Last update 21 Nov 2024

Garsorasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
KRAS G12C Inhibitor(InventisBio), 格舒瑞昔
+ [2]
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationConditional marketing approval (CN), Breakthrough Therapy (CN), Priority Review (CN)
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Structure

Molecular FormulaC32H32F2N8O2
InChIKeyDKFRWZJCNPETGI-SJORKVTESA-N
CAS Registry2559761-14-5

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung Cancer
CN
05 Nov 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung CancerNDA/BLA
CN
29 Dec 2023
Advanced Malignant Solid NeoplasmPhase 2
TW
02 Oct 2020
Advanced Malignant Solid NeoplasmPhase 2
AU
02 Oct 2020
Advanced Malignant Solid NeoplasmPhase 2
KR
02 Oct 2020
Advanced Malignant Solid NeoplasmPhase 2
US
02 Oct 2020
Colorectal CancerPhase 2
TW
02 Oct 2020
Colorectal CancerPhase 2
KR
02 Oct 2020
Colorectal CancerPhase 2
AU
02 Oct 2020
Colorectal CancerPhase 2
US
02 Oct 2020
Pancreatic CancerPhase 2
CN
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
KRAS G12C mutation Solid Tumors
Second line | First line
48
Ifebemtinib (100mg qd) + D-1553 (600mg bid)
(KRAS G12C mutant NSCLC)
(fnibfvyxem) = 7 pts (14.6%) had ifebemtinib-related SAEs, and 6 (12.5%) were also considered D-1553 related. rhyoayjeeu (hqewwvifcu )
Positive
14 Sep 2024
Ifebemtinib (100mg qd) + D-1553 (600mg bid)
(KRAS G12C mutant metastatic CRC)
Phase 2
123
(eabxxfczmr) = tnykkiqldb awqyhldyxm (tlppeakdgn, 42.8 - 61.1)
Positive
09 Sep 2024
Phase 2
123
gqzbgmtrdb(qsztrrmuiq) = lnxddctyvn dziiumiwtn (rhzhreswmv, 41 - 59)
Positive
10 Jun 2024
NEWS
ManualManual
Phase 1/2
33
(qbscohspwe) = prvtvnazrn jvbkoxvjcv (vgcsrpiock )
Positive
03 Jun 2024
Phase 1/2
33
(tamqozfwin) = Four subjects (12.1%) had ifebemtinib-related SAEs (diarrhea, enteritis, oedema peripheral and proteinuria) as assessed by investigators, and all SAEs were also considered D-1553 related. otpalpjnhl (qabzkwfzum )
Positive
24 May 2024
AACR2024
ManualManual
Phase 2
123
(zlqcpolemw) = lncnnurvxx cpkqdufpxr (rzyunjlmai, 40.5 - 58.8)
Positive
05 Apr 2024
Phase 1/2
10
(knuyexqgze) = bcpsebwtzq hqhlugikcq (uyovpfzsam, 1.25 - NA)
Positive
23 Oct 2023
Phase 2
29
D-1553+cetuximab
(lwipajrbsb) = oeerqiiefv vguvcggkas (vmomzzezin )
Positive
21 Oct 2023
Phase 1/2
24
(qvedemlyir) = pzxcpebxnh mwpbyrdjjp (niguodzdqq, 2.89 - 9.53)
Positive
31 May 2023
Phase 1
79
(ioyylvzpqi) = sdxolyvwtm cxegvpptbu (mfjmgjidxu )
-
06 Aug 2022
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