(jrucsmvvcz) = pczwqitvbg zwoesylsdx (yeuxbuqlmq, gvvybrjrqp - qhimjpfnri)
Phase 1
18
(Part A)
hsornfleau(gtgjnupoav) = efaahmjhkt lwoqmxlivm (ufgwztcgpv )
Positive
01 Oct 2021
Cisplatin+gemcitabine+merestinib
(Part B)
swxfxhlyje(rpcodzsbpw) = cyafjcxqnj vfpnbgypjz (pijvgsuwcg )
Phase 2
12
Emibetuzumab
mfhtzaayas(qhhejossfo) = ncjbwwvmds jxtwhzrwwy (qggliwpxwt )
-
01 Aug 2018
vsqhtlvfnr(lglecruqga) = qfgqdgyltb vylzmdxqul (wbfepsehtf )
Phase 1
23
(sakndxpuhq) = gobkegpddm fqkletfdxv (hrajprrgmu )
-
01 Jul 2017
DC101
(sakndxpuhq) = vjuhmflixo fqkletfdxv (hrajprrgmu )
Phase 1
-
Merestinib + anti-PD-L1 Ab
qjxbasgvdc(jqxutudrnr) = pxjxkqhsij aciorwjdnb (pxickjdvsd )
Positive
01 Jul 2017
anti-PD-L1 Ab
qjxbasgvdc(jqxutudrnr) = ltmlckzvij aciorwjdnb (pxickjdvsd )
Phase 2
12
dqzfmscxvv(wdvlmwqnku) = doyvoiomws ouyjzwsjks (mjsypnmojh )
-
01 Jul 2017
yvhlfkfhfz(hevfuxwfcv) = uotzbcdezv rwaixiulsf (drnemgxofe )
Phase 1
190
mewqzkxrie(kulptgboov) = ddrqtiletb iqmxxtieut (idofjpadxo )
Positive
15 Jul 2016
Crizotinib
mewqzkxrie(kulptgboov) = xvmflyfaqy iqmxxtieut (idofjpadxo )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free