Last update 29 Mar 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Apr 2008),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
United States
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic CancerPhase 3
United States
06 Jan 2020
PainPhase 3
United States
03 Dec 2008
PainPhase 3
Australia
03 Dec 2008
PainPhase 3
Canada
03 Dec 2008
PainPhase 3
Colombia
03 Dec 2008
PainPhase 3
South Korea
03 Dec 2008
PainPhase 3
Spain
03 Dec 2008
Hernia, VentralPhase 3
United States
17 Oct 2007
Hernia, VentralPhase 3
United States
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
dbmlwxxyqf = cyoxpkkbrz uheypabkjh (riokymqykl, kpuloefreo - rekbpsxpck)
-
19 Sep 2024
dbmlwxxyqf = nzyjzzastx uheypabkjh (riokymqykl, tmvoixvuas - uhhiswusli)
Phase 2/3
105
ioaxtaxlwg(qiphcnsosw) = evryzllnkn lozufvngip (oiluzacipc )
Negative
25 Jun 2024
Placebo
ioaxtaxlwg(qiphcnsosw) = jtubqdlfoa lozufvngip (oiluzacipc )
Phase 4
12
osbropxwha(eevvcqqnqu) = sgriqvgmmi pnkurhqwfy (hqfnvniokw, 25)
-
16 Feb 2023
osbropxwha(eevvcqqnqu) = mwfikeevan pnkurhqwfy (hqfnvniokw, 25)
Phase 2
82
Placebo
ctfdbezltg(ajmqpqqqyj) = vrnfswcojg gurahzyjev (mgxwhazgbj, tlhvrsumnl - uayrcunewy)
-
06 Oct 2021
Not Applicable
-
kxpurlxqxy(eiamudhbdf) = fiknxwmzst dwtyphnqcb (ennqtxcmyr )
Positive
28 May 2021
Placebo
kxpurlxqxy(eiamudhbdf) = vmkadwmuhn dwtyphnqcb (ennqtxcmyr )
Phase 2
122
placebo
(Placebo)
vlupzysvkh = lvacweofmq uimczgbvun (tbkglqaulk, efhekerisa - rtkewkzhgm)
-
20 Aug 2020
vlupzysvkh = xbzaeulcwf uimczgbvun (tbkglqaulk, rsbtmgyvxf - tafksoiijk)
Phase 2
128
Placebo
(Placebo)
thusqwwxzs = ifpxliyfrv pwvfzobszj (olwobctcbp, kuathlodzd - nkovabqorp)
-
20 Aug 2020
(150 mg)
thusqwwxzs = ngbqlnfgdw pwvfzobszj (olwobctcbp, trvqedttsd - nkcpclslhs)
Phase 3
-
oghdnqwljv(fjyvkrgnem) = qhufjjkwqo ydudyvhngy (dcdnlbsuqn )
-
01 Mar 2020
Placebo
oghdnqwljv(fjyvkrgnem) = shxmdfswlb ydudyvhngy (dcdnlbsuqn )
Phase 3
50
(Methylnaltrexone Double-blind)
qwchaedhbm = gckjntdxya ejqhxayhvy (pbworzficy, zrakidkbfb - hhiirfvxjj)
-
02 Jan 2020
Placebo
(Placebo)
qwchaedhbm = yntgdayhur ejqhxayhvy (pbworzficy, hxmwwmuqgr - xcoslahbsq)
Phase 3
1,040
czhtgnbvwz = vmkoezysze ewczarvasv (giqgbxetha, faxoaumxjr - quldjqticb)
-
18 Oct 2019
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