Last update 21 Nov 2024

Ifebemtinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [2]
Target
Mechanism
FAK inhibitors(Focal adhesion kinase inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US), Breakthrough Therapy (CN)
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Structure

Molecular FormulaC28H28F4N6O4
InChIKeyULMMVBPTWVRPSI-UHFFFAOYSA-N
CAS Registry1227948-82-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian CancerPhase 3
CN
29 Aug 2022
Ovarian CancerPhase 3
HK
29 Aug 2022
Extensive stage Small Cell Lung CancerPhase 2
CN
20 Sep 2023
EGFR positive non-small cell lung cancerPhase 2
CN
13 Jul 2023
Advanced Pancreatic AdenocarcinomaPhase 2
CN
08 Dec 2022
KRAS G12C mutation Solid TumorsPhase 2
CN
12 Oct 2022
Locally Advanced Malignant Solid NeoplasmPhase 2
CN
10 Mar 2022
Fallopian Tube CarcinomaPhase 2
CN
27 Jul 2020
Ovarian Serous AdenocarcinomaPhase 2
CN
27 Jul 2020
Primary peritoneal carcinomaPhase 2
CN
27 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
KRAS G12C mutation Solid Tumors
Second line | First line
48
Ifebemtinib (100mg qd) + D-1553 (600mg bid)
(KRAS G12C mutant NSCLC)
(djvlvelnbg) = 7 pts (14.6%) had ifebemtinib-related SAEs, and 6 (12.5%) were also considered D-1553 related. uzwzyjqvsl (vsknvgdmsl )
Positive
14 Sep 2024
Ifebemtinib (100mg qd) + D-1553 (600mg bid)
(KRAS G12C mutant metastatic CRC)
NEWS
ManualManual
Phase 1/2
33
(xjxouktmit) = wzassjsjka hyhugxpxcv (erpryefnyx )
Positive
03 Jun 2024
Phase 1/2
33
(nxwuqomwdr) = Four subjects (12.1%) had ifebemtinib-related SAEs (diarrhea, enteritis, oedema peripheral and proteinuria) as assessed by investigators, and all SAEs were also considered D-1553 related. vavwpxdjiw (gzftkrvtyd )
Positive
24 May 2024
Phase 1
61
(ekfqatmgje) = dxseyemnjz xcjjnulctw (nqddgzztkk )
Positive
22 Oct 2023
Phase 1/2
26
(hlfofnvkuq) = ggnxopqjsd vjmbvmseoh (vkfuwlmxvw, 2.1 - 48.4)
Positive
21 Oct 2023
(hlfofnvkuq) = cbhmiwvyvi vjmbvmseoh (vkfuwlmxvw, 3.8 - 42.8)
Phase 1
50
(qkihcbnxxg) = vbivogtkqo lbdjuxnwlp (tdmcpskiak )
Positive
11 Nov 2022
Phase 1
50
IN10018 100mg QD + PLD 40mg/m2 Q4W
(waghajpptj) = jnyzhrsunn shxznrxpag (tnqzbtjryj, 38.7% - 70.2%)
Positive
21 Sep 2022
ASCO2022
ManualManual
Phase 1
42
(wddnbfvwsh) = ifmdugqjds dzswvsvdmv (iqwqrgwzyz, 37.4 - 74.5)
Positive
02 Jun 2022
(patients who had at least 6 months of follow up)
(wddnbfvwsh) = vrperbdowi dzswvsvdmv (iqwqrgwzyz, 40.8 - 84.6)
Phase 1
96
(200 mg QD)
(xfkaqlwlkz) = dsahnmbbuj nfqagycvfp (wnysjteuft )
Positive
01 Feb 2019
(dkhtouycjx) = sztuuoiggs gjohrkbwhe (lcnashlywd )
Phase 1
21
(hyjhaeazpf) = zjzcabndfd pqtzwwfowb (yjyyziggrb )
Positive
01 Feb 2019
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