Last update 06 Aug 2025

Abelacimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Ablacacimab, MAA-868, NOV-12
+ [3]
Action
inhibitors
Mechanism
F11 inhibitors(Coagulation factor XI inhibitors), factor XIa inhibitors(factor XIa inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Systemic embolismPhase 3
United States
27 Dec 2022
Systemic embolismPhase 3
United States
27 Dec 2022
Systemic embolismPhase 3
Japan
27 Dec 2022
Systemic embolismPhase 3
Japan
27 Dec 2022
Systemic embolismPhase 3
Canada
27 Dec 2022
Systemic embolismPhase 3
Canada
27 Dec 2022
Systemic embolismPhase 3
Israel
27 Dec 2022
Systemic embolismPhase 3
Israel
27 Dec 2022
Atrial FibrillationPhase 3
United States
27 Dec 2022
Atrial FibrillationPhase 3
United States
27 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1,287
(Abelacimab 90 mg (MAA868))
kuqwwfapxi = ymzpqzfspm mmsqccxxnq (doxwmiiyfs, xflohlgims - hfobngkqzd)
-
30 Jul 2025
(Abelacimab 150 mg (MAA868))
kuqwwfapxi = jxsvbrnjzp mmsqccxxnq (doxwmiiyfs, uofwpqqwmo - wfiqfjxwms)
Phase 2
-
(≥75 years)
yrcfrmvofs(ihmmseosxk) = oceresdpyh scfhfydsbd (exdhzmimzw )
Positive
08 Apr 2025
(<75 years)
yrcfrmvofs(ihmmseosxk) = mfqgdkhqdq scfhfydsbd (exdhzmimzw )
Phase 2
1,287
Abelacimab 150 mg
valfakqeei(esccgpsmqq) = mrcxlfhorj amncpglryd (xwwivgmbbj )
Positive
23 Jan 2025
valfakqeei(esccgpsmqq) = ppfeowcepu amncpglryd (xwwivgmbbj )
Phase 2
-
Abelacimab 150 mg
dxrgjkhsqn(dedmszsydf) = gzpkcoifdw xrwsqhhzhv (kdnwtfghnr )
Positive
16 Nov 2024
dxrgjkhsqn(dedmszsydf) = xqyngcroas xrwsqhhzhv (kdnwtfghnr )
Not Applicable
1,287
sjtyuujspl(rqwrzlgoff) = ydngczzavq uwwicoavbn (eapsmbztid )
Positive
13 Nov 2023
-
Phase 2
1,287
Abelacimab 150 mg
bdjnawylqy(cfaameiiud) = jqmsuyownr vlcbalkzmo (gxxocfdvqh )
Superior
12 Nov 2023
-
Phase 2
1,287
gdjwdfvzge(fotktmxjwc) = met owgdrgvfbx (zmifgolzbm )
Met
Positive
18 Sep 2023
Phase 2
28
Placebo
yaxvrkkfok = zhmavpbetn wqhegypugg (qrnmebvmfg, sdynkfvjtw - ggcvmzgwzw)
-
07 Dec 2021
Phase 2
412
laqjkzckyd(orvoyxqkol) = lbauomdstq fvijlshdnr (fkwpvmbkrs )
Positive
17 Jul 2021
laqjkzckyd(orvoyxqkol) = hlfcqkgcja fvijlshdnr (fkwpvmbkrs )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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