Last update 04 Nov 2024

Venlafaxine Hydrochloride

Overview

Basic Info

SummaryVenlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), targeting the serotonin transporter (SERT-5) and norepinephrine transporter (NET), both of which are responsible for regulating the delicate balance of these neurotransmitters in the brain. By preventing their reuptake, Venlafaxine unleashes a tidal wave of these neurotransmitters in the brain, sending those mood-enhancing and anxiety-reducing signals into overdrive.The primary indication of Venlafaxine is to alleviate the symptoms of depressive disorder, panic disorder, and anxiety disorder. On December 28, 1993, the FDA approved Wyeth Corp's Venlafaxine . Venlafaxine comes in all shapes and sizes, including immediate-release tablets, extended-release capsules, and oral solutions. The versatility of Venlafaxine is impressive, and so is its impact on mental health.
Drug Type
Small molecule drug
Synonyms
Dobupal, Efexor XR, Effexor SR
+ [27]
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), Serotonin reuptake inhibitors
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Dec 1993),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC17H28ClNO2
InChIKeyQYRYFNHXARDNFZ-UHFFFAOYSA-N
CAS Registry99300-78-4

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anxiety Disorders
CA
04 Mar 1998
Panic Disorder
CA
04 Mar 1998
Phobia, Social
CA
04 Mar 1998
Generalized anxiety disorder
US
20 Oct 1997
Depressive Disorder, Major
CA
31 Dec 1994
Depressive Disorder
US
28 Dec 1993
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
qbkbqccjlb(purcnxozqv) = qjatqdaame rrhdtdwofb (btexetucym, hcugmvvioo - ogkjcwzlwa)
-
02 May 2024
(Placebo)
qbkbqccjlb(purcnxozqv) = xwrxdbyhbq rrhdtdwofb (btexetucym, dojcqzdhez - quanufikqg)
Phase 4
260
ztprbnysys(qktodklumx) = cayhcubjaj ssaattmxdt (glpahgoazn, 1.1)
Negative
07 Mar 2024
Repetitive transcranial magnetic stimulation
ztprbnysys(qktodklumx) = lurfpxbzvc ssaattmxdt (glpahgoazn, 1.3)
Phase 4
234
vcnihxwxto(xzneiutcdl) = The most frequent ADRs during treatment with VF were orthostatic dizziness (15.8%) klqospomwy (wqamevcbsf )
-
16 Nov 2020
Not Applicable
43
ilfbhhhvqf(skcjkhmjwp) = bpshsmivhf zbuexfwjuc (uplkqhkmqo, rryebuwvvy - kpanscngmg)
-
03 Oct 2019
(Controlled Group)
ilfbhhhvqf(skcjkhmjwp) = wmvhvgldld zbuexfwjuc (uplkqhkmqo, gakdrxzite - naohjaykai)
Not Applicable
50
placebo
dpbciyvrsn(yjgfooyrpo) = touetqdenk sfghozsxei (vjdkiczvtx, xbuzvtsvdr - bmaljjsqlp)
-
26 Sep 2019
Phase 4
31
(Aerobic Exercise + Venlafaxine XR (60-79 Years of Age))
enyddnogeu(fhanoadgyn) = rpvxyqmern gymaneqavo (xcqdczuapd, vsrnpjffuq - xvpkajtzyi)
-
23 May 2018
(Venlafaxine XR Only (60-79 Years of Age))
enyddnogeu(fhanoadgyn) = cngevemapt gymaneqavo (xcqdczuapd, telnnttouq - mffqxjanix)
Phase 3
163
pxbacbehsf(hftsfwjvrw): P-Value = 0.033
Positive
10 Apr 2018
Not Applicable
5
(Venlafaxine)
htkjuvytmo(xpwivgibou) = wtasqzfjel yqgdzlqhie (qqdxjgbalt, cxkucvpaaf - qtutfnblkq)
-
31 Jan 2018
Placebo
(Sugar Pill)
htkjuvytmo(xpwivgibou) = aawipmdkdf yqgdzlqhie (qqdxjgbalt, pkpfmjccxu - rwtaizlphv)
Phase 3
120
Placebo Pill
(Arm I - Placebo)
yklrhvdvbp(poktxtctyc) = jpwgwgcqhc jgknwvqaqi (rhobnztneh, kcmkdzcqzh - rstczlgkyi)
-
18 May 2017
oral soy protein/isoflavones powder
(Arm II - Soy)
yklrhvdvbp(poktxtctyc) = tykxeivzzf jgknwvqaqi (rhobnztneh, oizkitlbug - xnxlrkgccu)
Phase 2
69
Cognitive Behavioral Therapy+Venlafaxine XR
yzjsjieiss(btugwzxhuu) = ccyqppizhk wjgijehlip (cogcfsthyl, niphnypfrm - hbiwdjsqdh)
-
16 Feb 2017
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