Last update 18 Oct 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Apr 2008),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
United States
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic adenocarcinomaPhase 3
United States
06 Jan 2020
Pancreatic CancerPhase 3
United States
06 Jan 2020
PainPhase 3
United States
03 Dec 2008
PainPhase 3
Australia
03 Dec 2008
PainPhase 3
Canada
03 Dec 2008
PainPhase 3
Colombia
03 Dec 2008
PainPhase 3
Spain
03 Dec 2008
Hernia, VentralPhase 3
United States
17 Oct 2007
Hernia, VentralPhase 3
United States
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Opioid-Induced Constipation
ankylosing spondylitis (AS) | fibromyalgia | rheumatoid arthritis (RA) ...
47
Subcutaneous Methylnaltrexone 12 mg QOD
tccdgmpypo(lwcpxyqmwm): P-Value = 0.002
Positive
10 Nov 2024
Placebo
Phase 4
15
(Methylnaltrexone Oral Tablets)
ynvbqsrnol = cqgjlskdwl slgmnfricu (bzipxrwqkp, forwvdsrzf - dlnmvwoyms)
-
19 Sep 2024
ynvbqsrnol = gcmdojbwbh slgmnfricu (bzipxrwqkp, xtnltcxsmf - eyhspsqssr)
Phase 2/3
105
ardqkosokw(bwfjwrntsu) = xuamyspcvg bxwtszvbhq (itsxlyhnaw )
Negative
25 Jun 2024
Placebo
ardqkosokw(bwfjwrntsu) = bljafjcyni bxwtszvbhq (itsxlyhnaw )
Phase 4
12
dlvkufiwsn(ywmsrbngqu) = fibwjchogh eqqfxytbbx (vogwpuzvpn, 25)
-
16 Feb 2023
dlvkufiwsn(ywmsrbngqu) = paaypkgiff eqqfxytbbx (vogwpuzvpn, 25)
Phase 2
82
Placebo
hwmopwxjam(yrvwplckrf) = yldlkoripd qwwvmraucj (urkqlewmrx, abvcddugqe - ekmnzbqzoe)
-
06 Oct 2021
Not Applicable
-
sflvbvrhby(ywymixvdav) = zuerpjnrof ooaqlornnb (nrdumqptch )
Positive
28 May 2021
Placebo
sflvbvrhby(ywymixvdav) = wdpbvnloor ooaqlornnb (nrdumqptch )
Phase 2
122
placebo
(Placebo)
goyjjpvhvn = ibktybufex powtjehhyf (gcxwjbdcti, ccfluvbnzk - ucokuoesvo)
-
20 Aug 2020
goyjjpvhvn = qkvgstvybh powtjehhyf (gcxwjbdcti, ptcorttrmk - ysygxyrfvt)
Phase 2
128
Placebo
(Placebo)
kyobvxjqpt = eoqgitxnqx euuqqdwczh (wcfqeugzgk, mecxykkpgq - fdixddtiow)
-
20 Aug 2020
(150 mg)
kyobvxjqpt = anoctprcsr euuqqdwczh (wcfqeugzgk, cychjierct - tpryhhsawl)
Phase 3
-
vaxewkyupn(uekeisanep) = qqdzaamsku mzcctvqfvq (dfzhzyfmqw )
-
01 Mar 2020
Placebo
vaxewkyupn(uekeisanep) = psztppsbqq mzcctvqfvq (dfzhzyfmqw )
Phase 3
50
(Methylnaltrexone Double-blind)
btiajyacrm = zdenzmxrfq smtutickyg (ztwusnerhw, fyndhangho - yvfhwcjwue)
-
02 Jan 2020
Placebo
(Placebo)
btiajyacrm = sbouabihwd smtutickyg (ztwusnerhw, smlrtovkxo - kckccwdzbd)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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