ATP2C1 blockers(ATPase secretory pathway Ca2+ transporting 1 blockers), GABRA1 agonists(gamma-aminobutyric acid type A receptor subunit alpha1 agonists), GLRA1 agonists(glycine receptor alpha 1 agonists)

+ [1]

Therapeutic Areas

Other DiseasesNeoplasmsNervous System Diseases+ [2]

Active Indication

AnesthesiaBreast CancerReperfusion Injury+ [1]

Inactive Indication-

Originator Organization

AbbVie, Inc.

Active Organization

AbbVie, Inc.China Medical University Hospital

Stony Brook University Hospital

+ [2]

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (20 Apr 1990),

Anesthesia

Regulation-

Structure/Sequence

Molecular FormulaC4H3F7O

InChIKeyDFEYYRMXOJXZRJ-UHFFFAOYSA-N

CAS Registry28523-86-6

847

Clinical Trials associated with Sevoflurane

NCT06457958

/ WithdrawnPhase 4IIT

The Effect of Sevoflurane and Desflurane Anesthetic Agents Used in Elective Cholecystectomy Surgery on Heme Oxygenase-1 MRNA Expression and Heme Oxygenase-1 Protein Levels: a Comparative Prospective Study

General anesthesia is routinely administered to patients who undergo elective cholecystectomy. The most commonly used inhalation agents during general anesthesia are sevoflurane and desflurane. Participants who will undergo elective cholecystectomy surgery and meet the eligibility criteria will be randomized. Participants will be divided into two groups. One group will receive sevoflurane, and the other group will receive desflurane. Preoperative and postoperative blood samples will be taken from the participants. After the sample collection process is completed, the ELISA method will be used for measuring blood heme oxygenase-1 protein levels, and the PCR technique will be used for measuring blood heme oxygenase-1 mRNA gene expression. The increase in amounts between the two groups will be compared. This study aims to demonstrate the effects of the most commonly used inhalation agents on the levels of heme oxygenase-1 enzyme, which has been shown to be an important enzyme in cellular protection mechanisms, as well as on mRNA gene expression, and to determine which agent may be more effective in preventing cellular damage at the molecular level.

Start Date01 Jun 2025

Sponsor / Collaborator

Türkiye Bilimsel ve Teknolojik Arastirma Kurumu

ChiCTR2500095974

/ SuspendedEarly Phase 1

Comparison of anesthesia effect and recovery quality between remazolam benzosulfonate and sevoflurane in children undergoing painless circumcision

Start Date01 Apr 2025

Sponsor / Collaborator-

NCT06832683

/ Not yet recruitingNot ApplicableIIT

Comparison of the Efficacy of Intravenous Propofol-Ketamine and Sevoflurane Administered Via Face Mask in Children Undergoing Magnetic Resonance Imaging: A Prospective, Randomized, Parallel-Group Study

Magnetic resonance imaging (MRI) is becoming increasingly important in the diagnosis and follow-up of pediatric diseases. However, successful MRI requires complete and prolonged immobility, which can be challenging for young children and infants. To overcome this challenge, various anesthesia techniques are employed by anesthesiologists. The ideal anesthesia method for children during MRI should be both safe and enable rapid recovery, allowing the child to remain still during the procedure while minimizing risks during the recovery period.
**Sevoflurane has become a popular choice for this purpose due to its rapid onset, limited respiratory side effects at low concentrations, reduced airway irritation, and hemodynamic stability. However, propofol and ketamine, used as an alternative sedation method, are also being increasingly utilized during these procedures. The major side effects of propofol include respiratory depression, apnea, loss of protective reflexes, and hemodynamic instability. To minimize these side effects, some experts recommend the combined use of propofol and ketamine. This combination provides effective sedation while also contributing to a reduction in side effects.
In this context, the aim of our study is to compare the efficacy of intravenous propofol and ketamine with sevoflurane administered via a face mask during pediatric MRI.

Start Date31 Mar 2025

Sponsor / Collaborator-

100 Clinical Results associated with Sevoflurane

100 Translational Medicine associated with Sevoflurane

100 Patents (Medical) associated with Sevoflurane

14,700

Literatures (Medical) associated with Sevoflurane

01 Jun 2025·Medical Gas Research

Sevoflurane and its metabolic byproduct compound A induce nephrotoxicity: a systematic review and meta-analysis of animal studies

Review

Author: Sondekoppam, Rakesh V. ; Hong, Intek ; McConnell, Brie M. ; Özelsel, Timur J. P. ; Bigam, Kevin D.

Animal models investigating sevoflurane or compound A and renal function serve as the initial basis for concerns regarding renal injury following sevoflurane anesthesia and subsequent recommendations of minimum fresh gas flow, but this evidence basis has not been critically appraised. Primary literature searches were performed in MEDLINE OVID, PubMed, EMBASE, the Cochrane Library), the Cochrane Central Register of Controlled Trials, the International HTA Database, CINAHL, and Web of Science to identify randomized controlled trials and quasi-experimental studies in animals utilizing sevoflurane or compound A. The primary outcomes included renal function as determined by blood urea nitrogen, serum creatinine, creatinine clearance, and urine volume. The secondary outcomes included the serum fluoride concentration and histopathological findings. A total of 2537 records were screened, and 21 randomized controlled trials and 9 quasi-experimental animal studies were identified. No associations between sevoflurane exposure and subsequent changes in renal function (blood urea nitrogen, serum creatinine or changes in urine volume) were noted. A similar effect on renal function was observed following compound A exposure, but urine volume was elevated following compound A exposure. In addition, the histopathological damage following compound A exposure was observed only at concentrations that are unachievable in clinical practice. Our review of evidence from animal models revealed that sevoflurane usage was not associated with changes in renal function tests or urine volume. Histopathologic changes after sevoflurane exposure were either nonexistent or minor. Studies on compound A did not reveal an alteration in renal function, although histopathological evidence of injury was present when compound A was administered at very high, unphysiologic concentrations. In light of the existing evidence, the initial concerns of sevoflurane-related nephrotoxicity based on animal studies that leads to minimum fresh gas flow recommendations are called into question.

01 May 2025·Neuropharmacology

Enriched environment mitigates cognitive impairment in pre-adolescent mice following repeated neonatal sevoflurane exposure by reducing TTBK1 expression and Tau phosphorylation

Article

Author: Feng, Jingyu ; Yu, Jiafeng ; Li, Yun ; Wang, Yuanlin ; Wu, Banglin ; Yu, Yonghao ; Yu, Yang ; Yang, Yongyan

Enriched environment (EE) is a living setting that provides visual, olfactory, tactile, and cognitive stimulation and has demonstrated potential treatment results in neurodevelopmental diseases. We aimed to elucidate whether the neurodevelopmental toxicity of sevoflurane is linked to TTBK1 and Tau phosphorylation, as well as to evaluate the neuroprotective mechanism of EE on mice following sevoflurane exposure. Female mice were anesthetized at postnatal day 6 (P6) or P60 with 3% sevoflurane for two hours daily for three days. P6 mice received intraperitoneal injections of the TTBK1 inhibitor WHI-180 before anesthesia. The EE exposure was 2 hours daily from P9 to P29. Cognitive function was assessed using the Morris water maze and novel object recognition tests. Hippocampal and cerebral cortical tissues were collected to measure levels of TTBK1, Tau-PS422, AT8, T22, and total Tau. Co-localization of TTBK1 and Tau-PS422 was identified via immunofluorescence. The dendritic spine count and shape classification were analyzed by Golgi staining. The results indicated elevated levels of TTBK1, phosphorylated Tau-PS422, and AT8 in neonatal mice compared to adults. Sevoflurane increased the levels of TTBK1 and Tau phosphorylation, causing cognitive impairment. Both TTBK1 inhibitor and EE reversed the sevoflurane-induced increase in TTBK1 and phosphorylated Tau levels, decrease in dendritic spine density and maturity, and cognitive impairment. In conclusion, the overexpression of TTBK1 and phosphorylated Tau in neonatal mice brain contributed to cognitive dysfunction after repeated sevoflurane anesthesia. EE played a cerebro-protective role by inhibiting the TTBK1/Tau pathway and promoting the development of dendritic spines after sevoflurane anesthesia.

01 May 2025·Cytokine

Microglial pyroptosis induced by SENP7 via the cGAS/STING/IRF3 pathway contributes to neuronal apoptosis

Article

Author: Yang, Jinyue ; Xiao, Fei ; Hua, Ke ; Yao, Hanqing ; Liu, Lin

BACKGROUNDMaternal anesthetic exposure may exacerbate significant neurocognitive risks in the immature brains of fetuses. However, the mechanisms through which sevoflurane exposure during pregnancy results in cognitive impairments in offspring remain unclear.METHODSPregnant C57BL/6 mice (gestational day 14) were intervented with 2.5 % sevoflurane for 6 h. Morris water maze test and context fear conditioning test were utilized to evaluate the cognitive function of the offspring. BV2 cells were stimulated with LPS-ATP to evaluate the impacts of SENP7 on microglial pyroptosis. A co-culture experiment was conducted to investigate the apoptosis of mouse hippocampal neuronal cells induced by BV2 cells. The regulatory roles of SENP7 in the cGAS/STING/IRF3 pathway were assessed using an immunoprecipitation SUMOylation assay, along with Western blot analysis.RESULTSSevoflurane exposure during pregnancy resulted in cognitive impairments in offspring mice, which were associated with the upregulation of SENP7, Iba1, Caspase1, and GSDMD-N proteins, as well as the downregulation of NeuN and TH proteins in the brains of the offspring. The knockdown of SENP7 inhibited the elevation of GSDMD-N, Caspase1, and NLRP3 protein levels, subsequently reducing the concentrations of IL-1β and IL-18 in BV2 cells induced by LPS-ATP. Furthermore, SENP7 facilitated the activation of the cGAS/STING/IRF3 axis by regulating the deSUMOylation of cGAS, which triggered microglial pyroptosis and subsequently led to neuronal apoptosis.CONCLUSIONMaternal exposure to sevoflurane increased the expression of SENP7 in the brains of offspring and resulted in detrimental effects on cognitive function. This phenomenon was associated with neuronal apoptosis triggered by microglial pyroptosis, which was regulated by SENP7 through the cGAS/STING/IRF3 pathway.

News (Medical) associated with Sevoflurane

25 Nov 2024

·www.echemi.com

Heng Rui Medicine’s Profit Declines by 50%! Innovative Drug Companies Face Cliff-like Challenges

Traditional large pharmaceutical companies Hengrui Pharmaceutical and Stone Pharmaceutical Group, which have made remarkable achievements in research and development and business expansion, experienced a significant decline in profitability in the third quarter of 2024 when there was no fault in the innovative drug product line. In the face of competition from biotechnology companies, these two large pharmaceutical companies have achieved the revival of innovation transformation, especially Hengrui Pharmaceutical, which has been approved for the listing of 17 Class A new drugs in China, and ranks among the top three domestic listed drugs in the same target. The 12 innovative pharmacological products approved since 2021 should be in the market growth and climb stage. However, Hengrui Pharmaceutical's revenue in the third quarter of 2024 was 6.589 billion yuan, up 13% year-on-year, down 13% quarter-on-quarter, and the net profit attributable to the parent company was 1.188 billion yuan, up 1.91% year-on-year. If we take into account the capitalization of R&D expenditure of about $126 million, there is actually negative growth. What the hell happened? Hengrui Pharmaceutical's operation and research and development have not made mistakes, and there is no need to reflect. However, even with efforts and efforts, the results are still not satisfactory and there may still be certain problems. The traditional big pharma model of relying on domestic demand may have reached its limits. Although each innovative drug of Hengrui Pharmaceutical ranks among the top three in China, it faces fierce competition from small and medium-sized pharmaceutical companies in each segment, and there is no absolute leading advantage. Although Hengrui has a commercialized portfolio of 17 innovative drugs, its peak sales and life cycle are decisively influenced by the level of payment. Hengrui does not yet have a drug with annual sales of $1 billion, and there is no hope in the short term. Lack of peak sales, the number to gather, essentially did not leave the generic drug stage to win the model of quantity, earn hard money, and eventually may be a dream in ten years, in place. Based on Zbrutinib's sales in 2024, once you have a drug with annual sales of $2 billion, all domestic competitors will no longer matter, and you need to consider a higher level of issues. Geopolitical uncertainty looms, but innovation and internationalization are still the only way for traditional large pharmaceutical companies. Hengrui Pharmaceutical suddenly announced plans to secondary listing in Hong Kong, it seems to have the intention of breaking the game. As of the third quarter of 2024, Hengrui Pharmaceutical is in the New Drug application (NDA) stage or has been listed in the first class of new drugs and second class of new drugs summary. Innovative drugs bear social benefits and public welfare responsibilities in the domestic market. According to Galaxy Securities, according to the sales data of the world's top 25 best-selling drugs in 2021, assuming that the drug price level in the United States is 100%, the average drug price in the United Kingdom, the European Union and Japan is about 20%-25% of the United States, and the price system of innovative drugs in China is relatively low, and the average drug price is 10% of the United States. Innovative drugs benefit from positive externalities in the domestic market, including engineer dividends and clinical resource advantages. Considering the difference in payment environment, the reasonable conversion ratio of pharmacoeconomics in the United States and China may be about 1/7, while the actual rate is as low as 1/10, and the difference between them is the subsidy provided by innovative drugs to the positive externalities of the domestic market. In the 2024 medical insurance negotiations, a total of 162 general-name drugs participated in the negotiation/bidding, including 117 kinds outside the medical insurance list and 45 kinds in the list, with a passing rate of less than 50% in the expert review process, compared with 74.2% in 2022 and 63.8% in 2023. The average decline in new health insurance negotiations over the years: 59% in 2016, 44% in 2017, 57% in 2018, 61% in 2019, 51% in 2020, 62% in 2021, 60% in 2022, and 61.7% in 2023. The 2024 decline is about to be revealed. From a more macro perspective, on November 18, the Ministry of Finance announced the general public budget expenditure for the period from January to October 2024, and the health expenditure was 1,652.1 billion yuan, down 8.5% year-on-year, the largest decline among the 10 major expenditure subjects. Hengrui has not yet shaken off the shadow of centralized purchasing. Since the implementation of the ninth batch of national centralized procurement of products involving carpofungin acetate for injection from March 2024, sales in the first half of 2024 decreased by 279 million yuan compared with the same period last year; Among the products involved in local centralized procurement, the sales of ioformol injection, sevoflurane for inhalation and papaverine hydrochloride injection in the first half of 2024 decreased by 276 million yuan year-on-year. Three major generic drugs with sales of more than 1 billion yuan (Lomefloxacin/Lodisloxacin/Butorphanol) are still facing potential centralized procurement risks. In the third quarter of 2024, the net profit attributable to the parent company was 758 million yuan, down 50% year-on-year and 46% quarter-on-quarter, showing a cliff-like decline. Among the seven business lines, the anti-tumor therapy segment was the most competitive and saw the most severe decline in performance, with revenue in the third quarter and the first nine months down 31.2 percent and 17.6 percent year-on-year, respectively. This is mainly due to the price reduction of the two products, Jinyouli (PEGylated recombinant human granulocyte stimulating factor injection) and Dometic (Doxorubicin hydrochloride liposome injection), by about 58% and 23% respectively in the centralized drug procurement of the Beijing-Tianjin-Hebei "3+N" alliance. Revenue in the cardiovascular treatment field in the third quarter decreased by 26.7% year-on-year, mainly due to the fact that Xuanning (levoamlodipine maleate tablets and disperse tablets) was not selected for the eighth batch of national centralized procurement in 2023, resulting in a greater impact on its sales in hospitals that strictly implement the centralized procurement policy, especially the decline in the second quarter and the third quarter was more significant. In the third quarter, the revenue of the nervous system treatment field decreased by 15.8% year-on-year. The core product of Embip was mainly due to the strict control of the top drugs in the hospital in the environment of strict control of medical costs, resulting in a relatively large decline in sales.

Biosimilar

02 Apr 2024

·www.prnewswire.com

Mars Veterinary Health pilots industry-leading anaesthetic gas capture technology to reduce carbon emissions

World's leading provider of veterinary care will be first to introduce innovative in-clinic solution to support sustainability goals BIRMINGHAM, England, April 3, 2024 /PRNewswire/ -- Mars Veterinary Health, through its UK veterinary group Linnaeus and in partnership with Waltham Petcare Science Institute, today announced a first-of-its-kind partnership with SageTech Veterinary to pilot an innovative anaesthetic gas capture solution to help prevent harmful greenhouse gases from entering the atmosphere. During a typical anaesthetic procedure, less than five percent of the volatile anaesthetic agent delivered to a patient is absorbed and metabolised, leaving approximately 95 percent it to be exhaled. Continue Reading Mars Veterinary Health pilots industry-leading anaesthetic gas capture technology to reduce carbon emissions SageTech's trusted gas-capture technology—which is currently used in human healthcare—works by capturing the waste anaesthetic agent breathed out during an operation by safely adsorbing it into a specially developed reusable capture canister. These waste anaesthetic agents can then be extracted from the filter, avoiding current routes for disposal of volatile anaesthetic agents of incineration or release into the atmosphere. "As a leading provider of veterinary care, we have a responsibility to take climate action at scale and lead the way toward more sustainable practices," said Ellie West, RCVS and EBVS® European Specialist in Veterinary Anaesthesia and Analgesia, and Linnaeus Environmental Sustainability Lead. "Our innovative collaboration should help us take a significant step forward in our sustainability journey, aimed at contributing to a better future for the planet—and the people and pets who depend on it." A veterinary-industry first, Mars Veterinary Health's one-year pilot will start with 10 Linnaeus primary care and referral veterinary practices in the UK with the aim of reducing anaesthesia-related carbon emissions resulting from release or disposal of these agents and determining the efficiency of capture in its clinics, ultimately supporting its goal of reducing climate-change impacts. Mars Veterinary Health aims to use these learnings to explore the potential application of this technology across other parts of its business in the years to come. "At SageTech Veterinary, we are excited to share our developed technology and work alongside Mars Veterinary Health to significantly reduce the carbon footprint associated with the direct release of waste volatile anaesthetic agents to the environment," said Iain Menneer, CEO of SageTech Medical. "It has been wonderful to work with the Linnaeus and Waltham teams, and we are confident this pilot project will demonstrate to the veterinary profession how such collaborations can be a collective force for good." This industry-first pilot in sustainable veterinary care is consistent with Mars, Incorporated's Net Zero Roadmap, a detailed action plan for achieving net zero greenhouse gas emissions by 2050, as well as details on the company's progress and history of working on climate action. Details about Mars, Incorporated's wider sustainability—including climate—work can be found in its Sustainable in a Generation Scorecard. About Mars Veterinary Health Mars Veterinary Health is a global division of Mars Petcare dedicated to delivering high-quality pet healthcare to further its collective Purpose: A BETTER WORLD FOR PETS™. Mars Veterinary Health's 70,000 Associates across 3,000 global veterinary clinics put pets, people, and the planet first. The Mars Veterinary Health family includes Associates at AniCura, Banfield, BluePearl, Creature Comforts, Gentle Oak, Hillside, Linnaeus, Mount Pleasant, Tai Wai, VCA, VES, and VSH who demonstrate compassion and expertise while enabling 35 million pet visits each year. Learn more at marsveterinary.com. About Linnaeus Part of Mars Veterinary Health, Linnaeus is a highly respected community of more than 50 primary care and 17 referral veterinary practices based in the UK. Linnaeus employs over 6,000 pet-loving Associates with some of the country's finest vet and nursing teams who together are committed to excellence and delivering high-quality care to patients. Learn more at linnaeusgroup.co.uk. About Mars Science & Diagnostics Mars Science & Diagnostics is a division of Mars Petcare, a diverse business dedicated to one purpose: A BETTER WORLD FOR PETS™. Science & Diagnostics brings together the power of leading pet health science with expertise across diagnostics, data, and technology to improve outcomes in pet health. Antech, our global veterinary diagnostics business, spans in-house diagnostic laboratory instruments and consumables, including rapid assay diagnostic products and digital cytology services; local and cloud-based data services; practice information management software; reference laboratories; veterinary imaging and technology; education; and telemedicine with board-certified specialist support services. Our at-home diagnostics offering includes Wisdom Panel, the world's most accurate pet DNA test. For 60 years, our Waltham Petcare Science Institute has been advancing science to better understand pet health. About SageTech Veterinary The manufacture of virgin anaesthetic agents and their release as waste volatile gases is highly damaging to the environment and contributes significantly to the total carbon footprint of healthcare. SageTech Veterinary is part of SageTech Medical, a medical device and pharmaceutical company focused on the research, design, manufacture, and distribution of technologies for the capture and recycling of waste volatile anaesthetic agents in human and animal healthcare. Their unique circular economy solution safely captures volatile anaesthetic agents (sevoflurane, isoflurane, desflurane) through actively controlled adsorption onto a reusable capture canister. Learn more at sagetechveterinary.com. Photo - SOURCE Mars PetCare

12 Jan 2023

·www.medicalplasticsnews.com

Diamedica to showcase anaesthesia and respiratory solutions at Arab Health

UK manufacturer Diamedica will be showcasing how their portable systems can enable safe anaesthesia and respiratory support in limited resource settings at Arab Health 2023. Joining the ABHI UK Pavilion, the company will be showcasing its Glostavent DPA03 portable anaesthesia machine and the Diamedica Portable CPAP, a small, hands-free, neonatal CPAP device, designed to function in some of the world’s most challenging environments. Manufactured in the UK, the portable Glostavent DPA03 does not require electrical or battery power and is designed to function anywhere, from the field or working to an outreach hospital or rural clinic. Its two vaporisers make it suitable for use with Halothane, Isoflurane or Sevoflurane so users can maximise resources. Lightweight and assembled in two minutes, the system is contained in a tough Peli case, making it safe and easy to transport to help save lives. The system can be optionally supplied with a vital signs monitor, improving the safety and efficacy of anaesthesia provision to the patient. The portable system is designed to provide excellent economy of oxygen use, with just two litres per minute of oxygen providing the average patient with 50% FiO2. In low-resource settings, access to CPAP can be scarce. To meet this need, Diamedica have created the Diamedica Portable CPAP, a low cost, and portable CPAP device designed to support neonates and infants with respiratory distress syndrome. Manufactured with simplicity in mind, the system provides filtered room air through a patient cannula interface. It provides a compact and effective respiratory device for use in a range of settings including transport internally in the hospital or externally to another facility. The device can also be used when the number of patients in need of CPAP therapy exceeds the number of standalone CPAP machines available or when electricity or compressed gas supply is not readily available. Diamedica’s award-winning technology is already in use in more than 80 countries around the world. Charlotte Green, head of sales and marketing at Diamedica, said: “Arab Health sees thousands of industry players congregate in Dubai for four days of business and knowledge sharing, the perfect location to showcase our latest innovations. We look forward meeting key stakeholders and potential distributors to discuss our sustainable and innovative medical device solutions and demonstrate how our anaesthesia and respiratory solutions are specifically designed to perform to full capability in some of the most challenging environments around the world.” Diamedica’s product range extends from full hospital anaesthetic machines, oxygen concentrator driven CPAP, oxygen reservoir filling system, to portable anaesthesia and ventilation for field hospitals, outreach missions, conflict and humanitarian situations. All designed to bespoke specifications to suit low-resource settings. Recognised as an expert in the field, the company works hand-in-hand with in-country partners to provide training, education and distribution to equip their customers with the knowledge and resources they need. The Arab Health Exhibition & Congress is taking place from 30 January – 2 February 2023 at the Dubai Convention and Exhibition Centre. Throughout the exhibition, Diamedica will be located on the ABHI UK Pavilion – Stand H2.D14.

100 Deals associated with Sevoflurane

External Link

KEGG	Wiki	ATC	Drug Bank
D00547	Sevoflurane	N01AB08	DB01236

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Anesthesia	Japan	Maruishi Pharmaceutical Co., Ltd.	20 Apr 1990

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Breast Cancer	Preclinical	United States	Stony Brook University Hospital	02 Jun 2022
Reperfusion Injury	Preclinical	China	Xinjiang Medical University	01 Jan 2016
Alzheimer Disease	Preclinical	Taiwan Province	China Medical University Hospital	01 Jul 2012

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02697448 (CTgov)	Not Applicable	Atrial Fibrillation	135	propofol (Propofol)	vtoqmsumvt(ylqcgwimlj) = sygcitizmp fcqvgutesr (thjrafnqse, agkrdevzpq - msgnpnfpdj) View more	-	20 Aug 2024
				sevoflurane (Sevoflurane)	vtoqmsumvt(ylqcgwimlj) = sgyzwtikcy fcqvgutesr (thjrafnqse, hkkikekzlc - tqsmmdbgab) View more
NCT02053766 (CTgov)	Not Applicable	Mitochondrial Diseases	19	Dexmedetomidine (Dexmedetomidine (Precedex®))	qoqdvlqcku(rhgvuommru) = ymwwcylksn lkimncilyd (nafhlnvmuk, nvxvtfiimm - iuavodnymk) View more	-	17 Jul 2024
				Propofol (Propofol)	qoqdvlqcku(rhgvuommru) = klccfrsjgo lkimncilyd (nafhlnvmuk, yovguvutxa - xfamdazjvc) View more
NCT04355962 (Pubmed \| Ann Intensive Care) Manual	Phase 3	COVID-19 IL-6	60	Sevoflurane sedation	(ujoihgdzla) = lzfadcwqdy ammmwemwna (ipqaltyfsk ) View more	Negative	27 Mar 2024
				Continuous intravenous sedation	(ujoihgdzla) = gfqdbthkff ammmwemwna (ipqaltyfsk ) View more
NCT02660411 \| ChiCTR-IPR-15006209 (Pubmed \| Br J Anaesth)	Not Applicable	-	1,228	Propofol-based i.v. anaesthesia	(chwhfzenzb): adjusted hazard ratio = 1.02 (95% CI, 0.83 - 1.26), P-Value = 0.834 View more	Negative	01 Aug 2023
				Sevoflurane-based inhalational anaesthesia
NCT02662257 \| ChiCTR-IPR-15006209 (Pubmed)	Not Applicable	Delirium	1,228	Propofol-based anaesthesia	(abtyiorluh) = pawjyaiagi qklwrzhrcb (qfcrzsylyw )	Positive	01 Aug 2023
				Sevoflurane-based anaesthesia	(abtyiorluh) = cdqrgiewvc qklwrzhrcb (qfcrzsylyw )
NCT01975064 (CAN-study, Pubmed)	Phase 4	Breast Cancer	1,764	Propofol	spgcwtngvi(yndvfsnzhf) = nfncimjodh nzsllgbxfz (aogepnbvyh, 90.1 - 93.8)	Negative	01 Jun 2023
				Sevoflurane	spgcwtngvi(yndvfsnzhf) = uzwbfamjpz nzsllgbxfz (aogepnbvyh, 90.3 - 94.0)
NCT02489734 (CTgov)	Not Applicable	Emergence Delirium	109	Sevoflurane (Low Concentration (LC))	inehdnlser(lvcdtampqs) = wytpptusez zdbnakvnjk (bwznwokgaz, nlxfmyaqvo - yittejhqsb) View more	-	19 Aug 2021
				Sevoflurane (High Concentration (HC))	inehdnlser(lvcdtampqs) = nvmozcodyt zdbnakvnjk (bwznwokgaz, blicfkgerp - tpedxmosyh) View more
NCT02918877 (APLICS, CTgov)	Phase 1/2	Postoperative Complications \| Lung Injury \| Oxygen radical damage	51	Sevoflurane (Inhaled Anesthesia)	upuijmxsgb(txpglbquvp) = oxafragkef ublgephoxj (embxcfvpga, lhagxryoec - nmwwlvbssl) View more	-	05 May 2021
				Propofol (Intravenous Anesthesia)	upuijmxsgb(txpglbquvp) = njemlnoqrg ublgephoxj (embxcfvpga, chibuwdewx - izwrnfiksd) View more
NCT03498235 (Pubmed \| BMC Anesthesiol)	Early Phase 1	-	110	Propofol	eazlygwszq(unqiddjsmv) = ktchwqmsdj zcrcpvkynw (pebkhfhovm )	-	27 Jan 2021
				Sevoflurane	eazlygwszq(unqiddjsmv) = btumemxadf zcrcpvkynw (pebkhfhovm )
NCT03540030 (CTgov)	Phase 4	Opioid abuse \| Osteonecrosis \| Shoulder arthritis \| Rotator Cuff Tear Arthropathy	86	opioids (Observational)	vgthtkxnyy(ynadtzvzry) = diyjtqrufu vddrpckhtr (wexwysberm, fizywabgwn - oeedmdpnmp) View more	-	12 Oct 2020
				regional block+acetaminophen+propofol+toradol+desflurane+sevoflurane+IV lidocaine+rocuronium+Celecoxib+vecuronium+Gabapentin (Non-Opioid Intervention)	vgthtkxnyy(ynadtzvzry) = vcsocbcrgu vddrpckhtr (wexwysberm, lxvxikyiet - wphgqgajkv) View more

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