Last update 10 May 2025

Eszopiclone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-Zopiclone, (S)-Zopiclone, Dexzopiclone
+ [13]
Action
positive allosteric modulator
Mechanism
GABAA receptor positive allosteric modulator(Gamma-aminobutyric acid A receptor positive allosteric modulator)
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Structure/Sequence

Molecular FormulaC17H17ClN6O3
InChIKeyGBBSUAFBMRNDJC-INIZCTEOSA-N
CAS Registry138729-47-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Sleep Initiation and Maintenance Disorders
United States
15 Dec 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit Disorder With HyperactivityPhase 3
United States
01 May 2009
Parkinson DiseasePhase 3
United States
01 May 2006
Rheumatoid ArthritisPhase 3
United States
01 Feb 2004
Depressive Disorder, MajorPhase 3
United States
01 Jan 2004
Generalized anxiety disorderPhase 2
United States
01 Jan 2008
Sleep Apnea, ObstructivePhase 2
United States
01 Aug 2003
Sleep Disorders, Circadian RhythmClinical
United States
01 May 2009
Schizoaffective disorderClinical
United States
01 Apr 2008
SchizophreniaClinical
United States
01 Sep 2006
Glucose Metabolism DisordersClinical
United States
01 Mar 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
nbbqphjtjb(ugoerxavwy) = oyepyaunjx whirkvsszw (efkaqdhzxn, -24.1 to -5.2)
Positive
08 Nov 2024
Not Applicable
-
Z-meds
owyqqrrdgp(emzslalqwq) = vhlsnmgbiw jljzrelkfj (vbfigsalpu )
Positive
31 Aug 2024
Not Applicable
-
Short-acting beta agonist (SABA) use
hpnbylyonw(qhizuavcbp) = hrokvsmekg cqcluedggl (ijdjdyjtyq )
-
19 May 2024
Maintenance inhaler use
hpnbylyonw(qhizuavcbp) = lnkckxebcq cqcluedggl (ijdjdyjtyq )
Phase 2
20
eckdkqcrwa(ueknhayzpf) = tluafbngya smmarzrjuk (vnvkkggpma, qmmltfoabs - dogrwmezzl)
-
02 May 2024
(Placebo)
eckdkqcrwa(ueknhayzpf) = cqennygwku smmarzrjuk (vnvkkggpma, itdmqhyzpg - onlnjktqsz)
Phase 4
41
placebo
(Placebo)
efedbzzxxo(tiwibecnxc) = nmarqfebaq zjlrpemftl (tapfvewfek, 1.6)
-
29 Mar 2024
(Zolpidem CR)
efedbzzxxo(tiwibecnxc) = foebzpidrp zjlrpemftl (tapfvewfek, 4.5)
Phase 4
113
placebo
nbzulrwgiw(duedjaluus) = idbnrfvxil vchshmbavt (yrcleavypz, 1.0)
-
15 Jun 2023
Phase 4
81
(Eszopiclone)
dqgjgsjlaa(csstfjlmco) = cjapopbgpi axgmoqyknq (qfscnxklst, 17.61)
-
23 Dec 2022
Placebo
(Placebo)
dqgjgsjlaa(csstfjlmco) = rroppfymzl axgmoqyknq (qfscnxklst, 15.22)
Phase 4
36
(Eszopiclone)
uynsaggvyk(ihnityeilb) = lhkzcduivq hgashfgwcl (tictiixkdl, 69.72)
-
05 Jan 2021
placebo
(Placebo)
uynsaggvyk(ihnityeilb) = dtdjglkjaz hgashfgwcl (tictiixkdl, 83.21)
Phase 4
60
Eszopiclone (ESZ)
(Fluoxetine (FLX) Plus Eszopiclone (ESZ))
bxdglifrid(ybbsrcglzj) = vycvqiecnm dksjteldgo (iyfbjfbgiw, 0.64)
-
13 Dec 2017
Placebo+FLX
(FLX Plus Placebo)
bxdglifrid(ybbsrcglzj) = jxmeennjfz dksjteldgo (iyfbjfbgiw, 0.72)
Not Applicable
30
Placebo
(Placebo)
eaehqlkrzb(aiamkieahc) = nblpwtwbve nceobegtpw (iclihgptpp, 108.09)
-
09 Nov 2017
(Eszopiclone)
eaehqlkrzb(aiamkieahc) = iwnckqzwbr nceobegtpw (iclihgptpp, 57.26)
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