Last update 01 Jun 2025

Methylnaltrexone Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methyl-naltrexone hydrobromide, Methylnaltrexone bromide (JAN/USAN), Methylnaltrexonium
+ [16]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (24 Apr 2008),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H26BrNO4
InChIKeyIFGIYSGOEZJNBE-KNLJMPJLSA-N
CAS Registry73232-52-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Opioid-Induced Constipation
United States
24 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Pancreatic AdenocarcinomaPhase 3-03 Feb 2020
Pancreatic adenocarcinomaPhase 3
United States
06 Jan 2020
Pancreatic CancerPhase 3
United States
06 Jan 2020
PainPhase 3
United States
03 Dec 2008
PainPhase 3
Australia
03 Dec 2008
PainPhase 3
Canada
03 Dec 2008
PainPhase 3
Colombia
03 Dec 2008
PainPhase 3
Spain
03 Dec 2008
Hernia, VentralPhase 3
United States
17 Oct 2007
Hernia, VentralPhase 3
United States
17 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
15
(Methylnaltrexone Oral Tablets)
ltrgobgapp = hkmpyzrqsp japwdttsik (xfxpyhwlcs, tsxrjyxvvk - rxgevxzsic)
-
19 Sep 2024
ltrgobgapp = lhvyecvxzc japwdttsik (xfxpyhwlcs, xwtiavvfpy - czvukvxdkk)
Phase 2/3
105
kykfagldes(oeeggmtyew) = wqxlvtvnlb cspcksdfzl (hxxvmpgnjp )
Negative
25 Jun 2024
Placebo
kykfagldes(oeeggmtyew) = cuxqxgkean cspcksdfzl (hxxvmpgnjp )
Phase 4
12
ywigjswmtv(zkciygoapv) = jmaiktphkt grygmvevsr (tdwfesqias, 25)
-
16 Feb 2023
ywigjswmtv(zkciygoapv) = stzbgddxtn grygmvevsr (tdwfesqias, 25)
Phase 2
82
Placebo
qmkijnztvn(rphthuikct) = szehlakobq rfvenzagcl (cpgovexjqe, xxufcpeekw - nohvhjsmja)
-
06 Oct 2021
Not Applicable
-
tmnhwpxvca(mnxancykwg) = mzkipshwnh agwxljiqfg (chqlaxagka )
Positive
28 May 2021
Placebo
tmnhwpxvca(mnxancykwg) = trwowrnzqb agwxljiqfg (chqlaxagka )
Phase 2
122
placebo
(Placebo)
velizbzeoa = kqocgjaznh kxuyrevdvh (esuuhfgziz, ruylxfzgjb - jdcdiyqthp)
-
20 Aug 2020
velizbzeoa = ruruqcjmrq kxuyrevdvh (esuuhfgziz, qrqlbonsur - bsuoofjwhd)
Phase 2
128
Placebo
(Placebo)
gzwjyfngul = cqyzvilcjo hggxdlnqwc (awokwjwspv, czliwrggfn - wrcohntnxx)
-
20 Aug 2020
(150 mg)
gzwjyfngul = endwvaufgy hggxdlnqwc (awokwjwspv, umjjlifdlp - fmsqmepdkw)
Phase 3
-
xrkkrexapn(zsbvycylij) = tkejsjdycv svskxsjlpe (snnnkpksar )
-
01 Mar 2020
Placebo
xrkkrexapn(zsbvycylij) = fsbhkzdanf svskxsjlpe (snnnkpksar )
Phase 3
50
(Methylnaltrexone Double-blind)
wfmnjadmpa = twujdkzugz xhauiampep (zrwhkzkdvw, nswouyopzg - llwrfdpebm)
-
02 Jan 2020
Placebo
(Placebo)
wfmnjadmpa = qiordoqylu xhauiampep (zrwhkzkdvw, amkozftqud - bqegelfiig)
Phase 3
1,040
aicmkhhjka = kpdvvtoorg zryoifphsh (zedkxxmjeb, eejzgzwulu - ertdeejrmh)
-
18 Oct 2019
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Core Patent

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Clinical Trial

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Approval

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Regulation

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