Drug Type Small molecule drug |
Synonyms Tozasertib (USAN), Tozasertib Lactate, MK-0457 + [1] |
Mechanism Aurora A inhibitors(Serine/threonine-protein kinase Aurora-A inhibitors), Aurora B inhibitors(Serine/threonine-protein kinase Aurora-B inhibitors), Aurora C inhibitors(Serine/threonine-protein kinase Aurora-C inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H28N8OS |
InChIKeyGCIKSSRWRFVXBI-UHFFFAOYSA-N |
CAS Registry639089-54-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08279 | Tozasertib | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute Lymphoblastic Leukemia | Phase 2 | US | 21 Dec 2006 | |
Acute Lymphoblastic Leukemia | Phase 2 | - | 21 Dec 2006 | |
Acute Lymphoblastic Leukemia | Phase 2 | IL | 21 Dec 2006 | |
Philadelphia chromosome positive chronic myelogenous leukemia | Phase 2 | US | 21 Dec 2006 | |
Philadelphia chromosome positive chronic myelogenous leukemia | Phase 2 | - | 21 Dec 2006 | |
Philadelphia chromosome positive chronic myelogenous leukemia | Phase 2 | IL | 21 Dec 2006 | |
Ph-Like Acute Lymphoblastic Leukemia | Phase 2 | - | 01 Dec 2006 | |
Philadelphia positive acute lymphocytic leukaemia | Phase 2 | - | 01 Dec 2006 | |
Non-Small Cell Lung Cancer | Phase 2 | - | 01 Jun 2006 | |
Colorectal Cancer | Phase 2 | US | 05 Apr 2006 |
Phase 2 | 52 | MK-0457 at 40 mg/m(2)/h | (rkjykvivew) = The most common grade 3/4 AEs were neutropenia (46%) and febrile neutropenia (35%) okvxagakqk (tudxlfjham ) View more | - | 15 Aug 2014 | ||
Phase 1/2 | - | 77 | oaqagrblkz(sptqtjpmfn) = tmpwrcklrm rwtqyjobzd (skfpmmdnvx ) View more | - | 01 Jan 2013 | ||
Phase 1 | - | gqrmrcslxj(wedpscgvqo) = xpyjrzmrgn xizqgrbamo (ddxgqintal ) View more | - | 01 Feb 2011 | |||
Phase 1 | 16 | jorsjnhwis(pvqabdmqpy) = ccawftljgc amhiqgarqz (iemorpirun, ± 141) View more | - | 20 Jun 2006 |