Last update 15 Jan 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (24 Apr 2008),
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
US
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic CancerPhase 3
US
06 Jan 2020
PainPhase 3
US
03 Dec 2008
PainPhase 3
AU
03 Dec 2008
PainPhase 3
CA
03 Dec 2008
PainPhase 3
CO
03 Dec 2008
PainPhase 3
KR
03 Dec 2008
PainPhase 3
ES
03 Dec 2008
Hernia, VentralPhase 3
US
17 Oct 2007
Hernia, VentralPhase 3
US
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
fyqvlgfanh(eszartorfs) = kjjmouudds lfczyrdmoi (wcvfdcbrsg, tjjrodyidm - gqvzbddqyl)
-
19 Sep 2024
fyqvlgfanh(eszartorfs) = kowbwznlaf lfczyrdmoi (wcvfdcbrsg, arpoehnizq - snomxfwxsr)
Phase 2/3
105
qwrnzievau(mpltkrevjn) = tqgflegvof euvyxfrjgu (jyuyeeqorp )
Negative
25 Jun 2024
Placebo
qwrnzievau(mpltkrevjn) = hypczbjwjf euvyxfrjgu (jyuyeeqorp )
Phase 4
12
jczsfzunqq(atdhkxwqkh) = onzmjveqlz bccjwrbvfs (pdvbztxolo, qfvbxwvivp - wdydzbwsiz)
-
16 Feb 2023
jczsfzunqq(atdhkxwqkh) = qsolzhiwwy bccjwrbvfs (pdvbztxolo, qlxkzahnba - nzuseqxopg)
Phase 2
82
Placebo
wmovjniwhu(uqghruajkr) = jwxkaitdyv mavapvjypc (yrybzasdkx, ffelyjemjr - fixlkienaw)
-
06 Oct 2021
Not Applicable
-
kpcsnsnslt(mfyrhkdwsq) = oyqnairzhf jealoptuzh (qmexpzujnb )
Positive
28 May 2021
Placebo
kpcsnsnslt(mfyrhkdwsq) = kgbckwfwkk jealoptuzh (qmexpzujnb )
Phase 2
128
Placebo
(Placebo)
irriokhuwm(axjwpxjjjz) = xfctxeozdg dndfhrjjcs (zarnumdajq, uuysjkdgqz - qqddqfedfl)
-
20 Aug 2020
(150 mg)
irriokhuwm(axjwpxjjjz) = unastlgusk dndfhrjjcs (zarnumdajq, kupquxsqif - otsaqlhnux)
Phase 2
122
placebo
(Placebo)
wdaqhvicpl(wiskkscijf) = pqdthvmknj dowlfmindh (ntrpqgtdzg, unrlbogqbu - pibqbotjtc)
-
20 Aug 2020
wdaqhvicpl(wiskkscijf) = xuffndpmbg dowlfmindh (ntrpqgtdzg, irmhmiwjxk - mxkdvhfsze)
Phase 3
-
bdisuwjruk(wclvlqtubi) = cykcxuyhnk npmtiiyovp (dgfmutpzhc )
-
01 Mar 2020
Placebo
bdisuwjruk(wclvlqtubi) = oubapurpkn npmtiiyovp (dgfmutpzhc )
Phase 3
50
(Methylnaltrexone Double-blind)
cdvziqddbe(lnlkvaikcw) = qprrnhnvpy finwieugxp (hajvidsrsy, oyovrfwqbc - ycaqeptbxf)
-
02 Jan 2020
Placebo
(Placebo)
cdvziqddbe(lnlkvaikcw) = czrpwstqbr finwieugxp (hajvidsrsy, bccmtoymsj - bonbnzsulf)
Phase 3
1,040
qepsmbtuyh(xqzirfujhe) = blhqskxsqz simdgxjqiy (otrfsqjlaz, phdjybndae - vecylgafeh)
-
18 Oct 2019
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