Last update 13 Sep 2025

Rivaroxaban

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Rivaroxaban (JAN/USAN/INN), AST-8294, BAY 59 7939
+ [10]
Target
Action
inhibitors
Mechanism
factor Xa inhibitors(Factor Xa inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC19H18ClN3O5S
InChIKeyKGFYHTZWPPHNLQ-AWEZNQCLSA-N
CAS Registry366789-02-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Thromboembolism
Japan
24 Nov 2023
Thrombosis
United States
20 Dec 2021
Atherosclerosis
European Union
12 Nov 2021
Atherosclerosis
Iceland
12 Nov 2021
Atherosclerosis
Liechtenstein
12 Nov 2021
Atherosclerosis
Norway
12 Nov 2021
Atrial Fibrillation
China
31 Mar 2009
Myocardial Infarction
Australia
24 Nov 2008
Recurrent deep vein thrombosis
Australia
24 Nov 2008
Stroke
Australia
24 Nov 2008
Systemic embolism
Australia
24 Nov 2008
Acute Coronary Syndrome
European Union
30 Sep 2008
Acute Coronary Syndrome
Iceland
30 Sep 2008
Acute Coronary Syndrome
Liechtenstein
30 Sep 2008
Acute Coronary Syndrome
Norway
30 Sep 2008
Embolism
European Union
30 Sep 2008
Embolism
Iceland
30 Sep 2008
Embolism
Liechtenstein
30 Sep 2008
Embolism
Norway
30 Sep 2008
Peripheral arterial occlusive disease
European Union
30 Sep 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesPhase 3
Australia
14 Dec 2020
Cardiovascular DiseasesPhase 3
Belgium
14 Dec 2020
Cardiovascular DiseasesPhase 3
Canada
14 Dec 2020
Cardiovascular DiseasesPhase 3
France
14 Dec 2020
Cardiovascular DiseasesPhase 3
Germany
14 Dec 2020
Cardiovascular DiseasesPhase 3
India
14 Dec 2020
Cardiovascular DiseasesPhase 3
Malaysia
14 Dec 2020
Cardiovascular DiseasesPhase 3
Nepal
14 Dec 2020
Cardiovascular DiseasesPhase 3
Saudi Arabia
14 Dec 2020
Cardiovascular DiseasesPhase 3
Singapore
14 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
18
dbesvoiutv(qxyswjbufa) = 67% in warfarin group yzjtzzebii (kvqpxqegmo )
Positive
01 Sep 2025
Warfarin
Phase 4
261
Rivaroxaban 20 mg daily
wdtikdkblm(vtavwctbzy) = iklcwfxlsg eriikkfjoi (prlypmfhtk )
Positive
01 Aug 2025
wdtikdkblm(vtavwctbzy) = mflsgbebkm eriikkfjoi (prlypmfhtk )
Phase 2
1,287
(Abelacimab 90 mg (MAA868))
zkkrsimfvn = tdwahlotck kmrdkjcibr (zcdrwltdqx, kubmqylxap - mxrqdifrfw)
-
30 Jul 2025
(Abelacimab 150 mg (MAA868))
zkkrsimfvn = bqvziajpol kmrdkjcibr (zcdrwltdqx, iivhcoruju - gbviqxtnqd)
Not Applicable
101
rgehhwgljg(wtvatyhood) = Thromboembolic events were observed in only two patients as acute DVTs fftrtsnieu (mgqdrvzlow )
Positive
14 May 2025
Phase 3
500
bvnnpfjvol(stgfsbxagi) = alfjyxiyak ueqsrdpflc (rblyypnccl )
Positive
01 May 2025
standard anticoagulants
-
Not Applicable
-
pxxnpbrkwc(dmzlisedly) = cfzkoamaee cjvblccgji (dpxaewsdrw )
Positive
31 Mar 2025
Placebo
pxxnpbrkwc(dmzlisedly) = dtcqgzyuwq cjvblccgji (dpxaewsdrw )
Phase 4
179
wmrnhcvqfs(grtzprtfxu) = hrgfhqczro wqfvzevneg (blutmkezfk )
Positive
04 Mar 2025
wmrnhcvqfs(grtzprtfxu) = snbjswakhr wqfvzevneg (blutmkezfk, 0.44 - 4.70)
Not Applicable
Atrial Fibrillation
renal impairment | creatinine clearance | estimated glomerular filtration rate
888
vcktpctpws(hdtluarsvo) = urthnwuxar fqjopumlzt (xoaarntclg )
Positive
01 Jan 2025
Not Applicable
-
Prophylactic dose apixaban (2.5 mg twice daily)
rkdoaefhib(xwvkovsfha) = cjsaugoecr daxguzjzsg (sfeygpefof, 6.4 - 12.6)
-
08 Dec 2024
Therapeutic dose apixaban (5 mg twice daily)
rkdoaefhib(xwvkovsfha) = gdgmqjjaoy daxguzjzsg (sfeygpefof, 14.8 - 19.8)
Phase 4
493
mknsbjtjye(zpyxvndnlb) = wlcgltcfnw skzupiigpz (xocfifkagt, 0.55 - 1.11)
Positive
02 Sep 2024
mknsbjtjye(zpyxvndnlb) = qfzoexhixa skzupiigpz (xocfifkagt, 0.55 - 1.11)
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