KIR2DL1 antagonists(Killer cell immunoglobulin-like receptor 2DL1 antagonists), KIR2DL2 antagonists(Killer cell immunoglobulin-like receptor 2DL2 antagonists), KIR2DL3 antagonists(Killer cell immunoglobulin-like receptor 2DL3 antagonists)

Therapeutic Areas

NeoplasmsUrogenital Diseases

Active Indication

Recurrent Squamous Cell Carcinoma of the Head and NeckBladder Cancer

Inactive Indication

Acute Biphenotypic LeukemiaAcute Myeloid LeukemiaAdvanced cancer+ [8]

Originator Organization

Innate Pharma SA

Active Organization

Ono Pharmaceutical Co., Ltd.

Bristol Myers Squibb Co.

Inactive Organization

Innate Pharma SA

National Cancer Institute

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

Gene Sequence

Sequence Code 1260L

Source: *****

Sequence Code 10125384H

Source: *****

Clinical Trials associated with Lirilumab

NCT03532451 / CompletedPhase 1IIT

Phase Ib Feasibility Trial of Neoadjuvant Nivolumab/Lirilumab in Cisplatin-Ineligible Muscle-Invasive Bladder Cancer

Patients with muscle-invasive bladder cancer (MIBC) who can not receive cisplatin or refuse cisplatin therapy will receive nivolumab or nivolumab/lirilumab before a planned surgical procedure called a radical cystectomy (RC) to remove the bladder.
Nivolumab works by attaching to and blocking a molecule called Programmed Death-1 (PD-1). Lirilumab attaches to and blocks a group of molecules called Killer Cell Immunoglobulin-Like Receptor (KIR). PD-1 and KIR are proteins present mainly on immune system cells, and each controls part of the immune system by shutting it down. It is hoped that by binding to and inactivating these proteins, these drugs can enhance the body's ability to detect, attack and destroy cancer cells.
The purpose of this research study is to see whether nivolumab alone or combination of nivolumab and lirilumab given before surgery is effective in treating people who have bladder cancer, and to examine the side effects, good and bad, associated with nivolumab and lirilumab.

Start Date22 Mar 2019

Sponsor / Collaborator

Bristol Myers Squibb Co.

NCT03347123 / TerminatedPhase 1/2

A Phase 1/2, Open-Label, Dose-Escalation, Safety, Tolerability, and Efficacy Study of Epacadostat and Nivolumab in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies (ECHO-208)

The purpose of this study is to determine the safety, tolerability, and efficacy of epacadostat when given in combination with nivolumab and ipilimumab, and in combination with nivolumab and lirilumab, in participant with advanced or metastatic malignancies.

Start Date21 Mar 2018

Sponsor / Collaborator

Incyte Corp.

NCT03341936 / Active, not recruitingPhase 2IIT

Neodjuvant Nivolumab and Lirilumab, Followed by Surgery, Followed by Adjuvant Nivolumab and Lirilumab, in Patients With Relapsed, Resectable Squamous Cell Carcinoma of the Head and Neck

This research study is studying a combination of two immunotherapy drugs, as a possible treatment for locoregionally recurrent squamous cell carcinoma of the head and neck.
The immunotherapy drugs involved in this study are:
Nivolumab (Opdivo™)
Lirilumab

Start Date15 Mar 2018

Sponsor / Collaborator

Dana-Farber Cancer Institute, Inc.

[+1]

100 Clinical Results associated with Lirilumab

100 Translational Medicine associated with Lirilumab

100 Patents (Medical) associated with Lirilumab

Literatures (Medical) associated with Lirilumab

01 Dec 2023·European urology oncology

PrECOG PrE0807: A Phase 1b Feasibility Trial of Neoadjuvant Nivolumab Without and with Lirilumab in Patients with Muscle-invasive Bladder Cancer Ineligible for or Refusing Cisplatin-based Neoadjuvant Chemotherapy

Article

Author: Cetnar, Jeremy P ; Li-Ning-Tapia, Elsa ; Galsky, Matthew D ; Hahn, Noah M ; Grivas, Petros ; Koshkin, Vadim S ; Carducci, Michael A ; Chu, Xiangying ; Sundi, Debasish ; Gartrell, Benjamin A ; Dreicer, Robert ; Cole, Suzanne ; Jain, Rohit K ; Woo, Brianna

BACKGROUND AND OBJECTIVE:

Neoadjuvant cisplatin-based chemotherapy prior to radical cystectomy (RC) improves overall survival (OS) in muscle-invasive bladder cancer (MIBC). However, many patients are cisplatin ineligible; therefore, new treatment options are needed. Nivolumab without/with lirilumab prior to RC was investigated in cisplatin-ineligible patients in this phase 1b trial (NCT03532451) to determine its safety/feasibility.

METHODS:

Patients with localized MIBC received two doses of nivolumab (480 mg) alone (cohort 1) or with lirilumab (240 mg; cohort 2) prior to RC. Cohorts were enrolled sequentially. The key eligibility criteria were cT2-4aN0-1M0 stage and cisplatin ineligibility/refusal. The primary endpoint was the rate of grade (G) ≥3 treatment-related adverse events (TRAEs) as per Common Terminology Criteria for Adverse Events version 5.0. The key secondary endpoints included the proportion of patients who underwent RC >6 wk after the last dose, CD8+ T-cell density change between pretreatment transurethral resection of bladder tumor (TURBT) and post-treatment RC, ypT0N0,

KEY FINDINGS AND LIMITATIONS:

Among 43 patients enrolled (n = 13, cohort 1; n = 30, cohort 2), 13 and 29 completed intended neoadjuvant therapy, respectively, in cohorts 1 and 2, and 41 underwent RC. The median time from the last dose to RC was 4 wk. The G3 TRAEs occurred in 0% (90% confidence interval [CI] 0-21%) of patients in cohort 1 and 7% (90% CI 1-20%) in cohort 2; all these TRAEs resolved and no G4/5 TRAEs occurred. No patient had delayed RC for >6 wk. In cohorts 1 and 2, ypT0N0 rates for patients with MIBC and RC were 17% and 21%,

CONCLUSIONS AND CLINICAL IMPLICATIONS:

Neoadjuvant nivolumab-based immunotherapy was safe, feasible, and well tolerated in cisplatin-ineligible patients with MIBC. Although ypT0N0 rates were lower than expected, 2-yr survival rates seem to be comparable with those of other neoadjuvant immunotherapy trials. Nivolumab is being evaluated in the CA-017-078 trial (NCT03661320).

PATIENT SUMMARY:

For patients with muscle-invasive bladder cancer unable to receive cisplatin-based chemotherapy, treatment with nivolumab without and with lirilumab prior to radical cystectomy was safe, feasible, and well tolerated. Nivolumab-based immunotherapy showed lower pathologic response rates than but similar survival rates to other neoadjuvant immunotherapy trials.

16 Sep 2023·International journal of molecular sciences

Therapeutic Anti-KIR Antibody of 1-7F9 Attenuates the Antitumor Effects of Expanded and Activated Human Primary Natural Killer Cells on In Vitro Glioblastoma-like Cells and Orthotopic Tumors Derived Therefrom.

Article

Author: Shida, Yoichi ; Morimoto, Takayuki ; Nakamura, Mitsutoshi ; Nakase, Hiroyuki ; Maeoka, Ryosuke ; Tsujimura, Takahiro ; Yamada, Shuichi ; Nakagawa, Ichiro ; Nishimura, Fumihiko ; Park, Young-Soo ; Nakazawa, Tsutomu ; Matsuda, Ryosuke

Glioblastoma (GBM) is the leading malignant intracranial tumor, where prognosis for which has remained extremely poor for two decades. Immunotherapy has recently drawn attention as a cancer treatment, including for GBM. Natural killer (NK) cells are immune cells that attack cancer cells directly and produce antitumor immunity-related cytokines. The adoptive transfer of expanded and activated NK cells is expected to be a promising GBM immunotherapy. We previously established an efficient expansion method that produced highly purified, activated primary human NK cells, which we designated genuine induced NK cells (GiNKs). The GiNKs demonstrated antitumor effects in vitro and in vivo, which were less affected by blockade of the inhibitory checkpoint receptor programmed death 1 (PD-1). In the present study, we assessed the antitumor effects of GiNKs, both alone and combined with an antibody targeting killer Ig-like receptor 2DLs (KIR2DL1 and DL2/3, both inhibitory checkpoint receptors of NK cells) in vitro and in vivo with U87MG GBM-like cells and the T98G GBM cell line. Impedance-based real-time cell growth assays and apoptosis detection assays revealed that the GiNKs exhibited growth inhibitory effects on U87MG and T98G cells by inducing apoptosis. KIR2DL1 blockade attenuated the growth inhibition of the cell lines in vitro. The intracranial administration of GiNKs prolonged the overall survival of the U87MG-derived orthotopic xenograft brain tumor model. The KIR2DL1 blockade did not enhance the antitumor effects; rather, it attenuated it in the same manner as in the in vitro experiment. GiNK immunotherapy directly administered to the brain could be a promising immunotherapeutic alternative for patients with GBM. Furthermore, KIR2DL1 blockade appeared to require caution when used concomitantly with GiNKs.

01 Aug 2022·HLAQ4 · MEDICINE

Epitope characterization of a monoclonal antibody that selectively recognizes KIR2DL1 allotypes

Q4 · MEDICINE

Article

Author: Lopez‐Botet, Miguel ; Meazza, Raffaella ; Moretta, Lorenzo ; Falco, Michela ; Muntasell, Aura ; Pende, Daniela ; Bottino, Cristina ; Canevali, Paolo ; Alicata, Claudia

Killer immunoglobulin‐like receptor (KIR) genes code for a family of inhibitory and activating receptors, finely tuning NK cell function. Numerous studies reported the relevance of KIR allelic polymorphism on KIR expression, ligand affinity, and strength in signal transduction. Although KIR variability, including gene copy number and allelic polymorphism, in combination with HLA class I polymorphism, impacts both KIR expression and NK cell education, only a precise phenotypic analysis can define the size of the different KIRpos NK cell subsets. In this context, reagents recognizing a limited number of KIRs is essential. In this study, we have characterized the specificity of an anti‐KIR mAb termed HP‐DM1. Testing its binding to HEK‐293T cells transfected with plasmids coding for different KIRs, we demonstrated that HP‐DM1 mAb exclusively reacts with KIR2DL1. Using site‐directed mutagenesis, we identified the four amino acids relevant for HP‐DM1 recognition: M44, S67, R68, and T70. HP‐DM1 mAb binds to a conformational epitope including M44, the residue crucial for HLA‐C K80 recognition by KIR2DL1. Based on the HP‐DM1 epitope characterization, we could extend its reactivity to all KIR2DL1 allotypes identified except for KIR2DL1*022 and, most likely, KIR2DL1*020, predicting that it does not recognize any other KIR with the only exception of KIR2DS1*013. Moreover, by identifying the residues relevant for HP‐DM1 binding, continuously updating of its reactivity will be facilitated.

News (Medical) associated with Lirilumab

06 Oct 2021

·www.biospace.com

Natural Killer (NK) Cell Therapeutics Market: Cancer Segment to Offer Attractive Opportunities

Natural Killer (NK) Cell: Introduction Natural killer (NK) cells also known as K cells or killer cells. These are a type of white blood cells (lymphocyte) and a component of the innate immune system. Natural killer cells play an important role in the host rejection of virally infected cells and tumors. Natural killer cells are cytotoxic. Small granules in natural killer cell cytoplasm contain special proteins, such as proteases and perforin known as granzymes. Once the foreign cell reaches the proximity of the natural killer cell, the natural killer cells attack the foreign cells by releasing protein including perforin that forms stomas in the cell membrane of the target cell through which the associated molecules and granzymes can enter and then induces apoptosis. Natural killer cells are activated in response to macrophage-derived cytokines and interferons. Patient deficient in natural killer cells is highly prone to early phases of the herpes virus infection. Request Brochure of Report - Key Drivers of Global Natural Killer (NK) Cell Therapeutics Market The global natural killer (NK) cell therapeutics market is primarily driven by increase in usage of natural killer cells for the treatment of liver and infectious diseases across the globe. According to the Centers for Disease Control and Prevention, in the U.S., in 2016, deaths due to tuberculosis stood at 9,272, salmonella claimed 53,850 lives, Lyme disease caused 36,429 deaths, and 375 people died due to the meningococcal disease. The number of patient visits to physician with parasitic and infectious as the primary diagnosis was reported to be 15.5 million in the U.S. in the same year. Increase in patient population with infectious and liver diseases is a key driver of the global natural killer (NK) cell therapeutics market Rise in the awareness among the population about various immunotherapies and increase in research and development of bi-specific antibody for engaging natural killer cells to eliminate tumor cells are driving the global natural killer (NK) cell therapeutics market Request for Analysis of COVID-19 Impact on Natural Killer (NK) Cell Therapeutics Market – Natural Killer (NK) Cell Directed Antibodies Segment Held Major Share of Global Market Based on type, the global natural killer (NK) cell therapeutics market can be divided into natural killer (NK) cell therapies and natural killer (NK) cell directed antibodies Natural killer (NK) cell therapies segment can be further divided into CNDO-109, oNKord, natural killer cells, and others Natural killer (NK) cell directed antibodies segment can sub-divided into MOGAMULIZUMAB, Lirilumab, AFM13, NKTT 120, and others Natural killer (NK) cell directed antibodies segment accounted for a major market share in 2018. The dominance of the segment can be attributed to increase in the use of monoclonal antibodies (mAbs) for various diseases and easy availability of these drugs. Pre book Natural Killer (NK) Cell Therapeutics Market Report at Cancer Segment to Offer Attractive Opportunities In terms of application, the global natural killer (NK) cell therapeutics market can be classified into gastrointestinal diseases, immune-proliferative disorders, cancer, and others Cancer segment is expected to account for a major share of the global natural killer (NK) cell therapeutics market in 2027 The dominance of this segment can be attributed to the increase in prevalence rate of cancer across the globe Read More Information: Top of Form ReadR Key Players Operating in Global Market The global natural killer (NK) cell therapeutics market is highly consolidated with presence of few players accounting for the majority of the market share. Key players operating in the global natural killer (NK) cell therapeutics market are: Affimed Celgene Corporation Glycostem Nkarta Therapeutics Innate Pharma S.A Ziopharm Oncology, Inc. NantKwest NKT Therapeutics Inc. Fate Therapeutics Fortress Biotech Inc Browse more Market Reports: Breast Imaging Market: Early detection of lesions with the help of AI and ML has helped to improve clinical numbers. This phenomena is being further leveraged with advanced screening mammography, whereas this technique is gaining global recognition as one of the most effective methods for detecting early breast cancer. This explains why ionizing breast imaging dictates the highest revenue among all technologies in the breast imaging market. Centrifuge Market: The World Health Organization (WHO) announced a fresh set of laboratory biosafety guidelines that are associated with the novel coronavirus (COVID-19) for healthcare professionals. WHO continues to monitor developments and revise their recommendations, since coronavirus is limited, but rapidly growing in major economies. Specific manipulations in laboratories such as loading and unloading of sealed centrifuge cups, grinding, and blending may cause splashing of droplets and aerosols of potentially infectious materials. Hence, companies in the centrifuge market as well as lab professionals are notified about routine laboratory procedures to prevent further spread of COVID-19. Veterinary Endoscopes Market: A rise in pet population with gastrointestinal problem are more willing to undergo endoscopies surgeries and diagnosis at veterinary hospitals and clinic. This is expected to increase the number of endoscopy procedures thus propelling growth of the veterinary endoscopes market. About Us Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals. Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through ad hoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories. TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key to help enterprises reach right decision. Contact Mr. Rohit Bhisey Transparency Market Research State Tower, 90 State Street, Suite 700, Albany NY - 12207 United States USA - Canada Toll Free: 866-552-3453 Email: sales@transparencymarketresearch.com Website:

AntibodyCell Therapy

100 Deals associated with Lirilumab

External Link

KEGG	Wiki	ATC	Drug Bank
D10444	Lirilumab	-	DB11754

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Recurrent Squamous Cell Carcinoma of the Head and Neck	Phase 2	US	Bristol Myers Squibb Co.	15 Mar 2018
Myelodysplastic Syndromes	Phase 2	US	Bristol Myers Squibb Co.	21 Mar 2016
Chronic Lymphocytic Leukemia	Phase 2	US	Bristol Myers Squibb Co.	23 Jun 2015
Acute Biphenotypic Leukemia	Phase 2	US	National Cancer Institute	20 Apr 2015
Refractory acute myeloid leukemia	Phase 2	US	National Cancer Institute	20 Apr 2015
Relapsing acute myeloid leukemia	Phase 2	US	National Cancer Institute	20 Apr 2015
Advanced Malignant Solid Neoplasm	Phase 2	US	Bristol Myers Squibb Co.	07 Oct 2012
Advanced Malignant Solid Neoplasm	Phase 2	CA	Bristol Myers Squibb Co.	07 Oct 2012
Advanced Malignant Solid Neoplasm	Phase 2	FR	Bristol Myers Squibb Co.	07 Oct 2012
Advanced Malignant Solid Neoplasm	Phase 2	IT	Bristol Myers Squibb Co.	07 Oct 2012

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01714739 (CTgov)	Phase 1/2	Advanced Malignant Solid Neoplasm	337	Nivolumab+Lirilumab (Part 1/2 Liri 0.1 + Nivo 3)	tyiclesxbg(hjfqsebmxq) = udgogfknpa tydwsmkbvd (msjgnfinub, pxyqjfvcvl - fgkkrezauy) View more	-	02 Feb 2023
				Nivolumab+Lirilumab (Part 1/2: Liri 0.3 + Nivo 3)	tyiclesxbg(hjfqsebmxq) = knzgxmnjjx tydwsmkbvd (msjgnfinub, inpkruxeku - vewrobfrtj) View more
NCT03341936 (CTgov)	Phase 2	Recurrent Squamous Cell Carcinoma of the Head and Neck	29	Nivolumab+Lirilumab	kteotcvuux(wkiendrmvd) = acsorbrbyy fjrtriyvuh (sbgrtijuot, pvbhvukabd - rzhzkhdtpg) View more	-	16 Jun 2022
NCT03341936 (ASCO2021) Manual	Phase 2	Squamous Cell Carcinoma of Head and Neck Adjuvant \| Neoadjuvant	29	nivolumab+lirilumab	lwapatuzdw(yngkxjsyhd) = hrijuvtnfz tsmghdvnup (qliaabrfvd, 48 - 84) View more	Positive	28 May 2021
NCT03532451 (PrE0807, ASCO2021) Manual	Phase 1	Non-Muscle Invasive Bladder Neoplasms Neoadjuvant	43	Nivolumab	gossxxagdb(tuaaenrlyt) = dcvasvyrey xvhqxquvfo (juuqnytrzp ) View more	Positive	20 May 2021
				Nivolumab+Lirilumab	gossxxagdb(tuaaenrlyt) = mpqyfumwda xvhqxquvfo (juuqnytrzp, 1.2 - 19.5) View more
NCT02599649 (CTgov)	Phase 2	Leukemia \| Myelodysplastic Syndromes	10	Lirilumab (Low or Intermediate-1 MDS Group - Lirilumab)	kqmmlpjbzw(snbbhtklgh) = xoyqukcnbn jletwnyxwu (quutgucyus, lqlufpadam - hzkgjyzumq) View more	-	06 Jan 2020
				Nivolumab+Lirilumab (Low or Intermediate-1 MDS Group - Nivolumab + Lirilumab)	wmgpgfyavm(ibtireipqy) = ghviyvginb cvvzmdkdem (yavcygnrxa, eqglmdmixv - ufuysxhgit) View more
NCT02399917 (CTgov)	Phase 2	Refractory acute myeloid leukemia \| Acute Biphenotypic Leukemia \| Relapsing acute myeloid leukemia	36	Lirilumab+Azacitidine (Phase 1b Lead-in Cohort 1)	isumkiseez(dmoriucjup) = kkfksjplue ilomcfofxs (qfiigcxvgt, regegoqtxj - ggiiffocsg) View more	-	24 Sep 2019
				Lirilumab+Azacitidine (Phase 1b Lead-in Cohort 2)	isumkiseez(dmoriucjup) = gsfqjddklb ilomcfofxs (qfiigcxvgt, bztncnrfgm - xmqbwuorzg) View more
NCT01687387 (CTgov)	Phase 2	Acute Myeloid Leukemia	152	IPH2102 at 1 mg/kg (IPH2102 at 1 mg/kg)	mgcmqqckum(oviiwqfakg) = knjioutxlw vxzkpysxcw (uamyijmiup, hcerfqzcsh - ljanefymww) View more	-	08 Feb 2019
				Placebo (normal saline solution)+IPH2102 at 0.1 mg/kg (IPH2102 at 0.1 mg/kg)	mgcmqqckum(oviiwqfakg) = tihhkphccc vxzkpysxcw (uamyijmiup, cixkckeukb - iqkkhsjykc) View more
NCT02599649 (Pubmed \| Clin Lymphoma Myeloma Leuk)	Phase 2	Myelodysplastic Syndromes	10	Lirilumab	dniltekstp(zbupyjisri) = Five patients experienced 8 episodes of Grade ≥3 adverse events attributable to study drug, with the most frequent being infection or neutropenic fever (75%) thdiwdlnmz (vajdqmbiml )	-	01 Oct 2018
NCT02599649 (ASCO2018)	Phase 2	Myelodysplastic Syndromes	10	Lirilumab + 5-Azacitidine	xxuepjiuxk(pzshgxrvut) = 1 elevated bilirubin kicabmojpn (yukcljkiql ) View more	-	01 Jun 2018
NCT01714739 (Pubmed) Manual	Phase 1	Solid tumor \| Hematologic Neoplasms	37	lirilumab	auaivdgetz(jhlihnfbyb) = pruritus (19%), asthenia (16%), fatigue (14%), infusion-related reaction (14%), and headache (11%), mostly mild or moderate hgquqxdzqx (fervhdyjhl )	Positive	03 Apr 2018

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