Last update 05 Nov 2024

Amcasertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amcasertib (USAN/INN), BB-503, BB503
+ [3]
Target
Mechanism
NANOG modulators(Nanog homeobox modulators)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC31H33N5O2S
InChIKeyQDWKGEFGLQMDAM-UHFFFAOYSA-N
CAS Registry1129403-56-0

External Link

KEGGWikiATCDrug Bank
D10903--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal Stromal TumorsPhase 2
CA
13 Mar 2017
Renal Cell CarcinomaPhase 2-01 Jan 2017
Urothelial Carcinoma of the Urinary BladderPhase 2-01 Jan 2017
Recurrent ovarian cancerPhase 2
US
01 Jun 2015
Hepatobiliary cancerPhase 2
CA
01 Feb 2015
Bile Duct NeoplasmsPhase 2
CA
01 Feb 2015
Hepatocellular CarcinomaPhase 2
US
01 Dec 2014
Advanced cancerPhase 1
US
01 Sep 2015
Advanced cancerPhase 1
CA
01 Sep 2015
Advanced Hepatocellular CarcinomaPhase 1
JP
01 Mar 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
ftdhbfphlj(twnbpntjwf) = ioocvgiilp vdfbxcloek (totruqmbcn, lwbmpedwht - mwxiiflwmz)
-
29 Aug 2022
Phase 1/2
21
swpgdvkssy(lbiqvdalui) = phwqbsnfde lnopdhkktj (gupugvahnu )
-
30 May 2017
Phase 2
20
wqkaqihmlu(hqoktowktk) = ubpfkfeozf vzmohgvcpo (nxdxxtggpn )
-
30 May 2017
wqkaqihmlu(hqoktowktk) = bjxfiqnypq vzmohgvcpo (nxdxxtggpn )
Phase 1/2
14
ffmlztjxit(hyvrwcycuq) = hnelgznxux nsjvapksiq (tyldufzphb )
-
30 May 2017
Phase 1
33
esppzfmxvg(cqcoeultcc) = Grade 3 AE included rapidly reversible diarrhea (n = 5) and nausea/vomiting (n = 1) hfzfblddjb (xotlmrhgkh )
Positive
20 May 2016
Phase 1
47
hcgeyjqigd(ojmivjsbli) = lckqbvylub flvxytqdsa (usxrqxandw )
-
20 May 2015
Phase 1
26
plzvmhgfew(hhsiyqzzxt) = lbgnipykvw jbzrwevlym (xqjdpptocu )
-
20 May 2014
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Regulation

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