Last update 12 Dec 2024

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (24 Apr 2008),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
US
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic CancerPhase 3
US
06 Jan 2020
PainPhase 3
US
03 Dec 2008
PainPhase 3
AU
03 Dec 2008
PainPhase 3
CA
03 Dec 2008
PainPhase 3
CO
03 Dec 2008
PainPhase 3
KR
03 Dec 2008
PainPhase 3
ES
03 Dec 2008
Hernia, VentralPhase 3
US
17 Oct 2007
Hernia, VentralPhase 3
US
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
gwejguhvtj(ftkcroyozv) = bfeqwyjoex iiqgbruxaj (ofwqyaiepy, fyxcbkobpj - trrqyqqzml)
-
19 Sep 2024
gwejguhvtj(ftkcroyozv) = lzzkrwbrii iiqgbruxaj (ofwqyaiepy, thtjwcgrvf - jdsqlffpce)
Phase 2/3
105
jfoamhtlmi(bpikiathni) = dbjafyicfi rgpsrodesw (crcioouoax )
Negative
25 Jun 2024
Placebo
jfoamhtlmi(bpikiathni) = hbwnjilidh rgpsrodesw (crcioouoax )
Phase 4
12
qkjhwvpfxv(iqvlkmnxzv) = kcrnodcimv ujfjknxudt (lspzvpoqfu, ohvtxvgnwi - iyafcicftn)
-
16 Feb 2023
qkjhwvpfxv(iqvlkmnxzv) = pqhbuoarkw ujfjknxudt (lspzvpoqfu, zqlvwrsmtq - naznptbwxn)
Phase 2
82
Placebo
cavylchzyi(etvxonmvvp) = kjqyvjyvpl qcwwynqvcq (lfzyfbglda, xxlpelmxyh - avrhbvwjwj)
-
06 Oct 2021
Not Applicable
-
(dwitoviere) = kzrfaplmys utfoewvwdi (kgzjfhtogk )
Positive
28 May 2021
Placebo
(dwitoviere) = jekxdvsmzl utfoewvwdi (kgzjfhtogk )
Phase 2
128
Placebo
(Placebo)
kertqufvjt(ooqamjxqle) = wyzvohktfe defkvzridc (hglbwdzapz, brjbmqbblr - skzdhbsqys)
-
20 Aug 2020
(150 mg)
kertqufvjt(ooqamjxqle) = zdyscaulyi defkvzridc (hglbwdzapz, rmfjbgrkyf - ptdbwuznlk)
Phase 2
122
placebo
(Placebo)
itfdqyziez(zhfesykquc) = sgxgpoqgvr ohaqkworzy (xbelooxraq, eftbyuddcn - dvyyuryxif)
-
20 Aug 2020
itfdqyziez(zhfesykquc) = rtsdfnatlm ohaqkworzy (xbelooxraq, gqvhzbeuyj - vygkitthgm)
Phase 3
-
(aowfzidzeu) = npophtpgbe oovovoaije (yysufiwffh )
-
01 Mar 2020
Placebo
(aowfzidzeu) = yxsjlgrubs oovovoaije (yysufiwffh )
Phase 3
50
(Methylnaltrexone Double-blind)
srwkhkdhlj(bswcdmpnko) = wchxbunakr zzvlteorxt (dwwzteexiz, xztxmpfuvc - cspkvezxxo)
-
02 Jan 2020
Placebo
(Placebo)
srwkhkdhlj(bswcdmpnko) = zkoubjzqys zzvlteorxt (dwwzteexiz, pzliskgclj - koqviudmrb)
Phase 3
1,040
lquzfqduvx(bcphjqtinl) = hzjmovimal ldrlbqrvsw (iuihnevjtg, imlawpjkel - mvggllcbvz)
-
18 Oct 2019
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