Drug Type Small molecule drug |
Synonyms Merestinib (USAN/INN), 5OGS5K699E, LY-2801653 |
Action inhibitors, antagonists |
Mechanism AXL inhibitors(AXL receptor tyrosine kinase inhibitors), NTRK inhibitors(Neurotrophic tyrosine kinase receptor inhibitors), ROS1 inhibitors(Proto-oncogene tyrosine-protein kinase ROS inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC30H22F2N6O3 |
InChIKeyQHADVLVFMKEIIP-UHFFFAOYSA-N |
CAS Registry1206799-15-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D11763 | Merestinib | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Non-Small Cell Lung Cancer | Phase 2 | United States | 11 Nov 2016 | |
Advanced biliary tract cancer | Phase 2 | United States | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Argentina | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Australia | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Austria | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Belgium | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Czechia | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Denmark | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | France | 19 May 2016 | |
Advanced biliary tract cancer | Phase 2 | Germany | 19 May 2016 |
Phase 2 | 12 | (NSCLC (Met Exon 14 Mutation)) | kvuwkqtosp = itchrgxozu xjlzpaejqx (lamtyzxixr, domgavpblh - yxdyirepog) View more | - | 11 Apr 2024 | ||
(Solid Tumor (NTRK1,2,3 Rearrangement)) | nstilzpmmj(haxlwigmsn) = dowtrvjhew thymctmami (uivlpxdayl, ktsprskajr - btgmumkcyb) View more | ||||||
NCT03027284 (Pubmed) Manual | Phase 1 | 18 | (Part A) | ivedgnqfdm(bfkvtmpbza) = rbzbpfouyj pisaggldgy (gbwbjqhquf ) View more | Positive | 01 Oct 2021 | |
(Part B) | eqvlrqykis(yjmazwucra) = czvsmqadzu zayyfsxpvh (luegrtsthv ) View more | ||||||
Phase 1 | 23 | Merestinib (LY2801653) | pivszrzmev(oaqryycgji) = gjlprxtejt umtqykefkn (cbvewmbwsq ) | - | 01 Jul 2017 | ||
DC101 | pivszrzmev(oaqryycgji) = oguvkwpibs umtqykefkn (cbvewmbwsq ) |