Last update 24 Jun 2024

Garsorasib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
KRAS G12C Inhibitor(InventisBio), D 1553, D-1553
Target
Mechanism
KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (CN)

Structure

Molecular FormulaC32H32F2N8O2
InChIKeyDKFRWZJCNPETGI-SJORKVTESA-N
CAS Registry2559761-14-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
KRAS G12C mutant Non-small Cell Lung CancerPhase 3
CN
28 Mar 2024
KRAS G12C mutant Non-small Cell Lung CancerPhase 3
CN
28 Mar 2024
KRAS G12C mutation Solid TumorsPhase 2
CN
22 Dec 2021
Advanced Malignant Solid NeoplasmPhase 2
US
02 Oct 2020
Advanced Malignant Solid NeoplasmPhase 2
AU
02 Oct 2020
Advanced Malignant Solid NeoplasmPhase 2
KR
02 Oct 2020
Advanced Malignant Solid NeoplasmPhase 2
TW
02 Oct 2020
Colorectal CancerPhase 2
US
02 Oct 2020
Colorectal CancerPhase 2
AU
02 Oct 2020
Colorectal CancerPhase 2
KR
02 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
AACR2024
ManualManual
Phase 2
123
runrhtmmdr(amxjigbybw) = tecghudxxc uzztkdfxav (pxpusilijk, 40.5 ~ 58.8)
Positive
05 Apr 2024
Phase 1/2
10
fcxlawwgsa(eeebedvjxt) = qddovkacpq wxkbsnrrtt (vecndkzjfe, 1.25-NA)
Positive
23 Oct 2023
Phase 2
29
cnjujgldle(rrznhydesp) = glsjszlgdh djmakcvpgf (xnolrhbgeu )
Positive
21 Oct 2023
Phase 1/2
24
zppslfdfrb(tvahhhdwll) = rmceyxnabd etycdogotw (weoferhnbu, 2.89 - 9.53)
Positive
31 May 2023
Phase 1
79
xoohhkddxi(rvlgexrjta) = tgfsgxfpfq aylxfqfdqt (tknjnlklzu )
-
06 Aug 2022
Phase 1
Metastatic Solid Tumor
KRAS G12C Mutation
22
lutqrzanzp(nunjtmorpz) = skkuynjzmo qcjzollqla (flxiveffcy )
Positive
15 Jun 2022
Phase 1
Non-Small Cell Lung Cancer
KRAS G12C Mutation
28
mldovefkha(bykshoxcsp) = rrotrqcyhn jxvitmobsb (sssdniuhfk )
Positive
15 Jun 2022
Phase 1/2
-
zgpavhmrcx(slsxmfnjju) = urvsrtvoyp grwdwvmlel (wxsjmqczxd )
-
01 Jul 2021
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Regulation

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